Human clonal CD8 autoreactivity to an IGRP islet epitope shared between mice and men

Annals of the New York Academy of Sciences

Volumn 1103, Issue , 2007, Pages 192-195

  Unger, Wendy W J ^a   Pinkse, G G M ^a   Mulder Van Der Kracht, S ^a   Van Der Slik, A R ^a   Kester, M G D ^a   Ossendorp, F ^a   Drijfhout, J W ^a   Serreze, D V ^b   Roep, B O ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b JACKSON LABORATORY   (United States)

Author keywords

Antigen specific; Autoreactive cd8 t cells; Human t cell clone; IGRP

Indexed keywords

AUTOANTIGEN; CD8 ANTIGEN; EPITOPE; ISLET SPECIFIC GLUCOSE 6 PHOSPHATASE CATALYTIC SUBUNIT RELATED PROTEIN; PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CD8+ T LYMPHOCYTE; CELL DESTRUCTION; DIABETOGENESIS; HUMAN; IMMUNOREACTIVITY; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET BETA CELL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN TARGETING; SEQUENCE HOMOLOGY; T LYMPHOCYTE;

MUS;

EID: 34249107054     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1394.024     Document Type: Article

References (5)

1. SERREZE, D.V., E.H. LEITER, G.J. CHRISTIANSON, et al. 1994. Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant. Diabetes 43: 505-509.
2. FENNESSY, M., K. METCALFE, G.A. HITMAN, et al. 1994. A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population. Childhood Diabetes in Finland (DiMe) Study Group. Diabetologia 37: 937-944.
3. TAKAKI, T., M.P. MARRON, C.E. MATHEWS, et al. 2006. HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. J. Immunol. 176: 3257-3265.
4. SANTAMARIA, P., T. UTSUGI, B.J. PARK, et al. 1995. Beta-cell-cytotoxic CD8+T cells from nonobese diabetic mice use highly homologous T cell receptor alpha-chain CDR3 sequences. J. Immunol. 154: 2494-2503.
5. TAN, L., M.H. ANDERSEN, T. ELLIOTT, et al. 1997. An improved assembly assay for peptide binding to HLA-B*2705 and H-2K(k) class I MHC molecules. J. Immunol. Methods 209: 25-36.