Involvement of LEK1 in dendritic cell regulation of T cell immunity against Chlamydia

Journal of Immunology

Volumn 181, Issue 6, 2008, Pages 4037-4042

  He, Qing ^a,b   Eko, Francis O ^a   Lyn, Deborah ^a   Ananaba, Godwin A ^a,c   Bandea, Claudiu ^b   Martinez, Joseph ^b   Joseph, Kahaliah ^b   Kellar, Kathy ^b   Black, Carolyn M ^b   Igietseme, Joseph U ^a,b  

^a MOREHOUSE SCHOOL OF MEDICINE   (United States)

^b NATL CENTER FOR INFECTIOUS DISEASES   (United States)

^c CLARK ATLANTA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ANTISENSE OLIGONUCLEOTIDE; B7 ANTIGEN; CD14 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR7; CYTOSKELETON PROTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 4; INTERLEUKIN 9; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; VIMENTIN; BIOLOGICAL MARKER; CYTOKINE; LEK1 PROTEIN, MOUSE; NONHISTONE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL MATURATION; CELLULAR IMMUNITY; CHLAMYDIA; CYTOKINE RELEASE; CYTOSKELETON; DENDRITIC CELL; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; IMMUNOSTIMULATION; LYMPHOCYTE ACTIVATION; MICROORGANISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TH1 CELL; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CHLAMYDIA TRACHOMATIS; CYTOLOGY; DRUG ANTAGONISM; GENETICS; IMMUNOLOGY; MICROBIOLOGY; MOUSE MUTANT; PHYSIOLOGY; SECRETION; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELLS, CULTURED; CHLAMYDIA TRACHOMATIS; CHROMOSOMAL PROTEINS, NON-HISTONE; CYTOKINES; CYTOSKELETAL PROTEINS; DENDRITIC CELLS; FEMALE; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OLIGONUCLEOTIDES, ANTISENSE; T-LYMPHOCYTE SUBSETS;

EID: 56149112140     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.6.4037     Document Type: Article

References (21)

1. Hafner, L., and C. McNeilly. 2008. Vaccines for Chlamydia infections of the female genital tract. Future Microbiol. 3: 67-77.
2. Roan, N., and M. Starnbach. 2008. Immune-mediated control of Chlamydia infection. Cell. Microbiol. 10: 9-19.
3. Brunham, R., and J. Rey-Ladino. 2005. Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine. Nat. Rev. Immunol. 5: 149-161. (Pubitemid 40208904)
4. Steinman, R. M. 2007. Dendritic cells: understanding immunogenicity. Eur. J. Immunol. 37: S53-S60.
5. Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392: 245-252.
6. Zhang, D., X. Yang, H. Lu, G. Zhong, and R. C. Brunham. 1999. Immunity to Chlamydia trachomatis mouse pneumonitis induced by vaccination with live organisms correlates with early granulocyte-macrophage colony-stimulating factor and interleukin-12 production and with dendritic cell-like maturation. Infect. Immun. 67: 1606-1613. (Pubitemid 29144372)
7. Burns, S., and A. J. Thrasher. 2004. Dendritic cells: the bare bones of immunity. Curr. Biol. 14: R965-R967. (Pubitemid 39547949)
8. He, Q., T. T. Moore, F. O. Eko, D. Lyn, G. A. Ananaba, A. Martin, S. Singh, J. Lillard, J. Stiles, C. M. Black, and J. U. Igietseme. 2005. Molecular basis for the potency of IL-10-deficient dendritic cells as a highly efficient APC system for activating Th1 response. J. Immunol. 174: 4860-4869. (Pubitemid 40504570)
9. Burns, S., A. J. Thrasher, M. P. Blundell, L. Machesky, and G. E. Jones. 2001. Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation. Blood. 98: 1142-1149.
10. Westerberg, L., R. P. Wallin, G. Greicius, H. G. Ljunggren, and E. Severinson. 2003. Efficient antigen presentation of soluble, but not particulate, antigen in the absence of Wiskott-Aldrich syndrome protein. Immunol. 109: 384-391. (Pubitemid 36783264)
11. West, M. A., R. P. Wallin, S. P. Matthews, H. G. Svensson, R. Zaru, H. G. Ljunggren, A. R. Prescott, and C. Watts. 2004. Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling. Science 305: 1153-1157.
12. Benvenuti, F., S. Hugues, M. Walmsley, S. Ruf, L. Fetler, M. Popoff, V. L. Tybulewicz, and S. Amigorena. 2004. Requirement of Rac1 and Rac2 expression by mature dendritic cells for T cell priming. Science 305: 1150-1153. (Pubitemid 39100327)
13. Ashe, M., L. Pabon-Pena, E. Dees, K. L. Price, and D. Bader. 2004. LEK1 is a potential inhibitor of pocket protein-mediated cellular processes. J. Biol. Chem. 279: 664-676. (Pubitemid 38044871)
14. Soukoulis, V., S. Reddy, R. D. Pooley, Y. Feng, C. A. Walsh, and D. M. Bader. 2005. Cytoplasmic LEK1 is a regulator of microtubule function through its interaction with the LIS1 pathway. Proc. Natl. Acad. Sci. USA 102: 8549-8554. (Pubitemid 40862773)
15. Goodwin, R. L., L. M. Pabón-Peña, G. C. Foster, and D. M. Bader. 1999. The cloning and analysis of LEK1 identifies variations in the LEK/centromere protein F/mitosin gene family. J. Biol. Chem. 274: 18597-18604. (Pubitemid 129519264)
16. Diwu, Z., Y.-Z. Zhang, and R. Haugland. 1994. Novel site-selective fluorescent probes for lysosome and acidic organelle staining and long-term tracking. Cytometry 52: Abstract 426B.
17. Harding, C. 1995. Intracellular organelles involved in antigen processing and the binding of peptides to class II MHC molecules. Semin. Immunol. 7: 355-360.
18. Schuurhuis, D. H., N. Fu, F. Ossendorp, and C. J. Melief. 2006. Ins and outs of dendritic cells. Int. Arch. Allergy Immunol. 140: 53-72.
19. Zhang, J., A. Shehabeldin, L. A. da Cruz, J. Butler, A.-K. Somani, M. McGavin, I. Kozieradzki, A. O. dos Santos, A. Nagy, S. Grinstein, et al. 1999. Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott- Aldrich syndrome protein-deficient lymphocytes. J. Exp. Med. 190: 1329-1342.
20. Calle, Y., H.-C. Chou, A. Thrasher, and G. Jones. 2004. Wiskott-Aldrich syndrome protein and the cytoskeletal dynamics of dendritic cells. J. Pathol. 204: 460-469. (Pubitemid 39468157)
21. He, Q., L. Martinez-Sobrido, F. O. Eko, P. Palese, A. Garcia-Sastre, D. Lyn, D. Okenu, C. Bandea, G. A. Ananaba, C. M. Black, and J. U. Igietseme. 2007. Live-attenuated influenza viruses as delivery vectors for Chlamydia vaccines. Immunology 122: 28-37. (Pubitemid 47222592)