Dose-finding study with nicotine as a proconvulsant agent in PTZ-induced seizure model in mice

Journal of Biomedical Science

Volumn 15, Issue 6, 2008, Pages 755-765

  Sood, Nimisha ^a   Sahai, Ashok Kumar ^a   Medhi, Bikash ^b   Chakrabarti, Amitava ^b  

^a INDIRA GANDHI MEDICAL COLLEGE   (India)

^b POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Lipid peroxidation; Nicotine; Pentylenetetrazole; Seizure; Sodium valproate; Topiramate

Indexed keywords

GLUTATHIONE; MALONALDEHYDE; NICOTINE TARTRATE; PENTETRAZOLE; SUPEROXIDE DISMUTASE; TOPIRAMATE; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; IN VIVO STUDY; LIPID PEROXIDATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEIZURE;

ANIMALS; ANTICONVULSANTS; CONVULSANTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FRUCTOSE; GANGLIONIC STIMULANTS; MALE; MICE; NICOTINE; PENTYLENETETRAZOLE; SEIZURES; VALPROIC ACID;

MUS;

EID: 56349092801     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1007/s11373-008-9272-9     Document Type: Article

References (38)

1. Tayor P (2001) Agents acting at neuromuscular junction and autonomic ganglia. In: Hardman JG, Limibird LE (eds) The pharmacological basis of therapeutics. McGraw-Hill, New York, pp 193-213
2. J Czernin C Waldherr 2003 Cigarette smoking and coronary blood flow Prog Cardiovasc Dis 45 5 395 404
3. SS Hecht 2002 Cigarette smoking and lung cancer: chemical mechanisms and approaches to prevention Lancet Oncol 3 8 461 469
4. M Quik JM Kulak 2002 Nicotine and nicotinic receptors; relevance to Parkinson's disease Neurotoxicology 23 4-5 581 594
5. ED Levin AH Rezvani 2002 Nicotinic treatment for cognitive dysfunction Curr Drug Targets CNS Neurol Disord 1 4 423 431
6. MI Damaj W Glassco M Dukat BR Martin 1999 Pharmacological characterization of nicotine-induced seizures in mice J Pharmacol Exp Ther 291 3 1284 1291
7. MR Picciotto DH Brunzell BJ Caldarone 2002 Effect of nicotine and nicotinic receptors on anxiety and depression Neuroreport 13 9 1097 1106
8. V Itier D Bertrand 2001 Neuronal nicotinic receptors: from protein structure to function FEBS Lett 504 3 118 125
9. P Dobelis S Hutton Y Lu AC Collins 2003 GABAergic systems modulate nicotinic receptor-mediated seizures in mice J Pharmacol Exp Ther 306 3 1159 1166
10. EA Swinyard 1969 Laboratory evaluation of antiepileptic drugs. Review of laboratory methods Epilepsia 10 2 107 119
11. RW Olsen 1981 The GABA postsynaptic membrane receptor-ionophore complex. Site of action of convulsant and anticonvulsant drugs Mol Cell Biochem 39 261 279
12. RL Krall JK Penry BG White 1978 Antiepileptic drug development: II. Anticonvulsant drug screening Epilepsia 19 4 409 428
13. M Patel 2004 Mitochondrial dysfunction and oxidative stress: cause and consequence of epileptic seizures Free Radic Biol Med 37 12 1951 1962
14. D Franceschini R Paylor R Broide 2002 Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures Brain Res Mol Brain Res 98 1-2 29 40
15. O Giorgi M Orlandi D Lecca 1991 MK-801 prevents chemical kindling induced by pentylenetetrazol in rats Eur J Pharmacol 193 3 363 5
16. OH Lowry NJ Rosebrough AL Farr 1951 Protein measurement with the folin phenol reagent J Biol Chem 193 265 275
17. H Ohkawa N Ohishi K Yagi 1979 Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal Biochem 95 351 358
18. J Sedlak RH Lindsay 1968 Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent Anal Biochem 25 1 192 205
19. Y Kono 1978 Generation of superoxide radical during auto-oxidation of hydroxylamine and assay for SOD Arch Biochem Biophys 186 189 195
20. Luck H (1963) Catalase. In: Bergmeyer HW (ed) Methods of enzymatic analysis, Sect. 3. Academic Press, New York, pp 885-894
21. Ghosh MN (2005) Toxicity studies. In: Fundamentals of experimental pharmacology, 3rd edn. Hilton & Company, Kolkata, pp 190-197
22. LL Miner AC Collins 1989 Strain comparison of nicotine-induced seizure sensitivity and nicotinic receptors Pharmacol Biochem Behav 33 2 469 475
23. SL Cohen BJ Morley OC Snead 1981 An EEG analysis of convulsive activity produced by cholinergic agents Prog Neuropsychopharmacol 5 4 383 388
24. BM Conti-Tronconi KE McLane MA Raftery 1994 The nicotinic acetylcholine receptor: structure and autoimmune pathology Crit Rev Biochem Mol Biol 29 2 69 123
25. JA Stitzel JM Blanchette AC Collins 1998 Sensitivity to the seizure-inducing effects of nicotine is associated with strain-specific variants of the alpha 5 and alpha 7 nicotinic receptor subunit genes J Pharmacol Exp Ther 284 3 1104 1111
26. RS Broide R Salas D Ji 2002 Increased sensitivity to nicotine-induced seizures in mice expressing the L250T alpha 7 nicotinic acetylcholine receptor mutation Mol Pharmacol 61 3 695 705
27. JA Stitzel M Jimenez MJ Marks 2000 Potential role of the alpha4 and alpha6 nicotinic receptor subunits in regulating nicotine-induced seizures J Pharmacol Exp Ther 293 1 67 74
28. M Raggenbass D Bertrand 2002 Nicotinic receptors in circuit excitability and epilepsy J Neurobiol 53 4 580 589
29. B Buisson D Bertrand 2000 Nicotine addiction: the possible role of functional upregulation Trends Pharmacol Sci 23 3 130 136
30. Benowitz NL, Porchet H, Jacob P (1990) Wonnacotts Russell MAH, Stoleman IP (eds) Nicotine psychopharmacology: molecular, cellular and behavioral aspects. Oxford University Press, Oxford, pp 112-157
31. DS McGehee MJ Heath S Gelber 1995 Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors Science 269 5231 1692 1696
32. M Alkondon EX Albuquerque 2001 Nicotinic acetylcholine receptor alpha7 and alpha4beta2 subtypes differentially control GABAergic input to CA1 neurons in rat hippocampus J Neurophysiol 86 6 3043 3055
33. R Ramanjaneyulu MK Ticku 1984 Interactions of pentamethylenetetrazole and tetrazole analogues with the picrotoxinin site of the benzodiazepine-GABA receptor-ionophore complex Eur J Pharmacol 98 3-4 337 345
34. BS Meldrum 1984 Amino acid neurotransmitters and new approaches to anticonvulsant drug action Epilepsia 25 suppl 2 s140 s149
35. MR Gluck E Jayatilleke S Shaw 2000 CNS oxidative stress associated with the kainic acid rodent model of experimental epilepsy Epilepsy Res 39 1 63 71
36. N Patsoukis G Zervoudakis CD Georgiou 2005 Panagopoulos NT. Thiol redox state and lipid and protein oxidation in the mouse striatum after pentylenetetrazole-induced epileptic seizure Epilepsia 46 8 1205 1211
37. P Uma Devi KK Pillai D Vohora 2006 Modulation of pentylenetetrazolee- induced seizures and oxidative stress parameters by sodium valproate in the absence and presence of N-acetylcysteine Fundam Clin Pharmacol 20 3 247 253
38. AA Boldyrev MO Yuneva EV Sorokina 2001 Antioxidant systems in tissues of senescence accelerated mice Biochemistry (Mosc) 66 10 1157 1163