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Volumn 67, Issue 1, 2004, Pages 157-166

Lack of hypotriglyceridemic effect of gemfibrozil as a consequence of age-related changes in rat liver PPARα

Author keywords

Fibrates; Gemfibrozil; Hypolipidemic effect; Old age; PPAR ; Rat liver

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; CARNITINE PALMITOYLTRANSFERASE; GEMFIBROZIL; LEPTIN; MESSENGER RNA; MITOCHONDRIAL MEDIUM CHAIN ACYL COENZYME A DEHYDROGENASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 0344255575     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2003.08.034     Document Type: Article
Times cited : (36)

References (40)
  • 1
    • 0034565044 scopus 로고    scopus 로고
    • The biochemistry of aging
    • Knight J.A. The biochemistry of aging. Adv. Clin. Chem. 35:2001;1-62.
    • (2001) Adv. Clin. Chem. , vol.35 , pp. 1-62
    • Knight, J.A.1
  • 2
    • 0030749974 scopus 로고
    • Lipoprotein alterations and atherosclerosis in the elderly
    • Corti M.-C., Barbato G.-M., Baggio G. Lipoprotein alterations and atherosclerosis in the elderly. Curr. Opin. Lipidol. 8:1987;236-241.
    • (1987) Curr. Opin. Lipidol. , vol.8 , pp. 236-241
    • Corti, M.-C.1    Barbato, G.-M.2    Baggio, G.3
  • 3
    • 0033379344 scopus 로고    scopus 로고
    • Fibrates, dyslipoproteinemia and cardiovascular diseases
    • Watts G.F., Dimmitt S.B. Fibrates, dyslipoproteinemia and cardiovascular diseases. Curr. Opin. Lipidol. 10:1999;561-574.
    • (1999) Curr. Opin. Lipidol. , vol.10 , pp. 561-574
    • Watts, G.F.1    Dimmitt, S.B.2
  • 4
    • 0034668205 scopus 로고    scopus 로고
    • Role of the peroxisome proliferator-activated receptors (PPAR) in atherosclerosis
    • Neve B.P., Fruchart J.-C., Staels B. Role of the peroxisome proliferator-activated receptors (PPAR) in atherosclerosis. Biochem. Pharmacol. 60:2000;1245-1250.
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 1245-1250
    • Neve, B.P.1    Fruchart, J.-C.2    Staels, B.3
  • 5
    • 0034678088 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Insight into multiple cellular functions
    • Escher P., Wahli W. Peroxisome proliferator-activated receptors: insight into multiple cellular functions. Mutat. Res. 448:2000;121-138.
    • (2000) Mutat. Res. , vol.448 , pp. 121-138
    • Escher, P.1    Wahli, W.2
  • 6
    • 0032893056 scopus 로고    scopus 로고
    • Cholesterol and lipoprotein metabolism in aging: Reversal of hypercholesterolemia by growth hormone treatment in old rats
    • Parini P., Angelin B., Rudling M. Cholesterol and lipoprotein metabolism in aging: reversal of hypercholesterolemia by growth hormone treatment in old rats. Arterioscler Thromb. Vasc. Biol. 19:1999;832-839.
    • (1999) Arterioscler Thromb. Vasc. Biol. , vol.19 , pp. 832-839
    • Parini, P.1    Angelin, B.2    Rudling, M.3
  • 8
    • 0028232515 scopus 로고
    • Relationship between plasma lipids and palmitoyl-CoA hydrolase and synthetase activities with peroxisomal proliferation in rats treated with fibrates
    • Alegret M., Ferrando R., Vázquez M., Adzet T., Merlos M., Laguna J.C. Relationship between plasma lipids and palmitoyl-CoA hydrolase and synthetase activities with peroxisomal proliferation in rats treated with fibrates. Br. J. Pharmacol. 112:1994;551-556.
    • (1994) Br. J. Pharmacol. , vol.112 , pp. 551-556
    • Alegret, M.1    Ferrando, R.2    Vázquez, M.3    Adzet, T.4    Merlos, M.5    Laguna, J.C.6
  • 9
    • 0032796939 scopus 로고    scopus 로고
    • Different effect of simvastatin and atorvastatin on key enzymes involved in VLDL synthesis and catabolism in high fat/cholesterol fed rabbits
    • Verd J.C., Peris C., Alegret M., Díaz C., Hernández G., Vázquez M., Adzet T., Laguna J.C., Sánchez R.M. Different effect of simvastatin and atorvastatin on key enzymes involved in VLDL synthesis and catabolism in high fat/cholesterol fed rabbits. Br. J. Pharmacol. 127:1999;1479-1485.
    • (1999) Br. J. Pharmacol. , vol.127 , pp. 1479-1485
    • Verd, J.C.1    Peris, C.2    Alegret, M.3    Díaz, C.4    Hernández, G.5    Vázquez, M.6    Adzet, T.7    Laguna, J.C.8    Sánchez, R.M.9
  • 10
    • 0032894224 scopus 로고    scopus 로고
    • Quantitative RT-PCR: Pitfalls and potential
    • Freeman W.M., Walker S.J., Vrana E.V. Quantitative RT-PCR: pitfalls and potential. BioTechniques. 26:1999;112-125.
    • (1999) BioTechniques , vol.26 , pp. 112-125
    • Freeman, W.M.1    Walker, S.J.2    Vrana, E.V.3
  • 11
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam J.D., Lebovitz R.M., Roeder R.G. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acid Res. 11:1983;1475-1489.
    • (1983) Nucleic Acid Res. , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 12
    • 0024727219 scopus 로고
    • Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure
    • Sonnenberg J.L., Macgregor-Leon P.F., Curran T., Morgan J.I. Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure. Neuron. 3:1989;359-365.
    • (1989) Neuron , vol.3 , pp. 359-365
    • Sonnenberg, J.L.1    MacGregor-Leon, P.F.2    Curran, T.3    Morgan, J.I.4
  • 13
    • 0017184389 scopus 로고
    • A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principles of protein-dye binding
    • Bradford M.M. A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principles of protein-dye binding. Anal. Biochem. 72:1976;248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 14
    • 0028963743 scopus 로고
    • Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain
    • Kim J.B., Spotts G.D., Halvorsen Y., Shih H., Ellenberger T., Towle H.C., Spiegelman B.M. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain. Mol. Cell. Biol. 15:1995;2582-2588.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2582-2588
    • Kim, J.B.1    Spotts, G.D.2    Halvorsen, Y.3    Shih, H.4    Ellenberger, T.5    Towle, H.C.6    Spiegelman, B.M.7
  • 16
    • 0033623803 scopus 로고    scopus 로고
    • Differences in the formation of PPARα-RXR/acoPPRE complexes between responsive and non responsive species upon fibrate administration
    • Rodríguez R., Noé V., Cabrero A., Ciudad C.J., Laguna J.C. Differences in the formation of PPARα-RXR/acoPPRE complexes between responsive and non responsive species upon fibrate administration. Mol. Pharmacol. 58:2000;185-193.
    • (2000) Mol. Pharmacol. , vol.58 , pp. 185-193
    • Rodríguez, R.1    Noé, V.2    Cabrero, A.3    Ciudad, C.J.4    Laguna, J.C.5
  • 17
    • 0034957825 scopus 로고    scopus 로고
    • Regulation of liver carnitine palmitoyltransferase I gene expression by hormones and fatty acids
    • Louet J.-F., Le May C., Pégorier J.-P., Decaux J.-F., Girard J. Regulation of liver carnitine palmitoyltransferase I gene expression by hormones and fatty acids. Biochem. Soc. Trans. 29:2001;310-316.
    • (2001) Biochem. Soc. Trans. , vol.29 , pp. 310-316
    • Louet, J.-F.1    Le May, C.2    Pégorier, J.-P.3    Decaux, J.-F.4    Girard, J.5
  • 18
    • 0028033268 scopus 로고
    • The peroxisomal proliferator-activated receptor regulates mitochondrial fatty acid oxidative gene expression
    • Gulick T., Cresci S., Caira T., Moore D.D., Kelly D.P. The peroxisomal proliferator-activated receptor regulates mitochondrial fatty acid oxidative gene expression. Proc. Natl. Acad. Sci. U.S.A. 91:1994;11012-11016.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 11012-11016
    • Gulick, T.1    Cresci, S.2    Caira, T.3    Moore, D.D.4    Kelly, D.P.5
  • 20
    • 0032484123 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α activation modulates cellular redox status represses nuclear factor-κB signaling, and reduces inflammatory cytokine production in aging
    • Poynter M.E., Daynes R.A. Peroxisome proliferator-activated receptor α activation modulates cellular redox status represses nuclear factor-κB signaling, and reduces inflammatory cytokine production in aging. J. Biol. Chem. 273:1998;32833-32841.
    • (1998) J. Biol. Chem. , vol.273 , pp. 32833-32841
    • Poynter, M.E.1    Daynes, R.A.2
  • 21
    • 0032892175 scopus 로고    scopus 로고
    • Sterol regulatory element-binding proteins: Activators of cholesterol and fatty acid biosynthesis
    • Horton J.D., Shimomura I. Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis. Curr. Opin. Lipidol. 10:1999;143-150.
    • (1999) Curr. Opin. Lipidol. , vol.10 , pp. 143-150
    • Horton, J.D.1    Shimomura, I.2
  • 23
    • 0031048115 scopus 로고    scopus 로고
    • Increased lipogenic capacity of the islets of obese rats: A role in the pathogenesis of NIDDM
    • Lee Y., Hirose H., Zhou Y.-T., Esser V., McGarry J.D., Unger R.H. Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM. Diabetes. 46:1997;408-413.
    • (1997) Diabetes , vol.46 , pp. 408-413
    • Lee, Y.1    Hirose, H.2    Zhou, Y.-T.3    Esser, V.4    McGarry, J.D.5    Unger, R.H.6
  • 26
    • 0034914054 scopus 로고    scopus 로고
    • Diabetes and other coronary heart disease risk equivalents
    • James R.W. Diabetes and other coronary heart disease risk equivalents. Curr. Opin. Lipidol. 12:2001;425-431.
    • (2001) Curr. Opin. Lipidol. , vol.12 , pp. 425-431
    • James, R.W.1
  • 27
    • 0036230922 scopus 로고    scopus 로고
    • Leptin resistance during aging is independent of fat mass
    • Grabiely I., Ma X.H., Yang X.M., Rossetti L., Barzilai N. Leptin resistance during aging is independent of fat mass. Diabetes. 51:2002;1016-1021.
    • (2002) Diabetes , vol.51 , pp. 1016-1021
    • Grabiely, I.1    Ma, X.H.2    Yang, X.M.3    Rossetti, L.4    Barzilai, N.5
  • 28
    • 0028003839 scopus 로고
    • Regulation of the peroxisome proliferator-activated receptor α gene by glucocorticoids
    • Lemberger T., Staels B., Saladin R., Desvergne B., Auwerx J., Wahli W. Regulation of the peroxisome proliferator-activated receptor α gene by glucocorticoids. J. Biol. Chem. 269:1994;24527-24530.
    • (1994) J. Biol. Chem. , vol.269 , pp. 24527-24530
    • Lemberger, T.1    Staels, B.2    Saladin, R.3    Desvergne, B.4    Auwerx, J.5    Wahli, W.6
  • 29
    • 0034779607 scopus 로고    scopus 로고
    • Effects of fatty acids and growth hormone on liver fatty acid binding protein and PPARα in rat liver
    • Carlsson L., Lindén D., Jalouli M., Oscarsson J. Effects of fatty acids and growth hormone on liver fatty acid binding protein and PPARα in rat liver. Am. J. Physiol. Endocrinol. Metab. 281:2001;E772-E781.
    • (2001) Am. J. Physiol. Endocrinol. Metab. , vol.281
    • Carlsson, L.1    Lindén, D.2    Jalouli, M.3    Oscarsson, J.4
  • 30
    • 0028131951 scopus 로고
    • Dexamethasone and insulin demonstrate marked and opposite regulation of the steady-state mRNA level of the peroxisomal proliferator-activated receptor (PPAR) in hepatic cells - Hormonal modulation of fatty-acid-induced transcription
    • Steinger H.H., Sorensen H.N., Tugwood J.D., Skrede S., Spydevold O., Gautvik K.M. Dexamethasone and insulin demonstrate marked and opposite regulation of the steady-state mRNA level of the peroxisomal proliferator-activated receptor (PPAR) in hepatic cells - hormonal modulation of fatty-acid-induced transcription. Eur. J. Biochem. 225:1994;967-974.
    • (1994) Eur. J. Biochem. , vol.225 , pp. 967-974
    • Steinger, H.H.1    Sorensen, H.N.2    Tugwood, J.D.3    Skrede, S.4    Spydevold, O.5    Gautvik, K.M.6
  • 33
    • 0035808410 scopus 로고    scopus 로고
    • The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor α is inhibited by ethanol metabolism. a novel mechanism for the development of ethanol-induced fatty liver
    • Galli A., Pinaire J., Fischer M., Dorris R., Crabb D.W. The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor α is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver. J. Biol. Chem. 276:2001;68-75.
    • (2001) J. Biol. Chem. , vol.276 , pp. 68-75
    • Galli, A.1    Pinaire, J.2    Fischer, M.3    Dorris, R.4    Crabb, D.W.5
  • 34
    • 0028997684 scopus 로고
    • Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
    • Lee S.S., Pineau T., Drago J., Lee E.J., Owens J.W., Kroetz D.L., Fernandez-Salguero P.M., Westphal H., Gonzalez F.J. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell. Biol. 15:1995;3012-3022.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3012-3022
    • Lee, S.S.1    Pineau, T.2    Drago, J.3    Lee, E.J.4    Owens, J.W.5    Kroetz, D.L.6    Fernandez-Salguero, P.M.7    Westphal, H.8    Gonzalez, F.J.9
  • 35
    • 0030766476 scopus 로고    scopus 로고
    • Alterations in lipoprotein metabolism in peroxisome proliferator- activated receptor α-deficient mice
    • Peters J.M., Hennuyer N., Staels B., Fruchart J.C., Fievet C., Gonzalez F.J., Auwerx J. Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor α-deficient mice. J. Biol. Chem. 272:1997;28307-28312.
    • (1997) J. Biol. Chem. , vol.272 , pp. 28307-28312
    • Peters, J.M.1    Hennuyer, N.2    Staels, B.3    Fruchart, J.C.4    Fievet, C.5    Gonzalez, F.J.6    Auwerx, J.7
  • 37
    • 0033882630 scopus 로고    scopus 로고
    • Age-related changes in plasma leptin binding activity in rats: A comparison of a simple acid-ethanol precipitation technique with column chromatography
    • Mooradian A.D., Hurd R., Chehade J., Pun K., Haas M.J. Age-related changes in plasma leptin binding activity in rats: a comparison of a simple acid-ethanol precipitation technique with column chromatography. Proc. Soc. Exp. Biol. Med. 224:2000;273-277.
    • (2000) Proc. Soc. Exp. Biol. Med. , vol.224 , pp. 273-277
    • Mooradian, A.D.1    Hurd, R.2    Chehade, J.3    Pun, K.4    Haas, M.J.5
  • 39
    • 0035066651 scopus 로고    scopus 로고
    • Polyunsaturated fatty acid regulation gene transcription: A molecular mechanism to improve the metabolic syndrome
    • Clarke S.D. Polyunsaturated fatty acid regulation gene transcription: a molecular mechanism to improve the metabolic syndrome. J. Nutr. 131:2001;1129-1132.
    • (2001) J. Nutr. , vol.131 , pp. 1129-1132
    • Clarke, S.D.1
  • 40
    • 0033551846 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. a mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats
    • Xu J., Nakamura M.T., Cho H.P., Clarke S.D. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats. J. Biol. Chem. 274:1999;23577-23583.
    • (1999) J. Biol. Chem. , vol.274 , pp. 23577-23583
    • Xu, J.1    Nakamura, M.T.2    Cho, H.P.3    Clarke, S.D.4


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