Effects of dexamethasone on meconium aspiration syndrome in newborn piglets

Pediatric Research

Volumn 46, Issue 2, 1999, Pages 179-183

  Khan, Amir M ^a   Shabarek, Faten M ^a   Kutchback, James W ^a   Lally, Kevin P ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; DEXAMETHASONE; HEMOGLOBIN; OXYGEN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; BLOOD GAS ANALYSIS; CONTROLLED STUDY; DRUG EFFECT; END TIDAL CARBON DIOXIDE TENSION; INTRAVENOUS DRUG ADMINISTRATION; LUNG COMPLIANCE; LUNG FUNCTION; MECONIUM ASPIRATION; NEWBORN; NONHUMAN; OXYGEN THERAPY; PRIORITY JOURNAL; SWINE;

EID: 0032781189     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-199908000-00009     Document Type: Article

References (28)

1. Wiswell TE, Tuggle JM, Turner BS 1990 Meconium aspiration syndrome: have we made a difference? Pediatrics 85:715-721
2. Falciglia HS 1988 Failure to prevent meconium aspiration syndrome. Obstet Gynecol 71:349-353
3. Hernandez C, Little BB, Dax JS, Gilstrap III LC, Rosenfeld CR 1993 Prediction of the severity of meconium aspiration syndrome. Am J Obstet Gynecol 169:61-70
4. Peng TC, Gutcher GR, Van Dorsten JP 1996 A selective aggressive approach to the neonate exposed to meconium-stained amniotic fluid. Am J Obstet Gynecol 175:296-301
5. Wiswell TE, Bent RC 1993 Meconium staining and the meconium aspiration syndrome. Unresolved issues. Pediatr Clin North Am 40:955-981
6. Moses D, Holm BA, Spitale P, Liu MY, Enhorning G 1991 Inhibition of pulmonary surfactant function by meconium. Am J Obstet Gynecol 164:477-481
7. Clark DA, Nieman GF, Thompson JE, Paskanik AM, Rokhar JE, Bredenberg CE 1987 Surfactant displacement by meconium free fatty acids: an alternative explanation for atelectasis in meconium aspiration syndrome. J Pediatr 110:765-770
8. Davey AM, Becker JD, Davis JM 1993 Meconium aspiration syndrome: physiological and inflammatory changes in a newborn piglet model. Pediatr Pulmonol 16:101-108
9. Tyler DC, Murphy J, Cheney FW 1978 Mechanical and chemical damage to lung tissue caused by meconium aspiration. Pediatrics 62:454-459
10. Frantz ID, Wang NS, Thach BT 1975 Experimental meconium aspiration: effects of glucocorticoid treatment. J Pediatr 86:438-441
11. Yeh TF, Srinivasan G, Harris V, Pildes RS 1977 Hydrocortisone therapy in meconium aspiration syndrome: a controlled study. J Pediatr 90:140-143
12. van den Anker JN, van Loenen NT 1994 Dexamethasone in meconium aspiration. Eur J Pediatr 153:864
13. Soukka H, Halkola L, Aho H, Rautanen M, Kero P, Kaapa P 1997 Methylprednisolone attenuates the pulmonary hypertensive response in porcine meconium aspiration. Pediatr Res 42:145-150
14. Paranka MS, Walsh WF, Stancombe BB 1992 Surfactant lavage in a piglet model of meconium aspiration syndrome. Pediatr Res 31:625-628
15. Sun B, Curstedt T, Robertson B 1996 Exogenous surfactant improves ventilation efficiency and alveolar expansion in rats with meconium aspiration. Am J Respir Crit Care Med 154:764-770
16. Davis JM, Whitin J 1992 Prophylactic effects of dexamethasone in lung injury caused by hyperoxia and hyperventilation. J Appl Physiol 72:1320-1325
17. de Benedictis FM, Canny GJ, Levison H 1996 The role of corticosteroids in respiratory diseases of children. Pediatr Pulmonol 22:44-57
18. Findlay RD, Taeusch HW, Walther FJ 1996 Surfactant replacement therapy for meconium aspiration syndrome. Pediatrics 97:48-52
19. Sun B, Herting E, Curstedt T, Robertson B 1994 Exogenous surfactant improves lung compliance and oxygenation in adult rats with meconium aspiration. J Appl Physiol 77:1961-1971
20. Sun B, Curstedt T, Song GW, Robertson B 1993 Surfactant improves lung function and morphology in newborn rabbits with meconium aspiration. Biol Neonate 63:96-104
21. Holm BA, Enhorning G, Notter RH 1988 A biophysical mechanism by which plasma proteins inhibit lung surfactant activity. Chem Phys Lipids 49:49-55
22. Ryan SF, Ghassibi Y, Liau DF 1991 Effects of activated polymorphonuclear leukocytes upon pulmonary surfactant in vitro. Am J Respir Cell Mol Biol 4:33-41
23. Beers MF, Shuman H, Liley HG, Floros J, Gonzales LW, Yue N, Ballard PL 1995 Surfactant protein B in human fetal lung: developmental and glucocorticoid regulation. Pediatr Res 38:668-675
24. Ballard PL, Ning Y, Polk D, Ikegami M, Jobe AH 1997 Glucocorticoid regulation of surfactant components in immature lambs. Am J Physiol 273L:1048-1057
25. Begley CJ, Ogletree ML, Meyrick BO, Brigham KL 1984 Modification of pulmonary responses to endotoxemia in awake sheep by steroidal and nonsteroidal anti-inflammatory agents. Am Rev Respir Dis 130:1140-1146
26. Olson NC, Brown Jr TT, Anderson DL 1985 Dexamethasone and indomethacin modify endotoxin-induced respiratory failure in pigs. J Appl Physiol 58:274-284
27. Hales CA, Brandstetter RD, Neely CF, Peterson MB, Kong D, Watkins WD 1986 Methylprednisolone on circulating eicosanoids and vasomotor tone after endotoxin. J Appl Physiol 61:185-191
28. Yeh TF, Lin YJ, Lin HC, Wu JM, Lin HC 1998 Early postnatal dexamethasone therapy in infants with meconium aspiration syndrome. A randomized control trial. Pediatr Res 43:204