Immune markers of disease and therapeutic intervention in type 1 diabetes

Novartis Foundation Symposium

Volumn 292, Issue , 2008, Pages 159-171

  Roep, Bart O ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 2; PROINSULIN; RECEPTOR LIKE PROTEIN TYROSINE PHOSPHATASE;

ANIMAL; CD8+ T LYMPHOCYTE; CONFERENCE PAPER; HUMAN; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; MOUSE; NONOBESE DIABETIC MOUSE; PANCREAS ISLET BETA CELL; PATHOLOGY; REGULATORY T LYMPHOCYTE;

ANIMALS; BIOLOGICAL MARKERS; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; DIABETES MELLITUS, TYPE 1; GLUTAMATE DECARBOXYLASE; HUMANS; INSULIN-SECRETING CELLS; MICE; MICE, INBRED NOD; PROINSULIN; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 8; T-LYMPHOCYTES, REGULATORY;

EID: 56249106505     PISSN: 15282511     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (46)

1. Alizadeh BZ, Hanifi-Moghaddam P, Eerligh P et al 2006 Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes. Clin Exp Immunol 145:480-484
2. Alizadeh BZ, Eerligh P, van der Slik AR et al 2007a MICA marks additional risk factors for type 1 diabetes on extended HLA haplotypes: An association and meta-analysis. Mol Immunol 44:2806-2812
3. Alizadeh BZ, Valdigem G, Coenen MJ et al 2007b Association analysis of functional variants of the FcgRIIa and FcgRIIIa genes with type 1 diabetes, celiac disease and rheumatoid arthritis. Hum Mol Genet 16:2552-2559
4. Arif S, Tree TI, Astill TP et al 2004 Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Invest 113:451-463
5. Bosi E, Braghi S, Maffi P et al 2001 Autoantibody response to islet transplantation in type 1 diabetes. Diabetes 50:2464-2471
6. Bottazzo GF, Dean BM, McNally JM, MacKay EH, Swift PGF, Gamble DR 1985 In situ characterization of autoimmune phenomena and expression of HLA class II molecules in the pancreas in diabetic insulitis. N Engl J Med 313:353-360
7. Bouwman LH, Eerligh P, Terpstra OT et al 2005 Elevated levels of mannose-binding lectin at clinical manifestation of type 1 diabetes in juveniles. Diabetes 54:3002-3006
8. Di Lorenzo TP, Peakman M, Roep BO 2007 Translational mini-review series on type 1 diabetes: systematic analysis of T cell epitopes in autoimmune diabetes. Clin Exp Immunol 148:1-16
9. Douglas Petersen L, Van der Keur M, De Vries RRP, Roep BO 1999 Autoreactive and immunoregulatory T-cell subsets in insulin dependent diabetes mellitus. Diabetologia 42:443-449
10. Eerligh P, Roep BO, Giphart MJ, Koeleman BP 2004 Insulin-like growth factor 1 promoter polymorphism influences insulin gene variable number of tandem repeat-associated risk for juvenile onset type 1 diabetes. Tissue Antigens 63:568-571
11. Greening JE, Tree TI, Kotowicz KT et al 2003 Processing and presentation of the islet autoantigen GAD by vascular endothelial cells promotes transmigration of autoreactive T-cells. Diabetes 52:717-725
12. Herold KC, Hagopian W, Auger JA et al 2002 Anti-CD3 monoclonal antibody in new-onset type 1 diabetes. N Engl J Med 346:1692-1698
13. Huurman VA, Kalpoe JS, van de LP et al 2006 Choice of antibody immunotherapy influences cytomegalovirus viremia in simultaneous pancreas-kidney transplant recipients. Diabetes Care 29:842-847
14. Huurman VA, Decochez K, Mathieu C, Cohen IR, Roep BO 2007 Therapy with the hsp60 peptide DiaPep277 in C-peptide positive type 1 diabetes patients. Diabetes Metab Res Rev 23:269-275
15. Keymeulen B, Vandemeulebroucke E, Ziegler AG et al 2005 Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med 352:2598-2608
16. Keymeulen B, Gillard P, Mathieu C et al 2006 Correlation between beta cell mass and glycemic control in type 1 diabetic recipients of islet cell graft. Proc Natl Acad Sci USA 103: 17444-17449
17. Koeleman BP, Valdigem G, Eerligh P, Giphart MJ, Roep BO 2002 Seasonality of birth in patients with type 1 diabetes. Lancet 359:1246-1247
18. Lindley S, Dayan CM, Bishop A, Roep BO, Peakman M, Tree TI 2005 Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 54:92-99
19. Mallone R, Martinuzzi E, Blancou P et al 2007 CD8+ T-cell responses identify β-cell autoimmunity in human type 1 diabetes. Diabetes 56:613-621
20. Martin S, Wolf-Eichbaum D, Duinkerken G et al 2001 Development of type 1 diabetes despite severe hereditary B-lymphocyte deficiency. N Engl J Med 345:1036-1040
21. Naik RG, Beckers C, Wentwoord R et al 2004 Precursor frequencies of T-cells reactive to insulin in recent onset type 1 diabetes mellitus. J Autoimmun 23:55-61
22. Ouyang Q, Standifer NE, Qin H et al 2006 Recognition of HLA class I-restricted β-cell epitopes in type 1 diabetes. Diabetes 55:3068-3074
23. Panagiotopoulos C, Qin H, Tan R, Verchere CB 2003 Identification of a β-cell-specific HLA class I restricted epitope in type 1 diabetes. Diabetes 52:2647-2651
24. Peakman M, Tree TI, Endl J, van Endert P, Atkinson MA, Roep BO 2001 Characterization of preparations of GAD65, proinsulin, and the islet tyrosine phosphatase IA-2 for use in detection of autoreactive T-cells in type 1 diabetes: report of phase II of the Second International Immunology of Diabetes Society Workshop for Standardization of T-cell assays in type 1 diabetes. Diabetes 50:1749-1754
25. Pinkse GG, Tysma OH, Bergen CA et al 2005 Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes. Proc Natl Acad Sci USA 102:18425-18430
26. Roep BO 1996 T-cell responses to autoantigens in IDDM. The search for the Holy Grail. Diabetes 45:1147-1156
27. Roep BO 2003 The role of T-cells in the pathogenesis of type 1 diabetes: from cause to cure. Diabetologia 46:305-321
28. Roep BO, Arden SD, de Vries RR, Hutton JC 1990 T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins. Nature 345:632-634
29. Roep BO, Kallan AA, Duinkerken G et al 1995 T-cell reactivity to beta-cell membrane antigens associated with beta-cell destruction in IDDM. Diabetes 44:278-283
30. Roep BO, Kallan AA, Hazenbos WL et al 1991 T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes. Lancet 337:1439-1441
31. Roep BO, Atkinson MA, van Endert PM, Gottlieb PA, Wilson SB, Sachs JA 1999a Autoreactive T cell responses in insulin-dependent (type 1) diabetes mellitus. Report of the first international workshop for standardization of T cell assays. J Autoimmun 13:267-282
32. Roep BO, Stobbe I, Duinkerken G et al 1999b Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients. Diabetes 48:484-490
33. Schloot NC, Hanifi-Moghaddam P, Abenhus-Andersen N et al 2007 Association of immune mediators at diagnosis of Type 1 diabetes with later clinical remission. Diabet Med 24: 512-520
34. Standifer NE, Ouyang Q, Panagiotopoulos C et al 2006 Identification of novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives. Diabetes 55:3061-3067
35. Takaki T, Marron MP, Mathews CE et al 2006 HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. J Immunol 176:3257-3265
36. Toma A, Haddouk S, Briand JP et al 2005 Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients. Proc Natl Acad Sci USA 102:10581-10586
37. Tree TI, Duinkerken G, Willemen S, de Vries RR, Roep BO 2004 HLA-DQ-regulated T-cell responses to islet cell autoantigens insulin and GAD65. Diabetes 53:1692-1699
38. Unger WW, Pinkse GG, Mulder-van der Kracht S et al 2007 Human clonal CD8 autoreactivity to an IGRP islet epitope shared between mice and men. Ann N Y Acad Sci 1103:192-195
39. van de Linde P, Tysma OM, Medema JP et al 2006 Mechanisms of antibody immunotherapy on clonal islet reactive T cells. Hum Immunol 67:264-273
40. van der Slik AR, Koeleman BP, Verduijn W, Bruining GJ, Roep BO, Giphart MJ 2003 KIR in type 1 diabetes: disparate distribution of activating and inhibitory natural killer cell receptors in patients versus HLA-matched control subjects. Diabetes 52:2639-2642
41. van Halteren AG, van Etten E, de Jong EC, Bouillon R, Roep BO, Mathieu C 2002 Redirection of human autoreactive T-cells Upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3). Diabetes 51:2119-2125
42. van Halteren AG, Kardol MJ, Mulder A, Roep BO 2005 Homing of human autoreactive T cells into pancreatic tissue of NOD-scid mice. Diabetologia 48:75-82
43. van Kampen CA, van de Linde P, Duinkerken G et al 2005 Alloreactivity against repeated HLA mismatches of sequential islet grafts transplanted in non-uremic type 1 diabetes patients. Transplantation 80:118-126
44. van Etten E, Verlinden L, Giulietti A et al 2007 The vitamin D receptor gene FokI polymorphism: functional impact on the immune system. Eur J Immunol 37:395-405
45. Zhernakova A, Eerligh P, Barrera P et al 2005a CTLA4 is differentially associated with autoimmune diseases in the Dutch population. Hum Genet 118:58-66
46. Zhernakova A, Eerligh P, Wijmenga C, Barrera P, Roep BO, Koeleman BP 2005b Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population. Genes Immun 6:459-461