High-Dose Melphalan and Cyclophosphamide with Autologous Bone Marrow Rescue for Recurrent/ Progressive Malignant Brain Tumors in Children: A Pilot Pediatric Oncology Group Study

Journal of Clinical Oncology

Volumn 14, Issue 2, 1996, Pages 382-388

  Mahoney Jr , Donald H ^a   Strother, Douglas ^a   Camitta, Bruce ^a   Bowen, Thomas ^a   Ghim, Thad ^a   Pick, Terry ^a   Wall, Donna ^a   Yu, Lolie ^a   Shuster, Jonathan J ^a   Friedman, Henry ^a  

^a C/o Pediatric Oncology Group ^*

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MELPHALAN;

ADOLESCENT; ADULT; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BONE MARROW RESCUE; BONE MARROW TOXICITY; CANCER COMBINATION CHEMOTHERAPY; CANCER THERAPY; CHILD; CLINICAL ARTICLE; EPENDYMOMA; FEMALE; GERM CELL TUMOR; GLIOBLASTOMA; HUMAN; MALE; MEDULLOBLASTOMA; PRIORITY JOURNAL; TREATMENT OUTCOME;

ADOLESCENT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE MARROW TRANSPLANTATION; BRAIN NEOPLASMS; CHILD; CHILD, PRESCHOOL; COMBINED MODALITY THERAPY; CYCLOPHOSPHAMIDE; DRUG ADMINISTRATION SCHEDULE; EPENDYMOMA; FEMALE; GERMINOMA; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; MALE; MEDULLOBLASTOMA; MELPHALAN; PILOT PROJECTS; SURVIVAL RATE; TRANSPLANTATION, AUTOLOGOUS;

EID: 0030050173     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1996.14.2.382     Document Type: Article

References (41)

1. Allen JC, Bloom J, Ertel I, et al: Brain tumors in children: Current cooperative and institutional chemotherapy trials in newly diagnosed and recurrent disease. Semin Oncol 13:110-122, 1986
2. Van Eys J: Malignant tumors of the central nervous system, in Fernbach DJ, Vietti T (eds): Clinical Pediatric Oncology (ed 3). St Louis, MO, Mosby, 1991, pp 409-426
3. Lefkowitz IB, Packer RJ, Siegel KR, et al: Results of treatment of children with recurrent medulloblastoma/primitive neuroectodermal tumors with lomustine, cisplatin, and vincristine. Cancer 65:412-417, 1990
4. Torres CF, Rebsamen S, Silber JH, et al: Surveillance scanning of children with medulloblastoma. N Engl J Med 330:892-895, 1994
5. Murray JC, Kline NE, Woo SY, et al: Recurrent medulloblastoma in children portends a poor prognosis: A 25 year single institution review. Proceedings of the Sixth International Symposium on Pediatric Neuro-Oncology, Houston, TX, May 18-21, 1994 (abstr 47)
6. Ater JL, Needle MN: Progress and expectations in the treatment of childhood brain tumors. Cancer Bull 44:490-495, 1992
7. Allen JC, Bosl G, Walker R: Chemotherapy trials in recurrent primary intracranial germ cell tumors. J Neurooncol 3:147-152, 1985
8. Wiley J, Fresia A, Strauss L, et al: High dose carboplatin, etoposide, and cyclophosphamide with autologous bone marrow rescue in children and young adults with refractory solid or brain tumors. Proc Am Soc Clin Oncol 11:374, 1992 (abstr 1292)
9. Kalifa C, Hartmann O, Demeoeq F, et al: High dose busulfan and thiotepa with autologous bone marrow transplantation in childhood malignant brain tumors. A phase II study. Bone Marrow Transplant 9:227-233, 1992
10. Finlay JL: High dose chemotherapy with bone marrow rescue in children and young adults with malignant brain tumors. Proc Am Assoc Cancer Res 32:181, 1991 (abstr 1078)
11. Heideman RL, Douglass EC, Krance RA, et al: High dose chemotherapy and autologous bone marrow rescue followed by interstitial and external-beam radiotherapy in newly diagnosed pediatric malignant gliomas. J Clin Oncol 11:1458-1465, 1993
12. Friedman HS, Colvin OM, Ludeman SM, et al: Experimental chemotherapy of human medulloblastoma with classical alkylators. Cancer Res 46:2827-2833, 1986
13. Friedman HS, Colvin OM, Skapek SX, et al: Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents. Cancer Res 48:4189-4195, 1988
14. Taha IAK, Ahmad RA, Rogers DW, et al: Pharmacokinetics of melphalan in children following high dose intravenous injections. Cancer Chemother Pharmacol 10:212-216, 1983
15. Lazarus HM, Herzig RH, Graham-Pole J, et al: Intensive melphalan chemotherapy and cryopreserved autologous bone marrow transplantation for the treatment of refractory cancer. J Clin Oncol 6:359-367, 1983
16. Chamberlain MC, Prados MD, Silver P, et al: A phase II trial of oral melphalan in recurrent primary brain tumors. Am J Clin Oncol 11:52-54, 1988
17. Friedman HS, Schold SC, Mahaley MS, et al: Phase II treatment of medulloblastoma and pineoblastoma with melphalan: Clinical therapy based on experimental models of human medulloblastoma. J Clin Oncol 7:904-911, 1989
18. Longee DC, Friedman HS, Albright RE, et al: Treatment of patients with recurrent gliomas with cyclophosphamide and vincristine. J Neurosurg 72:583-588, 1990
19. Friedman HS, Mahaley MS, Schold SC, et al: Efficacy of vincristine and cyclophosphamide in the therapy of recurrent medulloblastoma. Neurosurgery 18:335-340, 1986
20. Allen JC, Helson L: High dose cyclophosphamide chemotherapy for recurrent CNS tumors in children. J Neurosurg 55:749-756, 1981
21. Kedar A, Maria BL, Graham-Pole J, et al: High dose chemotherapy with marrow reinfusion and hyperfractionated irradiation for children with high risk brain tumors. Med Pediatr Oncol 23:428-436, 1994
22. Groothuis DR, Lippitz BE, Fekete I, et al: The effect of an amino acid-lowering diet on the rate of melphalan entry into brain and xenotransplanted glioma. Cancer Res 52:5590-5596, 1992
23. Furman WL, Fairclough DL, Huhn RD, et al: Therapeutic effects and pharmacokinetcs of recombinant human granulocyte macrophage colony stimulating factor in childhood cancer patients receiving myelosuppressive chemotherapy. J Clin Oncol 9:1022-1028, 1991
24. Nemunaitis J, Singer JW, Buckner CD, et al: Use of recombinant human granulocyte-macrophage colony stimulating factor in autologous bone marrow transplantation for lymphoid malignancies. Blood 72:834-836, 1988
25. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481, 1958
26. Peto R, Pike MC, Armitage P, et al: Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II Analysis and examples. Br J Cancer 35:1-39, 1977
27. Graham ML, Yeager AM, Leventhal BG, et al: Treatment of recurrent and refractory pediatric solid tumor with high-dose busulfan and cyclophosphamide followed by autologous bone marrow rescue. J Clin Oncol 10:1857-1864, 1992
28. Peters WP, Eder JP, Henner WD: High-dose combination alkylating agents with autologous bone marrow support: A phase I trial. J Clin Oncol 4:646-654, 1986
29. Eder JP, Elias AD, Teicher BA: High dose combination alkylating agents and autologous bone marrow transplant for metastatic breast cancer. Bone Marrow Transplant 4:57, 1989 (abstr)
30. Samuels BL, Bitran JD: High-dose intravenous melphalan: A review. J Clin Oncol 13:1786-1799, 1995
31. Graham-Pole J, Lazarus HM, Herzig RH, et al: High dose melphalan therapy for the treatment of children with refractory neuroblastoma and Ewing's sarcoma. Am J Pediatr Hematol Oncol 6:17-26, 1984
32. Duerst R, Fasone D, Constine L, et al: Autologous bone marrow transplant for advanced neuroblastoma: Cytoreduction with cyclophosphamide, carboplatin, melphalan, and fractionated total body irradiation. Proc Am Soc Clin Oncol 12:426, 1993 (abstr 1469)
33. Goldberg MA, Antin JH, Guinan EC, et al: Cyclophosphamide cardiotoxicity: An analysis of dosing as a risk factor. Blood 68:1114-1118, 1986
34. Braverman AC, Antin JH, Plappert MT, et al: Cyclophosphamide cardiotoxicity in bone marrow transplantation: A prospective evaluation of new dosing regimens. J Clin Oncol 9:1215-1223, 1991
35. Hertenstein B, Stefanic M, Schmeiser T, et al: Cardiac toxicity of bone marrow transplantation: Predictive value of cardiologic evaluation before transplantation. J Clin Oncol 12:998-1004, 1994
36. Graham ML, Chaffee S, Kurtzberg J, et al: A phase I-II study of high dose melphalan and cyclophosphamide with autologous bone marrow and/or stem cell rescue for patients with high risk central nervous system tumors. Proc Am Soc Clin Oncol 12:182, 1993 (abstr 523)
37. Garvin J, Findlay J, Walker R, et al: High dose chemotherapy and autologous bone marrow rescue for high risk central nervous system tumors in children under six years of age. Proc Am Soc Clin Oncol 11:150, 1992 (abstr 421)
38. Finlay J, Garvin J, Allen J, et al: High dose chemotherapy with autologous marrow rescue (ABMR) in patients with recurrent medulloblastoma/primitive neuroectodermal tumors (PNET). Proc Am Soc Clin Oncol 13:176, 1994 (abstr 493)
39. Finlay J, August C, Packer R, et al: High dose multiagent chemotherapy followed by bone marrow 'rescue' for malignant astrocytomas of childhood and adolescence. J Neurooncol 9:239-248, 1990
40. Abrahamsen TG, Lange BJ, Packer RJ, et al: A phase I and II trial of dose-intensified cyclophosphamide and GM-CSF in pediatric malignant brain tumors. Am J Pediatr Hematol/Oncol 17:134-139, 1995
41. Kretschmar CS, Tarbell NJ, Barnes P, et al: Preradiation chemotherapy and hyperfractionated radiotherapy 66 Gy for children with brain stem tumors: A phase II study of the Pediatric Oncology Group No. 8833. Cancer 72:1404-1413, 1993