Rapid cardiovascular effects of dexamethasone in rabbits with meconium-induced acute lung injury

Canadian Journal of Physiology and Pharmacology

Volumn 86, Issue 11, 2008, Pages 804-814

  Mokra, Daniela ^a   Tonhajzerova, Ingrid ^a   Mokry, Juraj ^a   Drgova, Anna ^a   Petraskova, Maria ^a   Calkovska, Andrea ^a   Javorka, Kamil ^a  

^a University Teaching Hospital in Martin   (Slovakia)

Author keywords

Blood pressure; Dexamethasone; Glucocorticoids; Heart rate; Heart rate variability; Meconium aspiration; Nongenomic effects

Indexed keywords

DEXAMETHASONE; DEXAMPHETAMINE; OXYGEN; SODIUM CHLORIDE;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; HEART ARRHYTHMIA; HEART RATE; HEART RATE VARIABILITY; MECONIUM ASPIRATION; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARRHYTHMIAS, CARDIAC; BLOOD PRESSURE; CHINCHILLA; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART RATE; HUMANS; INFANT, NEWBORN; MECONIUM ASPIRATION SYNDROME; RABBITS; RESPIRATORY FUNCTION TESTS; TRACHEA;

EID: 56449098194     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y08-086     Document Type: Article

References (35)

1. Brotman, D.J., Girod, J.P., Garcia, M.J., Patel, J.V., Gupta, M., Posch, A., et al. 2005. Effects of short-term glucocorticoids on cardiovascular biomarkers. J. Clin. Endocrinol. Metab. 90: 3202-3208. doi:10.1210/jc.2004-2379. PMID:15769980.
2. Buttgereit, F., and Scheffold, A. 2002. Rapid glucocorticoid effects on immune cells. Steroids, 67: 529-534. doi:10.1016/S0039-128X(01)00171-4. PMID:11960631.
3. Cleary, G.M., and Wiswell, T.E. 1998. Meconium-stained amniotic fluid and meconium aspiration syndrome: an update. Pediatr. Clin. North Am. 45: 511-529. doi:10.1016/S0031-3955(05)70025-0.
4. da Costa, D.E., Nair, A.K., Pai, M.G., and Al Khusaiby, S.M. 2001. Steroids in full term infants with respiratory failure and pulmonary hypertension due to meconium aspiration syndrome. Eur. J. Pediatr. 160: 150-153. doi:10.1007/s004310000678. PMID:11277374.
5. Falkenstein, E., Tillmann, H.C., Christ, M., Feuring, M., and Wehling, M. 2000. Multiple actions of steroid hormones: a focus on rapid, nongenomic effects. Pharmacol. Rev. 52: 513-556. PMID:11121509.
6. Fernandes, A.B.S., Zin, W.A., and Rocco, P.R.M. 2005. Corticosteroids in acute respiratory distress syndrome. Braz. J. Med. Biol. Res. 38: 147-159. PMID:15785826.
7. Franco-Cereceda, A., and Liska, J. 2000. Potential of calcitonine gene-related peptide in coronary heart disease. Pharmacology, 60: 1-8. doi:10.1159/000028339. PMID:10629436.
8. Gumprecht, K., Sieroń-Rokicka, B., Gumprecht, J., and Grzeszczak, W. 2002. The influence of respiratory insufficiency on autonomic nervous system function in infants. Wiad. Lek. 55: 373-381. PMID:12428565.
9. Holopainen, R., Laine, J., Halkola, L., Aho, H., and Kääpä , P. 2001. Dexamethasone treatment attenuates pulmonary injury in piglet meconium aspiration. Pediatr. Res. 49: 162-168. doi:10.1203/00006450- 200102000-00006. PMID:11158508.
10. Hoover, D.B., Chang, Y., Hancock, J.C., and Zhang, L. 2000. Actions of tachykinins within the heart and their relevance to cardiovascular disease. Jpn. J. Pharmacol. 84: 367-373. doi:10.1254/jjp.84.367. PMID:11202607.
11. Jain, R., Bali, H., Sharma, V.K., and Kumar, B. 2005. Cardiovascular effects of corticosteroid pulse therapy: a prospective controlled study on pemphigus patients. Int. J. Dermatol. 44: 285-288. doi:10.1111/j.1365- 4632.2004.02587.x. PMID:15811078.
12. Kääpä, P. 2004. Corticosteroid treatment in meconium aspiration syndrome: a solution for better outcome? Acta Paediatr. 93: 5-7. PMID:14989430.
13. Khan, A.M., Shabarek, F.M., Kutchback, J.W., and Lally, K.P. 1999. Effects of dexamethasone on meconium aspiration syndrome in newborn piglets. Pediatr. Res. 46: 179-183. doi:10.1203/00006450-199908000-00009. PMID:10447112.
14. Malpas, S.C. 2002. Neural influences on cardiovascular variability: possibilities and pitfalls. Am. J. Physiol. Heart Circ. Physiol. 282: H6-H20. PMID:11748042.
15. Marsland, A.L., Gianaros, P.J., Prather, A.A., Jennings, J.R., Neumann, S.A., and Manuck, S.B. 2007. Stimulated production of proinflammatory cytokines covaries inversely with heart rate variability. Psychosom. Med. 69: 709-716. doi:10.1097/PSY.0b013e3181576118. PMID:17942840.
16. Moguilevski, V.A., Shiel, L., Oliver, J., and McGrath, B.P. 1996. Power spectral analysis of heart-rate variability reflects the level of cardiac autonomic activity in rabbits. J. Auton. Nerv. Syst. 58: 18-24. doi:10.1016/0165-1838(95)00112-3. PMID:8740655.
17. Mokra, D., and Mokry, J. 2007. Inflammation in meconium aspiration syndrome: targets for pharmacological modulation. Curr. Pediatr. Rev. 3: 248-263. doi:10.2174/157339607782411547.
18. Mokra, D., Mokry, J., Drgova, A., Bulikova, J., Petraskova, M., and Calkovska, A. 2007. Single-dose vs. two-dose dexamethasone effects on lung inflammation and airway reactivity in meconium-instilled rabbits. J. Physiol. Pharmacol. 58(Suppl 5): 379-387. PMID:18204150.
19. Mokry, J., Mokra, D., Antosova, M., Bulikova, J., Calkovska, A., and Nosalova, G. 2006a. Dexamethasone alleviates meconium-induced airway hyperresponsiveness and lung inflammation in rabbits. Pediatr. Pulmonol. 41: 55-60. doi:10.1002/ppul.20330. PMID:16229002.
20. Mokry, J., Remenova, T., and Javorka, K. 2006b. Changes in respiratory rate, blood pressure and heart rate variability in rabbits during orthostasis. Acta Vet. (Brno), 75: 3-12. doi:10.2754/avb200675010003.
21. Murray, D.R. 2003. What is 'heart rate variability' and is it blunted by tumor necrosis factor? Chest, 123: 664-667. doi:10.1378/chest.123.3.664. PMID:12628855.
22. Nonell, A., Bodenseh, S., Lederbogen, F., Kopf, D., Hamann, B., Gilles, M., and Deuschle, M. 2005. Chronic but not acute hydrocortisone treatment shifts the response to an orthostatic challenge towards parasympathetic activity. Neuroendocrinology, 81: 63-68. doi:10.1159/000084894. PMID:15809515.
23. Ohama, Y., and Ogawa, Y. 1999. Treatment of meconium aspiration syndrome with surfactant lavage in an experimental rabbit model. Pediatr. Pulmonol. 28: 18-23. doi:10.1002/(SICI)1099-0496(199907)28:1〈18::AID- PPUL4〉3.0.CO;2-O. PMID:10406046.
24. Schäcke, H., Döcke, W.-D., and Asadullah, K. 2002. Mechanisms involved in the side effects of glucocorticoids. Pharmacol. Ther. 96: 23-43. doi:10.1016/S0163-7258(02)00297-8. PMID:12441176.
25. Scheuer, D.A., and Mifflin, A.W. 2001. Glucocorticoids modulate baroreflex control of renal sympathetic nerve activity. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280: R1440-R1449. PMID:11294766.
26. Schmidt, B.M.W., Montealegre, A., Janson, C.P., Martin, N., Stein-Kemmesies, C., Scherhag, A., et al. 1999. Short term cardiovascular effects of aldosterone in healthy male volunteers. J. Clin. Endocrinol. Metab. 84: 3528-3533. doi:10.1210/jc.84.10.3528. PMID:10522990.
27. Soukka, H., Halkola, L., Aho, H., Rautanen, M., Kero, P., and Kääpä, P. 1997. Methylprednisolone attenuates the pulmonary hypertensive response in porcine meconium aspiration. Pediatr. Res. 42: 145-150. doi:10.1203/00006450-199708000-00003. PMID:9262214.
28. Stellato, C. 2004. Post-transcriptional and nongenomic effects of glucocorticoids. Proc. Am. Thorac. Soc. 1: 255-263. doi:10.1513/pats. 200402-015MS. PMID:16113443.
29. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. 1996. Heart rate variability: standards for measurement, physiological interpretation, and clinical use. Circulation, 93: 1043-1065. PMID:8598068.
30. van Ravenswaaij-Arts, C.M., Kollee, L.A., Hopman, J.C., Stoelinga, G.B., and van Geijn, H.P. 1993. Heart rate variability. Ann. Intern. Med. 118: 436-447. PMID:8439119.
31. Whitworth, J.A., Schyvens, C.G., Zhang, Y., Andrews, M.C., Mangos, G.J., and Kelly, J.J. 2002. The nitric oxide system in glucocorticoid-induced hypertension. J. Hypertens. 20: 1035-1043. doi:10.1097/00004872- 200206000-00003. PMID:12023661.
32. Wilder, J. 1957. The law of initial values in neurology and psychiatry. J. Nerv. Ment. Dis. 13: 73-86.
33. Wu, J.M., Yeh, T.F., Wang, J.Y., Wang, J.N., Lin, Y.J., Hsieh, W.S., and Lin, C.H. 1999. The role of inflammation in the development of pulmonary hypertension in newborn with meconium aspiration syndrome (MAS). Pediatr. Pulmonol. S18: 205-208. doi:10.1002/(SICI)1099-0496(1999)27:18+〈205: :AID-PPU L66〉3.0.CO;2-0.
34. Yasuma, F., Hirai, M., and Hayano, J. 2001. Differential effects of hypoxia and hypercapnia on respiratory sinus arrhythmia in conscious dogs. Jpn. Circ. J. 65: 738-742. doi:10.1253/jcj.65.738. PMID:11502051.
35. Zhang, E., Hiroma, T., Sahashi, T., Taki, A., Yoda, T., and Nakamura, T. 2005. Airway lavage with exogenous surfactant in an animal model of meconium aspiration syndrome. Pediatr. Int. 47: 237-241. doi:10.1111/j.1442-200x. 2005.02056.x. PMID: 15910443.