Antiobesity designed multiple ligands: Synthesis of pyrazole fatty acid amides and evaluation as hypophagic agents

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 23, 2008, Pages 10098-10105

  Alvarado, Mario ^a   Goya, Pilar ^a   Macías González, Manuel ^b   Pavón, Francisco Javier ^d   Serrano, Antonia ^d   Jagerovic, Nadine ^a   Elguero, Jose ^a   Gutiérrez Rodríguez, Angel ^c   García Granda, Santiago ^c   Suardíaz, Margarita ^d   Rodríguez de Fonseca, Fernando ^d  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b Instituto de Salud Carlos III   (Spain)

^c UNIVERSITY OF OVIEDO   (Spain)

^d HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

Author keywords

DMLs; Oleylamide; PPAR ; Pyrazole

Indexed keywords

2 [4 [2 [3 CYCLOHEXYL 1 (4 CYCLOHEXYLBUTYL)UREIDO]ETHYL]PHENYLTHIO] 2 METHYLPROPIONIC ACID; ANOREXIGENIC AGENT; ANTIOBESITY AGENT; CANNABINOID; CANNABINOID RECEPTOR; N (1 HEXADECYL) 1,5 BIS(4 CHLOROPHENYL) 1H PYRAZOLE 3 CARBOXAMIDE; N (1 HEXADECYL) 5 (4 CHLOROPHENYL) 1 (2,4 DICHLOROPHENYL) 1H PYRAZOLE 3 CARBOXAMIDE; N (1 HEXADECYL) 5 (4 CHLOROPHENYL) 1 (2,4 DICHLOROPHENYL) 4 METHYL 1H PYRAZOLE 3 CARBOXAMIDE; N (1 HEXADECYL) 5 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOLE 3 CARBOXAMIDE; N (1 OLEYL) 1,5 BIS(4 CHLOROPHENYL) 1H PYRAZOLE 3 CARBOXAMIDE; N (1 OLEYL) 5 (4 CHLOROPHENYL) 1 (2,4 DICHLOROPHENYL) 4 METHYL 1H PYRAZOLE 3 CARBOXAMIDE; N (1 OLEYL) 5 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOLE 3 CARBOXAMIDE; N (1 OLEYL) 5 (CHLOROPHENYL) 1 (2,4 DICHLOROPHENYL) 1H PYRAZOLE 3 CARBOXAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; FOOD INTAKE; HUMAN; HUMAN CELL; HYPOTHERMIA; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; RAT;

AMIDES; ANIMALS; ANTI-OBESITY AGENTS; CANNABINOIDS; EATING; FATTY ACIDS; GLUTATHIONE TRANSFERASE; MICE; PPAR ALPHA; PYRAZOLES; RATS; RATS, WISTAR;

RATTUS;

EID: 56049118644     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.023     Document Type: Article

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