Intravenous apyrase administration reduces arterial thrombosis in a rabbit model of endothelial denudation in vivo

Blood Coagulation and Fibrinolysis

Volumn 15, Issue 7, 2004, Pages 545-551

  Costa, Andry F ^a   Gamermann, Patrícia W ^b   Picon, Paula X ^b   Mosmann, Marcos P ^b   Kettlun, Ana Maria ^c   Valenzuela, Maria Antonieta ^c   Sarkis, João J F ^b   Battastini, Ana Maria O ^b   Picon, Paulo D ^a  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c UNIVERSITY OF CHILE   (Chile)

Author keywords

Apyrase; CD39; Experimental model; NTPDase; Rabbits; Thrombosis

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADRENALIN; APYRASE; VIPER VENOM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; AORTA BALLOON; ARTERY THROMBOSIS; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; MALE; NONHUMAN; PRIORITY JOURNAL; THROMBOSIS PREVENTION; TREATMENT OUTCOME; VASCULAR ENDOTHELIUM;

ADENINE NUCLEOTIDES; ANIMALS; AORTA; APYRASE; BALLOON DILATATION; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; EPINEPHRINE; INJECTIONS, INTRAVENOUS; PLANT PROTEINS; RABBITS; SOLANUM TUBEROSUM; THROMBOSIS; VASOCONSTRICTOR AGENTS; VIPER VENOMS;

EID: 5644222548     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001721-200409000-00003     Document Type: Article

References (43)

1. Wu KK, Thiagarajan P. Role of endothelium in thrombosis and hemostasis. Annu Rev Med 1996; 47:315-331.
2. Marcus AJ, Broekman MJ, Drosopoulos JH, Islam N, Alyonycheva TN, Safier LB, et al. The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39. J Clin Invest 1997; 99: 1351-1360.
3. Schafer AI. Vascular endothelium: in defense of blood fluidity. J Clin Invest 1997; 99:1143-1144.
4. Rongen GA, Floras JS, Lenders JW, Thien T, Smits P. Cardiovascular pharmacology of purines. Clin Sci (Lond) 1997; 92:13-24.
5. Koziak K, Sevigny J, Robson SC, Siegel JB, Kaczmarek E. Analysis of CD39/ATP diphosphohydrolase (ATPDase) expression in endothelial cells, platelets and leukocytes. Thromb Haemost 1999; 82:1538-1544.
6. Rongen GA, Smits P, Thien T. Characterization of ATP-induced vasodilation in the human forearm vascular bed. Circulation 1994; 90:1891-1898.
7. Kaczmarek E, Koziak K, Sevigny J, Siegel JB, Anrather J, Beaudoin AR, et al. Identification and characterization of CD39/vascular ATP diphosphohydrolase. J Biol Chem 1996; 271:33116-33122.
8. Sevigny J, Sundberg C, Braun N, Guckelberger O, Csizmadia E, Qawi I, et al. Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation. Blood 2002; 99:2801-2809.
9. Marcus AJ, Broekman MJ, Drosopoulos JH, Pinsky DJ, Islam N, Maliszewsk CR. Inhibition of platelet recruitment by endothelial cell CD39/ecto-ADPase: significance for occlusive vascular diseases. Ital Heart J 2001;2:824-830.
10. Robson SC, Cooper DK, d'Apice AJ. Disordered regulation of coagulation and platelet activation in xenotransplantation. Xenotransplantation 2000; 7:166-176.
11. Kawashima Y, Nagasawa T, Ninomiya H. Contribution of ecto-5′- nucleotidase to the inhibition of platelet aggregation by human endothelial cells. Blood 2000; 96:2157-2162.
12. Goepfert C, Imai M, Brouard S, Csizmadia E, Kaczmarek E, Robson SC. CD39 modulates endothelial cell activation and apoptosis. Mol Med 2000; 6:591-603.
13. Imai M, Kaczmarek E, Koziak K, Sevigny J, Goepfert C, Guckelberger O, et al. Suppression of ATP diphosphohydrolase/CD39 in human vascular endothelial cells. Biochemistry 1999; 38:13473-13479.
14. Enjyoji K, Sevigny J, Lin Y, Frenette PS, Christie PD, Esch JS, et al. Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Nat Med 1999; 5:1010-1017.
15. Handa M, Guidotti G. Purification and cloning of a soluble ATP-diphosphohydrolase (apyrase) from potato tubers (Solanum tuberosum). Biochem Biophys Res Commun 1996; 218:916-923.
16. Gayle RB, III, Maliszewski CR, Gimpel SD, Schoenborn MA, Caspary RG, Richards C, et al. Inhibition of platelet function by recombinant soluble ecto-ADPase/CD39. J Clin Invest 1998; 101:1851-1859.
17. Koyamada N, Miyatake T, Candinas D, Hechenleitner P, Siegel J, Hancock WW, et al. Apyrase administration prolongs discordant xenograft survival. Transplantation 1996; 62:1739-1743.
18. Imai M, Takigami K, Guckelberger O, Lin Y, Sevigny J, Kaczmarek E, et al. CD39/vascular ATP diphosphohydrolase modulates xenograft survival. Transplant Proc 2000; 32:969.
19. Imai M, Takigami K, Guckelberger O, Kaczmarek E, Csizmadia E, Bach FH, Robson SC. Recombinant adenoviral mediated CD39 gene transfer prolongs cardiac xenograft survival. Transplantation 2000; 70:864-870.
20. Gangadharan SP, Imai M, Rhynhart KK, Sevigny J, Robson SC, Conte MS. Targeting platelet aggregation: CD39 gene transfer augments nucleoside triphosphate diphosphohydrolase activity in injured rabbit arteries. Surgery 2001; 130:296-303.
21. Constantinides P, Chakravarti RN. Rabbit arterial thrombosis production by systemic procedures. Arch Pathol 1961; 72:79-90.
22. Johnstone MT, Botnar RM, Perez AS, Stewart R, Quist WC, Hamilton JA, Manning WJ. In vivo magnetic resonance imaging of experimental thrombosis in a rabbit model. Arterioscler Thromb Vasc Biol 2001; 21:1556-1560.
23. Abela GS, Picon PD, Friedl SE, Gebara OC, Miyamoto A, Federman M, Tofler GH, Muller JE. Triggering of plaque disruption and arterial thrombosis in an atherosclerotic rabbit model. Circulation 1995; 91:776-784.
24. Picon PD, Goncalves SC, Wainstein MV, Costa AF, Mengarda CV, Machado RP, et al. Atherosclerosis and acute arterial thrombosis in rabbits: a model using balloon desendothelization without dietary intervention. Braz J Med Biol Res 1997; 30:415-417.
25. Iturry-Yamamoto GR, Ribeiro JP, Battastini AMO, Sarkis J, Edelweiss MI, Martins N, et al. Experimental model of acute arterial thrombosis, reduction of the ADPase and aTPase activities in vessel wall and activation of the blood coagulation provoked by the thrombosis-triggering protocol (TTP) [abstract]. Rev Soc Arg Cardiol 1999; 67:53.
26. Kettlun AM, Uribe L, Calvo V, Silva S, Rivera J, Mancilla M, et al. Properties of two apyrases from Solanum tuberosum. Phytochemistry 1982; 21:551-558.
27. 2+-stimulated ATPase activity. Anal Biochem 1986; 157:375-380.
28. Anitschkow N. Experimental atherosclerosis in animals. In: Cowdry EV (editor): Arteriosclerosis - a survey to the problem. New York: MacMillan; 1933.
29. Sslowjew A. Experimentelleuntersuchungen über die bedeutung von lokader Schädigung für die lipoidablagerung in der arterienwand. Zeittschr FD Exp Med 1929; 69:94-97.
30. Baumgartner HR. Eine neue methode zur erzeugung vor thromben durch gezielte uberdehnung der gefässwand. S Ges Exp Med 1963; 137: 227-230.
31. Hellem A. The adhesiveness of human blood platelets in vitro. Scand J Clin Lab Invest 1960; 12:1-6.
32. Gaarder A, Jonsen J, Laland S, Hellem A, Owren PA. Adenosine diphosphate in red cells as a factor in the adhesiveness of human blood platelets. Nature 1961; 192:531-532.
33. Robson SC, Sevigny J, Imai M, Guckelberger O, Enjyoji K. Thromboregulatory potential of endothelial CD39/nucleoside triphosphate diphosphohydrolase: modulation of purinergic signalling in platelets. Emerging Therap Targets 2000; 4:155-171.
34. Lieberman GE, Lewis GP, Peters TJ. A membrane-bound enzyme in rabbit aorta capable of inhibiting adenosine-diphosphate-induced platelet aggregation. Lancet 1977; 2:330-332.
35. Yagi K, Arai Y, Kato N, Hirota K, Miura Y. Purification of ATP diphosphohydrolase from bovine aorta microsomes. Eur J Biochem 1989; 180:509-513.
36. Yagi K, Shinbo M, Hashizume M, Shimba LS, Kurimura S, Miura Y. ATP diphosphohydrolase is responsible for ecto-ATPase and ecto-ADPase activities in bovine aorta endothelial and smooth muscle cells. Biochem Biophys Res Commun 1991; 180:1200-1206.
37. Cote YP, Picher M, St Jean P, Beliveau R, Potier M, Beaudoin AR. Identification and localization of ATP-diphosphohydrolase (apyrase) in bovine aorta: relevance to vascular tone and platelet aggregation. Biochim Biophys Acta 1991; 1078:187-191.
38. Cote YP, Ouellet S, Beaudoin AR. Kinetic properties of type-II ATP diphosphohydrolase from the tunica media of the bovine aorta. Biochim Biophys Acta 1992; 1160:246-250.
39. Cote YP, Filep JG, Battistini B, Gauvreau J, Sirois P, Beaudoin AR. Characterization of ATP-diphosphohydrolase activities in the intima and media of the bovine aorta: evidence for a regulatory role in platelet activation in vitro. Biochim Biophys Acta 1992; 1139:133-142.
40. Sevigny J, Levesque FP, Grondin G, Beaudoin AR. Purification of the blood vessel ATP diphosphohydrolase, identification and localisation by immunological techniques. Biochim Biophys Acta 1997; 1334:73-88.
41. Marcus AJ, Safier LB, Hajjar KA, Ullman HL, Islam N, Broekman MJ, Eiroa AM. Inhibition of platelet function by an aspirin-insensitive endothelial cell ADPase. Thromboregulation by endothelial cells. J Clin Invest 1991; 88:1690-1696.
42. Robson SC, Schulte Am EJ, Bach FH. Factors in xenograft rejection. Ann NY Acad Sci 1999; 875:261-276.
43. Pinsky DJ, Broekman MJ, Peschon JJ, Stocking KL, Fujita T, Ramasamy R, et al. Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain. J Clin Invest 2002; 109:1031-1040.