Evaluation of the efficacy and safety for use of two sedation and analgesia protocols to facilitate assisted ventilation of healthy dogs

American Journal of Veterinary Research

Volumn 69, Issue 10, 2008, Pages 1351-1359

  Ethier, Michael R ^a   Mathews, Karol A ^a   Valverde, Alexander ^a   Kerr, Carolyn ^a   Bersenas, Alexa M ^a   Nykamp, Stephanie G ^a   Davis, Clive ^b  

^a UNIVERSITY OF GUELPH   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE; DIAZEPAM; DIHYDROMORPHINE; FENTANYL; LACTIC ACID; MEDETOMIDINE; MIDAZOLAM; MORPHINE; PROPOFOL;

ALKALINITY; ANALGESIA; ANESTHESIA INDUCTION; ANIMAL EXPERIMENT; ARTICLE; ASSISTED VENTILATION; BODY POSITION; CONTROLLED STUDY; DOG; FEMALE; HEART INDEX; HEART RATE; LUNG MINUTE VOLUME; MALE; MOUTH HYGIENE; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN TRANSPORT; PHYSIOTHERAPY; RESPIRATORY FUNCTION; SEDATION; URINE VOLUME;

ANALGESICS; ANALGESICS, OPIOID; ANIMALS; BLOOD PRESSURE; DOGS; FEMALE; HEART RATE; HYDROMORPHONE; HYPNOTICS AND SEDATIVES; LIQUID VENTILATION; MALE; MEDETOMIDINE; MIDAZOLAM; MORPHINE; REFERENCE VALUES; SAFETY; STROKE VOLUME; TREATMENT OUTCOME; VASCULAR RESISTANCE;

ANIMALIA; CANIS FAMILIARIS;

EID: 56049121952     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.69.10.1351     Document Type: Article

References (44)

1. Hopper K, Haskins SC, Kass PH, et al. Indications, management, and outcome of long-term positive-pressure ventilation in dogs and cats: 148 cases (1990-2001). J Am Vet Med Assoc 2007;230:64-75.
2. Clare M, Hopper K. Mechanical ventilation: ventilator settings, patient management, and nursing care. Compend Contin Educ Pract Vet 2005;27:256-269.
3. Vassilev E, McMichael M. An overview of positive pressure ventilation. J Vet Emerg Crit Care 2004;14:15-21.
4. Campbell VL, King LG. Pulmonary function, ventilator management, and outcome of dogs with thoracic trauma and pulmonary contusions: 10 cases (1994-1998). J Am Vet Med Assoc 2000;217:1505-1509.
5. Vassilakopoulos T, Petrof BJ. Ventilator-induced diaphragmatic dysfunction. Am J Respir Crit Care Med 2004;169:336-341.
6. Shekerdemian L, Bohn D. Cardiovascular effects of mechanical ventilation. Arch Dis Child 1999;80:475-480.
7. Pinsky MR. Cardiovascular issues in respiratory care. Chest 2005;128:592S-597S.
8. Putensen C, Muders T, Varelmann D, et al. The impact of spontaneous breathing during mechanical ventilation. Curr Opin Crit Care 2006;12:13-18.
9. Mellema MS, Haskins SC. Weaning from mechanical ventilation. Clin Tech Small Anim Pract 2000;15:157-164.
10. Muellejans B, López A, Cross MH, et al. Remifentanil versus fentanyl for analgesia based sedation to provide patient comfort in the intensive care unit: a randomized, double-blind controlled trial. Crit Care 2004;8:R1-R11.
11. Kress JP, Hall JB. Sedation in the mechanically ventilated patient. Crit Care Med 2006;34:2541-2546.
12. Breen D, Karabinis A, Malbrain M, et al. Decreased duration of mechanical ventilation when comparing analgesia based sedation using remifentanil with standard hypnotic-based sedation for up to 10 days in intensive care unit patients: randomised trial. Crit Care 2005;9:R200-R210.
13. Pandharipande P, Ely EW. Narcotic-based sedation regimens for critically ill mechanically ventilated patients. Crit Care 2005;9:247-248.
14. Haskins S, King LG. Positive pressure ventilation. In: King LG, eds. Textbook of respiratory disease in dogs and cats. St Louis: WB Saunders Co, 2004;217-229.
15. Drellich S. Principles of mechanical ventilation. Vet Clin Small Anim 2002;32:1087-1100.
16. Ramsay M, Savage T, Simpson B, et al. Controlled sedation with alphaxalone-alphadolone. Br Med J (Clin Res Ed) 1974;2:656-659.
17. Ambuel B, Hamlett KW, Marx CM, et al. Assessing distress in pediatric intensive care environments: the COMFORT scale. J Pediatr Psychol 1992; 17:95-109.
18. Haskins S, Pascoe PJ, Ilkiw JE, et al. Reference cardiopulmonary values in normal dogs. Comp Med 2005;55:156-161.
19. Sinclair MD. A review of the physiological effects of α2-agonists related to the clinical use of medetomidine in small animal practice. Can Vet J 2003;44:885-895.
20. Cullen LK. Medetomidine sedation in dogs and cats: a review of its pharmacology, antagonism and dose. Br Vet J 1996;152:519-531.
21. Wilson KC, Reardon C, Theodore AC, et al. Propylene glycol toxicity: a severe iatrogenic illness in ICU patients receiving IV benzodiazepines: a case series and prospective, observational pilot study. Chest 2005;128:1674-1681.
22. Carson SS, Kress JP, Pohlman AS, et al. A randomized trial of intermittent lorazepam vs. propofol with daily interruption in mechanically ventilated patients. Crit Care Med 2006;34:1324-1332.
23. Kress JP, Pohlman AS, O'Connor MF, et al. Daily interruption of sedation infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000;342:1471-1477.
24. Gronert GA, Haskins SC, Steffey EP, et al. Plasma electrolyte and metabolite concentrations associated with pentobarbital or pentobarbital-propofol anesthesia during three weeks' mechanical ventilation and intensive care in dogs. Lab Anim Sci 1998;48:513-519.
25. Grimm KA, Tranquilli WJ, Gross DR, et al. Cardiopulmonary effects of fentanyl in conscious dogs and dogs sedated with a continuous rate infusion of medetomidine. Am J Vet Res 2005;66:1222-1226.
26. Hughes JM, Nolan AM. Total intravenous anesthesia in greyhounds: pharmacokinetics of propofol and fentanyl - a preliminary study. Vet Surg 1999;28:513-524.
27. Sano T, Nishimura R, Kanazawa H, et al. Pharmacokinetics of fentanyl after single intravenous injection and constant rate infusion in dogs. Vet Anaesth Analg 2006;33:266-273.
28. Pypendop BH, Verstegen JP. Hemodynamic effects of medetomidine in the dog: a dose titration study. Vet Surg 1998;27:612-622.
29. Glowaski MM, Wetmore LA. Propofol: application in veterinary sedation and anesthesia. Clin Tech Small Anim Pract 1999;14:1-9.
30. Fulton B, Sorkin EM. Propofol: an overview of its pharmacology and a review of its clinical efficacy in intensive care sedation. Drugs 1995;50:636-657.
31. Klide AM. Cardiopulmonary effects of enflurane and isoflurane in the dog. Am J Vet Res 1976;37:127-131.
32. Valverde A, Dyson DH, Cockshutt JR, et al. Comparison of the hemodynamic effects of halothane alone and halothane combined with epidurally administered morphine for anesthesia in ventilated dogs. Am J Vet Res 1991;52:505-509.
33. Steffey EP, Gillespie JR, Berry JD. Circulatory effects of halothane and halothane-nitrous oxide anesthesia in the dog: controlled ventilation. Am J Vet Res 1974;35:1289-1293.
34. Doursout MF, Joseph PM, Liang YY, et al. Role of propofol and its solvent, intralipid, in nitric oxide-induced peripheral vasodilation in dogs. Br J Anaesth 2002;89:492-498.
35. Short CE, Bufalari A. Propofol anesthesia. Vet Clin Small Anim 1999;29:747-769.
36. Rivers EP, Ander DS, Powell D. Central venous oxygen saturation monitoring in the critically ill patient. Curr Opin Crit Care 2001;7:204-211.
37. Gunkel CI, Valverde A, Morey TE, et al. Comparison of non-invasive cardiac output measurement by partial carbon dioxide rebreathing with the lithium dilution method in anesthetized dogs. J Vet Emerg Crit Care 2004;14:187-195.
38. Baylis PH. The syndrome of inappropriate antidiuretic hormone secretion. Int J Biochem Cell Biol 2003;35:1495-1499.
39. Kokko H, Hall PD, Aftin LB. Fentanyl-associated syndrome of inappropriate antidiuretic hormone secretion. Pharmacotherapy 2002;22:1188-1192.
40. Terpstra TL, Terpstra TL. Syndrome of inappropriate antidiuretic hormone secretion: recognition and management. Medsurg Nurs 2000;9:61-68.
41. Robertson SA, Hauptman JG, Nachreiner RF, et al. Effects of acetylpromazine or morphine on urine production in halothane-anesthetized dogs. Am J Vet Res 2001;62:1922-1927.
42. Bark H, Le Roith D, Nyska M, et al. Elevations in plasma ADH levels during PEEP ventilation in the dog: mechanisms involved. Am J Physiol 1980;239:E474-E481.
43. Baratz RA, Philbin DM, Patterson RW. Plasma antidiuretic hormone and urinary output during continuous positive-pressure breathing in dogs. Anesthesiology 1971;34:510-513.
44. Udy A, Deacy N, Barnes D, et al. Tramadol-induced hyponatremia following unicompartmental knee replacement surgery. Anaesthesia 2005;60:814-816.