Midpregnancy vaginal fluid defensins, bacterial vaginosis, and risk of preterm delivery

Obstetrics and Gynecology

Volumn 112, Issue 3, 2008, Pages 524-531

  Holzman, Claudia B ^a   Xu, Jia ^b   Arvidson, Cindy G ^b   Chung, Hwan ^b   Goepfert, Alice R ^b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DEFENSIN; NEUTROPHIL PEPTIDE 1; NEUTROPHIL PEPTIDE 2; NEUTROPHIL PEPTIDE 3; UNCLASSIFIED DRUG; ALPHA DEFENSIN; BIOLOGICAL MARKER;

ADOLESCENT; ADULT; AFRICAN AMERICAN; ARTICLE; CAUCASIAN; CHLAMYDIASIS; CONTROLLED STUDY; FEMALE; GONORRHEA; HUMAN; MAJOR CLINICAL STUDY; PREGNANT WOMAN; PREMATURE LABOR; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; RACE DIFFERENCE; RISK ASSESSMENT; SECOND TRIMESTER PREGNANCY; TERM BIRTH; TRICHOMONIASIS; UNITED STATES; VAGINA DISCHARGE; VAGINITIS; COMPARATIVE STUDY; ETHNOLOGY; IMMUNOLOGY; METABOLISM; PREGNANCY; PREMATURITY; RISK; RISK FACTOR; VAGINA;

ADULT; AFRICAN AMERICANS; ALPHA-DEFENSINS; BIOLOGICAL MARKERS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; ODDS RATIO; PREGNANCY; PREMATURE BIRTH; PROSPECTIVE STUDIES; RISK FACTORS; VAGINA; VAGINOSIS, BACTERIAL;

EID: 55949120216     PISSN: 00297844     EISSN: None     Source Type: Journal    
DOI: 10.1097/AOG.0b013e318184209b     Document Type: Article

References (40)

1. Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and preterm delivery. N Engl J Med 2000;342:1500-7.
2. Hillier SL, Martius J, Krohn M, Kiviat N, Holmes KK, Eschenbach DA. A case-control study of chorioamnionic infection and histologic chorioamnionitis in prematurity. N Engl J Med 1988;319:972-8.
3. Romero R, Espinoza J, Goncalves LF, Kusanovic JP, Friel LA, Nien JK. Inflammation in preterm and term labour and delivery. Semin Fetal Neonatal Med 2006;11:317-26.
4. Fredricks DN, Fiedler TL, Marrazzo JM. Molecular identification of bacteria associated with bacterial vaginosis. N Engl J Med 2005;353:1899-911.
5. Nugent RP, Krohn MA, Hillier SL. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol 1991;29:297-301.
6. Hillier SL, Nugent RP, Eschenbach DA, Krohn MA, Gibbs RS, Martin DH, et al. Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. The Vaginal Infections and Prematurity Study Group. N Engl J Med 1995;333:1737-42.
7. Leitich H, Bodner-Adler B, Brunbauer M, Kaider A, Egarter C, Husslein P. Bacterial vaginosis as a risk factor for preterm delivery: a meta-analysis. Am J Obstet Gynecol 2003;189: 139-47.
8. Peipert JF, Montagno AB, Cooper AS, Sung CJ. Bacterial vaginosis as a risk factor for upper genital tract infection. Am J Obstet Gynecol 1997;177:1184-7.
9. Wiesenfeld HC, Hillier SL, Krohn MA, Amortegui AJ, Heine RP, Landers DV, et al. Lower genital tract infection and endometritis: insight into subclinical pelvic inflammatory disease. Obstet Gynecol 2002;100:456-63.
10. Allsworth JE, Peipert JF. Prevalence of bacterial vaginosis: 2001-2004 National Health and Nutrition Examination Survey data. Obstet Gynecol 2007;109:114-20.
11. Goldenberg RL, Klebanoff MA, Nugent R, Krohn MA, Hillier S, Andrews WW. Bacterial colonization of the vagina during pregnancy in four ethnic groups. Vaginal Infections and Prematurity Study Group. Am J Obstet Gynecol 1996;174: 1618-21.
12. Rajamanoharan S, Low N, Jones SB, Pozniak AL. Bacterial vaginosis, ethnicity, and the use of genital cleaning agents: a case control study. Sex Transm Dis 1999;26:404-9.
13. Goldenberg RL, Iams JD, Mercer BM, Meis PJ, Moawad AH, Copper RL, et al. The preterm prediction study: the value of new vs standard risk factors in predicting early and all spontaneous preterm births. NICHD MFMU Network. Am J Public Health 1998;88:233-8.
14. Andrews WW, Sibai BM, Thom EA, Dudley D, Ernest JM, McNellis D, et al. Randomized clinical trial of metronidazole plus erythromycin to prevent spontaneous preterm delivery in fetal fibronectin-positive women. Obstet Gynecol 2003;101: 847-55.
15. Carey JC, Klebanoff MA, Hauth JC, Hillier SL, Thom EA, Ernest JM, et al. Metronidazole to prevent preterm delivery in pregnant women with asymptomatic bacterial vaginosis. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. N Engl J Med 2000;342:534-40.
16. Goldenberg RL, Mwatha A, Read JS, Adeniyi-Jones S, Sinkala M, Msmanga G, et al. The HPTN 024 Study: the efficacy of antibiotics to prevent chorioamnionitis and preterm birth. Am J Obstet Gynecol 2006;194:650-61.
17. Guaschino S, Ricci E, Franchi M, Frate GD, Tibaldi C, Santo DD, et al. Treatment of asymptomatic bacterial vaginosis to prevent pre-term delivery: a randomised trial. Eur J Obstet Gynecol Reprod Biol 2003;110:149-52.
18. Hauth JC, Goldenberg RL, Andrews WW, DuBard MB, Copper RL. Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis. N Engl J Med 1995;333:1732-6.
19. Klebanoff MA, Carey JC, Hauth JC, Hillier SL, Nugent RP, Thom EA, et al. Failure of metronidazole to prevent preterm delivery among pregnant women with asymptomatic Trichomonas vaginalis infection. N Engl J Med 2001;345: 487-93.
20. Leitich H, Brunbauer M, Bodner-Adler B, Kaider A, Egarter C, Husslein P. Antibiotic treatment of bacterial vaginosis in pregnancy: a meta-analysis. Am J Obstet Gynecol 2003;188: 752-8.
21. McDonald H, Brocklehurst P, Parsons J. Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database of Systematic Reviews 2005, Issue 1. Art. No.: CD000262. DOI: 10.1002/14651858.CD000262.pub3.
22. Bals R. Epithelial antimicrobial peptides in host defense against infection. Respir Res 2000;1:141-50.
23. Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 2003;3:710-20.
24. Quayle AJ, Porter EM, Nussbaum AA, Wang YM, Brabec C, Yip KP, et al. Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract. Am J Pathol 1998;152:1247-58.
25. Valore EV, Park CH, Quayle AJ, Wiles KR, McCray PB Jr, Ganz T. Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. J Clin Invest 1998;101:1633-42.
26. Zanetti M. Cathelicidins, multifunctional peptides of the innate immunity. J Leukoc Biol 2004;75:39-48.
27. Selsted ME, Harwig SS, Ganz T, Schilling JW, Lehrer RI. Primary structures of three human neutrophil defensins. J Clin Invest 1985;76:1436-9.
28. Heine RP, Wiesenfeld H, Mortimer L, Greig PC. Amniotic fluid defensins: potential markers of subclinical intrauterine infection. Clin Infect Dis 1998;27:513-8.
29. Balu RB, Savitz DA, Ananth CV, Hartmann KE, Miller WC, Thorp JM, et al. Bacterial vaginosis, vaginal fluid neutrophil defensins, and preterm birth. Obstet Gynecol 2003;101:862-8.
30. Holzman C, Bullen B, Fisher R, Paneth N, Reuss L, Prematurity Study Group. Group PS. Pregnancy outcomes and community health: the POUCH study of preterm delivery. Paediatr Perinat Epidemiol 2001;15 suppl:136-58.
31. Porter E, Yang H, Yavagal S, Preza GC, Murillo O, Lima H, et al. Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions. Infect Immun 2005;73:4823-33.
32. SAS Institute. Base SAS 9.1.3 procedures guide. 2nd ed. Cary (NC): SAS Institute; 2006.
33. Rao JN, Scott AJ. The analysis of categorical data from complex sample surveys - Chi-squared tests for goodness of fit and independence in 2-way tables. J Am Stat Assoc 1981;76: 221-30.
34. Hosmer DW, Lemeshow S. Applied logistic regression. 2nd ed. New York (NY): John Wiley & Sons; 2000.
35. Balu RB, Savitz DA, Ananth CV, Hartmann KE, Miller WC, Thorp JM, et al. Bacterial vaginosis and vaginal fluid defensins during pregnancy. Am J Obstet Gynecol 2002;187:1267-71.
36. Chen H, Xu Z, Peng L, Fang X, Yin X, Xu N, et al. Recent advances in the research and development of human defensins. Peptides 2006;27:931-40.
37. Holst N, Oian P, Aune B, Jenssen TG, Burhol PG. Increased plasma levels of vasoactive intestinal polypeptide in pre-eclampsia. Br J Obstet Gynaecol 1991;98:803-6.
38. Simhan HN, Anderson BL, Krohn MA, Heine RP, Martinez de Tejada B, Landers DV, et al. Host immune consequences of asymptomatic Trichomonas vaginalis infection in pregnancy. Am J Obstet Gynecol 2007;196:59.e1-5.
39. Cotch MF, Pastorek JG 2nd, Nugent RP, Hillier SL, Gibbs RS, Martin DH, et al. Trichomonas vaginalis associated with low birth weight and preterm delivery. The Vaginal Infections and Prematurity Study Group. Sex Transm Dis 1997;24:353-60.
40. Pereira L, Culhane J, McCollum K, Agnew K, Nyirjesy P. Variation in microbiologic profiles among pregnant women with bacterial vaginosis. Am J Obstet Gynecol 2005; 193:746-51.