|
|
Volumn 9, Issue 11, 2001, Pages 3013-3021
|
|
Synthesis and phosphodiesterase inhibitory activity of new sildenafil analogues containing a carboxylic acid group in the 5′-sulfonamide moiety of a phenyl ring
a
|
|
Author keywords
[No Author keywords available]
|
|
Indexed keywords
5 [5 (4 HYDROXYCARBONYLETHYL)PIPERIDINYLSULFONYL] 2 PROPOXYPHENYL] 1 METHYL 3 PROPYL 1,6 DIHYDRO 7H PYRAZOLO[4,3 D]PYRIMIDIN 7 ONE;
PHOSPHODIESTERASE;
PHOSPHODIESTERASE INHIBITOR;
SILDENAFIL;
SILDENAFIL DERIVATIVE;
UNCLASSIFIED DRUG;
CARBOXYLIC ACID;
CYCLIC GMP;
ISOENZYME;
PHENYL GROUP;
PROPIONIC ACID DERIVATIVE;
SULFONAMIDE;
ARTICLE;
CATTLE;
DRUG DESIGN;
DRUG STRUCTURE;
DRUG SYNTHESIS;
ENZYME INHIBITION;
IC 50;
IN VITRO STUDY;
NONHUMAN;
NUCLEAR MAGNETIC RESONANCE;
RABBIT;
RETINA;
STRUCTURE ACTIVITY RELATION;
THROMBOCYTE;
DRUG ACTIVITY;
DRUG POTENCY;
DRUG SELECTIVITY;
ENZYME ASSAY;
3',5'-CYCLIC-GMP PHOSPHODIESTERASE;
ANIMALS;
CARBOXYLIC ACIDS;
CATTLE;
DRUG EVALUATION, PRECLINICAL;
HUMANS;
IMPOTENCE;
INHIBITORY CONCENTRATION 50;
ISOENZYMES;
MALE;
PHOSPHODIESTERASE INHIBITORS;
PHOSPHORIC DIESTER HYDROLASES;
PIPERAZINES;
RABBITS;
STRUCTURE-ACTIVITY RELATIONSHIP;
SULFONAMIDES;
|
|
EID: 0034812246
PISSN: 09680896
EISSN: None
Source Type: Journal
DOI: 10.1016/S0968-0896(01)00200-0 Document Type: Article |
|
Times cited : (53)
|
|
References (21)
|
