Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan

Diabetes

Volumn 50, Issue 2, 2001, Pages 340-347

  Chan, Sue L F ^a   Mourtada, Mirna ^b   Morgan, Noel G ^b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b KEELE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE ACTIVATOR; CALCIUM CHANNEL; CYCLIC AMP; EFAROXAN; FORSKOLIN; GLUCOSE; IMIDAZOLE DERIVATIVE; IMIDAZOLINE DERIVATIVE; ISOBUTYLMETHYLXANTHINE; KU 14R; PHOSPHODIESTERASE INHIBITOR; POTASSIUM CHANNEL; POTASSIUM CHLORIDE; REAGENT; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; BENZOFURAN DERIVATIVE; BUCLADESINE; DIAZOXIDE; INSULIN;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CHANNEL GATING; DRUG ACTIVITY; DRUG EFFECT; ELECTROPORATION; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; ANIMAL; DRUG POTENTIATION; IN VITRO STUDY; METABOLISM; PANCREAS ISLET; PERMEABILITY; PHYSIOLOGY; SECRETION; WISTAR RAT;

1-METHYL-3-ISOBUTYLXANTHINE; ADENOSINE TRIPHOSPHATE; ANIMALS; BENZOFURANS; BUCLADESINE; CYCLIC AMP; DIAZOXIDE; GLUCOSE; IMIDAZOLES; INSULIN; ISLETS OF LANGERHANS; MALE; PERMEABILITY; PHOSPHODIESTERASE INHIBITORS; POTASSIUM CHANNELS; RATS; RATS, WISTAR;

EID: 0034746438     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.2.340     Document Type: Article

References (41)

1. Stimulation of insulin secretion by efaroxan may involve interaction with potassium channels
2. Imidazolines and pancreatic hormone secretion
3. 2-adrenoceptor antagonist efaroxan in relation to plasma glucose and insulin levels in the rat
4. Effects of imidazolines and derivatives on insulin secretion and vascular resistance in perfused rat pancreas
5. ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 β-cell line
6. Phentolamine, a deceptive tool to investigate sympathetic nervous control of insulin release
7. No evidence for PKC activation in stimulation of insulin secretion by phentolamine
8. Heterogeneous characteristics of imidazoline-induced insulin secretion
9. Imidazoline compounds stimulate insulin release by inhibition of KATP channels and interaction with the exocytotic machinery
10. Signaling and sites of interaction for RX871024 and sulfonylurea in the stimulation of insulin release
11. Secretory, biosynthetic and cationic responses to 2-(N-phenyl-inndoyl)imidazoline in rat pancreatic islets
12. Effector systems involved in the insulin secretory responses to efaroxan and RX871024 in rat islets of Langerhans
13. Multiple effector mechanisms regulate the insulin secretory response to the imidazoline RX871024 in isolated rat pancreatic islets
14. ATP channels in insulin secreting cells
15. + channels in mouse pancreatic β-cells
16. + channels in pancreatic β-cells
17. + channels and insulinotrophic action by the antiarrhythmic agent, cibenzoline
18. ATP channels is mediated by Kir6.2
19. ATP channels by binding to Kir6.2
20. Affinity isolation of imidazoline binding proteins from rat brain using 5-amino-efaroxan as ligand
21. 2-adrenoceptor antagonist efaroxan involves a novel, stereoselective, binding site
22. The putative endogenous imidazoline receptor ligand, clonidine-displacing substance, is a potent insulin secretagogue in rat and human islets of Langerhans
23. Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release
24. Drug-induced desensitisation of insulinotropic actions of sulphonylureas
25. Characteristics of desensitization of insulin secretion in fully in vitro systems
26. Phosphoinositide hydrolysis and insulin secretion in response to glucose are impaired in isolated rat islets by prolonged exposure to the sulfonylurea tolbutamide
27. Glyburide and tolbutamide induce desensitisation of insulin release in rat pancreatic islets by different mechanisms
28. Seeing through a glass darkly: Casting light on the imidazoline "I" sites
29. Characterisation of new efaroxan derivatives for use in purification of inudazoline binding sites
30. σ-receptor ligands and imidazoline secretagogues mediate their insulin secretory effects by activating distinct receptor systems in isolated islets
31. Maintenance of human normal cells in continuous culture: Preliminary report. Cultivation of mesoblastic tumors and normal cells and notes on methods of cultivation
32. Calculation and control of free divalent cations in solutions used for membrane fusion studies
33. 2+-induced exocytosis in mouse pancreatic B-cells
34. 2+-dependent exocytosis in pancreatic beta cells
35. Protein kinase A takes center stage in ATP-dependent insulin secretion
36. Insulin secretion and protein phosphorylation in PKC-depleted islets of Langerhans
37. Effect of the new imidazoline derivative S-22068 (PMS 847) on insulin secretion in vitro and glucose turnover in vivo in rats
38. Experimental benefit of moxonidine on glucose metabolism and insulin secretion in the fructose-fed rat
39. Exposure to glibenclamide increases rat beta cells sensitivity to glucose
40. Cellular origins of hexokinase in pancreatic islets
41. Porin proteins in mitochondria from rat pancreatic islet cells and white adipocytes: Identification and regulation of hexokinase binding by the sulfonylurea glimepiride