Hemoglobin-based oxygen carriers as rescue therapy: justified experiment or unnecessary risk?

Journal of Clinical Anesthesia

Volumn 20, Issue 7, 2008, Pages 489-491

  Sarani, Babak ^a   Pryor, John ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTIFICIAL BLOOD; CELL SAVER; POLYMERIZED HEMOGLOBIN; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ANEMIA; BLEEDING; BLOOD TRANSFUSION; EDITORIAL; HUMAN; JEHOVAH'S WITNESS; OXYGEN TRANSPORT; PRIORITY JOURNAL;

BLOOD SUBSTITUTES; BLOOD TRANSFUSION; DECISION MAKING; HEMOGLOBINS; HUMANS; ISCHEMIA; JEHOVAH'S WITNESSES;

EID: 56449085463     PISSN: 09528180     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jclinane.2008.07.001     Document Type: Editorial

References (17)

1. Mackenzie C., Jaberi M., Genuit T., Katamuluwa S., and Rodriguez A. 179 Management of hemorrhagic shock when blood is not an option. J Clin Anesth 20 (2008) 538-541
2. Cohn S.M. Blood substitutes in surgery. Surgery 127 (2000) 599-602
3. Hill G.E., Frawley W.H., Griffith K.E., Forestner J.E., and Minei J.P. Allogeneic blood transfusion increases the risk of postoperative bacterial infection: a meta-analysis. J Trauma 54 (2003) 908-914
4. Blajchman M.A. Immunomodulation and blood transfusion. Am J Ther 9 (2002) 389-395
5. Hébert P.C., Wells G., Blajchman M.A., et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 340 (1999) 409-417
6. Corash L. Inactivation of infectious pathogens in labile blood components: meeting the challenge. Transfus Clin Biol 8 (2001) 138-145
7. Natanson C., Kern S., Lurie P., Banks S., and Wolfe S. Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: a meta-analysis. JAMA 299 (2008) 2304-2312
8. FDA Center for Biologics Evaluation and Research. Transcript of Blood Products Advisory Committee Meeting. http://www.fda.gov/ohrms/dockets/ac/06/transcripts/2006-4270t1-01-BPAC.pdf accessed June 2008
9. Schechter A.N., and Gladwin M.T. Hemoglobin and the paracrine and endocrine functions of nitric oxide. N Engl J Med 348 (2003) 1483-1485
10. Hughes Jr. G.S., Antal E.J., Locker P.K., Francom S.F., Adams W.J., and Jacobs Jr. E.E. Physiology and pharmacokinetics of a novel hemoglobin-based oxygen carrier in humans. Crit Care Med 24 (1996) 756-764
11. Stern S., Rice J., Philbin N., et al. Resuscitation with the hemoglobin-based oxygen carrier, HBOC-201, in a swine model of severe uncontrolled hemorrhage and traumatic brain injury. Shock (2008) May 19 [electronic publication ahead of print]
12. Manning J.E., Katz L.M., Brownstein M.R., Pearce L.B., Gawryl M.S., and Baker C.C. Bovine hemoglobin-based oxygen carrier (HBOC-201) for resuscitation of uncontrolled, exsanguinating liver injury in swine. Carolina Resuscitation Research Group. Shock 13 (2000) 152-159
13. McNeil C.J., Smith L.D., Jenkins L.D., York M.G., and Josephs M.J. Hypotensive resuscitation using a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) leads to reversal of anaerobic metabolism. J Trauma 50 (2001) 1063-1075
14. Sprung J., Kindscher J.D., Wahr J.A., et al. The use of bovine hemoglobin glutamer-250 (Hemopure) in surgical patients: results of a multicenter, randomized, single-blinded trial. Anesth Analg 94 (2002) 799-808
15. Levy J.H., Goodnough L.T., Greilich P.E., et al. Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, double-blind trial. J Thorac Cardiovasc Surg 124 (2002) 35-42
16. Okie S. Access before approval-a right to take experimental drugs?. N Engl J Med 355 (2006) 437-440
17. Rubin B.K., and Steinberg K.P. Respiratory controversies in the critical care setting. When caring for critically ill patients, do clinicians have a responsibility to be innovative and try unproven approaches when accepted approaches are failing?. Respir Care 52 (2007) 408-415