CNS oxidative stress associated with the kainic acid rodent model of experimental epilepsy

Epilepsy Research

Volumn 39, Issue 1, 2000, Pages 63-71

  Gluck, Martin R ^a   Jayatilleke, Elizabeth ^a   Shaw, Spencer ^a   Rowan, A James ^a   Haroutunian, Vahram ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Animal model; Cortex; Epilepsy; Hippocampus; Kainic acid; Oxidative stress

Indexed keywords

ANTIOXIDANT; BIOCHEMICAL MARKER; CARBONYL DERIVATIVE; GLUTATHIONE; GLUTATHIONE DISULFIDE; KAINIC ACID; PROTEIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; BRAIN CORTEX; BRAIN INJURY; BRAIN REGION; CEREBELLUM; CONTROLLED STUDY; EPILEPSY; HIPPOCAMPUS; LIPID OXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SEIZURE;

ANIMALS; CEREBELLUM; CEREBRAL CORTEX; EPILEPSY; EXCITATORY AMINO ACID AGONISTS; GLUTATHIONE; GLUTATHIONE DISULFIDE; HIPPOCAMPUS; KAINIC ACID; MALE; OXIDATIVE STRESS; RATS; RATS, INBRED F344; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0033958555     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(99)00111-4     Document Type: Article

References (25)

1. Arnaiz S.L., Travacio M., Llesuy S., Arnaiz G. Regional vulnerability to oxidative stress in a model of experimental epilepsy. Neurochem. Res. 23:1998;1477-1483.
2. Ben-Ari Y. Limbic seizure and brain damage produced by kainic acid mechanisms and relevance to human temporal lobe epilepsy. Neuroscience. 14:1985;375-403.
3. Ben-Ari Y., Tremblay E., Otterson O.P., Meldrum B.S. The role of epileptic activity in hippocampal and 'remote' cerebral lesions induced by kainic acid. Brain Res. 191:1980;79-97.
4. Beni G., Moretti A. Are reactive oxygen species involved in Alzheimer's disease? Neurobiol. Aging. 16:1995;661-674.
5. Chittajallu R., Braithwaite S.P., Clarke R.J., Henley J.M. Kainate receptors: subunits, synaptic localization and function. Trends Pharmacol. Sci. 20:1999;26-35.
6. Culcasi M., Lafon-Cazal M., Pietri S., Brockaert J. Glutamate receptors induce a burst of superoxide via activation of nitric oxide synthase in arginine-depleted neurons. J. Biol. Chem. 17:1994;12589-12593.
7. Danscher G., Fjerdingstad E.J., Fjerdingstad E., Fredens K. Heavy metal content in subdivisions of the rat hippocampus (zinc, lead and copper). Brain Res. 112:1976;442-446.
8. Dexter D.T., Holley A.E., Flitter W.D., Slater T.F., Wells F.R., Lees D.S.E., Jenner P., Marsden D.C. Increased levels of hydroperoxides in the parkinsonian substantia nigra - an HPLC and EPR study. Mov. Disord. 9:1994;92-97.
9. +: implications for neurodegeneration. J. Neurochem. 63:1994;584-591.
10. Esterbauer H., Schaur R.J., Zollner H. Chemistry and biology of 4-hydroxynonenal, malondialdehyde and related aldehydes. Free Radic. Biol. Med. 11:1991;81-128.
11. Evans M.C., Griffiths T., Meldrum B.S. Kainic acid seizures and the reversibility of calcium loading in vulnerable neurons in the hippocampus. Neuropathol. Appl. Neurobiol. 10:1984;285-302.
12. Floyd R.A. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J. 4:1990;2587-2597.
13. Griffith O.W. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 106:1980;207-212.
14. Griffiths T., Evans M.C., Meldrum B.S. Intracellular calcium accumulation in rat hippocampus during seizures induced by bicucullline or L-allyllysine. Neuroscience. 10:1983;385-395.
15. Hirata H., Cadet J.L. Kainate-induced hippocampal DNA damage is attenuated in superoxide dismutase transgenic mice. Brain Res. Mol. Biol. Res. 48:1997;145-148.
16. Kim H., Choi D., Jhoo W., Lee D., Koo C., Kim C. Aspalactone, a new antiplatelet agent, attenuates the neurotoxicity induced by kainic acid in the rat. Life Sci. 61:1997;373-381.
17. Levine R.L., Garland D., Oliver C.N., Amici A., Climent I., Lenz A., Ahn B.W., Shaltiel S., Stadtman E.R. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 186:1990;464-478.
18. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with folin reagent. J. Biol. Chem. 193:1951;265-272.
19. Meldrum B.S. First Alfred Meyer Memorial Lecture: epileptic brain damage: a consequence and a cause of seizures. Neuropathol. Neurobiol. 23:1997;185-202.
20. Murakami K., Kondo T., Epstein C.J., Chan P.H. Overexpression of CuZn-superoxide dismutase reduces hippocampal injury after global ischemia in transgenic mice. Stroke. 28:1997;1797-1804.
21. Oliver C.N., Starke-Reed P.E., Stadtman E.R., Liku G.J., Carney J.M., Floyd R.A. Oxidative damage to proteins, loss of glutamine synthetase activity and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain. Proc. Natl. Acad. Sci. USA. 87:1990;5144-5147.
22. Reiter, R., Tang, L., Garcia, J.J., Munoz-Hoyos, A. 1997. Pharmacological actions of melatonin in oxygen radical pathophysiology. Life Sci. 60, 2255-2271.
23. Sperk G. Kainic acid seizures in the rat. Prog. Neurobiol. 42:1994;1-32.
24. Tang L., Reiter R., Li Z., Ortiz G.G., Yu B.P., Garcia J.J. Melatonin reduces the increase in 8-hydroxy-deoxyguanosine levels in the brain and liver of kainic acid- treated rats. Mol. Cell. Biochem. 178:1998;299-303.
25. Treiman D.M. Electroclinical features of Status Epilepticus. J. Clin. Neurophysiol. 12:1995;343-362.