Molecular modeling and experimental evidence for hypericin as a substrate for mitochondrial complex III; mitochondrial photodamage as demonstrated using specific inhibitors

Free Radical Biology and Medicine

Volumn 45, Issue 11, 2008, Pages 1581-1590

  Theodossiou, Theodossis Athanassios ^a   Papakyriakou, Athanasios ^a   Hothersall, John Stephen ^b  

^a INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Complex III; Cytochrome c; DU145 cells; Free radicals; Hypericin; Mitochondria; Mitochondrial inhibitors; Molecular modeling; Ubiquinone

Indexed keywords

ANTIMYCIN A1; HYPERICIN; MYXOTHIAZOL; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; UBIQUINOL CYTOCHROME C REDUCTASE;

ARTICLE; BINDING SITE; CANCER CELL; CONTROLLED STUDY; DRUG INHIBITION; EXPERIMENTAL STUDY; HUMAN; HUMAN CELL; MOLECULAR MODEL; PHOTOSENSITIZATION; PRIORITY JOURNAL; PROSTATE CARCINOMA; SUBMITOCHONDRIAL PARTICLE;

ANTIMYCIN A; BINDING SITES; CELL LINE, TUMOR; CYTOCHROMES C; ELECTRON TRANSPORT COMPLEX III; HUMANS; LIGHT; METHACRYLATES; MITOCHONDRIA; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; MODELS, MOLECULAR; PERYLENE; SPECTROPHOTOMETRY, ULTRAVIOLET; SUBMITOCHONDRIAL PARTICLES; THIAZOLES; UBIQUINONE;

EID: 56249105770     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2008.09.015     Document Type: Article

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