Targeting platelet aggregation: CD39 gene transfer augments nucleoside triphosphate diphosphohydrolase activity in injured rabbit arteries

Surgery

Volumn 130, Issue 2, 2001, Pages 296-303

  Gangadharan, Sidhu P ^a,b   Imai, Masato ^a,b   Rhynhart, Kurt K ^a,b   Sévigny, Jean ^a,b   Robson, Simon C ^a,b   Conte, Michael S ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; APYRASE; BETA GALACTOSIDASE; CD39 ANTIGEN; HYDROLASE; NUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTERY INJURY; ARTICLE; BLOOD VESSEL WALL; CELL PROTECTION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME LOCALIZATION; FEMORAL ARTERY; GENE TARGETING; GENE TRANSFER; IMMUNOHISTOCHEMISTRY; INCUBATION TIME; NONHUMAN; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE FIBER; THROMBOCYTE AGGREGATION;

EID: 0034896524     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1067/msy.2001.116032     Document Type: Article

References (29)

1. Collaborative overview of randomised trials of antiplatelet therapy - II: Maintenance of vascular graft or arterial patency by antiplatelet therapy: Antiplatelet Trialists' Collaboration
2. Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty: The EPIC Investigation
3. Prevention of arterial thrombosis by adenovirus-mediated transfer of cyclooxygenase gene
4. Local overexpression of thrombomodulin for in vivo prevention of arterial thrombosis in a rabbit model
5. Gene therapy inhibiting neointimal vascular lesion: In transfer of endothelial cell nitric oxide synthase gene
6. Origin, metabolism and function of extracellular adenine nucleotides in the blood
7. ADP receptors on platelets
8. Identification and characterization of CD39/vascular ATP diphosphohydrolase
9. Identification and localization of ATP-diphosphohydrolase (apyrase) in bovine aorta: Relevance to vascular tone and platelet aggregation
10. Inhibition of platelet function by an aspirin-insensitive endothelial cell ADPase: Thromboregulation by endothelial cells
11. Contribution of ecto-5′-nucleotidase to the inhibition of platelet aggregation by human endothelial cells
12. CD39 is an ecto-(Ca2+,Mg2+)-apyrase
13. Loss of rat glomerular ATP diphosphohydrolase activity during reperfusion injury is associated with oxidative stress reactions
14. Loss of ATP diphosphohydrolase activity with endothelial cell activation
15. Experimental endotoxemia in pregnancy: In situ glomerular microthrombus formation associated with impaired glomerular adenosine diphosphatase activity
16. Modulation of nucleotide triphosphate diphosphohydrolase-1 (NTPDase-1)cd39 in xenograft rejection
17. Recombinant adenoviral mediated CD39 gene transfer prolongs cardiac xenograft survival
18. Monocyte adhesion to balloon-injured arteries: The influence of endothelial cell seeding
19. Purification of the blood vessel ATP diphosphohydrolase, identification and localisation by immunological techniques
20. Purification of pancreas type-I ATP diphosphohydrolase and identification by affinity labelling with the 5′-p-fluorosulphonylbenzoyladenosine ATP analogue
21. A malachite green colorimetric assay for protein phosphatase activity
22. A simple, fluorescent method to internally label platelets suitable for physiological measurements
23. The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39
24. Characterization of ATP-diphosphohydrolase activities in the intima and media of the bovine aorta: Evidence for a regulatory role in platelet activation in vitro
25. Apyrase administration prolongs discordant xenograft survival
26. ADP plays an important role in mediating platelet aggregation and cyclic flow variations in vivo in stenosed and endothelium-injured canine coronary, arteries
27. Inhibition of platelet function by recombinant soluble ecto-ADPase/CD39
28. Platelet adhesion and thrombus formation on subendothelium in platelets deficient in glycoproteins IIb-IIIa, Ib, and storage granules
29. The role of platelet membrane glycoproteins Ib and IIb-IIIa in platelet adherence to human artery subendothelium