Aspergillus nidulans UDP-galactopyranose mutase, encoded by ugmA plays key roles in colony growth, hyphal morphogensis, and conidiation

Fungal Genetics and Biology

Volumn 45, Issue 12, 2008, Pages 1533-1542

  El Ganiny, Amira M ^a   Sanders, David A R ^a   Kaminskyj, Susan G W ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Aspergillus nidulans; Cell wall; Conidiation; Galactofuranose; Hyphal morphogenesis; UDP galactopyranose mutase

Indexed keywords

ARTICLE; ASEXUAL SPORE; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIDULANS; CELL STRUCTURE; DEVELOPING COUNTRY; FUNGAL GENE; FUNGAL METABOLISM; FUNGAL STRAIN; FUNGAL VIRULENCE; FUNGUS GROWTH; FUNGUS HYPHAE; GENE DELETION; GENE MUTATION; GENE SEQUENCE; LIFE CYCLE; MORPHOGENESIS; NONHUMAN; OSMOLARITY; PREVALENCE; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; UGMA GENE; URIDINE DIPHOSPHATE GALACTOPYRANOSE GENE; WILD TYPE;

ASPERGILLUS NIDULANS; CULTURE MEDIA; FUNGAL PROTEINS; GENE DELETION; HYPHAE; INTRAMOLECULAR TRANSFERASES; MICROSCOPY, ELECTRON, TRANSMISSION; MORPHOGENESIS; SPORES, FUNGAL;

ASPERGILLUS FUMIGATUS; EMERICELLA NIDULANS; FUNGI;

EID: 56049113754     PISSN: 10871845     EISSN: 10960937     Source Type: Journal    
DOI: 10.1016/j.fgb.2008.09.008     Document Type: Article

References (46)

1. Adams T.H., Wieser J.K., and Yu J.-H. Asexual sporulation in Aspergillus nidulans. Microbiol. Mol. Biol. Rev. 62 (1998) 35-54
2. Arathoon E.G. Clinical efficacy of echinocandin antifungals. Curr. Opin. Infect. Dis. 14 (2001) 685-691
3. Bakker H., Kleczka B., Gerardy-Schahn R., and Routier F.H. Identification and partial characterization of two eukaryotic UDP-galactopyranose mutases. Biol. Chem. 386 (2005) 657-661
4. Bennett J.E., Bhattacharjee A.K., and Glaudemans C.P.J. Galactofuranosyl groups are immunodominant in Aspergillus fumigatus galactomannan. Mol. Immunol. 22 (1984) 251-254
5. Beverly S.M., Owens K.L., Showalter M., Griffith C.L., Doering T.L., Jones V.C., and McNeil M.R. Eukaryotic UDP-galactopyranose mutase (GLF gene) in microbial and metazoal pathogens. Eukaryot. Cell. 4 (2005) 1147-1154
6. Carrillo-Munoz A.J., Giusiano G., Ezkurra P.A., and Quindos G. Antifungal agents: mode of action in yeast cells. Rev. Esp. Quimioterap. 19 (2006) 130-139
7. Chamilos G., and Kontoyiannis D.P. Update on antifungal resistance mechanisms of Aspergillus fumigatus. Drug Resist. Updat. 8 (2005) 344-358
8. Costachel C., Coddeville B., Latge J.-P., and Fontaine T. Glycosylphosphatidylinostol-anchored fungal polysaccharide in Aspergillus fumigatus. J. Biol. Chem. 280 (2005) 39835-39842
9. Cowen L. The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype. Nat. Rev. Micro. 6 (2008) 187-198
10. Damveld R.A., Franken A., Arentshorst M., Punt P.J., Klis F.M., van den Hondel C.A.M.J.J., and Ram A.F.J. A novel screening method for cell wall mutants in Aspergillus niger identifies UDP-galactopyranose mutase as an important protein in fungal cell wall biosynthesis. Genetics 178 (2008) 873-881
11. García-Rodriguez L., Durán A., and Roncero C. Calcofluor antifungal action depends on chitin and a functional high-osmolarity glycerol response (HOG) pathway: evidence for a physiological role of the Saccharomyces cerevisiae HOG pathway under non-inducing conditions. J. Bacteriol. 182 (2000) 2428-2437
12. García-Ruiz J.C., Amutio E., and Pontón J. Invasive fungal infection in immunocompromised patients. Rev. Iberoam. Micol. 21 (2004) 55-62
13. Guest G.M., and Momany M. Analysis of cell wall sugars in the pathogen Aspergillus fumigatus and the saprophyte Aspergillus nidulans. Mycologia 92 (2000) 1047-1050
14. Hill T.W., Loprete D.M., Momany M., Harsch M., Livesay J.A., Mirchandani A., Murdock J.J., Vaughan M.J., and Watt M.B. Isolation of cell wall mutants in Aspergillus nidulans by screening for hypersensitivity to Calcofluor White. Mycologia 98 (2006) 399-409
15. Kaminskyj S.G.W. Septum position is marked at the tip of Aspergillus nidulans hyphae. Fungal. Genet. Biol. 31 (2000) 105-113
16. Kaminskyj S.G.W. Fundamentals of growth, storage, genetics and microscopy of Aspergillus nidulans. Fungal. Genet. Newsl. 48 (2001) 25-31
17. Kaminskyj S.G.W., and Hamer J.E. Hyp loci control cell pattern formation in the vegetative mycelium of Aspergillus nidulans. Genetics 148 (1998) 669-680
18. Kaminskyj S.G.W., and Heath I.B. Integrin and spectrin homologues, and cytoplasm-wall adhesion in tip growth. J. Cell Sci. 108 (1995) 849-856
19. Kim J., Campbell B., Mahoney N., Chan K., Molyneux R., and May G. Chemosensitization prevents tolerance of Aspergillus fumigatus to antimycotic drugs. Biochem. Biophys. Res. Commun. 372 (2008) 266-271
20. Kleczka B., Lamerz A.-C., Zandbergen G., Wenzel A., Gerardy-Schahn R., Wiese M., and Routier F.H. Targeted gene deletion of Leishmania major UDP-galactopyranose mutase leads to attenuated virulence. J. Biol. Chem. 282 (2007) 10498-10505
21. KPO1 gene. J. Biol. Chem. 272 (1997) 4121-4128
22. Latgé J.-P., Kobayashi H., Debeaupuis J.-P., Diaquin M., Sarfati J., Wieruszeski J.-M., Parra E., Bouchara J.-P., and Fournet B. Chemical and immunological characterization of the extracellular galactomannan of Aspergillus fumigatus. Infect. Immun. 62 (1994) 5424-5433
23. Leitao E.A., Bitte V.C.B., Haido R.M.T., Valente A.P., Peter-Katalinic J., Letzel M., de Souza L.M., and Barreto-Bergter E. β-Galactofuranose-containing O-linked oligosaccharides present in the cell wall peptidogalactomannan of Aspergillus fumigatus contain immunodominant epitopes. Glycobiology 13 (2003) 681-692
24. Loffler J., and Stevens D.A. Antifungal drug resistance. CID 36 Suppl. 1 (2003) S31-S41
25. Maertens J., Theunissen K., Lodewyck T., Lagrou K., and Eldere J. Advances in the serological diagnosis of invasive Aspergillus infections in patients with haematological disorders. Mycoses 50 Suppl. 1 (2007) 2-17
26. Nassau P.M., Martin S.L., Brown R.E., Weston A., Monsey D., McNeil M.R., and Duncan K. Galactofuranose biosynthesis in Escherichia coli K-12: identification and cloning of UDP-galactopyranose mutase. J. Bacteriol. 178 (1996) 1047-1052
27. Nayak T., Szewczyk E., Oakley C.E., Osmani A., Ukil L., Murray S.L., Hynes M.J., Osmani S.A., and Oakley B.R. A versatile and efficient gene-targeting system in Aspergillus nidulans. Genetics 172 (2006) 1557-1566
28. Notermans S., Veeneman G.H., van Zuylen C.W.E.M., Hoogerhout P., and van Boom J.H. (1→5)-linked β-d-galactofuranosides are immunodominant in extracellular polysaccharides of Penicillum and Aspergillus species. Mol. Immunol. 25 (1998) 975-979
29. Osmani A.H., Oakley B.R., and Osmani S.A. Identification and analysis of essential Aspergillus nidulans genes using the heterokaryon rescue technique. Nat. Protoc. 1 (2006) 2517-2526
30. Pan F., Jackson M., Ma Y., and McNeil M. Cell wall core galactofuran is essential for growth of Mycobacteria. J. Bacteriol. 183 (2001) 3991-3998
31. Pederson L.L., and Turco S.J. Galactofuranose metabolism: a potential target for antimicrobial chemotherapy. Cell. Mol. Life Sci. 60 (2003) 259-266
32. Randhawa G.K., and Sharma G. Echinocandins: a promising new antifungal group. Indian J. Pharmacol. 36 (2004) 65-71
33. Sanders D.A.R., Staines A.G., McMahon S.A., McNeil M.R., Whitfield C., and Naismith J.H. UDP-galactopyranose mutase has a novel structure and mechanism. Nat. Struct. Biol. 8 (2001) 858-863
34. Schmalhorst P.S., Krappmann S., Vervecken S.W., Rohde M., Müller M., Braus G.H., Contreras R., Braun A., Bakker H., and Routier F.H. Contribution of galactofuranose to the virulence of the opportunistic pathogen Aspergillus fumigatus. Eukaryot. Cell 7 (2008) 1268-1277
35. Shaw B.D., and Momany M.M. Aspergillus nidulans polarity mutant swoA is complemented by protein O-mannosyltransferase pmtA. Fungal. Genet. Biol. 37 (2002) 263-270
36. Shi X., Sha Y., and Kaminskyj S. Aspergillus nidulans hypA regulates morphogenesis through the secretion pathway. Fungal. Genet. Biol. 41 (2004) 75-88
37. Spath G.F., Epstein L., Leader B., Singer S.M., Avila H.A., Turco S.J., and Beverley S.M. Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major. Proc. Natl. Acad. Sci. USA 97 (2000) 9258-9263
38. Stevenson G.G., Andrianopoulos K., Hobbs M., and Reeves P.R. Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colonic acid. J. Bacteriol. 178 (1996) 4885-4893
39. Stynen D., Sarafati J., Goris A., Prevost M.-C., Lesourd M., Kamphuis H., Darras V., and Latgé J.-P. Rat monoclonal antibodies against Aspergillus galactomannan. Infect. Immun. 60 (1992) 2237-2245
40. Szewczyk E., Nayak T., Oakley C.E., Edgerton H., Xiong Y., Taheri-Talesh N., Osmani S.A., and Oakley B.R. Fusion PCR and gene targeting in Aspergillus nidulans. Nat. Protoc. 1 (2007) 3111-3120
41. Tawara S., Ikeda F., Maki K., Morishita Y., Otomo K., Teratani N., Goto T., Tomishima M., Ohki H., Yamada A., Kawabata K., Takasugi H., Sakane K., Tanaka H., Matsumoto F., and Kuwahara S. In vitro activities of a new lipopeptide antifungal agent, FK463, against a variety of clinically important fungi. Antimicrob. Agents Chemother. 44 (2000) 57-62
42. Trinci A.P.J. A study of the kinetics of hyphal extension and branch initiation of fungal mycelia. J. Gen. Microbiol. 81 (1974) 225-236
43. Wallis G.L.F., Hemming F.W., and Peberdy J.F. β-Galactofuranoside glycoconjygate on the conidia and conidiophores of Aspergillus niger. FEMS Microbiol. Lett. 201 (2001) 21-27
44. Weston A., Stern R.J., Lee R.E., Nassau P.M., Monsey D., Martin S.L., Scherman M.S., Besra G.S., Duncan K., and McNeil M.R. Biosynthetic origin of mycobacterial cell wall galactopyranosyl residues. Tuberc. Lung Dis. 78 (1998) 123-131
45. Whitfield C., Richards J.C., Perry M.B., Clarke B.R., and Maclean L.L. Expression of two structurally distinct d-galactan O antigens in the lipopolysaccharide of Klebsiella pneumoniae serotype O1. J. Bacteriol. 173 (1991) 1420-1431
46. Yang Y., El-Ganiny A.M., Bray G.E., Sanders D.A.R., and Kaminskyj S.G.W. Aspergillus nidulans hypB encodes a Sec7-domain protein important for hyphal morphogenesis. Fungal. Genet. Biol. 45 (2008) 749-759