Hepatic gene expression changes in an experimental model of accelerated senescence: The SAM-P8 mouse

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 63, Issue 10, 2008, Pages 1043-1052

  Vilà, Laia ^a   Roglans, Núria ^a   Alegret, Marta ^a   Camins, Antoni ^a   Pallàs, Mercè ^a   Sánchez, Rosa María ^a   Vázquez Carrera, Manuel ^a   Laguna, Juan Carlos ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Inflammation; Liver; SAM mice; Xenobiotic metabolism

Indexed keywords

HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR JUNB; UNCLASSIFIED DRUG;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; ELECTROPHORETIC MOBILITY; EXPERIMENTAL MODEL; GENE EXPRESSION REGULATION; GENETIC SELECTION; IMMUNE RESPONSE; INFLAMMATION; LIVER; MALE; MOUSE; NEUROPATHOLOGY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SENESCENCE; SENESCENCE ACCELERATED MOUSE; WESTERN BLOTTING; XENOBIOTIC METABOLISM;

MUS; RODENTIA;

EID: 55949132620     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/63.10.1043     Document Type: Article

References (36)

1. Day JC. Population projections of the United States by age, sex, race and Hispanic origin: 1993-1950. Washington, DC: U.S. Department of Commerce Bureau of Census; 2003:25-1104.
2. Zenilman ME. Surgery in the elderly. Curr Probl Surg. 1998;35: 99-179.
3. Corti MC, Barbato CM, Baggio G. Lipoprotein alterations and atherosclerosis in the elderly. Curr Opin Lipidol. 1997;8:236-241.
4. Toth MJ, Tchernof A. Lipid metabolism in the elderly. Eur J Clin Nutr. 2000;54:S121-S125.
5. Sanguino E, Bejarano R, Alegret M, et al. Sexual dimorphism in lipid metabolic phenotype associated with old age in Sprague-Dawley rats. Exp Gerontol. 2004;39:1295-1306.
6. Vilà L, Roglans N, Alegret M, et al. Hypertriglyceridemia and hepatic steatosis in senescence accelerated mouse associate to changes in lipid-related gene expression. J Gerontol A Biol Sci Med Sci. 2007;62:1219-1227.
7. Takeda T, Hosokawa M, Takeshita S, et al. A new murine model of accelerated senescence. Mech Ageing Dev. 1981;17:183-194.
8. Butterfield DA, Poon HF. The senescence-accelerated prone mouse (SAMP-8): a model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease. Exp Gerontol. 2005;40:774-783.
9. Ye X, Meeker HC, Koxlowski PB, et al. Pathological changes in the liver of a senescence accelerated mouse strain (SAMP8): a mouse model for the study of liver diseases. Histol Histopathol. 2004; 19:1141-1151.
10. Helenius M, Hänninen M, Lehtinen SK, Salminen A. Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NFκB transcription factor in mouse cardiac muscle. J. Mol Cell Cardiol. 1996;28:487-498.
11. Bradford MM. A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principles of protein-dye binding. Anal Biochem. 1976;72:248-254.
12. Roglans N, Sanguino E, Peris C, et al. Atorvastatin treatment induced peroxisome proliferator-activated receptor α expression and decreased plasma nonesterified fatty acids and liver triglyceride in fructose-fed rats. J. Pharmacol Exp Ther. 2002;302:232-239.
13. Lazarow PB. Assay of peroxisomal β-oxidation of fatty acids. Methods Enzymol. 1981;72:315-319.
14. Sanguino E, Ramón M, Michalik L, et al. Lack of hypotriglyceridemic effect of gemfibrozil and age-related changes in rat liver PPARα. Biochem Pharmacol. 2004;67:157-166.
15. Sanguino E, Roglans N, Alegret M, Sánchez RM, Vázquez- Carrera M, Laguna JC. Prevention of age-related changes in rat cortex transcription factor activator protein-1 by hypolipidemic drugs. Biochem Pharmacol. 2005;68:1411-1421.
16. Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol. 2002;4:E141-E136.
17. Gachon F, Olela FF, Schaad O, Descombes P, Schibler U. The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic metabolism. Cell Metab. 2006;4:25-36.
18. Takeda K, Hosokawa M, Michalik L. Senescence-accelerated mouse (SAM): a novel murine model of senescence. Exp Gerontol. 1997;32:105-109.
19. Okuda T, Higashi Y, Kokame K, Tanaka C, Kondoh H, Miyauchi T. Ndrg-1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves. Mol Cell Biol. 2004;24:3949-3956.
20. Berger P, Sirkowski EE, Scherer SS, Suter U. Expression analysis of the N-Myc downstream-regulated gene 1 indicates that myelinating Schwann cells are the primary disease target in hereditary motor and sensory neuropathy. Neurobiol Dis. 2004;17:290-299.
21. Hirata K, Masuda K, Morikawa W, et al. N-myc downstream-regulated gene 1 expression in injured sciatic nerves. Glia. 2004;47: 325-334.
22. Qyang Y, Chambers SM, Wang P, et al. Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage. Biochemistry. 2004;43:5352-5359.
23. Feng R, Wang H, Wang J, Shrom D, Zeng X, Tsien JZ. Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2. Proc Natl Acad Sci U S A. 2004;101:8162-8167.
24. Yaghootfam A, Gielselmann V, Eckhardt M. Delay of myelin formation in arylsulphatase A-delicient mice. Eur J Neurosci. 2005;21:711-720.
25. Wei X, Zhang Y, Zhou J. Alzheimer's disease-related gene expression in the brain of senescence accelerated mouse. Neurosci Lett. 1999;268:139-142.
26. Beckman K, Ames BN. The free radical theory of aging matures. Physiol Rev. 1998;78:547-581.
27. Sarkar D, Fisher PB. Molecular mechanisms of aging-associated inflammation. Cancer Lett. 2006;236:13-23.
28. Chand HS, Foster DC, Kisiel W. Structure, function and biology of tissue factor pathway inhibitor-2. Thromb Haemost. 2005;94:1122-1130.
29. Tomasini R, Seux M, Nowak J, et al. TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity. Oncogene. 2005;24:8093-8104.
30. Larbi A, Kempf J, Wistuba-Hamprecht K, Haug C, Pawalec G. The heat shock proteins in cellular aging: is zinc the missing link? Biogerontology. 2006;7:399-408.
31. Bowie A, O'Neill LAJ. Oxidative stress and nuclear factor-κB activation. A reassessment of the evidence in the light of recent discoveries. Biochem Pharmacol. 2000;59:13-23.
32. Supakar PC, Jung MH, Song CS, Chatterjee B, Roy AK. Nuclear factor κB functions as a negative regulator for the rat androgen receptor gene and NF-κB activity increases during the age-dependent desensitization of the liver. J Biol Chem. 1995;270:837-842.
33. Spencer NFL, Poynter ME, Im S-Y, Daynes RA. Constitutive activation of NF-κB in an animal model of aging. Int Immunol. 1997;9:1581-1588.
34. Okada H, Kimura MT, Tan D, et al. Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas. Int J Oncol. 2005;26:369-377.
35. Wauthier V, Verbeeck RK, Calderon PB. The effect of ageing on cytochrome p459 enzymes: consequences for drug biotransformation in the elderly. Curr Med Chem. 2007;14:745-757.
36. Wang H, LeCluyse EL. Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes. Clin Pharmacokinet. 2003; 42:1331-1357.