메뉴 건너뛰기




Volumn , Issue , 2004, Pages 691-704

The Role of MAO-B Inhibitors in the Treatment of Parkinson’s Disease

Author keywords

[No Author keywords available]

Indexed keywords


EID: 56749085287     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/9780203508596-64     Document Type: Chapter
Times cited : (3)

References (109)
  • 1
    • 84996074735 scopus 로고
    • The pharmacology of selegiline ((-)deprenyl), New aspects
    • Knoll, J., The pharmacology of selegiline ((-)deprenyl), New aspects, Acta Neurol. Scand., Suppl., 126:83–91, 1989.
    • (1989) Acta Neurol. Scand., Suppl , vol.126 , pp. 83-91
    • Knoll, J.1
  • 2
    • 9044227267 scopus 로고
    • Comparison of therapeutic effects and mor-tality data of levodopa and levodopa combined with selegiline in patients with early, mild Parkinson’s dis-ease. Parkinson’s Disease Research Group of the United Kingdom
    • Lees, A. J., Comparison of therapeutic effects and mor-tality data of levodopa and levodopa combined with selegiline in patients with early, mild Parkinson’s dis-ease. Parkinson’s Disease Research Group of the United Kingdom, B. M. J., 311(7020):1602–7, Dec. 16, 1995.
    • (1995) B. M. J , vol.311 , Issue.7020 , pp. 1602-1607
    • Lees, A.J.1
  • 3
    • 0020997395 scopus 로고
    • Deprenyl (selegiline): The history of its devel-opment and pharmacological action
    • Knoll, J., Deprenyl (selegiline): The history of its devel-opment and pharmacological action, Acta Neurol. Scand., Suppl., 95:57–80, 1983.
    • (1983) Acta Neurol. Scand., Suppl , vol.95 , pp. 57-80
    • Knoll, J.1
  • 4
    • 0000960697 scopus 로고
    • Influence of isonicotinic acid hydrazide (INH) and 1-isonicotinic-2isopropyl hydrazide (IIH) on bacterial and mammalian enzymes
    • Zeller, E. A., Barsky, J., Fouts, J. E., Kirchheimer, W. F., Van Orden, I. S., Influence of isonicotinic acid hydrazide (INH) and 1-isonicotinic-2isopropyl hydrazide (IIH) on bacterial and mammalian enzymes, Experientia., 8:349–350, 1952.
    • (1952) Experientia , vol.8 , pp. 349-350
    • Zeller, E.A.1    Barsky, J.2    Fouts, J.E.3    Kirchheimer, W.F.4    Van Orden, I.S.5
  • 5
    • 0001137465 scopus 로고
    • Hypertensive crisis due to monoamine oxidase inhibitors
    • Blackwell, B., Hypertensive crisis due to monoamine oxidase inhibitors, Lancet, 11:849–851, 1963.
    • (1963) Lancet , vol.11 , pp. 849-851
    • Blackwell, B.1
  • 6
    • 84873775524 scopus 로고
    • Monoamine oxidase inhibitors, tyramine and cheese
    • Horwitz, D., Lovenberg, W., Engelmann, K., Sjoerdsma, A., Monoamine oxidase inhibitors, tyramine and cheese, JAMA, 188:1108–1110, 1964.
    • (1964) JAMA , vol.188 , pp. 1108-1110
    • Horwitz, D.1    Lovenberg, W.2    Engelmann, K.3    Sjoerdsma, A.4
  • 7
    • 76549174465 scopus 로고
    • Phenylisopropylmethylpropinylamine (E-250), a new spectrum psychic energizer
    • Knoll, J., Ecseri, Z., Kelemen, K., Nievel, J., Knoll, B., Phenylisopropylmethylpropinylamine (E-250), a new spectrum psychic energizer, Arch Int. Pharmacodyn. Ther., 155(1):154–64, May, 1965.
    • (1965) Arch Int. Pharmacodyn. Ther , vol.155 , Issue.1 , pp. 154-164
    • Knoll, J.1    Ecseri, Z.2    Kelemen, K.3    Nievel, J.4    Knoll, B.5
  • 8
    • 0014314486 scopus 로고
    • Some observations upon a new inhibitor of monoamine oxidase in brain tissue
    • Johnston, J. P., Some observations upon a new inhibitor of monoamine oxidase in brain tissue, Biochem. Phar-macol., 17(7):1285–97, July, 1968.
    • (1968) Biochem. Phar-Macol , vol.17 , Issue.7 , pp. 1285-1297
    • Johnston, J.P.1
  • 9
    • 0020689143 scopus 로고
    • Combination treatment with selective monoamine oxi-dase inhibitors and dopaminergic agonists in Parkin-son’s disease: Biochemical and clinical observations
    • Riederer, P., Jellinger, K., Danielczyk, W., Seemann, D., Ulm, G., Reynolds, G. P., Birkmayer, W., Koppel, H., Combination treatment with selective monoamine oxi-dase inhibitors and dopaminergic agonists in Parkin-son’s disease: Biochemical and clinical observations, Adv., Neurol., 37:159–76, 1983.
    • (1983) Adv., Neurol , vol.37 , pp. 159-176
    • Riederer, P.1    Jellinger, K.2    Danielczyk, W.3    Seemann, D.4    Ulm, G.5    Reynolds, G.P.6    Birkmayer, W.7    Koppel, H.8
  • 10
    • 34250928307 scopus 로고
    • Hornykiewicz, Verteilung von noradrenalin und dopamine (3-hydroxytyramin) im gehirn des men-schen und ihr verhalten bei erkrankungen des extrapy-ramidalen systems
    • Ehringer, H. Hornykiewicz, Verteilung von noradrenalin und dopamine (3-hydroxytyramin) im gehirn des men-schen und ihr verhalten bei erkrankungen des extrapy-ramidalen systems, Klin Wschr., 38:1236–1239, 1960.
    • (1960) Klin Wschr , vol.38 , pp. 1236-1239
    • Ehringer, H.1
  • 11
    • 0017858597 scopus 로고
    • Recent advances in research on Parkin-sonism
    • Rinne, U. K., Recent advances in research on Parkin-sonism, Acta Neurol. Scand., Suppl., 67:77–113, 1978.
    • (1978) Acta Neurol. Scand., Suppl , vol.67 , pp. 77-113
    • Rinne, U.K.1
  • 12
    • 0019185890 scopus 로고
    • L-deprenyl, a selective monoam-ine oxidase type-B inhibitor in endogenous depression
    • Mann, J., Gershon, S., L-deprenyl, a selective monoam-ine oxidase type-B inhibitor in endogenous depression, Life Sci., 17;26(11):877–82, March, 1980.
    • (1980) Life Sci., 17 , vol.26 , Issue.11 , pp. 877-882
    • Mann, J.1    Gershon, S.2
  • 13
    • 0017594522 scopus 로고
    • Dopamine is a monoamine oxidase B substrate in man
    • Glover, V., Sandler, M., Owen, F., Riley, G. J., Dopamine is a monoamine oxidase B substrate in man, Nature, 6;265(5589):80–1, January 6, 1977.
    • (1977) Nature , vol.265 , Issue.5589 , pp. 80-81
    • Glover, V.1    Sandler, M.2    Owen, F.3    Riley, G.J.4
  • 15
    • 84996051573 scopus 로고
    • Selegiline in the treat-ment of Parkinson’s disease
    • Heinonen, E. H., Rinne, U. K., Selegiline in the treat-ment of Parkinson’s disease, Acta Neurol. Scand., Suppl., 126:103–11, 1989.
    • (1989) Acta Neurol. Scand., Suppl , vol.126 , pp. 103-111
    • Heinonen, E.H.1    Rinne, U.K.2
  • 17
    • 0023808041 scopus 로고
    • Mechanis-tic positron emission tomography studies: Demonstra-tion of a deuterium isotope effect in the monoamine oxidase-catalyzed binding of [11C]L-deprenyl in living baboon brain
    • Fowler, J. S., Wolf, A. P., MacGregor, R. R., Dewey, S. L., Logan, J., Schlyer, D. J., Langstrom, B., Mechanis-tic positron emission tomography studies: Demonstra-tion of a deuterium isotope effect in the monoamine oxidase-catalyzed binding of [11C]L-deprenyl in living baboon brain, J. Neurochem., 51(5):1524–34, Novem-ber, 1988.
    • (1988) J. Neurochem , vol.51 , Issue.5 , pp. 1524-1534
    • Fowler, J.S.1    Wolf, A.P.2    Macgregor, R.R.3    Dewey, S.L.4    Logan, J.5    Schlyer, D.J.6    Langstrom, B.7
  • 19
    • 0017831619 scopus 로고
    • Monoamine oxidase activity during (–)-deprenil therapy: Human brain post-mortem studies
    • Riederer, P., Youdim, M. B., Birkmayer, W., Jellinger, K., Monoamine oxidase activity during (–)-deprenil therapy: Human brain post-mortem studies, Adv. Bio-chem. Psychopharmacol., 19:377–82, 1978.
    • (1978) Adv. Bio-Chem. Psychopharmacol , vol.19 , pp. 377-382
    • Riederer, P.1    Youdim, M.B.2    Birkmayer, W.3    Jellinger, K.4
  • 20
    • 0018840087 scopus 로고
    • Deprenyl is a selective inhibitor of brain MAO-B in the long-term treatment of Parkinsons’s disease
    • Reiderer, P., Reynolds, G. P., Deprenyl is a selective inhibitor of brain MAO-B in the long-term treatment of Parkinsons’s disease, Br. J. Clin. Pharmacol., Jan., 9(1): 98–9, 1980.
    • (1980) Br. J. Clin. Pharmacol., Jan , vol.9 , Issue.1 , pp. 98-99
    • Reiderer, P.1    Reynolds, G.P.2
  • 21
    • 0022496317 scopus 로고
    • Monoamine oxidase activ-ity and monoamine metabolism in brains of parkinso-nian patients treated with l-deprenyl
    • Riederer, P., Youdim, M. B., Monoamine oxidase activ-ity and monoamine metabolism in brains of parkinso-nian patients treated with l-deprenyl, J. Neurochem., 46(5):1359–65, May, 1986.
    • (1986) J. Neurochem , vol.46 , Issue.5 , pp. 1359-1365
    • Riederer, P.1    Youdim, M.B.2
  • 22
    • 0019243780 scopus 로고
    • Dopamine oxi-dation and its inhibition by (-)-deprenyl in man
    • Glover, V., Elsworth, J. D., Sandler, M., Dopamine oxi-dation and its inhibition by (-)-deprenyl in man, J. Neu-ral. Transm., Suppl., (16):163–72, 1980.
    • (1980) J. Neu-Ral. Transm., Suppl , Issue.16 , pp. 163-172
    • Glover, V.1    Elsworth, J.D.2    Sandler, M.3
  • 24
    • 0022638352 scopus 로고
    • Metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor in rat: Relationship of metabolism to MAO-B inhibitory potency
    • Yoshida, T., Yamada, Y., Yamamoto, T., Kuroiwa, Y., Metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor in rat: Relationship of metabolism to MAO-B inhibitory potency, Xenobiotica,16(2):129–36, February, 1986.
    • (1986) Xenobiotica , vol.16 , Issue.2 , pp. 129-136
    • Yoshida, T.1    Yamada, Y.2    Yamamoto, T.3    Kuroiwa, Y.4
  • 25
    • 0018380364 scopus 로고
    • Substrate and inhib-itor selectivity of human heart monoamine oxidase
    • Parkinson, D., Callingham, B. A., Substrate and inhib-itor selectivity of human heart monoamine oxidase, Bio-chem. Pharmacol., 15;28(10):1639–43, 1979.
    • (1979) Bio-Chem. Pharmacol , vol.28 , Issue.10 , pp. 1639-1643
    • Parkinson, D.1    Callingham, B.A.2
  • 26
    • 0023231210 scopus 로고
    • Effects of d-methamphetamine on monkey brain monoamine oxi-dase, in vivo and in vitro
    • Egashira, T., Yamamoto, T., Yamanaka, Y., Effects of d-methamphetamine on monkey brain monoamine oxi-dase, in vivo and in vitro, Jpn. J. Pharmacol., 45(1): 79–88, 1987.
    • (1987) Jpn. J. Pharmacol , vol.45 , Issue.1 , pp. 79-88
    • Egashira, T.1    Yamamoto, T.2    Yamanaka, Y.3
  • 27
    • 0022394212 scopus 로고
    • Deprenyl protects dopamine neurons from the neurotoxic effect of1-methyl-4-phe-nylpyridinium ion
    • Mytilineou, C., Cohen, G., Deprenyl protects dopamine neurons from the neurotoxic effect of1-methyl-4-phe-nylpyridinium ion, J. Neurochem., 45(6):1951–3, December 1985.
    • (1985) J. Neurochem , vol.45 , Issue.6 , pp. 1951-1953
    • Mytilineou, C.1    Cohen, G.2
  • 28
    • 0023651785 scopus 로고
    • Drug trial for Parkinson’s
    • Lewin, R., Drug trial for Parkinson’s, Science, 12;236 (4807):1420, June 12, 1987.
    • (1987) Science, 12 , vol.236 , Issue.4807 , pp. 1420
    • Lewin, R.1
  • 29
    • 0023794326 scopus 로고
    • Deprenyl antagonizes acute lethality of1-methyl-4-phe-nyl-1,2,3,6-tetrahydropyridine in mice
    • Fuller, R. W., Hemrick-Luecke, S. K., Perry, K. W., Deprenyl antagonizes acute lethality of1-methyl-4-phe-nyl-1,2,3,6-tetrahydropyridine in mice, J. Pharmacol. Exp. Ther., 247(2):531–5, 1988.
    • (1988) J. Pharmacol. Exp. Ther , vol.247 , Issue.2 , pp. 531-535
    • Fuller, R.W.1    Hemrick-Luecke, S.K.2    Perry, K.W.3
  • 31
    • 0020680904 scopus 로고
    • Chronic parkinsonism in humans due to a product of meperidine-analog synthesis
    • Langston, J. W., Ballard, P. A., Tetrud, J. W., Irwin, I., Chronic parkinsonism in humans due to a product of meperidine-analog synthesis, Science, 219:979–980, 1983.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.A.2    Tetrud, J.W.3    Irwin, I.4
  • 32
    • 0021276089 scopus 로고
    • Active uptake of MPP+ a metabolite of MPTP by brain synapto-somes
    • Chiba, K., Trevor, A., Castagnoli, N. Jr., Active uptake of MPP+ a metabolite of MPTP by brain synapto-somes, Biochem. Biophys. Res. Commun., 120: 574–578, 1984.
    • (1984) Biochem. Biophys. Res. Commun , vol.120 , pp. 574-578
    • Chiba, K.1    Trevor, A.2    Castagnoli, N.3
  • 33
    • 0021224694 scopus 로고
    • Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by monoamine oxidase inhibitors
    • Heikkila, R. E., Manzino, L., Cabbat, F. S., Duvoisin, R. C., Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by monoamine oxidase inhibitors, Nature, 311:467–469, 1984.
    • (1984) Nature , vol.311 , pp. 467-469
    • Heikkila, R.E.1    Manzino, L.2    Cabbat, F.S.3    Duvoisin, R.C.4
  • 34
    • 0030300166 scopus 로고    scopus 로고
    • Deprenyl in the treatment of Parkinson’s disease: Clinical effects and speculations on mechanism of action
    • Olanow, C. W., Deprenyl in the treatment of Parkinson’s disease: Clinical effects and speculations on mechanism of action, J. Neural. Transm., Suppl., 48:75–84, 1996.
    • (1996) J. Neural. Transm., Suppl , vol.48 , pp. 75-84
    • Olanow, C.W.1
  • 35
  • 36
    • 0014189254 scopus 로고
    • Clinical trial of a new type promptly acting psychoenergetic agent (phenyl-isopro-pyl-methylpropinyl-HCl, “E-250”)
    • Varga, E., Tringer, L., Clinical trial of a new type promptly acting psychoenergetic agent (phenyl-isopro-pyl-methylpropinyl-HCl, “E-250”), Acta Med. Acad. Sci. Hung., 23(3):289–95, 1967.
    • (1967) Acta Med. Acad. Sci. Hung , vol.23 , Issue.3 , pp. 289-295
    • Varga, E.1    Tringer, L.2
  • 38
    • 73049129373 scopus 로고
    • 3,4-dihydrox-yphenylalanin (DOPA) effect bei der Parkinsonakinese
    • Birkmayer, W., Hornykiewicz, O., Der L 3,4-dihydrox-yphenylalanin (DOPA) effect bei der Parkinsonakinese, Wien, Klin. Wochenschr., 73:787–788, 1961.
    • (1961) Wien, Klin. Wochenschr , vol.73 , pp. 787-788
    • Birkmayer, W.1    Hornykiewicz, O.2    Der, L.3
  • 39
    • 0013850801 scopus 로고
    • On the treatment of Par-kinson’s syndrome with monoamine oxidase inhibitors alone and in combination with L-dopa
    • Gerstenbrand, F., Prosenz, P., On the treatment of Par-kinson’s syndrome with monoamine oxidase inhibitors alone and in combination with L-dopa, Praxis, 18, 54(46):1373–7, November 18, 1965.
    • (1965) Praxis, 18 , vol.54 , Issue.46 , pp. 1373-1377
    • Gerstenbrand, F.1    Prosenz, P.2
  • 41
    • 0016414699 scopus 로고
    • The potentiation of the anti akinetic effect after L-dopa treatment by an inhibitor of MAO-B
    • Birkmayer, W., Riederer, P., Youdim, M. B., Linauer, W., The potentiation of the anti akinetic effect after L-dopa treatment by an inhibitor of MAO-B, Deprenil, J. Neural. Transm., 36(3-4):303–326, 1975.
    • (1975) Deprenil, J. Neural. Transm , vol.36 , Issue.3-4 , pp. 303-326
    • Birkmayer, W.1    Riederer, P.2    Youdim, M.B.3    Linauer, W.4
  • 42
    • 0017345412 scopus 로고
    • Implications of combined treatment with “Madopar” and L-deprenil in Parkinson’s disease. A long-term study
    • Birkmayer, W., Riederer, P., Ambrozi, L., Youdim, M. B., Implications of combined treatment with “Madopar” and L-deprenil in Parkinson’s disease. A long-term study, Lancet, 1(8009):439–43, February 26, 1977.
    • (1977) Lancet , vol.1 , Issue.8009 , pp. 439-443
    • Birkmayer, W.1    Riederer, P.2    Ambrozi, L.3    Youdim, M.B.4
  • 43
    • 0018159795 scopus 로고
    • Experi-ences with L-deprenyl in Parkinsonism
    • Csanda, E., Antal J., Antony, M., Csanaky, A., Experi-ences with L-deprenyl in Parkinsonism, J. Neural. Transm., 43(3–4):263–9, 1978.
    • (1978) J. Neural. Transm , vol.43 , Issue.3-4 , pp. 263-269
    • Csanda, E.1    Antal, J.2    Antony, M.3    Csanaky, A.4
  • 44
    • 0020987665 scopus 로고
    • Deprenyl (selegiline) in the treatment of Parkinson’s disease
    • Birkmayer, W., Deprenyl (selegiline) in the treatment of Parkinson’s disease, Acta Neurol. Scand., Suppl., 95:103–5, 1983.
    • (1983) Acta Neurol. Scand., Suppl , vol.95 , pp. 103-105
    • Birkmayer, W.1
  • 45
    • 84984117804 scopus 로고
    • Deprenyl (selegiline) in the treatment of Parkinson’s disease
    • Rinne, U. K., Deprenyl (selegiline) in the treatment of Parkinson’s disease, Acta Neurol. Scand., Suppl., 95:107–11, 1983.
    • (1983) Acta Neurol. Scand., Suppl , vol.95 , pp. 107-111
    • Rinne, U.K.1
  • 46
    • 84984095450 scopus 로고
    • Deprenyl (selegiline) in combination treatment of Parkinson’s dis-ease
    • Gerstenbrand, F., Ransmayr, G., Poewe, W., Deprenyl (selegiline) in combination treatment of Parkinson’s dis-ease, Acta Neurol. Scand., Suppl., 95:123–6, 1983.
    • (1983) Acta Neurol. Scand., Suppl , vol.95 , pp. 123-126
    • Gerstenbrand, F.1    Ransmayr, G.2    Poewe, W.3
  • 48
    • 0018071280 scopus 로고
    • Recent observa-tions on the clinical pharmacology of (-) deprenyl
    • Stern, G. M., Lees, A. J., Sandler, M., Recent observa-tions on the clinical pharmacology of (-) deprenyl, J. Neural. Transm., 43(3–4):245–51, 1978.
    • (1978) J. Neural. Transm , vol.43 , Issue.3-4 , pp. 245-251
    • Stern, G.M.1    Lees, A.J.2    Sandler, M.3
  • 49
    • 0019124920 scopus 로고
    • Deprenyl in the management of response fluc-tuations in patients with Parkinson’s disease on levodopa
    • Schachter, M., Marsden, C. D., Parkes, J. D., Jenner, P., Testa, B., Deprenyl in the management of response fluc-tuations in patients with Parkinson’s disease on levodopa, J. Neurol. Neurosurg. Psychiatry, 43(11): 1016–21, 1980.
    • (1980) J. Neurol. Neurosurg. Psychiatry , vol.43 , Issue.11 , pp. 1016-1021
    • Schachter, M.1    Marsden, C.D.2    Parkes, J.D.3    Jenner, P.4    Testa, B.5
  • 50
    • 0018908950 scopus 로고
    • The “on-off” phenomena in Parkinson’s disease—treatment and theoretical considerations
    • Goldstein, L., The “on-off” phenomena in Parkinson’s disease—treatment and theoretical considerations, Mt. Sinai J. Med., 47(1):80–4, 1980.
    • (1980) Mt. Sinai J. Med , vol.47 , Issue.1 , pp. 80-84
    • Goldstein, L.1
  • 52
    • 0021004847 scopus 로고
    • Deprenyl (selegiline) combined with levodopa and a decarboxylase inhibitor in the treat-ment of Parkinson’s disease
    • Presthus, J., Hajba, A., Deprenyl (selegiline) combined with levodopa and a decarboxylase inhibitor in the treat-ment of Parkinson’s disease, Acta Neurol. Scand., Suppl., 95:127–33, 1983.
    • (1983) Acta Neurol. Scand., Suppl , vol.95 , pp. 127-133
    • Presthus, J.1    Hajba, A.2
  • 53
    • 0021852048 scopus 로고
    • The effect of L-Deprenyl on on-off phenomena in Par-kinson’s disease
    • Brodersen, P., Philbert, A., Gulliksen, G., Stigard, A., The effect of L-Deprenyl on on-off phenomena in Par-kinson’s disease, Acta Neurol. Scand., 71(6):494–7, 1985.
    • (1985) Acta Neurol. Scand , vol.71 , Issue.6 , pp. 494-497
    • Brodersen, P.1    Philbert, A.2    Gulliksen, G.3    Stigard, A.4
  • 54
    • 0023506732 scopus 로고
    • Therapeutic efficacy of R-(-)-deprenyl as adjuvant therapy in advanced parkinsonism
    • Fischer, P. A., Baas, H., Therapeutic efficacy of R-(-)-deprenyl as adjuvant therapy in advanced parkinsonism, J. Neural. Transm., Suppl., 25:137–47, 1987.
    • (1987) J. Neural. Transm., Suppl , vol.25 , pp. 137-147
    • Fischer, P.A.1    Baas, H.2
  • 55
    • 0023462451 scopus 로고
    • Double-blind trial of R-(-)-deprenyl for the “on-off” effect complicating Par-kinson’s disease
    • Golbe, L. I., Duvoisin, R. C., Double-blind trial of R-(-)-deprenyl for the “on-off” effect complicating Par-kinson’s disease, J. Neural. Transm., Suppl., 25:123–9, 1987.
    • (1987) J. Neural. Transm., Suppl , vol.25 , pp. 123-129
    • Golbe, L.I.1    Duvoisin, R.C.2
  • 56
    • 0023507276 scopus 로고
    • Deprenyl versus placebo in Parkinson dis-ease: A double-blind study
    • Lieberman, A. N., Gopinathan, G., Neophytides, A., Foo, S. H., Deprenyl versus placebo in Parkinson dis-ease: A double-blind study, N. Y. State J. Med., 87(12): 646–9, 1987.
    • (1987) N. Y. State J. Med , vol.87 , Issue.12 , pp. 646-649
    • Lieberman, A.N.1    Gopinathan, G.2    Neophytides, A.3    Foo, S.H.4
  • 57
    • 0023788954 scopus 로고
    • Two weeks of treatment with deprenyl (selegiline) does not prolong L-dopa effect in Parkinsonian patients: A double-blind cross-over placebo-controlled trial
    • Rascol, O., Montastruc, J. L., Senard, J. M., Demonet, J. F., Simonetta, M., Rascol, A., Two weeks of treatment with deprenyl (selegiline) does not prolong L-dopa effect in Parkinsonian patients: A double-blind cross-over placebo-controlled trial, Neurology, 38(9): 1387–91, 1988.
    • (1988) Neurology , vol.38 , Issue.9 , pp. 1387-1391
    • Rascol, O.1    Montastruc, J.L.2    Senard, J.M.3    Demonet, J.F.4    Simonetta, M.5    Rascol, A.6
  • 58
    • 84996123514 scopus 로고
    • Selegiline in the treatment of daily fluctuations in disability of parkinsonian patients with long-term levodopa treat-ment
    • Heinonen, E. H., Rinne, U. K., Tuominen, J., Selegiline in the treatment of daily fluctuations in disability of parkinsonian patients with long-term levodopa treat-ment, Acta Neurol. Scand., Suppl., 126:113–8, 1989.
    • (1989) Acta Neurol. Scand., Suppl , vol.126 , pp. 113-118
    • Heinonen, E.H.1    Rinne, U.K.2    Tuominen, J.3
  • 59
    • 84996113682 scopus 로고
    • Double-blind, crossover placebo controlled trial of selegiline in Parkinson’s dis-ease—an interim analysis
    • Teychenne, P. F., Parker, S., Double-blind, crossover placebo controlled trial of selegiline in Parkinson’s dis-ease—an interim analysis, Acta Neurol. Scand., Suppl., 126:119–25, 1989.
    • (1989) Acta Neurol. Scand., Suppl , vol.126 , pp. 119-125
    • Teychenne, P.F.1    Parker, S.2
  • 60
    • 84996059578 scopus 로고
    • Selegiline and levodopa in early or moderately advanced Parkinson’s disease: A double-blind controlled short-and long-term study
    • Sivertsen, B., Dupont, E., Mikkelsen, B., Mogensen, P., Rasmussen, C., Boesen, F., Heinonen, E., Selegiline and levodopa in early or moderately advanced Parkinson’s disease: A double-blind controlled short-and long-term study, Acta Neurol. Scand., Suppl., 126:147–52, 1989.
    • (1989) Acta Neurol. Scand., Suppl , vol.126 , pp. 147-152
    • Sivertsen, B.1    Dupont, E.2    Mikkelsen, B.3    Mogensen, P.4    Rasmussen, C.5    Boesen, F.6    Heinonen, E.7
  • 61
    • 84996094637 scopus 로고
    • Combination of selegiline and controlled release levodopa in the treatment of fluctuations of clin-ical disability in parkinsonian patients
    • C. D., Chouza, C., Aljanati, R., Scaramelli, A., De Medina, O., Caamano, J. L., Buzo, R., Fernandez, A., Romero, S., Combination of selegiline and controlled release levodopa in the treatment of fluctuations of clin-ical disability in parkinsonian patients, Acta Neurol. Scand., Suppl., 126:127–37, 1989.
    • (1989) Acta Neurol. Scand., Suppl , vol.126 , pp. 127-137
    • Chouza, C.1    Aljanati, R.2    Scaramelli, A.3    De Medina, O.4    Caamano, J.L.5    Buzo, R.6    Fernandez, A.7    Romero, S.8
  • 62
    • 0023784118 scopus 로고
    • Deprenyl as symptomatic therapy in Par-kinson’s disease
    • Golbe, L. I., Deprenyl as symptomatic therapy in Par-kinson’s disease, Clin. Neuropharmacol., 11(5): 387–400, 1988.
    • (1988) Clin. Neuropharmacol , vol.11 , Issue.5 , pp. 387-400
    • Golbe, L.I.1
  • 63
    • 0024456653 scopus 로고
    • Effect of deprenyl on the progression of disability in early Parkinson’s disease
    • The Parkinson Study Group, Effect of deprenyl on the progression of disability in early Parkinson’s disease, N. Engl. J. Med., 321(20):1364–71, November 16, 1989.
    • (1989) N. Engl. J. Med , vol.321 , Issue.20 , pp. 1364-1371
  • 64
    • 0024457355 scopus 로고
    • DATATOP: A multicenter con-trolled clinical trial in early Parkinson’s disease
    • Parkinson Study Group, DATATOP: A multicenter con-trolled clinical trial in early Parkinson’s disease, Arch Neurol., 46(10):1052–60, 1989.
    • (1989) Arch Neurol , vol.46 , Issue.10 , pp. 1052-1060
  • 65
    • 0024343466 scopus 로고
    • The effect of deprenyl (selegiline) on the natural history of Parkinson’s disease
    • Tetrud, J. W., Langston, J. W., The effect of deprenyl (selegiline) on the natural history of Parkinson’s disease, Science, 245(4917):519–22, August 4, 1989.
    • (1989) Science , vol.245 , Issue.4917 , pp. 519-522
    • Tetrud, J.W.1    Langston, J.W.2
  • 67
    • 0026596575 scopus 로고
    • Selegiline as initial treatment in de novo parkinsonian patients
    • Myllyla, V. V., Sotaniemi, K. A., Vuorinen, J. A., Hei-nonen, E. H., Selegiline as initial treatment in de novo parkinsonian patients, Neurology, 42(2):339–43, 1992.
    • (1992) Neurology , vol.42 , Issue.2 , pp. 339-343
    • Myllyla, V.V.1    Sotaniemi, K.A.2    Vuorinen, J.A.3    Hei-Nonen, E.H.4
  • 69
    • 0026308237 scopus 로고
    • Deprenyl’s effect at slowing progression of parkinsonian disability: The DATATOP study. The Parkinson Study Group
    • LeWitt, P. A., Deprenyl’s effect at slowing progression of parkinsonian disability: The DATATOP study. The Parkinson Study Group, Acta Neurol. Scand., Suppl., 136:79–86, 1991.
    • (1991) Acta Neurol. Scand., Suppl , vol.136 , pp. 79-86
    • Lewitt, P.A.1
  • 70
    • 0026660604 scopus 로고
    • An interim report of the effect of selegiline (L-deprenyl) on the progression of disability in early Parkinson’s disease
    • Shoulson, I., An interim report of the effect of selegiline (L-deprenyl) on the progression of disability in early Parkinson’s disease, The Parkinson Study Group, Eur. Neurol., 32 Suppl. 1:46–53, 1992.
    • (1992) The Parkinson Study Group, Eur. Neurol , vol.32 , pp. 46-53
    • Shoulson, I.1
  • 71
    • 0026469784 scopus 로고
    • The antiparkinson efficacy of deprenyl derives from transient improvement that is likely to be symptomatic
    • Schulzer, M., Mak, E., Calne, D. B., The antiparkinson efficacy of deprenyl derives from transient improvement that is likely to be symptomatic, Ann. Neurol., 32(6):795–8, 1992.
    • (1992) Ann. Neurol , vol.32 , Issue.6 , pp. 795-798
    • Schulzer, M.1    Mak, E.2    Calne, D.B.3
  • 72
    • 0028897256 scopus 로고    scopus 로고
    • Comparative study of sele-giline plus L-dopa-carbidopa versus L-dopa-carbidopa alone in the treatment of Parkinson’s disease
    • Brannan, T., Yahr, M. D., Comparative study of sele-giline plus L-dopa-carbidopa versus L-dopa-carbidopa alone in the treatment of Parkinson’s disease, Ann. Neu-rol., 37(1):95–8, January, 1995.
    • Ann. Neu-Rol , vol.37 , Issue.1 , pp. 95-98
    • Brannan, T.1    Yahr, M.D.2
  • 73
    • 0031946558 scopus 로고    scopus 로고
    • Current sta-tus of selegiline as a neuroprotective agent in Parkin-son’s disease
    • Olanow, C. W., Mytilineou, C., Tatton, W., Current sta-tus of selegiline as a neuroprotective agent in Parkin-son’s disease, Mov. Disord., 13 Suppl., 1:55–8, 1998.
    • (1998) Mov. Disord , vol.13 , pp. 55-58
    • Olanow, C.W.1    Mytilineou, C.2    Tatton, W.3
  • 75
    • 0036231440 scopus 로고    scopus 로고
    • Impact of sustained deprenyl (selegiline) in levodopa-treated Parkinson’s disease: A randomized placebo-controlled extension of the deprenyl and tocopherol antioxidative therapy of parkinsonism trial
    • Shoulson, I., Oakes, D., Fahn, S., Lang, A., Langston, J. W., LeWitt, P., Olanow, C. W., Penney, J. B., Tanner, C., Kieburtz, K., Rudolph, A., Impact of sustained deprenyl (selegiline) in levodopa-treated Parkinson’s disease: A randomized placebo-controlled extension of the deprenyl and tocopherol antioxidative therapy of parkinsonism trial, Ann. Neurol., 51(5):604–12, 2002.
    • (2002) Ann. Neurol , vol.51 , Issue.5 , pp. 604-612
    • Shoulson, I.1    Oakes, D.2    Fahn, S.3    Lang, A.4    Langston, J.W.5    Lewitt, P.6    Olanow, C.W.7    Penney, J.B.8    Tanner, C.9    Kieburtz, K.10    Rudolph, A.11
  • 77
    • 9044227267 scopus 로고
    • Comparison of therapeutic effects and mor-tality data of levodopa and levodopa combined with selegiline in patients with early, mild Parkinson’s dis-ease
    • Lees, A. J., Comparison of therapeutic effects and mor-tality data of levodopa and levodopa combined with selegiline in patients with early, mild Parkinson’s dis-ease, Parkinson’s Disease Research Group of the United Kingdom, B. M. J., 16;311(7020):1602–7, 1995.
    • (1995) Parkinson’s Disease Research Group of the United Kingdom, B. M. J , vol.311 , Issue.7020 , pp. 1602-1607
    • Lees, A.J.1
  • 79
    • 0031045492 scopus 로고    scopus 로고
    • Selegiline and mortality in Parkinson’s disease: Another view
    • Lees, A. J., Head, J., Shlomo, Y. B., Selegiline and mortality in Parkinson’s disease: Another view, Ann. Neurol., 41(2):282–3, 1997.
    • (1997) Ann. Neurol , vol.41 , Issue.2 , pp. 282-283
    • Lees, A.J.1    Head, J.2    Shlomo, Y.B.3
  • 80
    • 0031893241 scopus 로고    scopus 로고
    • Mortality in DATATOP: A mul-ticenter trial in early Parkinson’s disease
    • Parkinson Study Group, Mortality in DATATOP: A mul-ticenter trial in early Parkinson’s disease, Ann. Neurol., 43(3):318–25, 1998.
    • (1998) Ann. Neurol , vol.43 , Issue.3 , pp. 318-325
  • 81
    • 0030815245 scopus 로고    scopus 로고
    • Selegiline and excess mortality
    • Oakes, D., Selegiline and excess mortality, Clin. Neu-ropharmacol., 20(6):542, 1997.
    • (1997) Clin. Neu-Ropharmacol , vol.20 , Issue.6 , pp. 542
    • Oakes, D.1
  • 82
    • 0032542955 scopus 로고    scopus 로고
    • Investigation by Parkinson’s Disease Research Group of United King-dom into excess mortality seen with combined levodopa and selegiline treatment in patients with early, mild Par-kinson’s disease: Further results of randomized trial and confidential inquiry
    • Ben-Shlomo, Y., Churchyard, A., Head, J., Hurwitz, B., Overstall, P., Ockelford, J., Lees, A. J., Investigation by Parkinson’s Disease Research Group of United King-dom into excess mortality seen with combined levodopa and selegiline treatment in patients with early, mild Par-kinson’s disease: Further results of randomized trial and confidential inquiry, B. M. J.;316(7139):1191–6, 1998
    • (1998) B. M. J , vol.316 , Issue.7139 , pp. 1191-1196
    • Ben-Shlomo, Y.1    Churchyard, A.2    Head, J.3    Hurwitz, B.4    Overstall, P.5    Ockelford, J.6    Lees, A.J.7
  • 83
    • 0034719031 scopus 로고    scopus 로고
    • Selegiline and mortality in sub-jects with Parkinson’s disease: A longitudinal commu-nity study
    • Donnan, P. T., Steinke, D. T., Stubbings, C., Davey, P. G., MacDonald, T. M., Selegiline and mortality in sub-jects with Parkinson’s disease: A longitudinal commu-nity study, Neurology, 55(12):1785–9, December 26, 2000.
    • (2000) Neurology , vol.55 , Issue.12 , pp. 1785-1789
    • Donnan, P.T.1    Steinke, D.T.2    Stubbings, C.3    Davey, P.G.4    Macdonald, T.M.5
  • 84
    • 0035856448 scopus 로고    scopus 로고
    • Ten-year follow-up of three different initial treat-ments in de-novo PD: A randomized trial
    • Lees, A. J., Katzenschlager, R., Head, J., Ben-Shlomo, Y., Ten-year follow-up of three different initial treat-ments in de-novo PD: A randomized trial, Neurology, 13;57(9):1687–94, November, 2001.
    • (2001) Neurology , vol.57 , Issue.9 , pp. 1687-1694
    • Lees, A.J.1    Katzenschlager, R.2    Head, J.3    Ben-Shlomo, Y.4
  • 85
    • 0030956709 scopus 로고    scopus 로고
    • Selegiline as the primary treatment of Parkinson’s disease—a long-term double-blind study
    • Myllyl, V. V., Sotaniemi, K. A., Hakulinen, P., Maki-Ikol, O., Heinonen, E. H., Selegiline as the primary treatment of Parkinson’s disease—a long-term double-blind study, Acta Neurol. Scand., 95:211–218, 1997.
    • (1997) Acta Neurol. Scand , vol.95 , pp. 211-218
    • Myllyl, V.V.1    Sotaniemi, K.A.2    Hakulinen, P.3    Maki-Ikol, O.4    Heinonen, E.H.5
  • 87
    • 0036163534 scopus 로고    scopus 로고
    • The effect of selegiline in the treatment of people with Alzheimer’s disease: A meta-analysis of published tri-als
    • Wilcock, G. K., Birks, J., Whitehead, A., Evans, S. J., The effect of selegiline in the treatment of people with Alzheimer’s disease: A meta-analysis of published tri-als, Int. J. Geriatr. Psychiatry, 17(2):175–83, 2002.
    • (2002) Int. J. Geriatr. Psychiatry , vol.17 , Issue.2 , pp. 175-183
    • Wilcock, G.K.1    Birks, J.2    Whitehead, A.3    Evans, S.J.4
  • 89
    • 0036523716 scopus 로고    scopus 로고
    • Treatment of peri-odic limb movements in sleep with selegiline HCl
    • Grewal, M., Hawa, R., Shapiro, C., Treatment of peri-odic limb movements in sleep with selegiline HCl, Mov. Disord., 17(2):398–401, 2002.
    • (2002) Mov. Disord , vol.17 , Issue.2 , pp. 398-401
    • Grewal, M.1    Hawa, R.2    Shapiro, C.3
  • 90
    • 0036049808 scopus 로고    scopus 로고
    • Effects of selegiline (l-deprenyl) during smoking and short-term abstinence
    • Houtsmuller, E. J., Thornton, J. A., Stitzer, M. L., Effects of selegiline (l-deprenyl) during smoking and short-term abstinence, Psychopharmacology, (Berl.), 163(2): 213–20, 2002.
    • (2002) Psychopharmacology, (Berl.) , vol.163 , Issue.2 , pp. 213-220
    • Houtsmuller, E.J.1    Thornton, J.A.2    Stitzer, M.L.3
  • 91
    • 0036245077 scopus 로고    scopus 로고
    • Effects of selegiline on fronto-temporal dementia: A neuropsychological evaluation
    • Moretti, R., Torre, P., Antonello, R. M., Cazzato, G., Bava, A., Effects of selegiline on fronto-temporal dementia: A neuropsychological evaluation, Int. J. Geri-atr. Psychiatry, 17(4):391–2, 2002.
    • (2002) Int. J. Geri-Atr. Psychiatry , vol.17 , Issue.4 , pp. 391-392
    • Moretti, R.1    Torre, P.2    Antonello, R.M.3    Cazzato, G.4    Bava, A.5
  • 92
    • 0006117895 scopus 로고    scopus 로고
    • Therapeutic strategies in Parkinson’s dis-ease
    • Jankovic, J. J., Tolosa, E., Eds., 4th ed., Lippincott, Philadelphia, P. A
    • Jankovic, J. J., Therapeutic strategies in Parkinson’s dis-ease, in Jankovic, J. J., Tolosa, E., Eds., Parkinson’s disease and Movement Disorders, 4th ed., Lippincott, Philadelphia, P. A., 2002.
    • (2002) Parkinson’s Disease and Movement Disorders
    • Jankovic, J.J.1
  • 93
    • 8044223003 scopus 로고
    • Therapies to extend duration of levodopa action
    • Koller, W. C., Paulson, G., Eds., Marcel Dekker, New York
    • LeWitt, P., Therapies to extend duration of levodopa action, in Koller, W. C., Paulson, G., Eds., Therapy of Parkinson’s Disease, 2nd ed., Marcel Dekker, New York, 77–90, 1995.
    • (1995) Therapy of Parkinson’s Disease, 2Nd Ed , pp. 77-90
    • Lewitt, P.1
  • 94
    • 0034973443 scopus 로고    scopus 로고
    • An algorithm (decision tree) for the management of Parkinson’s dis-ease (2001): Treatment guidelines
    • Olanow, C. W., Watts, R. L., Koller, W. C., An algorithm (decision tree) for the management of Parkinson’s dis-ease (2001): Treatment guidelines, Neurology, 56(11 Suppl., 5):S1–S88, June, 2001.
    • (2001) Neurology , vol.56 , Issue.11 , pp. SS1-S88
    • Olanow, C.W.1    Watts, R.L.2    Koller, W.C.3
  • 95
    • 85160178206 scopus 로고    scopus 로고
    • Zydis selegiline reduces “off” time in Parkinson’s disease patients with motor fluctuations: A 3-month, randomized, placebo-controlled study (sub-mitted). 96
    • Waters, C. H., Sethi, K. D., Hauser, R. A., Molho, E., Bertoni, J. M., Zydis selegiline reduces “off” time in Parkinson’s disease patients with motor fluctuations: A 3-month, randomized, placebo-controlled study (sub-mitted). 96. Longer-term Zydis selegiline study.
    • Longer-Term Zydis Selegiline Study
    • Waters, C.H.1    Sethi, K.D.2    Hauser, R.A.3    Molho, E.4    Bertoni, J.M.5
  • 96
    • 0035130289 scopus 로고    scopus 로고
    • Rasa-giline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B
    • Youdim, M. B. H., Gross, A., Finberg, J. P. M., Rasa-giline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B, British Journal of Pharmacology, 132:500–506, 2001.
    • (2001) British Journal of Pharmacology , vol.132 , pp. 500-506
    • Youdim, M.B.H.1    Gross, A.2    Finberg, J.P.M.3
  • 97
    • 0031596710 scopus 로고    scopus 로고
    • Effects of N-propargyl-1-(R)aminoindan (rasagiline) in models of motor and cognition disorders
    • Speiser, Z., Levy, R., Cohen, S., Effects of N-propargyl-1-(R)aminoindan (rasagiline) in models of motor and cognition disorders, J. Neural. Transm., Suppl., 52:287–300, 1998.
    • (1998) J. Neural. Transm., Suppl , vol.52 , pp. 287-300
    • Speiser, Z.1    Levy, R.2    Cohen, S.3
  • 98
    • 0034519674 scopus 로고    scopus 로고
    • Rasagiline mesylate, a new mao-B inhibitor for the treatment of Parkinson’s disease: A double-blind study as adjunctive therapy to levodopa
    • Rabey, J. M., Huberman, S. M., Melamed, E., Korczyn, A., Giladi, N., Inzelberg, R., Djaldetti, R., Klein, C., Berecz, G., Rasagiline mesylate, a new mao-B inhibitor for the treatment of Parkinson’s disease: A double-blind study as adjunctive therapy to levodopa, Clinical Neu-ropharmacology, 23(6):324–330, 2000.
    • (2000) Clinical Neu-Ropharmacology , vol.23 , Issue.6 , pp. 324-330
    • Rabey, J.M.1    Huberman, S.M.2    Melamed, E.3    Korczyn, A.4    Giladi, N.5    Inzelberg, R.6    Djaldetti, R.7    Klein, C.8    Berecz, G.9
  • 99
    • 0037198060 scopus 로고    scopus 로고
    • Novel neuropro-tective anti-Alzheimer drugs with anti-depressant activ-ity derived from the anti-parkinson drug, rasagiline
    • Youdim, M. B. H. and Weinstock, M., Novel neuropro-tective anti-Alzheimer drugs with anti-depressant activ-ity derived from the anti-parkinson drug, rasagiline, Mech. Ageing Dev., 123(8):1081–6, April 30, 2002.
    • (2002) Mech. Ageing Dev , vol.123 , Issue.8 , pp. 1081-1086
    • Youdim, M.B.H.1    Weinstock, M.2
  • 100
    • 0034941767 scopus 로고    scopus 로고
    • The anti-parkinson drug rasagiline and its cholinesterase inhibitor derivatives exert neuroprotection unrelated to MAO inhibition in cell culture and in vivo
    • Youdim, M. B., Wadia, A., Tatton, W., Weinstock, M., The anti-parkinson drug rasagiline and its cholinesterase inhibitor derivatives exert neuroprotection unrelated to MAO inhibition in cell culture and in vivo, Ann. NY Acad. Sci., 939:450–8, June, 2001.
    • (2001) Ann. NY Acad. Sci , vol.939 , pp. 450-458
    • Youdim, M.B.1    Wadia, A.2    Tatton, W.3    Weinstock, M.4
  • 101
    • 0036677312 scopus 로고    scopus 로고
    • Mitochondrial permeability transition medi-ates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan
    • Akao, Y., Maruyama, W., Shimizu, S., Yi, H., Nakagawa, Y., Shamoto-Nagai, M., Youdim, M. B., Tsujimoto, Y., Naoi, M., Mitochondrial permeability transition medi-ates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan, J. Neuro-chem., 82(4):913–23, 2002.
    • (2002) J. Neuro-Chem , vol.82 , Issue.4 , pp. 913-923
    • Akao, Y.1    Maruyama, W.2    Shimizu, S.3    Yi, H.4    Nakagawa, Y.5    Shamoto-Nagai, M.6    Youdim, M.B.7    Tsujimoto, Y.8    Naoi, M.9
  • 102
    • 0037189081 scopus 로고    scopus 로고
    • An anti-parkinson’s disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic bcl-2 in human dopaminergic SH-SY5Y cells
    • Akao, Y., Maruyama, W., Yi, H., Shamoto-Nagai, M., Youdim, M. B., Naoi, M., An anti-parkinson’s disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic bcl-2 in human dopaminergic SH-SY5Y cells, Neurosci. Lett., 326(2):105–8, June 28, 2002.
    • (2002) Neurosci. Lett , vol.326 , Issue.2 , pp. 105-108
    • Akao, Y.1    Maruyama, W.2    Yi, H.3    Shamoto-Nagai, M.4    Youdim, M.B.5    Naoi, M.6
  • 103
    • 0034884148 scopus 로고    scopus 로고
    • Transfection-enforced Bcl-2 overexpres-sion and an anti-parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehydes-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl®salsolinol
    • Maruyama, W., Akao, Y., Youdim, M. B. H., Davis, B. A., Naoi, M., Transfection-enforced Bcl-2 overexpres-sion and an anti-parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehydes-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl®salsolinol, Journal of Neuro-chemistry, 78:727–735, 2001.
    • (2001) Journal of Neuro-Chemistry , vol.78 , pp. 727-735
    • Maruyama, W.1    Akao, Y.2    Youdim, M.B.H.3    Davis, B.A.4    Naoi, M.5
  • 104
    • 0034877461 scopus 로고    scopus 로고
    • Rasagiline and its (S) enantiomer increase survival and prevent stroke in salt-loaded stroke-prone spontaneously hypertensive rats
    • Eliash, S., Speiser, Z., Cohen, S., Rasagiline and its (S) enantiomer increase survival and prevent stroke in salt-loaded stroke-prone spontaneously hypertensive rats, J. Neural. Transm., 108(8–9):909–23, 2001.
    • (2001) J. Neural. Transm , vol.108 , Issue.8-9 , pp. 909-923
    • Eliash, S.1    Speiser, Z.2    Cohen, S.3
  • 106
    • 0036894795 scopus 로고    scopus 로고
    • A controlled trial of rasagiline in early Parkinson’s disease, The Tempo Study
    • Parkinson Study Group, A controlled trial of rasagiline in early Parkinson’s disease, The Tempo Study, Arch Neurol., 59:1937–1943, December, 2002.
    • (2002) Arch Neurol , vol.59 , pp. 1937-1943
  • 109
    • 85160152962 scopus 로고    scopus 로고
    • A controlled trial of rasagiline in Parkinson’s disease patients with levodopa-related motor fluctuations (Presto Study)
    • San Fran-cisco, CA, October, 19–22
    • Parkinson Study Group, A controlled trial of rasagiline in Parkinson’s disease patients with levodopa-related motor fluctuations (Presto Study), American Neurolog-ical Association 128th Annual Meeting and the 6th Annual Neurology Outcomes Symposium, San Fran-cisco, CA, October, 19–22, 2003.
    • (2003) American Neurolog-Ical Association 128Th Annual Meeting and the 6Th Annual Neurology Outcomes Symposium


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.