Increased L-arginine transport via system b0,+ in human proximal tubular cells exposed to albumin

Clinical Science

Volumn 111, Issue 6, 2006, Pages 389-399

  Ashman, Neil ^a   Brunini, Tatiana M ^b   Mann, Giovanni E ^c   Mendes Ribeiro, A Claudio ^b,d   Yaqoob, Muhammad M ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d FEDERAL UNIVERSITY OF THE STATE OF RIO DE JANEIRO   (Brazil)

Author keywords

Albumin; Amino acid transport; Arginine; Phosphoinositide 3 kinase (PI3K); Polyamine; Proliferation; Proximal tubular epithelial cell; System b0,+

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ARGININE; HUMAN ALBUMIN; LYSINE; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

AMINO ACID TRANSPORT; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENDOCYTOSIS; HUMAN; HUMAN CELL; KIDNEY PROXIMAL TUBULE; KINETICS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ALBUMINS; AMINO ACID TRANSPORT SYSTEMS, BASIC; ARGININE; BIOLOGICAL TRANSPORT; CELL PROLIFERATION; HUMANS; KIDNEY TUBULES, PROXIMAL; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 33845408122     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20060158     Document Type: Article

References (53)

1. Deves, R. and Boyd, C. A. (1998) Transporters for cationic arnino acids in animal cells: discovery, structure, and function. Physiol. Rev. 78, 487-545
2. Kanai, Y., Segawa, H., Chairoungdua, A. et al. (2000) Amino acid transporters: molecular structure and physiological roles. Nephrol. Dial. Transplant. 15 (Suppl. 6), 9-10
3. Chillaron, J., Roca, R., Valencia, A., Zorzano, A. and Palacin, M. (2001) Heteromeric amino acid transporters: biochemistry, genetics, and physiology. Am. J. Physiol. Renal Physiol. 281, F995-F1018
4. Bauch, C. and Verrey, F. (2002) Apical heterodimeric cystine and cationic amino acid transporter expressed in MDCK cells. Am. J. Physiol. Renal Physiol. 283, F181-F189
5. Bauch, C., Forster, N., Loffing-Cueni, D., Summa, V. and Verrey, F. (2003) Functional cooperation of epithelial heteromeric amino acid transporters expressed in Madin-Darby canine kidney cells. J. Biol. Chem. 278, 1316-1322
6. 0,+ -like amino acid transport system in a 'renal proximal tubular' cell line (OK cells). J. Biol. Chem. 271, 10569-10576
7. Chillaron, J., Estevez, R., Mora, C. et al. (1996) Obligatory amino acid exchange via systems bo, +-like and y + L-like. A tertiary active transport mechanism for renal reabsorption of cystine and dibasic amino acids. J. Biol. Chem. 271, 17761-17770
8. Fernandez, E., Torrents, D., Chillaron, J., Martin Del Rio, R., Zorzano, A. and Palacin, M. (2003) Basolateral LAT-2 has a major role in the transepithelial flux of L-cystine in the renal proximal tubule cell line OK. J. Am. Soc. Nephrol. 14, 837-847
9. Torrents, D., Estevez, R., Pineda, M. et al. (1998) Identification and characterization of a membrane protein (y + L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y + L. A candidate gene for lysinuric protein intolerance. J. Biol. Chem. 273, 32437-32445
10. Mendes Ribeiro, A. C. and Brunini, T. M. (2004) L-Arginine transport in disease. Curr. Med. Chem. Cardiovasc. Hematol. Agents 2, 123-131
11. Moss, M. B., Brunini, T. M., Soares De Moura, R. et al. (2004) Diminished L-arginine bioavailability in hypertension. Clin. Sci. 107, 391-397
12. Mendes Ribeiro, A. C., Brunini, T. M., Ellory, J. C. and Mann, G. E. (2001) Abnormalities in L-arginine transport and nitric oxide biosynthesis in chronic renal and heart failure. Cardiovasc. Res. 49, 697-712
13. Mann, G. E., Yudilevich, D. L. and Sobrevia, L. (2003) Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells. Physiol. Rev. 83, 183-252
14. Bogle, R. G., Baydoun, A. R., Pearson, J. D., Moncada, S. and Mann, G. E. (1992) L-Arginine transport is increased in macrophages generating nitric oxide. Biochem. J. 284, 15-18
15. Closs, E. I., Scheld, J. S., Sharafi, M. and Forstermann, U. (2000) Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: role of cationic amino acid transporters. Mol. Pharmacol. 57, 68-74
16. Xiao, S., Wagner, L., Mahaney, J. and Baylis, C. (2001) Uremic levels of urea inhibit L-arginine transport in cultured endothelial cells. Am. J. Physiol. Renal Physiol. 280, F989-F995
17. +L. Pflügers Arch. 445, 547-550
18. Durante, W., Liao, L., Iftikhar, I., Cheng, K. and Schafer, A. I. (1996) Platelet-derived growth factor regulates vascular smooth muscle cell proliferation by inducing cationic amino acid transporter gene expression. J. Biol. Chem. 271, 11838-11843
19. Ignarro, L. J., Buga, G. M., Wei, L. H., Bauer, P. M., Wu, G. and del Soldato, P. (2001) Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation. Proc. Natl. Acad. Sci. U.S.A. 98, 4202-4208
20. 1 stimulates L-arginine transport and metabolism in vascular smooth muscle cells: role in polyamine and collagen synthesis. Circulation 103, 1121-1127
21. Nelin, L. D., Krenz, G. S., Chicoine, L. G., Dawson, C. A. and Schapira, R. M. (2002) L-Arginine uptake and metabolism following in vivo silica exposure in rat lungs. Am. J. Respir. Cell Mol. Biol. 26, 348-355
22. Ashman, N., Harwood, S. M., Kieswich, J. et al. (2005) Albumin stimulates cell growth, L-arginine transport, and metabolism to polyamines in human proximal tubular cells. Kidney Int. 67, 1878-1889
23. Sepulveda, F. V. and Pearson, J. D. (1985) Cationic amino acid transport by two renal epithelial cell lines: LLC-PK1 and MDCK cells. J. Cell Physiol. 123, 144-150
24. Edwards, R. M., Stack, E. J. and Trizna, W. (1998) Interaction of L-arginine analogs with L-arginine uptake in rat renal brush border membrane vesicles. J. Pharmacol. Exp. Ther. 285, 1019-1022
25. Wu, F., Cholewa, B. and Mattson, D. L. (2000) Characterization of L-arginine transporters in rat renal inner medullary collecting duct. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278, R1506-R1512
26. Kakoki, M., Kim, H. S., Arendshorst, W. J. and Mattson, D. L. (2004) L-Arginine uptake affects nitric oxide production and blood flow in the renal medulla. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 287, R1478-R1485
27. Schwanz, I. F., Schwartz, D., Traskonov, M. et al. (2002) L-Arginine transport is augmented through up-regulation of tubular CAT-2 mRNA in ischemic acute renal failure in rats. Kidney Int. 62, 1700-1706
28. Schwartz, D., Schwartz, I. F., Gnessin, E. et al. (2003) Differential regulation of glomerular arginine transporters (CAT-1 and CAT-2) in lipopolysaccharide-treated rats. Am. J. Physiol. Renal Physiol. 284, F788-F795
29. Schwartz, I. F., Iaina, A., Benedict, Y. et al. (2004) Augmented arginine uptake, through modulation of cationic amino acid transporter-1, increases GFR in diabetic rats. Kidney Int. 65, 1311-1319
30. Schwartz, I. F., Ayalon, R., Chernichovski, T. et al. (2006) Arginine uptake is attenuated through modulation of cationic amino-acid transporter-1, in uremic rats. Kidney Int. 69, 298-303
31. Brunskill, N. J. (2004) Albumin signals the coming of age of proteinuric nephropathy. J. Am. Soc. Nephrol. 15, 504-505
32. Ryan, M. J., Johnson, G., Kirk, J., Fuerstenberg, S. M., Zager, R. A. and Torok-Storb, B. (1994) HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney. Kidney Int. 45, 48-57
33. Closs, E. I. and Mann, G. E. (1999) Identification of carrier systems in plasma membranes of mammalian cells involved in transport of L-arginine. Methods Enzymol. 301, 78-91
34. Gomes, P., Xu, J., Serrao, P., Doria, S., Jose, P. A. and Soares-da-Silva, P. (2002) Expression and function of sodium transporters in two opossum kidney cell clonal sublines. Am. J. Physiol. Renal Physiol. 283, F73-F85
35. Ayuk, P. T., Sibley, C. P., Donnai, P., D'Souza, S. and Glazier, J. D. (2000) Development and polarization of cationic amino acid transporters and regulators in the human placenta. Am. J. Physiol. Cell Physiol. 278, C1162-C1171
36. Feliubadalo, L., Font, M., Purroy, J. et al. (1999) Non-type I cystinuria caused by mutations in SLC7A9, encoding a subunit (bo, + AT) of rBAT. Nat. Genet. 23, 52-57
37. +L in cultured human fibroblasts: normal phenotype of cells from LPI subjects. Am. J. Physiol. Cell Physioh 279, C1829-C1837
38. Hyde, R., Taylor, P. M. and Hundal, H. S. (2003) Amino acid transporters: roles in amino acid sensing and signalling in animal cells. Biochem. J. 373, 1-18
39. Cui, Z., Tuladhar, R., Hart, S. L., Marber, M. S., Pearson, J. D. and Baydoun, A. R. (2005) Rate of transport of L-arginine is independent of the expression of inducible nitric oxide synthase in HEK 293 cells. Nitric Oxide 12, 21-30
40. Brunskill, N. J., Stuart, J., Tobin, A. B., Walls, J. and Nahorski, S. (1998) Receptor-mediated endocytosis of albumin by kidney proximal tubule cells is regulated by phosphatidylinositide 3-kinase. J. Clin. Invest. 101, 2140-2150
41. Dixon, R. and Branskill, N. J. (1999) Activation of mitogenic pathways by albumin in kidney proximal tubule epithelial cells: implications for the pathophysiology of proteinuric states. J. Am. Soc. Nephrol. 10, 1487-1497
42. Eisenbach, G. M., Weise, M. and Stolte, H. (1975) Amino acid reabsorption in the rat nephron. Free flow micropuncture study. Pflügers Arch. 357, 63-76
43. Fernandez, E., Carrascal, M., Rousaud, F. et al. (2002) rBAT-b(0,+)AT heterodimer is the main apical reabsorption system for cystine in the kidney. Am. J. Physiol. Renal Physiol. 283, F540-F548
44. Lee, E. M., Pollock, C. A., Drumm, K., Barden, J. A. and Poronnik, P. (2003) Effects of pathophysiological concentrations of albumin on NHE3 activity and cell proliferation in primary cultures of human proximal tubule cells. Am. J. Physiol. Renal Physiol. 285, F748-F757
45. Christensen, H. N. (1989) Distinguishing amino acid transport systems of a given cell or tissue. Methods Enzymol. 173, 576-616
46. Reade, M. C., Clark, M. F., Young, J. D. and Boyd, C. A. (2002) Increased cationic amino acid flux through a newly expressed transporter in cells overproducing nitric oxide from patients with septic shock. Clin. Sci. 102, 645-650
47. Nakajima, H., Takenaka, M., Kaimori, J. Y. et al. (2004) Activation of the signal transducer and activator of transcription signaling pathway in renal proximal tubular cells by albumin. J. Am. Soc. Nephrol. 15, 276-285
48. Low, B. C. and Grigor, M. R. (1995) Angiotensin II stimulates system y+ and cationic amino acid transporter gene expression in cultured vascular smooth muscle cells. J. Biol. Chem. 270, 27577-27583
49. Fafournoux, P., Bruhat, A. and Jousse, C. (2000) Amino acid regulation of gene expression. Biochem. J. 351, 1-12
50. Brosnan, M. E. and Brosnan, J. T. (2004) Renal arginine metabolism. J. Nutr. 134, 2791S-2795S
51. Escobales, N., Rivera-Correa, M., Altieri, P. I. and Rodriguez, J. F. (2000) Relationship between NO synthesis, arginine transport, and intracellular arginine levels in vascular smooth muscle cells. Amino Acids 19, 451-468
52. Caso, G., McNurlan, M. A., McMillan, N. D., Eremin, O. and Garlick, P. J. (2004) Tumour cell growth in culture: dependence on arginine. Clin. Sci. 107, 371-379
53. Shen, L. J., Lin, W. C., Beloussow, K. and Shen, W. C. (2003) Resistance to the anti-proliferative activity of recombinant arginine deiminase in cell culture correlates with the endogenous enzyme, argininosuccinate synthetase. Cancer Lett. 191, 165-170