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Volumn 27, Issue 4, 2006, Pages 931-940

Recent advances in the research and development of human defensins

Author keywords

Antimicrobial peptide; Genetic engineering; Human defensin

Indexed keywords

ALPHA DEFENSIN; BETA DEFENSIN; CYSTEINE; DEFENSIN;

EID: 33645393209     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2005.08.018     Document Type: Review
Times cited : (116)

References (69)
  • 1
    • 0032169557 scopus 로고    scopus 로고
    • Humanβ-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung
    • R. Bals, X. Wang, Z. Wu, T. Freeman, V. Bafna, and M. Zasloff Humanβ-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung J Clin Invest 102 1998 874 880
    • (1998) J Clin Invest , vol.102 , pp. 874-880
    • Bals, R.1    Wang, X.2    Wu, Z.3    Freeman, T.4    Bafna, V.5    Zasloff, M.6
  • 3
    • 0347668617 scopus 로고    scopus 로고
    • Recombinant human β-defensin-2 gene expression in transfected COS-7 cells
    • S.H. Cai, J. Du, X.N. Chen, N. Huang, and B.Y. Wang Recombinant human β-defensin-2 gene expression in transfected COS-7 cells J. WCUMS 31 2000 433 437
    • (2000) J. WCUMS , vol.31 , pp. 433-437
    • Cai, S.H.1    Du, J.2    Chen, X.N.3    Huang, N.4    Wang, B.Y.5
  • 4
    • 9244261554 scopus 로고    scopus 로고
    • Transfection and expression of recombinant human β-defensin-2 gene in insect cells
    • S.H. Cai, J. Du, N. Huang, and B.Y. Wang Transfection and expression of recombinant human β-defensin-2 gene in insect cells J Sichuan Univ 35 6 2004 832 835
    • (2004) J Sichuan Univ , vol.35 , Issue.6 , pp. 832-835
    • Cai, S.H.1    Du, J.2    Huang, N.3    Wang, B.Y.4
  • 5
    • 18944392939 scopus 로고    scopus 로고
    • Efficient production of a soluble fusion protein containing human beta-defensin-2 in E. coli cell-free system
    • H.Q. Chen, Z.N. Xu, N.Z. Xu, and P.L. Cen Efficient production of a soluble fusion protein containing human beta-defensin-2 in E. coli cell-free system J Biotechnol 115 2005 307 315
    • (2005) J Biotechnol , vol.115 , pp. 307-315
    • Chen, H.Q.1    Xu, Z.N.2    Xu, N.Z.3    Cen, P.L.4
  • 6
    • 0032717048 scopus 로고    scopus 로고
    • Diversity of antimicrobial peptides and their mechanisms of action
    • R.M. Epand, and H.J. Vogel Diversity of antimicrobial peptides and their mechanisms of action Biochimica et Biophysica Acta 1462 1999 11 28
    • (1999) Biochimica et Biophysica Acta , vol.1462 , pp. 11-28
    • Epand, R.M.1    Vogel, H.J.2
  • 7
    • 0036215113 scopus 로고    scopus 로고
    • Cloning and expression of human beta-defensin-2 gene in Escherichia coli
    • X.M. Fang, L. Peng, Z.N. Xu, J.M. Wu, and P.L. Cen Cloning and expression of human beta-defensin-2 gene in Escherichia coli Protein Peptide Lett 9 2001 31 37
    • (2001) Protein Peptide Lett , vol.9 , pp. 31-37
    • Fang, X.M.1    Peng, L.2    Xu, Z.N.3    Wu, J.M.4    Cen, P.L.5
  • 8
    • 21744462099 scopus 로고    scopus 로고
    • Human beta-defensins: Differential activity against Candidal species and regulation by Candida albicans
    • Z. Feng, B. Jiang, J. Chandra, M. Ghannoum, S. Nelson, and Weinberg Human beta-defensins: differential activity against Candidal species and regulation by Candida albicans J Dent Res 84 2005 445 450
    • (2005) J Dent Res , vol.84 , pp. 445-450
    • Feng, Z.1    Jiang, B.2    Chandra, J.3    Ghannoum, M.4    Nelson, S.5    Weinberg6
  • 9
    • 0027218376 scopus 로고
    • Defensins promote fusion and lysis of negatively charged membranes
    • G. Fujii, ME. Selsted, and D. Eisenberg Defensins promote fusion and lysis of negatively charged membranes Protein Sci 2 1993 1301 1312
    • (1993) Protein Sci , vol.2 , pp. 1301-1312
    • Fujii, G.1    Selsted, M.E.2    Eisenberg, D.3
  • 10
    • 0032005344 scopus 로고    scopus 로고
    • Antimicrobial peptides of vertebrates
    • T. Ganz, and R.I. Lehrer Antimicrobial peptides of vertebrates Curr Opin Immunol 10 1998 41 44
    • (1998) Curr Opin Immunol , vol.10 , pp. 41-44
    • Ganz, T.1    Lehrer, R.I.2
  • 11
    • 0028707742 scopus 로고
    • Biosythesis of defensins and other antimicrobial peptides. Antimicrobial peptides
    • Wiley, chichester
    • Ganz T. Biosythesis of defensins and other antimicrobial peptides. Antimicrobial peptides. Wiley, chichester (Ciba Foundation symposium 186) 1994; p. 62-76.
    • (1994) Ciba Foundation Symposium 186 , pp. 62-76
    • Ganz, T.1
  • 13
    • 0030861378 scopus 로고    scopus 로고
    • Antimicrobial peptides of phagocytes and epithelia
    • T. Ganz, and J. Weiss Antimicrobial peptides of phagocytes and epithelia Seminars Hematol 34 1997 343 354
    • (1997) Seminars Hematol , vol.34 , pp. 343-354
    • Ganz, T.1    Weiss, J.2
  • 16
    • 0028707742 scopus 로고
    • Biosynthesis of defensins and other antimicrobial peptides. Antimicrobial peptides
    • Wiley, Chichester
    • Ganz T. Biosynthesis of defensins and other antimicrobial peptides. Antimicrobial peptides. Wiley, Chichester (Ciba Foundation Symposium 186) 1994; p. 62-76.
    • (1994) Ciba Foundation Symposium 186 , pp. 62-76
    • Ganz, T.1
  • 17
    • 0035430147 scopus 로고    scopus 로고
    • Human beta-defensin 4: A novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity
    • J.R. Garcia, A. Krause, S. Schulz, F.J. Rodriguez-Jimenez, E. Kluver, and K. Adermann Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity FASEB J 15 2001 1819 1821
    • (2001) FASEB J , vol.15 , pp. 1819-1821
    • Garcia, J.R.1    Krause, A.2    Schulz, S.3    Rodriguez-Jimenez, F.J.4    Kluver, E.5    Adermann, K.6
  • 18
    • 33645403766 scopus 로고    scopus 로고
    • GenBank, http://www.ncbi.nlm.nih.gov
  • 20
    • 0035937107 scopus 로고    scopus 로고
    • Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic
    • J. Harder, J. Bartels, E. Christophers, and J.M. Schroder Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic J Biol Chem 276 8 2001 5707 5713
    • (2001) J Biol Chem , vol.276 , Issue.8 , pp. 5707-5713
    • Harder, J.1    Bartels, J.2    Christophers, E.3    Schroder, J.M.4
  • 23
    • 0030785439 scopus 로고    scopus 로고
    • Elevated concentrations of human neutrophil peptides in plasma, blood, and body fluids from patients with infections
    • T. Ihi, M. Nakazato, H. Mukae, and S. Matsukura Elevated concentrations of human neutrophil peptides in plasma, blood, and body fluids from patients with infections Clin Infect Dis 25 1997 1134 1140
    • (1997) Clin Infect Dis , vol.25 , pp. 1134-1140
    • Ihi, T.1    Nakazato, M.2    Mukae, H.3    Matsukura, S.4
  • 25
    • 0027390031 scopus 로고
    • Defensin-6 mRNA in human Paneth cells: Implications for antimicrobial peptides in host defense of the human bowel
    • D.E. Jones, and C.L. Bevins Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel FEBS Lett 315 1993 187 192
    • (1993) FEBS Lett , vol.315 , pp. 187-192
    • Jones, D.E.1    Bevins, C.L.2
  • 26
    • 0026457997 scopus 로고
    • Paneth cells of the human small intestine express an antimicrobial peptide gene
    • D.E. Jones, and C.L. Bevins Paneth cells of the human small intestine express an antimicrobial peptide gene J Biol Chem 267 1992 23216 23225
    • (1992) J Biol Chem , vol.267 , pp. 23216-23225
    • Jones, D.E.1    Bevins, C.L.2
  • 27
    • 0031662487 scopus 로고    scopus 로고
    • Expression of the peptide antibiotic human beta-defensin 1 in cultured gingival epithelial cells and gingival tissue
    • S. Krisanaprakornkit, A. Weinberg, C.N. Perez, and B.A. Dale Expression of the peptide antibiotic human beta-defensin 1 in cultured gingival epithelial cells and gingival tissue Infect Immun 66 1998 4222 4228
    • (1998) Infect Immun , vol.66 , pp. 4222-4228
    • Krisanaprakornkit, S.1    Weinberg, A.2    Perez, C.N.3    Dale, B.A.4
  • 28
    • 0033067196 scopus 로고    scopus 로고
    • Antimicrobial peptides in mammalian and insect host defence
    • R.I. Lehrer, and T. Ganz Antimicrobial peptides in mammalian and insect host defence Curr Opin Immunol 11 1999 23 27
    • (1999) Curr Opin Immunol , vol.11 , pp. 23-27
    • Lehrer, R.I.1    Ganz, T.2
  • 29
    • 0030449497 scopus 로고    scopus 로고
    • Endogenous vertebrate antibiotics: Defensins, protegrins, and other cysteine-rich antimicrobial peptides
    • R.I. Lehrer, and T. Ganz Endogenous vertebrate antibiotics: defensins, protegrins, and other cysteine-rich antimicrobial peptides Ann N Y Acad Sci 797 1996 228 439
    • (1996) Ann N Y Acad Sci , vol.797 , pp. 228-439
    • Lehrer, R.I.1    Ganz, T.2
  • 30
    • 0027474382 scopus 로고
    • Defensins: Antimicrobial and cytotoxic peptides of mammalian cells
    • R.I. Lehrer, A.K. Lichtenstein, and T. Ganz Defensins: antimicrobial and cytotoxic peptides of mammalian cells Annu Rev Immunol 11 1993 105 128
    • (1993) Annu Rev Immunol , vol.11 , pp. 105-128
    • Lehrer, R.I.1    Lichtenstein, A.K.2    Ganz, T.3
  • 31
    • 0022886732 scopus 로고
    • In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes
    • A. Lichtenstein, T. Ganz, and M.E. Selsted In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes Bolld 1986 1407 1410
    • (1986) Bolld , pp. 1407-1410
    • Lichtenstein, A.1    Ganz, T.2    Selsted, M.E.3
  • 32
    • 0027462245 scopus 로고
    • The structure of neutrophil defensin genes
    • R. Linzmeier, D. Michaelson, L. Liu, and T. Ganz The structure of neutrophil defensin genes FEBS Lett 321 1993 267 273
    • (1993) FEBS Lett , vol.321 , pp. 267-273
    • Linzmeier, R.1    Michaelson, D.2    Liu, L.3    Ganz, T.4
  • 33
    • 0032548181 scopus 로고    scopus 로고
    • Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation
    • L. Liu, L. Wang, H.P. Jia, C. Zhao, H.H. Heng, and B.C. Schutte Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation Gene 222 1998 237 244
    • (1998) Gene , vol.222 , pp. 237-244
    • Liu, L.1    Wang, L.2    Jia, H.P.3    Zhao, C.4    Heng, H.H.5    Schutte, B.C.6
  • 34
    • 0031213832 scopus 로고    scopus 로고
    • The human β-defensin-1 and α-defensins are encoded by adjacent genes: Two pepide families with differing disulfide topology share a common ancestry
    • L. Liu, C. Zhao, H.H. Heng, and T. Ganz The human β-defensin-1 and α-defensins are encoded by adjacent genes: two pepide families with differing disulfide topology share a common ancestry Genomics 43 1997 316 320
    • (1997) Genomics , vol.43 , pp. 316-320
    • Liu, L.1    Zhao, C.2    Heng, H.H.3    Ganz, T.4
  • 36
    • 0030471387 scopus 로고    scopus 로고
    • Synthesis, cloning and expression of genes for antibacterial peptides magainin, bombinin and cecropin
    • K.A. Martemyanov, A.S. Spirin, and A.T. Gudkov Synthesis, cloning and expression of genes for antibacterial peptides magainin, bombinin and cecropin Biotechnol. Lett. 18 1996 1357 1362
    • (1996) Biotechnol. Lett. , vol.18 , pp. 1357-1362
    • Martemyanov, K.A.1    Spirin, A.S.2    Gudkov, A.T.3
  • 37
    • 0344483901 scopus 로고    scopus 로고
    • Production of beta-defensin antimicrobial peptides by oral mucosa and salivary glands
    • M. Mathews, H.P. Jia, J.M. Guthmiller, G. Losh, S. Graham, and G.K. Johnson Production of beta-defensin antimicrobial peptides by oral mucosa and salivary glands Infect Immun 67 1999 2740 2745
    • (1999) Infect Immun , vol.67 , pp. 2740-2745
    • Mathews, M.1    Jia, H.P.2    Guthmiller, J.M.3    Losh, G.4    Graham, S.5    Johnson, G.K.6
  • 38
    • 4344559551 scopus 로고    scopus 로고
    • High-level expression of soluble human β-defensin-2 in Escherichia coli
    • L. Peng, Z.N. Xu, X.M. Fang, F. Wang, and P.L. Cen High-level expression of soluble human β-defensin-2 in Escherichia coli Process Biochem 39 2004 2199 2205
    • (2004) Process Biochem , vol.39 , pp. 2199-2205
    • Peng, L.1    Xu, Z.N.2    Fang, X.M.3    Wang, F.4    Cen, P.L.5
  • 39
    • 3142662719 scopus 로고    scopus 로고
    • Preferential codons enhancing the expression level of recombinant human β-defensin-2 in Escherichia coli
    • L. Peng, Z.N. Xu, X.M. Fang, F. Wang, S. Yang, and P.L. Cen Preferential codons enhancing the expression level of recombinant human β-defensin-2 in Escherichia coli Protein Peptide Lett 11 4 2004 339 344
    • (2004) Protein Peptide Lett , vol.11 , Issue.4 , pp. 339-344
    • Peng, L.1    Xu, Z.N.2    Fang, X.M.3    Wang, F.4    Yang, S.5    Cen, P.L.6
  • 41
    • 0027445909 scopus 로고
    • Recombinat DNA procedures for producing small natimcrobial cationic peptides in bacteria
    • K.L. Piers, M.H. Brown, and RE.W. Hancock Recombinat DNA procedures for producing small natimcrobial cationic peptides in bacteria Gene 134 1993 7 13
    • (1993) Gene , vol.134 , pp. 7-13
    • Piers, K.L.1    Brown, M.H.2    Hancock, R.W.3
  • 42
    • 0030913746 scopus 로고    scopus 로고
    • Broad-spectrum antimicrobial activity of human intestinal defensin 5
    • E.M. Porter, E.V. Dam, E.V. Valore, and T. Ganz Broad-spectrum antimicrobial activity of human intestinal defensin 5 Infect Immun 65 1997 2396 2401
    • (1997) Infect Immun , vol.65 , pp. 2396-2401
    • Porter, E.M.1    Dam, E.V.2    Valore, E.V.3    Ganz, T.4
  • 43
  • 44
    • 0031898688 scopus 로고    scopus 로고
    • Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract
    • A.J. Quayle, E.M. Porter, A.A. Nussbaum, Y.M. Wang, C. Brabec, and K.P. Yip Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract Am J Pathol 152 1998 1247 1258
    • (1998) Am J Pathol , vol.152 , pp. 1247-1258
    • Quayle, A.J.1    Porter, E.M.2    Nussbaum, A.A.3    Wang, Y.M.4    Brabec, C.5    Yip, K.P.6
  • 45
    • 0037293097 scopus 로고    scopus 로고
    • Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis
    • F.J. Rodriguez-Jimenez, A. Krause, S. Schulz, W.G. Forssmann, J.R. Conejo-Garcia, and R. Schreeb Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis Genomics 81 2003 175 183
    • (2003) Genomics , vol.81 , pp. 175-183
    • Rodriguez-Jimenez, F.J.1    Krause, A.2    Schulz, S.3    Forssmann, W.G.4    Conejo-Garcia, J.R.5    Schreeb, R.6
  • 46
    • 0037040913 scopus 로고    scopus 로고
    • The solution structures of the human β-defensins lead to a better understanding of the potent bactericidal activity of HBD-3 against Staphylococcus aureus
    • D.J. Schibli, H.N. Hunter, V. Aseyev, T.D. Starner, J.M. Wiencek, and P.B. McCray Jr. The solution structures of the human β-defensins lead to a better understanding of the potent bactericidal activity of HBD-3 against Staphylococcus aureus J Biol Chem 277 2002 8279 8289
    • (2002) J Biol Chem , vol.277 , pp. 8279-8289
    • Schibli, D.J.1    Hunter, H.N.2    Aseyev, V.3    Starner, T.D.4    Wiencek, J.M.5    McCray Jr., P.B.6
  • 48
    • 0033213989 scopus 로고    scopus 로고
    • Epithelial antimicrobial peptides: Innate local host response elements
    • J.M. Schröder Epithelial antimicrobial peptides: innate local host response elements CMLS Cell Mol Life Sci 56 1999 32 46
    • (1999) CMLS Cell Mol Life Sci , vol.56 , pp. 32-46
    • Schröder, J.M.1
  • 49
    • 0038933757 scopus 로고    scopus 로고
    • Epithelial peptide antibiotics
    • J.M. Schröder Epithelial peptide antibiotics Biochem Pharmacol 57 1999 121 134
    • (1999) Biochem Pharmacol , vol.57 , pp. 121-134
    • Schröder, J.M.1
  • 53
    • 0027981211 scopus 로고
    • Structure and dynamics of the neutrophil defensins NP-2, NP-5, and HNP-1: NMR studies of amide hydrogen exchange kinetics
    • J.J. Skalicky, M.E. Selsted, and A. Pardi Structure and dynamics of the neutrophil defensins NP-2, NP-5, and HNP-1: NMR studies of amide hydrogen exchange kinetics Proteins 20 1994 52 67
    • (1994) Proteins , vol.20 , pp. 52-67
    • Skalicky, J.J.1    Selsted, M.E.2    Pardi, A.3
  • 54
    • 0039171375 scopus 로고    scopus 로고
    • Studies on the expression of transferred human a-defensin HNP1 gene in tracheal epithelial cells cultivated in vitro
    • B. Tang, N. Huang, Q. Wu, and B.Y. Wang Studies on the expression of transferred human a-defensin HNP1 gene in tracheal epithelial cells cultivated in vitro Chin J Microbiol Immunol 19 1999 481 484
    • (1999) Chin J Microbiol Immunol , vol.19 , pp. 481-484
    • Tang, B.1    Huang, N.2    Wu, Q.3    Wang, B.Y.4
  • 56
    • 0029978338 scopus 로고    scopus 로고
    • Intramolecular Inhibition of Human Defensin HNP-1 by its propiece
    • E.V. Valore, E. Martin, S.S. Harwig, and T. Ganz Intramolecular Inhibition of Human Defensin HNP-1 by its propiece J Clin Invest 97 7 1996 1624 1629
    • (1996) J Clin Invest , vol.97 , Issue.7 , pp. 1624-1629
    • Valore, E.V.1    Martin, E.2    Harwig, S.S.3    Ganz, T.4
  • 58
    • 4444343822 scopus 로고    scopus 로고
    • Fusion expression of human beta-defensin-2 from multiple joined genes in Escherichia coli
    • F. Wang, X.M. Fang, Z.N. Xu, L. Peng, and P.L. Cen Fusion expression of human beta-defensin-2 from multiple joined genes in Escherichia coli Preparat Biochem Biotechnol 34 3 2004 215 225
    • (2004) Preparat Biochem Biotechnol , vol.34 , Issue.3 , pp. 215-225
    • Wang, F.1    Fang, X.M.2    Xu, Z.N.3    Peng, L.4    Cen, P.L.5
  • 59
    • 2942729771 scopus 로고    scopus 로고
    • Activity of alpha- and theta-defensins against primary isolates of HIV-1
    • W. Wang, S.M. Owen, D.L. Rudolph, A.M. Cole, T. Hong, and A.J. Waring Activity of alpha- and theta-defensins against primary isolates of HIV-1 J Immunol 173 1 2004 515 520
    • (2004) J Immunol , vol.173 , Issue.1 , pp. 515-520
    • Wang, W.1    Owen, S.M.2    Rudolph, D.L.3    Cole, A.M.4    Hong, T.5    Waring, A.J.6
  • 60
    • 0024370068 scopus 로고
    • Purification and characterization of human neutrophil peptide 4, a new member of the defensin family
    • C.G. Wilde, J.E. Griffith, M.N. Marra, J.L. Snable, and R.W. Scott Purification and characterization of human neutrophil peptide 4, a new member of the defensin family J Biol Chem 264 1989 11200 11203
    • (1989) J Biol Chem , vol.264 , pp. 11200-11203
    • Wilde, C.G.1    Griffith, J.E.2    Marra, M.N.3    Snable, J.L.4    Scott, R.W.5
  • 61
    • 33645398452 scopus 로고    scopus 로고
    • Cloning and expression of beta-defensin-2 gene in E. coli
    • J. Xu, X.M. Fang, L. Peng, F. Wang, and Z.N. Xu Cloning and expression of beta-defensin-2 gene in E. coli Intensive Care Med 29 2003 S124
    • (2003) Intensive Care Med , vol.29 , pp. 124
    • Xu, J.1    Fang, X.M.2    Peng, L.3    Wang, F.4    Xu, Z.N.5
  • 62
    • 14044269478 scopus 로고    scopus 로고
    • Expression of human beta-defensin-2 with multiple joined genes in Escherichia coli
    • Z.N. Xu, F. Wang, L. Peng, X.M. Fang, and P.L. Cen Expression of human beta-defensin-2 with multiple joined genes in Escherichia coli Appl Biochem Biotechnol 120 2005 1 13
    • (2005) Appl Biochem Biotechnol , vol.120 , pp. 1-13
    • Xu, Z.N.1    Wang, F.2    Peng, L.3    Fang, X.M.4    Cen, P.L.5
  • 63
    • 0036721626 scopus 로고    scopus 로고
    • Identification of multiple novel epididymis-specific beta-defensin isoforms in the humans and mice
    • Y. Yamaguchi, T. Nagase, R. Makita, S. Fukuhara, T. Tomita, and T. Tominaga Identification of multiple novel epididymis-specific beta-defensin isoforms in the humans and mice J Immunol 169 2002 2516 2523
    • (2002) J Immunol , vol.169 , pp. 2516-2523
    • Yamaguchi, Y.1    Nagase, T.2    Makita, R.3    Fukuhara, S.4    Tomita, T.5    Tominaga, T.6
  • 64
    • 0033569408 scopus 로고    scopus 로고
    • β-Defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6
    • D. Yang, O. Chertov, S.N. Bykovskaia, Q. Chen, M.J. Buffo, and J. Shogan β-Defensins: linking innate and adaptive immunity through dendritic and T cell CCR6 Science 286 1999 525 528
    • (1999) Science , vol.286 , pp. 525-528
    • Yang, D.1    Chertov, O.2    Bykovskaia, S.N.3    Chen, Q.4    Buffo, M.J.5    Shogan, J.6
  • 65
    • 0036828999 scopus 로고    scopus 로고
    • Contribution of human α-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor
    • L.Q. Zhang, W.J. Yu, T. He, J. Yu, R.E. Caffrey, and E.A. Dalmasso Contribution of human α-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor Science 298 2002 995 1000
    • (2002) Science , vol.298 , pp. 995-1000
    • Zhang, L.Q.1    Yu, W.J.2    He, T.3    Yu, J.4    Caffrey, R.E.5    Dalmasso, E.A.6
  • 66
    • 33645415350 scopus 로고    scopus 로고
    • Expression of human defensin-I (HNP-I) in E. coli
    • M.C. Zhang, and G.C. Zheng Expression of human defensin-I (HNP-I) in E. coli Chin Biochem J 13 1997 264 269
    • (1997) Chin Biochem J , vol.13 , pp. 264-269
    • Zhang, M.C.1    Zheng, G.C.2
  • 67
    • 0039625325 scopus 로고    scopus 로고
    • Human defensin-1 (HNP-1) expression in tobacco: A preliminary observation on Anti-TMV activity of the transgenic tobacco plants
    • M.C. Zhang, and G.C. Zheng Human defensin-1 (HNP-1) expression in tobacco: a preliminary observation on Anti-TMV activity of the transgenic tobacco plants Acta Botanica Sinica 39 1997 574 576
    • (1997) Acta Botanica Sinica , vol.39 , pp. 574-576
    • Zhang, M.C.1    Zheng, G.C.2
  • 68
    • 33645423261 scopus 로고    scopus 로고
    • Transient expression on human defensin-1 (HNP-1) in tobacco protoplast
    • M.C. Zhang, and G.C. Zheng Transient expression on human defensin-1 (HNP-1) in tobacco protoplast Acta Biologiae Experimentalis Sinica 30 1997 209 211
    • (1997) Acta Biologiae Experimentalis Sinica , vol.30 , pp. 209-211
    • Zhang, M.C.1    Zheng, G.C.2
  • 69
    • 0030569343 scopus 로고    scopus 로고
    • Widespread expression of beta-defensin HBD-1 in human secretory glands and epithelial cells
    • C.Q. Zhao, I. Wang, and R.I. Lehre Widespread expression of beta-defensin HBD-1 in human secretory glands and epithelial cells FEBS Lett 396 1996 319 322
    • (1996) FEBS Lett , vol.396 , pp. 319-322
    • Zhao, C.Q.1    Wang, I.2    Lehre, R.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.