Insulin-like growth factor 1 promoter polymorphism influences insulin gene variable number of tandem repeat-associated risk for juvenile onset type 1 diabetes

Tissue Antigens

Volumn 63, Issue 6, 2004, Pages 568-571

  Eerligh, P ^a   Roep, B O ^a   Giphart, M J ^a   Koeleman, B P C ^a,b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

IGF1; INS VNTR; Type 1 diabetes

Indexed keywords

INSULIN; MICROSATELLITE DNA; SOMATOMEDIN C;

ALLELE; ARTICLE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC VARIABILITY; HUMAN; INHERITANCE; INSULIN DEPENDENT DIABETES MELLITUS; JUVENILE DIABETES MELLITUS; PRIORITY JOURNAL; PROMOTER REGION; VARIABLE NUMBER OF TANDEM REPEAT;

CHROMOSOME MAPPING; DIABETES MELLITUS, TYPE 1; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; MINISATELLITE REPEATS; PROMOTER REGIONS (GENETICS);

EID: 2942607377     PISSN: 00012815     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0001-2815.2004.00229.x     Document Type: Article

References (20)

1. Bruining GJ. Association between infant growth before onset of juvenile type-1 diabetes and autoantibodies to IA-2. Netherlands Kolibrie Study Group of Childhood Diabetes. Lancet 2000: 356: 655-6.
2. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 1995: 16: 3-34.
3. Stewart CE, Rotwein P. Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors. Physiol Rev 1996: 76: 1005-26.
4. Le Roith D. Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors. N Engl J Med 1997: 336: 633-40.
5. Brocardo MG, Schillaci R, Galeano A, Radrizzani M, White V, Guerrico AG et al. Early effects of insulin-like growth factor-1 in activated human T lymphocytes. J Leukoc Biol 2001: 70: 297-305.
6. Vaessen N, Heutink P, Janssen JA, Witteman JC, Testers L, Hofman A et al. A polymorphism in the gene for IGF-I: functional properties and risk for type 2 diabetes and myocardial infarction. Diabetes 2001: 50: 637-42.
7. Rosen CJ, Kurland ES, Vereault D, Adler RA, Rackoff PJ, Craig WY et al. Association between serum insulin growth factor-I (IGF-I) and a simple sequence repeat in IGF-I gene: implications for genetic studies of bone mineral density. J Clin Endocrinol Metab 1998: 83: 2286-90.
8. Bennett ST, Lucassen AM, Gough SC, Powell EE, Undlien DE, Pritchard LE et al. Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nat Genet 1995: 9: 284-92.
9. Ong KK, Phillips DI, Fall C, Poulton J, Bennett ST, Golding J et al. The insulin gene VNTR, type 2 diabetes and birth weight. Nat Genet 1999: 21: 262-3.
10. Vafiadis P, Ounissi-Benkalha H, Palumbo M, Grabs R, Rousseau M, Goodyer CG et al. Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes. J Clin Endocrinol Metab 2001: 86: 3705-10.
11. Vafiadis P, Bennett ST, Todd JA, Nadeau J, Grabs R, Goodyer CG et al. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet: 15: 289-97.
12. Undlien DE, Bennett ST, Todd JA, Akselsen HE, Ikaheimo I, Reijonen H et al. Insulin gene region-encoded susceptibility to IDDM maps upstream of the insulin gene. Diabetes 1995: 44: 620-5.
13. Dunger DB, Ong KK, Huxtable SJ, Sherriff A, Woods KA, Ahmed ML et al. Association of the INS VNTR with size at birth. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Nat Genet 1998: 19: 98-100.
14. Bennett ST, Todd JA. Human type 1 diabetes and the insulin gene: principles of mapping polygenes. Annu Rev Genet 1996: 30: 343-70.
15. Bonner-Weir S. Life and death of the pancreatic beta cells. Trends Endocrinol Metab 2000: 11: 375-8.
16. Bonner-Weir S. Perspective: Postnatal pancreatic beta cell growth. Endocrinology 2000: 141: 1926-9.
17. Hales CN. Fetal and infant growth and impaired glucose tolerance in adulthood: the "thrifty phenotype" hypothesis revisited. Acta Paediatr Suppl 1997: 422: 73-7.
18. Khaw KT. Genetics and environment: Geoffrey Rose revisited. Lancet 1994: 343: 838-9.
19. Dudbridge F, Koeleman BP, Todd JA, Clayton DG. Unbiased application of the transmission/disequilibrium test to multilocus haplotypes. Am J Hum Genet 2000: 66: 2009-12.
20. Koeleman BP, Dudbridge F, Cordell HJ, Todd JA. Adaptation of the extended transmission/disequilibrium test to distinguish disease associations of multiple loci: the conditional extended transmission/disequilibrium test. Ann Hum Genet 2000: 64: 207-13.