Spray-dried lipid-hyaluronan-polymethacrylate microparticles for drug delivery in the peritoneum

Journal of Biomedical Materials Research - Part A

Volumn 87, Issue 3, 2008, Pages 825-831

  Domnina, Yuliya A ^a   Yeo, Yoon ^b,c   Tse, Julie Y ^d   Bellas, Evangelia ^d   Kohane, Daniel S ^e  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b PURDUE UNIVERSITY   (United States)

^c PURDUE UNIVERSITY   (United States)

^d Massachusetts Institute of Technology Cambridge   (United States)

^e BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Adhesion; Biocompatibility; Microparticles; Peritoneum; Phospholipid

Indexed keywords

ABS RESINS; ACIDS; ADHESION; BIOCOMPATIBILITY; DRUG DELIVERY; FORMING; ORGANIC ACIDS; PHOSPHOLIPIDS; SELF PHASE MODULATION; STATISTICAL PROCESS CONTROL; ANIMALS; POLYMERS;

CONTROLLED RELEASES; DRUG RELEASES; EUDRAGIT E100; HYALURONAN; HYALURONIC ACIDS; INFLAMMATORY RESPONSES; MICROPARTICLES; NO FORMATIONS; PERITONEUM; POLYMERIC SYSTEMS; FREE PARTICLES;

CONTROLLED DRUG DELIVERY;

1600 KDA; ALBUMIN; EUDRAGIT; EUDRAGIT E 100; FITC ALBUMIN; FLUORESCEIN ISOTHIOCYANATE; HYALURONIC ACID; MICROSPHERE; SPHINGOMYELIN; UNCLASSIFIED DRUG; POLYMETHACRYLIC ACID; ACRYLIC ACID DERIVATIVE; ALBUMINOID; BIOMATERIAL; DRUG CARRIER; EUDRAGIT E100; EXCIPIENT; POLYMER; POLYMETHACRYLIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; INFLAMMATION; MALE; MOUSE; NONHUMAN; PEPTIDE MAPPING; PERITONEUM; PERITONEUM ADHESION; SPRAY DRYING; CELL ADHESION; DRUG RELEASE; PARTICLE SIZE; ANIMAL; DRUG EFFECT; SCANNING ELECTRON MICROSCOPY;

ACRYLATES; ALBUMINS; ANIMALS; BIOCOMPATIBLE MATERIALS; DRUG CARRIERS; EXCIPIENTS; HYALURONIC ACID; MALE; MICE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PERITONEUM; POLYMERS; POLYMETHACRYLIC ACIDS; SPHINGOMYELINS;

EID: 56349088480     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.31741     Document Type: Article

References (20)

1. Kohane DS, Tse JY, Yeo Y, Padera R, Shubina M, Langer R. Biodegradable polymeric microspheres and nanospheres for drug delivery in the peritoneum. J Biomed Mater Res 2006; 77:351-361.
2. Ar'Rajab A, Ahren B, Rozga J, Bengmark S. Phosphatidylcholine prevents postoperative peritoneal adhesions: An experimental study in the rat. J Surg Res 1991;50:212-215.
3. Ar'Rajab A, Snoj M, Larsson K, Bengmark S. Exogenous phospholipid reduces postoperative peritoneal adhesions in rats. Eur J Surg 1995;161:341-344,
4. Treutner KH, Bertram P, Lerch MM, Klimaszewski M, Petrovic-Kallholm S, Sobesky J, Winkeltau G, Schumpelick V. Prevention of postoperative adhesions by single intraperitoneal medication. J Surg Res 1995;59:764-771.
5. Muller SA, Treutner KH, Tietze L, Anurov M, Titkova S, Polivoda M, Oettinger AP, Schumpelick V. Efficacy of adhesion prevention and impact on wound healing of intraperitoneal phospholipids. J Surg Res 2001;96:68-74.
6. Muller SA, Treutner KH, Tietze L, Anurov M, Titkova S, Polivoda M, Oettinger AP, Schumpelick V. Influence of intraperitoneal phospholipid dosage on adhesion formation and wound healing at different intervals after surgery. Langenbecks Arch Surg 2001;386:278-284.
7. Falk K, Holmdahl L, Halvarsson M, Larsson K, Lindman B, Bengmark S. Polymers that reduce intraperitoneal adhesion formation. Br J Surg 1998;85:1153-1156.
8. Becker JM, Dayton MT, Fazio VW, Beck DE, Stryker SJ, Wexner SD, Wolff BG, Roberts PL, Smith LE, Sweeney SA, Moore M. Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: A prospective, randomized, double-blind multicenter study. J Am Coll Surg 1996;183:297-306.
9. Yeo Y, Highley CB, Bellas E, Ito T, Marini R, Langer R, Kohane DS. In situ cross-linkable hyaluronic acid hydrogels prevent post-operative abdominal adhesions in a rabbit model. Biomaterials 2006;27:4698-4705.
10. Kohane DS, Anderson DG, Yu C, Langer R. pH-triggered release of macromolecules from spray-dried polymethacrylate microparticles. Pharm Res 2003;20:1533-1538.
11. Kohane DS, Lipp M, Kinney RC, Anthony DC, Louis DN, Lotan N, Langer R. Biocompatibility of lipid-protein-sugar particles containing bupivacaine in the epineurium. J Biomed Mater Res 2002;59.450-459.
12. Kohane DS, Smith SE, Louis DN, Colombo G, Ghoroghchian P, Hunfeld NG, Berde CB, Langer R. Prolonged duration local anesthesia from tetrodotoxin-enhanced local anesthetic microspheres. Pain 2003;104:415-421.
13. Haining WN, Anderson DG, Little SR, von Bergwelt-Baildon MS, Cardoso AA, Alves P, Kosmatopoulos K, Nadler LM, Langer R, Kohane DS. pH-triggered microparticles for peptide vaccination. J Immunol 2004;173:2578-2585.
14. Kohane DS, Lipp M, Kinney RC, Lotan N, Langer R. Sciatic nerve blockade with lipid-protein-sugar particles containing bupivacaine. Pharm Res 2000;17:1243-1249.
15. Colombo G, Langer R, Kohane DS. Effect of excipient composition on the biocompatibility of bupivacaine-containing microparticles at the sciatic nerve. J Biomed Mater Res A 2004;68:651-659.
16. Colombo G, Padera R, Langer R, Kohane DS. Prolonged duration local anesthesia with lipid-protein-sugar particles containing bupivacaine and dexamethasone. J Biomed Mater Res A 2005;75:458-464.
17. Kohane DS, Holmes GL, Chau Y, Zurakowski D, Langer R, Cha BH. Effectiveness of muscimol-containing microparticles against pilocarpine-induced focal seizures. Epilepsia 2002,43: 1462-1468.
18. Kohane DS, Plesnila N, Thomas SS, Le D, Langer R, Moskowitz MA. Lipid-sugar particles for intracranial drug delivery: Safety and biocompatibility. Brain Res 2002;946:206-213.
19. Ben-Jebria A, Chen D, Eskew ML, Vanbever R, Langer R, Edwards DA. Large porous particles for sustained protection from carbachol-induced bronchoconstriction in guinea pigs. Pharm Res 1999;16:555-561.
20. Keith K. Spray Drying Handbook. New York: John Wiley & Sons; 1991.