Urinary sucrose and fructose as biomarkers of sugar consumption: Comparison of normal weight and obese volunteers

International Journal of Obesity

Volumn 32, Issue 11, 2008, Pages 1736-1740

  Joosen, A M C P ^a   Kuhnle, G G C ^a   Runswick, S A ^a   Bingham, S A ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

Fructose; Obesity; Sucrose; Sugar consumption; Urine

Indexed keywords

BIOLOGICAL MARKER; FRUCTOSE; SUCROSE;

ADULT; AGED; ARTICLE; BODY MASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; FEMALE; HUMAN; MALE; OBESITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUGAR INTAKE; URINARY EXCRETION; URINE LEVEL;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BODY MASS INDEX; DIET; FEMALE; FOOD HABITS; FRUCTOSE; HUMANS; MALE; MIDDLE AGED; OBESITY; SUCROSE; SWEETENING AGENTS;

EID: 56549089038     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2008.145     Document Type: Article

References (20)

1. Tasevska N, Runswick SA, McTaggart A, Bingham SA. Urinary sucrose and fructose as biomarkers for sugar consumption. Cancer Epidemiol Biomarkers Prev 2005; 14: 1287-1294.
2. Bingham S, Luben R, Welch A, Tasevska N, Wareham N, Khaw KT. Epidemiologic assessment of sugars consumption using biomarkers: comparisons of obese and nonobese individuals in the European prospective investigation of cancer Norfolk. Cancer Epidemiol Biomarkers Prev 2007; 16: 1651-1654.
3. Deane N, Smith HW. Fate of inulin and sucrose in normal subjects as determined by a urine reinfusion technique. J Clin Invest 1955; 34: 681-684.
4. Xing J, Chen JD. Alterations of gastrointestinal motility in obesity. Obes Res 2004; 12: 1723-1732.
5. Wisen O, Johansson C. Gastrointestinal function in obesity: motility, secretion, and absorption following a liquid test meal. Metabolism 1992; 41: 390-395.
6. Brun P, Castagliuolo I, Leo VD, Buda A, Pinzani M, Palu G et al. Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 2007; 292: G518-G525.
7. Kiely JM, Noh JH, Svatek CL, Pitt HA, Swartz-Basile DA. Altered small intestinal absorptive enzyme activities in leptin-deficient obese mice: influence of bowel resection. J Pediatr Surg 2006; 41: 1243-1249.
8. Ferraris RP, Vinnakota RR. Intestinal nutrient transport in genetically obese mice. Am J Clin Nutr 1995; 62: 540-546.
9. Department of Health. Dietary Reference Values for Food, Energy and Nutrients for the United Kingdom (Report on Health and Social Subjects No. 41). HMSO: London, 1991.
10. Bingham SA, Williams R, Cole TJ, Price CP, Cummings JH. Reference values for analytes of 24-h urine collections known to be complete. Ann Clin Biochem 1988; 25 (Part 6): 610-619.
11. Bingham S, Cummings JH. The use of 4-aminobenzoic acid as a marker to validate the completeness of 24 h urine collections in man. Clin Sci (Lond) 1983; 64: 629-635.
12. Jakobsen J, Ovesen L, Fagt S, Pedersen AN. Para-aminobenzoic acid used as a marker for completeness of 24 h urine: assessment of control limits for a specific HPLC method. Eur J Clin Nutr 1997; 51: 514-519.
13. Kuhnle GGC, Joosen AMCP, Wood TR, Runswick SA, Griffin JL, Bingham SA. Detection and quantification of sucrose as dietary biomarker using gas chromatography and liquid chromatography with mass spectrometry. Rapid Commun Mass Spectrom 2008; 22: 1-4.
14. Johansson G, Bingham S, Vahter M. A method to compensate for incomplete 24-hour urine collections in nutritional epidemiology studies. Public Health Nutr 1999; 2: 587-591.
15. Luceri C, Caderni G, Lodovici M, Spagnesi MT, Monserrat C, Lancioni L et al. Urinary excretion of sucrose and fructose as a predictor of sucrose intake in dietary intervention studies. Cancer Epidemiol Biomarkers Prev 1996; 5: 167-171.
16. Nelson M, Black AE, Morris JA, Cole TJ. Between- and within-subject variation in nutrient intake from infancy to old age: estimating the number of days required to rank dietary intakes with desired precision. Am J Clin Nutr 1989; 50: 155-167.
17. Bingham SA. The dietary assessment of individuals: methods, accuracy, new techniques and recommendations. Nutr Abstr Rev 1987; 57: 705-742.
18. Khazaeinia T, Jamali F. A comparison of gastrointestinal permeability induced by diclofenac-phospholipid complex with diclofenac acid and its sodium salt. J Pharm Pharm Sci 2003; 6: 352-359.
19. Mankertz J, Schulzke JD. Altered permeability in inflammatory bowel disease: pathophysiology and clinical implications. Curr Opin Gastroenterol 2007; 23: 379-383.
20. Kawabata H, Meddings JB, Uchida Y, Matsuda K, Sasahara K, Nishioka M. Sucrose permeability as a means of detecting diseases of the upper digestive tract. J Gastroenterol Hepatol 1998; 13: 1002-1006.