Efficacy of high-dose chemotherapy or standard salvage therapy in patients with recurrent medulloblastoma

Neuro-Oncology

Volumn 10, Issue 5, 2008, Pages 745-751

  Gururangan, Sridharan ^a   Krauser, Jeanne ^a   Watral, Melody A ^a   Driscoll, Tim ^a   Larrier, Nicole ^a   Reardon, David A ^a   Rich, Jeremy N ^a   Quinn, Jennifer A ^a   Vredenburgh, James J ^a   Desjardins, Annick ^a   McLendon, Roger E ^a   Fuchs, Herbert ^a   Kurtzberg, Joanne ^a   Friedman, Henry S ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Angiogenesis; Avastin; Bevacizumab; Bio markers; Glioblastoma; Glioma

Indexed keywords

ANTINEOPLASTIC AGENT; BUSULFAN; CARBOPLATIN; CISPLATIN; CLORETAZINE; CYCLOPHOSPHAMIDE; ETOPOSIDE; IRINOTECAN; MELPHALAN; METHOTREXATE; PLATINUM DERIVATIVE; TEMOZOLOMIDE; VINCRISTINE;

ADOLESCENT; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; HUMAN; MEDULLOBLASTOMA; MULTIPLE CYCLE TREATMENT; PRESCHOOL CHILD; RECURRENT CANCER; SALVAGE THERAPY; SCHOOL CHILD; TREATMENT OUTCOME; ADULT; CEREBELLUM TUMOR; DISEASE FREE SURVIVAL; KAPLAN MEIER METHOD; MORTALITY; MULTIMODALITY CANCER THERAPY; RETROSPECTIVE STUDY; TUMOR RECURRENCE;

ADOLESCENT; ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CEREBELLAR NEOPLASMS; CHILD; CHILD, PRESCHOOL; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; HUMANS; KAPLAN-MEIERS ESTIMATE; MEDULLOBLASTOMA; NEOPLASM RECURRENCE, LOCAL; RETROSPECTIVE STUDIES; SALVAGE THERAPY;

EID: 56149109821     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1215/15228517-2008-044     Document Type: Article

References (26)

1. Duffner PK, Cohen ME, Myers MH, Heise HW. Survival of children with brain tumors: SEER Program, 1973-1980. Neurology. 1986;36:597-601.
2. Gajjar A, Chintagumpala M, Ashley D, et al. Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial. Lancet Oncol. 2006;7:813-820.
3. Packer RJ, Gajjar A, Vezina G, et al. Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. J Clin Oncol. 2006;24:4202-4208.
4. Gururangan S, Gardner S, Finlay JL. Autologous hemapoeitic stem cell transplantation after high dose chemotherapy for primary malignant tumors of the central nervous system. In: Atkinson K, Champlin R, Ritz J, Fibbe WE, Ljungman P, Brenner MK, eds. Clinical Bone Marrow and Blood Stem Cell Transplantation (3rd ed.). New York: Cambridge University Press; 2003:716-731.
5. Dunkel IJ, Boyett JM, Yates A, et al. High-dose carboplatin, thiotepa, and etoposide with autologous stem-cell rescue for patients with recurrent medulloblastoma. Children's Cancer Group. J Clin Oncol. 1998;16:222-228.
6. Dupuis-Girod S, Hartmann O, Benhamou E, et al. Will high dose chemotherapy followed by autologous bone marrow transplantation supplant cranio-spinal irradiation in young children treated for medulloblastoma? J Neurooncol. 1996;27:87-98.
7. Fouladi M, Shih C-S, Gilger E, et al. Role of high dose chemotherapy and autologous stem cell rescue in children with recurrent CNS malignancies [abstract]. Hematologica Rep. 2006;2:5.
8. Graham ML, Herndon JE 2nd, Casey JR, et al. High-dose chemotherapy with autologous stem-cell rescue in patients with recurrent and high-risk pediatric brain tumors. J Clin Oncol. 1997;15:1814-1823.
9. Guruangan S, Dunkel IJ, Goldman S, et al. Myeloablative chemotherapy with autologous bone marrow rescue in young children with recurrent malignant brain tumors. J Clin Oncol. 1998;16:2486-2493.
10. Massimino M, Gandola L, Spreafico F, et al. No salvage for relapsing already irradiated medulloblastoma if rescued with high-dose chemotherapy ± re-irradiation [abstract]. Hematologica Rep. 2006;2:11.
11. McLendon RE, Enterline DS. Tumors of specialized tissues of central neuroepithelial origin. In: Bigner DD, McLendon RE, Bruner JM, eds. Russell and Rubinstein's Pathology of Tumors of the Nervous System. New York: Oxford University Press; 1998:25-30.
12. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457-480.
13. Packer RJ. Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma. Curr Neurol Neurosci Rep. 2007;7:130-132.
14. Frei E 3rd, Teicher BA, Holden SA, Cathcart KN, Wang YY. Preclinical studies and clinical correlation of the effect of alkylating dose. Cancer Res. 1988;48:6417-6423.
15. Bode U, Simon A, Hasan C, Zimmerman M, Fleischhack G. The role of HD chemotherapy (CT) in the treatment of therapy-resistant CNS PNETs, HIT-REZ-97 results [abstract]. Hematologica Rep. 2006;2:2.
16. Shih CS, Hale GA, Gronewold L, et al. High-dose chemotherapy with autologous stem cell rescue for children with recurrent malignant brain tumors. Cancer. 2008;112:1345-1353.
17. Duffner PK, Horowitz ME, Krischer JP, et al. The treatment of malignant brain tumors in infants and very young children: an update of the Pediatric Oncology Group experience. Neuro-Oncology. 1999;1:152-161.
18. Bowers DC, Gargan L, Weprin BE, et al. Impact of site of tumor recurrence upon survival for children with recurrent or progressive medullo-blastoma. J Neurosurg. 2007;107:5-10.
19. Walter AW, Mulhern RK, Gajjar A, et al. Survival and neurodevelop-mental outcome of young children with medulloblastoma at St Jude Children's Research Hospital. J Clin Oncol. 1999;17:3720-3728.
20. Mahoney DH Jr, Strother D, Camitta B, et al. High-dose melphalan and cyclophosphamide with autologous bone marrow rescue for recurrent/progressive malignant brain tumors in children: a pilot Pediatric Oncology Group study. J Clin Oncol. 1996;14:382-388.
21. Kamen BA, Rubin E, Aisner J, Glatstein E. High-time chemotherapy or high time for low dose. J Clin Oncol. 2000;18:2935-2937.
22. Belza MG, Donaldson SS, Steinberg GK, Cox RS, Cogen PH. Medullo-blastoma: freedom from relapse longer than 8 years - a therapeutic cure? J Neurosurg. 1991;75:575-582.
23. Torres CF, Rebsamen S, Silber JH, et al. Surveillance scanning of children with medulloblastoma. N Engl J Med. 1994;330:892-895.
24. Ashley DM, Meier L, Kerby T, et al. Response of recurrent medulloblas-toma to low-dose oral etoposide. J Clin Oncol. 1996;14:1922-1927.
25. Baruchel S, Diezi M, Hargrave D, et al. Safety and pharmacokinetics of temozolomide using a dose-escalation, metronomic schedule in recurrent paediatric brain tumours. Eur J Cancer. 2006;42:2335-2342.
26. Gilbertson RJ. Medulloblastoma: signalling a change in treatment. Lancet Oncol. 2004;5:209-218.