Substituent control of DNA binding modes in a series of chalcogenoxanthylium photosensitizers as determined by isothermal titration calorimetry and topoisomerase I DNA unwinding assay

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 24, 2008, Pages 10221-10227

  McKnight, Ruel E ^a   Onogul, Bilgehan ^a   Polasani, Shivani R ^a   Gannon II, Michael K ^b   Detty, Michael R ^b  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Chalcogenoxanthylium dyes; DNA binding; Isothermal titration calorimetry; Topoisomerase I unwinding assay

Indexed keywords

CHALCOGEN; CHALCOGENOXANTHYLIUM DERIVATIVE; DNA TOPOISOMERASE; PHOTOSENSITIZING AGENT; UNCLASSIFIED DRUG;

ARTICLE; DNA DENATURATION; DNA SUPERCOILING; DRUG DNA BINDING; DRUG SYNTHESIS; ISOTHERMAL TITRATION CALORIMETRY;

CALORIMETRY; DNA; DNA TOPOISOMERASES, TYPE I, BACTERIAL; FLUORESCENT DYES; HETEROCYCLIC COMPOUNDS, 3-RING; PHOTOSENSITIZING AGENTS;

EID: 56349092410     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.051     Document Type: Article

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