Randomized clinical trial of metronidazole plus erythromycin to prevent spontaneous preterm delivery in fetal fibronectin-positive women

Obstetrics and Gynecology

Volumn 101, Issue 5, 2003, Pages 847-855

  Andrews, William W ^a   Sibai, Baha M ^a   Thom, Elizabeth A ^a   Dudley, Donald ^a   Ernest, J M ^a   McNellis, Donald ^a   Leveno, Kenneth J ^a   Wapner, Ronald ^a   Moawad, Atef ^a   O'Sullivan, Mary J ^a   Caritis, Steve N ^a   Iams, Jay D ^a   Langer, Oded ^a   Miodovnik, Menachem ^a   Dombrowski, Mitchell ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; ERYTHROMYCIN; FIBRONECTIN; METRONIDAZOLE; PLACEBO;

ABDOMINAL PAIN; ACADEMIC ACHIEVEMENT; ADULT; ANOREXIA; ANTIBIOTIC THERAPY; ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ETHNOLOGY; FEMALE; FETUS; FETUS MONITORING; FOLLOW UP; HUMAN; INCIDENCE; INFORMED CONSENT; LABORATORY TEST; MAJOR CLINICAL STUDY; MARRIAGE; MATERNAL AGE; MULTICENTER STUDY; NAUSEA; PILL; PREMATURE LABOR; PRENATAL SCREENING; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; RISK MANAGEMENT; SECOND TRIMESTER PREGNANCY; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME; UTERINE CERVIX; VAGINA; VAGINITIS; VOMITING;

EID: 0037650216     PISSN: 00297844     EISSN: 1873233X     Source Type: Journal    
DOI: 10.1016/s0029-7844(03)00172-8     Document Type: Article

References (20)

1. Hack M, Fanaroff AA. Outcomes of children of extremely low birthweight and gestational age. Semin Neonatol 2000;5:89-106.
2. Ventura SJ, Martin JA, Curtin SC, Mathews TJ. Report of final natality statistics, 1995. Monthly vital statistics report, vol 45, no 11 supplement. Hyattsville, Maryland: National Center for Health Statistics, 1997:1-81.
3. Andrews WW, Goldenberg RL, Hauth JC. Preterm labor: Emerging role of genital tract infections. Infect Agents Dis 1995;4:196-211.
4. Gibbs RS, Romero R, Hillier SL, Eschenbach DA, Sweet RL. A review of premature birth and subclinical infection. Am J Obstet Gynecol 1992;166:1515-28.
5. Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and preterm delivery. N Engl J Med 2000;342:1500-7.
6. Andrews WW, Hauth JC, Goldenberg RL. Infection and preterm birth. Am J Perinatol 2000;17:357-65.
7. Kimberlin DF, Andrews WW. Bacterial vaginosis: Association with adverse pregnancy outcome. Semin Perinatol 1998;22:242-50.
8. Morales WJ, Schorr S, Albritton J. Effect of metronidazole in patients with preterm birth in preceding pregnancy and bacterial vaginosis: A placebo-controlled, double-blind study. Am J Obstet Gynecol 1994;171:345-7.
9. Hauth JC, Goldenberg RL, Andrews WW, DuBard MB, Copper RL. Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis. N Engl J Med 1995;333:1732-6.
10. McDonald HM, O'Loughlin JA, Vigneswaran R, Jolley PT, Harvey JA, Bof A, et al. Impact of metronidazole therapy on preterm birth in women with bacterial vaginosis flora (Gardnerella vaginalis): A randomized, placebo controlled trial. Br J Obstet Gynaecol 1997;104:1391-7.
11. Carey JC, Klebanoff MA, Hauth JC, Hillier SL, Thom EA, Ernest JM, et al. Metronidazole to prevent preterm delivery in pregnant women with asymptomatic bacterial vaginosis. N Engl J Med 2000;342:534-40.
12. Klebanoff MA, Carey JC, Hauth JC, Hillier SL, Nugent RO, Thom EA, et al. Failure of metronidazole to prevent preterm delivery among pregnant women with asymptomatic Trichomonas vaginalis infection. N Engl J Med 2001;345:487-93.
13. Goldenberg RL, Mercer BM, Meis PJ, Copper RL, Das A, McNellis D. The Preterm Prediction Study: Fetal fibronectin testing and spontaneous preterm birth. Obstet Gynecol 1996;87:643-8.
14. Lockwood CJ, Senyei AE, Dische MR, Casal D, Shah KD, Thung SN, et al. Fetal fibronectin in cervical and vaginal secretions as a predictor of preterm delivery. N Engl J Med 1991;325:669-74.
15. Feinberg RF, Kliman HJ, Lockwood CJ. Is oncofetal fibronectin a trophoblast glue for human implantation? Am J Pathol 1991;138:537-43.
16. Goldenberg RL, Thom E, Moawad AH, Johnson F, Roberts J, Caritus SN, et al. The Preterm Prediction Study: Fetal fibronectin, bacterial vaginosis and peripartum infection. Obstet Gynecol 1996;87:656-60.
17. Goepfert AR, Goldenberg RL, Andrews WW, Hauth JC, Mercer B, Iams J, et al. The Preterm Prediction Study: Quantitative fetal fibronectin values and the prediction of spontaneous preterm birth. Am J Obstet Gynecol 2000; 183:1480-3.
18. Nugent RP, Krohn MA, Hillier SL. Reliability of diagnosing bacterial vaginosis by a standardized method of Gram stain interpretation. J Clin Microbiol 1991;29:297-301.
19. Wei LJ, Lachin JM. Properties of the urn randomization in clinical trials. Control Clin Trials 1988;9:345-64.
20. Lan KKG, DeMets DL. Discrete sequential boundaries for clinical trials. Biometrika 1983;70:659-63.