Kynurenine 3-monooxygenase from Pseudomonas fluorescens: Substrate-like inhibitors both stimulate flavin reduction and stabilize the flavin-peroxo intermediate yet result in the production of hydrogen peroxide

Biochemistry

Volumn 47, Issue 47, 2008, Pages 12420-12433

  Crozier Reabe, Karen R ^b   Phillips, Robert S ^a   Moran, Graham R ^b  

^a UNIVERSITY OF GEORGIA   (United States)

^b UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ENZYMES; HYDROGEN; HYDROGEN PEROXIDE; OXIDATION; RATE CONSTANTS;

A STABLES; ABSORBANCE DATUMS; ABSORPTION BANDS; DIOXYGEN; FLAVIN COFACTOR; HYDROXYLASE; MONOOXYGENASE; NEUROLOGICAL DISORDERS; OXIDIZED ENZYMES; PRODUCT RELEASES; PRODUCTION OF HYDROGENS; PSEUDOMONAS FLUORESCENS; RATE OF REDUCTIONS; REDUCTION POTENTIALS; SPECTRAL CHANGES; TRYPTOPHAN CATABOLISMS;

HYDROGEN PRODUCTION;

3 NITROBENZOYLALANINE; BENZOYLALANINE; DECAY ACCELERATING FACTOR; HYDROGEN PEROXIDE; KYNURENINE; KYNURENINE 3 MONOOXYGENASE; LIGAND; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXYGEN; OXYGENASE INHIBITOR; QUERCETIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ABSORPTION; ADDITION REACTION; ARTICLE; DRUG STRUCTURE; ENZYME METABOLISM; ENZYME STABILITY; ENZYME SUBSTRATE; HYDROXYLATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PSEUDOMONAS FLUORESCENS; REDUCTION KINETICS; SPECTRUM; STIMULATION; STOICHIOMETRY;

ENZYME INHIBITORS; FLAVINS; HYDROGEN PEROXIDE; KINETICS; KYNURENINE; KYNURENINE 3-MONOOXYGENASE; LIGANDS; OXIDATION-REDUCTION; PSEUDOMONAS FLUORESCENS; SODIUM CHLORIDE;

PSEUDOMONAS FLUORESCENS;

EID: 56749122099     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi8010434     Document Type: Article

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