Antisense inhibition of ATM gene enhances the radiosensitivity of head and neck squamous cell carcinoma in mice

Journal of Experimental and Clinical Cancer Research

Volumn 27, Issue 1, 2008, Pages

  Zou, Jian ^a   Qiao, Xiaoming ^a   Ye, Huiping ^a   Yang, Yuqiong ^a   Zheng, Xuelian ^a   Zhao, Houyu ^a   Liu, Shixi ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; ATM ANTISENSE OLIGODEOXYNUCLEOTIDE; ATM PROTEIN; LIPOSOME; MESSENGER RNA; UNCLASSIFIED DRUG; ANTISENSE OLIGONUCLEOTIDE; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER RADIOTHERAPY; CANCER SURVIVAL; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CLONOGENIC ASSAY; CONTROLLED STUDY; DNA SYNTHESIS; FEMALE; FLOW CYTOMETRY; HEAD AND NECK CARCINOMA; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; METHODOLOGY; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; RADIATION DOSE; RADIOSENSITIVITY; REAL TIME POLYMERASE CHAIN REACTION; SOLID TUMOR; SQUAMOUS CELL CARCINOMA; WESTERN BLOTTING; X RAY; ANIMAL; C3H MOUSE; DRUG ANTAGONISM; GENETIC TRANSFECTION; GENETICS; HEAD AND NECK TUMOR; METABOLISM; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; DNA-BINDING PROTEINS; FEMALE; HEAD AND NECK NEOPLASMS; MICE; MICE, INBRED C3H; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; RADIATION, IONIZING; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS;

EID: 56349113774     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/1756-9966-27-56     Document Type: Article

References (24)

1. Combination radiation and adenovirus-mediated P16(INK4A) gene therapy in a murine model for head and neck cancer. JG Rhee D Li BW O'Malley Jr M Suntharalingam, ORL; journal for oto-rhino-laryngology and its related specialties 2003 65 144 54 12925815
2. Radiosensitization of head/neck squamous cell carcinoma by adenovirus-mediated expression of the Nbs1 protein. JG Rhee D Li M Suntharalingam C Guo BW O'Malley Jr JP Carney, International journal of radiation oncology, biology, physics 2007 67 273 8 17189075
3. A new immunocompetent murine model for oral cancer. BW O'Malley Jr KA Cope CS Johnson MR Schwartz, Arch Otolaryngol Head Neck Surg 1997 123 1 20 24 9006499
4. Characterization of a spontaneously arising murine squamous cell carcinoma (SCC VII) as a prerequisite for head and neck cancer immunotherapy. D Khurana EA Martin JL Kasperbauer, Head & neck 2001 23 899 906 10.1002/hed.1130 11592238
5. Relationship between clonogenic radiosensitivity, radiation-induced apoptosis and DNA damage/repair in human colon cancer cells. AL Dunne ME Price C Mothersill SR McKeown T Robson DG Hirst, British journal of cancer 2003 89 2277 83 10.1038/sj.bjc.6601427 14676806
6. Expression of ATM in ataxia telangiectasia fibroblasts rescues defects in DNA double-strand break repair in nuclear extracts. Y Li MP Carty GG Oakley MM Seidman M Medvedovic K Dixon, Environmental and molecular mutagenesis 2001 37 128 40 10.1002/em.1020
7. Radiosensitivity of human tumour cells is correlated with the induction but not with the repair of DNA double-strand breaks. RA El-Awady E Dikomey J Dahm-Daphi, British journal of cancer 2003 89 593 601 10.1038/sj.bjc.6601133 12888835
8. Ability to repair DNA double-strand breaks related to cancer susceptibility and radiosensitivity. K Sakata M Someya Y Matsumoto M Hareyama, Radiation medicine 2007 25 433 8 10.1007/s11604-007-0161-3 18026900
9. ATM and related protein kinases: safeguarding genome integrity. Y Shiloh, Nature reviews 2003 3 155 68 10.1038/nrc1011 12612651
10. Maintaining integrity. Y Shiloh AR Lehmann, Nature cell biology 2004 6 923 8 10.1038/ncb1004-923 15459720
11. Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. E Berkovich RJ Monnat Jr MB Kastan, Nature cell biology 2007 9 683 90 10.1038/ncb1599 17486112
12. Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Y Peng RG Woods H Beamish, Cancer research 2005 65 1670 7 10.1158/0008-5472.CAN-04-3451 15753361
13. The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. M Morales JW Theunissen CF Kim R Kitagawa MB Kastan JH Petrini, Genes & development 2005 19 3043 54 16357220 10.1101/gad.1373705
14. Relationship between DNA double-strand break rejoining and cell survival after exposure to ionizing radiation in human fibroblast strains with differing ATM/p53 status: implications for evaluation of clinical radiosensitivity. R Mirzayans D Severin D Murray, International journal of radiation oncology, biology, physics 2006 66 1498 505 17126209
15. DNA damage-induced cell-cycle phase regulation of p53 and p21waf1 in normal and ATM-defective cells. D Delia E Fontanella C Ferrario L Chessa S Mizutani, Oncogene 2003 22 7866 9 10.1038/sj.onc.1207086 14586414
16. Bendamustine induces G2 cell cycle arrest and apoptosis in myeloma cells: the role of ATM-Chk2-Cdc25A and ATM-p53-p21-pathways. L Gaul S Mandl-Weber P Baumann B Emmerich R Schmidmaier, Journal of cancer research and clinical oncology 2008 134 245 53 10.1007/s00432-007-0278-x
17. ATM gene regulates oxygen-glucose deprivation-induced nuclear factor-kappaB DNA-binding activity and downstream apoptotic cascade in mouse cerebrovascular endothelial cells. KJ Yin SD Chen JM Lee J Xu CY Hsu, Stroke; a journal of cerebral circulation 2002 33 2471 7 12364740
18. Relationships between clonogenic cell survival, DNA damage and chromosomal radiosensitivity in nine human cervix carcinoma cell lines. AM Eastham J Atkinson CM West, International journal of radiation biology 2001 77 295 302 10.1080/09553000010017108 11258843
19. The relationship between cellular radiosensitivity and radiation-induced DNA damage measured by the comet assay. S Wada H Kurahayashi Y Kobayashi, The Journal of veterinary medical science/the Japanese Society of Veterinary Science 2003 65 471 7 12736429
20. Prediction of cellular radiosensitivity from DNA damage induced by gamma-rays and carbon ion irradiation in canine tumor cells. S Wada T Van Khoa Y Kobayashi, The Journal of veterinary medical science/the Japanese Society of Veterinary Science 2005 67 1089 95 16327218
21. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. K Savitsky A Bar-Shira S Gilad, Science 1995 268 5218 1749 1753 10.1126/science.7792600 7792600
22. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. E Riballo M Kuhne N Rief, Molecular cell 2004 16 715 24 10.1016/j.molcel.2004.10.029 15574327
23. The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks. MF Lavin, DNA repair 2004 3 1515 20 10.1016/j.dnarep.2004.07.001 15380107
24. Atm-deficient mice: an osteoporosis model with defective osteoblast differentiation and increased osteoclastogenesis. N Rasheed X Wang QT Niu J Yeh B Li, Human molecular genetics 2006 15 1938 48 10.1093/hmg/ddl116 16644862