Vitamin C induced oxidation of eye lens gamma crystallins

Biochimie

Volumn 80, Issue 4, 1998, Pages 283-288

  Atalay, A ^a   Ogus, A ^a   Bateman, O ^b   Slingsby, C ^b  

^a HACETTEPE UNIVERSITY   (Turkey)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Ascorbate; Eye lens; Metal catalysed oxidation; Reactive oxygen species; crystallins

Indexed keywords

2 OXOGLUTARIC ACID; ASCORBIC ACID; GAMMA CRYSTALLIN; PYRUVIC ACID;

ARTICLE; DIMERIZATION; LENS; MASS SPECTROMETRY; NONHUMAN; OXIDATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DENATURATION;

EID: 0032052268     PISSN: 03009084     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-9084(98)80068-0     Document Type: Article

References (27)

1. 1 Ames BN, Shigenaga MK, Hagen TM (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proc Nad Acad Sci USA, 90, 7915-7922
2. 2 Delaye M, Tardieu A (1983) Short-range order of crystallin proteins accounts for eye lens transparency. Nature (Lond) 302, 415-417
3. 3 Spector A (1984) Oxidation and Cataract. In: Human cataract formation. Ciba Foundation Symposium 106, Pitman, London, 48-64
4. 4 Harding J (1991) Cataract: Biochemistry, epidemiology and pharmacology. Chapman & Hall, London
5. 5 Taylor A (1992) Role of nutrients in delaying cataract. Ann NY Acad Sci 669, 111-124
6. 6 Chiou SH (1983) DNA-scission and protein-scission activities of ascorbate in the presence of copper-ion and a copper-peptide complex. J Biochem 94, 1259-1267
7. 7 Miller DM, Buetther GR, Aust SD (1990) Transition-metals as catalysts of autoxidation reactions. Free Rad Biol Med 8, 95-100
8. 8 Halliwell B, Gutteridge JMC (1990) Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 186, 1-85
9. 2 in aqueous humor. Exp Eye Res 38, 87-93
10. 10 Spector A, Garner WH (1981) Hydrogen peroxide and human cataract. Exp Eye Res 33, 673-681
11. 11 Garland D (1990) Role of site-specific, metal catalyzed oxidation in lens during aging and cataract - a hypothesis. Exp Eye Res 50, 677-682
12. 12 Garland D, Zigler SJ, Jr, Kinoshita J (1986) Structural changes in bovine lens crystallins induced by ascorbate, metal, and oxygen. Arch Biochem Biophys 251, 771-776
13. 13 Thomson JA, Siezen RJ, Kaplan ED, Messmer M, Chakrabarti B (1989) Comparative studies of βs-crystallins from human, bovine, rat and rabbit lenses. Curr Eye Res 8, 139-149
14. 14 Palme S, Slingsby C, Jaenicke R (1997) Mutational analysis of hydrophobic domain interactions in γβ-crystallin from bovine eye lens. Protein Sci 6, 1529-1536
15. 15 Najmudin S, Nalini V, Driessen HPC, Slingsby C, Blundell TL, Moss DS, Lindley PF (1993) Structure of the bovine eye lens protein γB (γII)-crystallin at 1.47 Å. Acta Cryst D49, 223-233
16. 16 Quax-Jeuken Y, Driessen H, Leunissen J, Quax W, de Jong W, Bloemendal, H (1985) βs-Crystallin: structure and evolution of a distinct member of the βγ-crystallin superfamily. EMBO J 4, 2597-2602
17. 17 Zarina S, Slingsby C, Jaenicke R, Zaidi ZH, Driessen H, Srinivasan N (1994) Three-dimensional model and quaternary structure of the human eye lens protein γS-crystallin based on β-and γ-crystallin X-ray coordinates and ultracentrifugation. Protein Sci 3, 1840-1846
18. 18 Slingsby C, Bateman OA (1990) Rapid separation of bovine β-crystallin subunits βB1, βB2, βB3,βA3 and βA4. Exp Eye Res 51, 21-26
19. 19 Laemmli UK (1970) Cleavage of the structural proteins during assembly of the head of bacteriophage T4. Nature 227, 680-685
20. 20 Wray W, Boulikas T, Wray VP, Hancock R (1981) Silver staining of proteins in polyacrylamide gels. Anal Biochem 118, 197-203
21. 21 Hay RE, Woods WD, Church RL, Petrash JM (1987) cDNA clones encoding bovine γ-crystallins. Biochem Biophys Res Commun 146, 332-338
22. 22 Wannermacher CF, Spector A (1968) Protein synthesis in the core of calf lens. Exp Eye Res 7, 623-635
23. 23 Stadtman ER, Oliver CN (1991) Metal-catalysed oxidation of proteins. J Biol Chem 266, 2005-2008
24. 24 Cui X-L, Qin C, Zigler JS, Jr (1994) Residual EDTA bound by lens crystallins accounts for their reported resistance to copper-catalyzed oxidative damage. Arch Biochem Biophys 308, 207-213
25. 25 Varma SD, Devamanoharan PS, Morris SM (1990) Photoinduction of cataracts in rat lens in vitro - preventive effect of pyruvate. Exp Eye Res 50, 805-812
26. 26 Varma SD, Ramachandran S, Devamanoharan PS, Morris SM, Ali AH (1995) Prevention of oxidative damage to rat lens by pyruvate in vitro - possible attenuation in vivo. Curr Eye Res 14, 643-649
27. 27 Hunt JV, Simpson JA, Dean RT (1988) Hydroperoxide-mediated fragmentation of proteins. Biochem J 250, 87-93