Inhibition of crystallin ascorbylation by nucleophilic compounds in the hSVCT2 mouse model of lenticular aging

Investigative Ophthalmology and Visual Science

Volumn 49, Issue 11, 2008, Pages 4945-4952

  Fan, Xingjun ^a   Monnier, Vincent M ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 N CARBOXYMETHYLLYSINE; ACETYLSALICYLIC ACID; ADVANCED GLYCATION END PRODUCT; AMINOGUANIDINE; CRYSTALLIN; DEHYDROASCORBIC ACID; GLUTATHIONE; GUANIDINE DERIVATIVE; K2P PROTEIN; LENS PROTEIN; LYSINE; NC I; NCI II; NUCLEOPHILE; PENICILLAMINE; PENTOSIDINE; PYRIDOXAMINE; UNCLASSIFIED DRUG; ANTIOXIDANT; ASCORBIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CATARACT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS LINKING; DISEASE MODEL; DRUG MECHANISM; FEMALE; FLUORESCENCE; FOOD INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INTERVENTION STUDY; LIQUID CHROMATOGRAPHY; MALE; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; STRUCTURE ACTIVITY RELATION; TRANSGENIC MOUSE; AGING; ANIMAL; C57BL MOUSE; COMPARATIVE STUDY; DRUG EFFECT; LENS; METABOLISM; SPECTROFLUOROMETRY;

AGING; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; CATARACT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLINS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLYCOSYLATION END PRODUCTS, ADVANCED; LENS, CRYSTALLINE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; SPECTROMETRY, FLUORESCENCE;

EID: 56149115549     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-1813     Document Type: Article

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