-
1
-
-
37249076524
-
Development of protease inhibitors and the fight with drug-resistant HIV-1 variants
-
Mitsuya H., Maeda K., Das D., and Ghosh A.K. Development of protease inhibitors and the fight with drug-resistant HIV-1 variants. Adv. Pharmacol. 56 (2008) 169-197
-
(2008)
Adv. Pharmacol.
, vol.56
, pp. 169-197
-
-
Mitsuya, H.1
Maeda, K.2
Das, D.3
Ghosh, A.K.4
-
2
-
-
34548684745
-
HIV drug shows promise as potential cancer treatment
-
Cohen J. HIV drug shows promise as potential cancer treatment. Science 317 (2007) 1305
-
(2007)
Science
, vol.317
, pp. 1305
-
-
Cohen, J.1
-
3
-
-
0039730001
-
How an inhibitor of the HIV-I protease modulates proteasome activity
-
Schmidtke G., Holzhutter H.G., Bogyo M., Kairies N., Groll M., de Giuli R., Emch S., and Groettrup M. How an inhibitor of the HIV-I protease modulates proteasome activity. J. Biol. Chem. 274 (1999) 35734-35740
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 35734-35740
-
-
Schmidtke, G.1
Holzhutter, H.G.2
Bogyo, M.3
Kairies, N.4
Groll, M.5
de Giuli, R.6
Emch, S.7
Groettrup, M.8
-
4
-
-
38049093745
-
Nelfinavir, a new anti-cancer drug with pleiotropic effects and many paths to autophagy
-
Gills J.J., Lopiccolo J., and Dennis P.A. Nelfinavir, a new anti-cancer drug with pleiotropic effects and many paths to autophagy. Autophagy 4 (2008) 107-109
-
(2008)
Autophagy
, vol.4
, pp. 107-109
-
-
Gills, J.J.1
Lopiccolo, J.2
Dennis, P.A.3
-
5
-
-
4344600371
-
Chemoresistance in human ovarian cancer: the role of apoptotic regulators
-
Fraser M., Leung B., Jahani-Asl A., Yan X., Thompson W.E., and Tsang B.K. Chemoresistance in human ovarian cancer: the role of apoptotic regulators. Reprod. Biol. Endocrinol. 1 (2003) 66
-
(2003)
Reprod. Biol. Endocrinol.
, vol.1
, pp. 66
-
-
Fraser, M.1
Leung, B.2
Jahani-Asl, A.3
Yan, X.4
Thompson, W.E.5
Tsang, B.K.6
-
6
-
-
34547205231
-
Resistance to chemotherapy in ovarian carcinoma
-
Lage H., and Denkert C. Resistance to chemotherapy in ovarian carcinoma. Recent Results Cancer Res. 176 (2007) 51-60
-
(2007)
Recent Results Cancer Res.
, vol.176
, pp. 51-60
-
-
Lage, H.1
Denkert, C.2
-
7
-
-
25144489068
-
Overview of cell death signaling pathways
-
Jin Z., and El-Deiry W.S. Overview of cell death signaling pathways. Cancer Biol. Ther. 4 (2005) 139-163
-
(2005)
Cancer Biol. Ther.
, vol.4
, pp. 139-163
-
-
Jin, Z.1
El-Deiry, W.S.2
-
8
-
-
58149145772
-
The metastasis-associated gene MTA1 is upregulated in advanced ovarian cancer, represses ERbeta, and enhances expression of oncogenic cytokine GRO
-
Dannenmann C., Shabani N., Friese K., Jeschke U., Mylonas I., and Brüning A. The metastasis-associated gene MTA1 is upregulated in advanced ovarian cancer, represses ERbeta, and enhances expression of oncogenic cytokine GRO. Cancer Biol. Ther. 11 (2008) 1462-1465
-
(2008)
Cancer Biol. Ther.
, vol.11
, pp. 1462-1465
-
-
Dannenmann, C.1
Shabani, N.2
Friese, K.3
Jeschke, U.4
Mylonas, I.5
Brüning, A.6
-
9
-
-
24344454687
-
Glucocorticoids inhibit cell death in ovarian cancer and up-regulate caspase inhibitor cIAP2
-
Runnebaum I.B., and Brüning A. Glucocorticoids inhibit cell death in ovarian cancer and up-regulate caspase inhibitor cIAP2. Clin. Cancer Res. 11 (2005) 6325-6332
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 6325-6332
-
-
Runnebaum, I.B.1
Brüning, A.2
-
10
-
-
34548132882
-
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its therapeutic potential in breast and gynecologic cancers
-
Kendrick J.E., Estes J.M., Straughn Jr J.M., Alvarez R.D., and Buchsbaum D.J. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its therapeutic potential in breast and gynecologic cancers. Gynecol. Oncol. 106 (2007) 614-622
-
(2007)
Gynecol. Oncol.
, vol.106
, pp. 614-622
-
-
Kendrick, J.E.1
Estes, J.M.2
Straughn Jr, J.M.3
Alvarez, R.D.4
Buchsbaum, D.J.5
-
11
-
-
34247132169
-
Efficacy of anti-death receptor 5 (DR5) antibody (TRA-8) against primary human ovarian carcinoma using a novel ex vivo tissue slice model
-
Estes J.M., Oliver P.G., Straughn Jr. J.M., Zhou T., Wang W., Grizzle W.E., Alvarez R.D., Stockard C.R., LoBuglio A.F., and Buchsbaum D.J. Efficacy of anti-death receptor 5 (DR5) antibody (TRA-8) against primary human ovarian carcinoma using a novel ex vivo tissue slice model. Gynecol. Oncol. 105 (2007) 291-298
-
(2007)
Gynecol. Oncol.
, vol.105
, pp. 291-298
-
-
Estes, J.M.1
Oliver, P.G.2
Straughn Jr., J.M.3
Zhou, T.4
Wang, W.5
Grizzle, W.E.6
Alvarez, R.D.7
Stockard, C.R.8
LoBuglio, A.F.9
Buchsbaum, D.J.10
-
12
-
-
39249083325
-
Anti-tumor activity of the TRA-8 anti-DR5 antibody in combination with cisplatin in an ex vivo human cervical cancer model
-
Kendrick J.E., Straughn Jr J.M., Oliver P.G., Wang W., Nan L., Grizzle W.E., Stockard C.R., Alvarez R.D., and Buchsbaum D.J. Anti-tumor activity of the TRA-8 anti-DR5 antibody in combination with cisplatin in an ex vivo human cervical cancer model. Gynecol. Oncol. 108 (2008) 591-597
-
(2008)
Gynecol. Oncol.
, vol.108
, pp. 591-597
-
-
Kendrick, J.E.1
Straughn Jr, J.M.2
Oliver, P.G.3
Wang, W.4
Nan, L.5
Grizzle, W.E.6
Stockard, C.R.7
Alvarez, R.D.8
Buchsbaum, D.J.9
-
13
-
-
34547819299
-
The promise of TRAIL-potential and risks of a novel anticancer therapy
-
Koschny R., Walczak H., and Ganten T.M. The promise of TRAIL-potential and risks of a novel anticancer therapy. J. Mol. Med. 85 (2007) 923-935
-
(2007)
J. Mol. Med.
, vol.85
, pp. 923-935
-
-
Koschny, R.1
Walczak, H.2
Ganten, T.M.3
-
14
-
-
33947368690
-
TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window
-
Koschny R., Ganten T.M., Sykora J., Haas T.L., Sprick M.R., Kolb A., Stremmel W., and Walczak H. TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window. Hepatology 45 (2007) 649-658
-
(2007)
Hepatology
, vol.45
, pp. 649-658
-
-
Koschny, R.1
Ganten, T.M.2
Sykora, J.3
Haas, T.L.4
Sprick, M.R.5
Kolb, A.6
Stremmel, W.7
Walczak, H.8
-
15
-
-
42249113878
-
Treatment of human colon cancer xenografts with TRA-8 anti-death receptor 5 antibody alone or in combination with CPT-11
-
Oliver P.G., LoBuglio A.F., Zinn K.R., Kim H., Nan L., Zhou T., Wang W., and Buchsbaum D.J. Treatment of human colon cancer xenografts with TRA-8 anti-death receptor 5 antibody alone or in combination with CPT-11. Clin. Cancer Res. 14 (2008) 2180-2189
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 2180-2189
-
-
Oliver, P.G.1
LoBuglio, A.F.2
Zinn, K.R.3
Kim, H.4
Nan, L.5
Zhou, T.6
Wang, W.7
Buchsbaum, D.J.8
-
16
-
-
50349092260
-
A phase 1 study of mapatumumab (fully human monoclonal antibody to TRAIL-R1) in patients with advanced solid malignancies
-
Hotte S.J., Hirte H.W., Chen E.X., Siu L.L., Le L.H., Corey A., Iacobucci A., MacLean M., Lo L., Fox N.L., and Oza A.M. A phase 1 study of mapatumumab (fully human monoclonal antibody to TRAIL-R1) in patients with advanced solid malignancies. Clin. Cancer Res. 14 (2008) 3450-3455
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 3450-3455
-
-
Hotte, S.J.1
Hirte, H.W.2
Chen, E.X.3
Siu, L.L.4
Le, L.H.5
Corey, A.6
Iacobucci, A.7
MacLean, M.8
Lo, L.9
Fox, N.L.10
Oza, A.M.11
-
17
-
-
47949092316
-
Apomab: an agonist monoclonal antibody directed against Death Receptor 5/TRAIL-Receptor 2 for use in the treatment of solid tumors
-
Camidge D.R. Apomab: an agonist monoclonal antibody directed against Death Receptor 5/TRAIL-Receptor 2 for use in the treatment of solid tumors. Expert Opin. Biol. Ther. 8 (2008) 1167-1176
-
(2008)
Expert Opin. Biol. Ther.
, vol.8
, pp. 1167-1176
-
-
Camidge, D.R.1
-
18
-
-
33947141832
-
Proteasome inhibitors sensitize ovarian cancer cells to TRAIL induced apoptosis
-
Saulle E., Petronelli A., Pasquini L., Petrucci E., Mariani G., Biffoni M., Ferretti G., Scambia G., Benedetti-Panici P., Cognetti F., Humphreys R., Peschle C., and Testa U. Proteasome inhibitors sensitize ovarian cancer cells to TRAIL induced apoptosis. Apoptosis 12 (2007) 635-655
-
(2007)
Apoptosis
, vol.12
, pp. 635-655
-
-
Saulle, E.1
Petronelli, A.2
Pasquini, L.3
Petrucci, E.4
Mariani, G.5
Biffoni, M.6
Ferretti, G.7
Scambia, G.8
Benedetti-Panici, P.9
Cognetti, F.10
Humphreys, R.11
Peschle, C.12
Testa, U.13
-
19
-
-
0031945015
-
Surface expression of TRAIL/Apo-2 ligand in activated mouse T and B cells
-
Mariani S.M., and Krammer P.H. Surface expression of TRAIL/Apo-2 ligand in activated mouse T and B cells. Eur. J. Immunol. 28 (1998) 1492-1498
-
(1998)
Eur. J. Immunol.
, vol.28
, pp. 1492-1498
-
-
Mariani, S.M.1
Krammer, P.H.2
-
20
-
-
34247477638
-
HIV protease inhibitors modulate apoptosis signaling in vitro and in vivo
-
Vlahakis S.R., Bennett S.A., Whitehead S.N., and Badley A.D. HIV protease inhibitors modulate apoptosis signaling in vitro and in vivo. Apoptosis 12 (2007) 969-977
-
(2007)
Apoptosis
, vol.12
, pp. 969-977
-
-
Vlahakis, S.R.1
Bennett, S.A.2
Whitehead, S.N.3
Badley, A.D.4
-
21
-
-
40049103926
-
HIV protease inhibitors impact on apoptosis
-
Rizza S.A., and Badley A.D. HIV protease inhibitors impact on apoptosis. Med. Chem. 4 (2008) 75-79
-
(2008)
Med. Chem.
, vol.4
, pp. 75-79
-
-
Rizza, S.A.1
Badley, A.D.2
-
22
-
-
45749103615
-
HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice
-
Hisatomi T., Nakazawa T., Noda K., Almulki L., Miyahara S., Nakao S., Ito Y., She H., Kohno R., Michaud N., Ishibashi T., Hafezi-Moghadam A., Badley A.D., Kroemer G., and Miller J.W. HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice. J. Clin. Invest. 118 (2008) 2025-2038
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 2025-2038
-
-
Hisatomi, T.1
Nakazawa, T.2
Noda, K.3
Almulki, L.4
Miyahara, S.5
Nakao, S.6
Ito, Y.7
She, H.8
Kohno, R.9
Michaud, N.10
Ishibashi, T.11
Hafezi-Moghadam, A.12
Badley, A.D.13
Kroemer, G.14
Miller, J.W.15
-
23
-
-
4544253103
-
Mitochondrial effects of antiretroviral therapies in asymptomatic patients
-
López S., Miró O., Martínez E., Pedrol E., Rodríguez-Santiago B., Milinkovic A., Soler A., García-Viejo M.A., Nunes V., Casademont J., Gatell J.M., and Cardellach F. Mitochondrial effects of antiretroviral therapies in asymptomatic patients. Antivir. Ther. 9 (2004) 47-55
-
(2004)
Antivir. Ther.
, vol.9
, pp. 47-55
-
-
López, S.1
Miró, O.2
Martínez, E.3
Pedrol, E.4
Rodríguez-Santiago, B.5
Milinkovic, A.6
Soler, A.7
García-Viejo, M.A.8
Nunes, V.9
Casademont, J.10
Gatell, J.M.11
Cardellach, F.12
-
24
-
-
30444452551
-
In vivo effects of highly active antiretroviral therapies containing the protease inhibitor nelfinavir on mitochondrially driven apoptosis
-
Miró O., Villarroya J., Garrabou G., López S., Rodríguez de la Concepción M., Pedrol E., Martínez E., Giralt M., Gatell J.M., Cardellach F., Casademont J., and Villarroya F. In vivo effects of highly active antiretroviral therapies containing the protease inhibitor nelfinavir on mitochondrially driven apoptosis. Antivir. Ther. 10 (2005) 945-951
-
(2005)
Antivir. Ther.
, vol.10
, pp. 945-951
-
-
Miró, O.1
Villarroya, J.2
Garrabou, G.3
López, S.4
Rodríguez de la Concepción, M.5
Pedrol, E.6
Martínez, E.7
Giralt, M.8
Gatell, J.M.9
Cardellach, F.10
Casademont, J.11
Villarroya, F.12
-
25
-
-
34548827350
-
A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo
-
Gills J.J., Lopiccolo J., Tsurutani J., Shoemaker R.H., Best C.J., Abu-Asab M.S., Borojerdi J., Warfel N.A., Gardner E.R., Danish M., Hollander M.C., Kawabata S., Tsokos M., Figg W.D., Steeg P.S., Dennis P.A., and Nelfinavir. A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo. Clin. Cancer Res. 13 (2007) 5183-5194
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 5183-5194
-
-
Gills, J.J.1
Lopiccolo, J.2
Tsurutani, J.3
Shoemaker, R.H.4
Best, C.J.5
Abu-Asab, M.S.6
Borojerdi, J.7
Warfel, N.A.8
Gardner, E.R.9
Danish, M.10
Hollander, M.C.11
Kawabata, S.12
Tsokos, M.13
Figg, W.D.14
Steeg, P.S.15
Dennis, P.A.16
Nelfinavir17
-
26
-
-
45749106028
-
Phase I trial of the human immunodeficiency virus protease inhibitor nelfinavir and chemoradiation for locally advanced pancreatic cancer
-
Brunner T.B., Geiger M., Grabenbauer G.G., Lang-Welzenbach M., Mantoni T.S., Cavallaro A., Sauer R., Hohenberger W., and McKenna W.G. Phase I trial of the human immunodeficiency virus protease inhibitor nelfinavir and chemoradiation for locally advanced pancreatic cancer. J. Clin. Oncol. 26 (2008) 2699-2706
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 2699-2706
-
-
Brunner, T.B.1
Geiger, M.2
Grabenbauer, G.G.3
Lang-Welzenbach, M.4
Mantoni, T.S.5
Cavallaro, A.6
Sauer, R.7
Hohenberger, W.8
McKenna, W.G.9
|