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Volumn 105, Issue 44, 2008, Pages 17109-17114

Plasminogen mediates the atherogenic effects of macrophage-expressed urokinase and accelerates atherosclerosis in apoE-knockout mice

Author keywords

Aneurysm; Aorta; Proteolysis

Indexed keywords

APOLIPOPROTEIN E; PLASMINOGEN; UROKINASE;

EID: 55949112237     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0808650105     Document Type: Article
Times cited : (34)

References (29)
  • 1
    • 3242735794 scopus 로고    scopus 로고
    • The functions of plasminogen in cardiovascular disease
    • Plow EF, Hoover-Plow J (2004) The functions of plasminogen in cardiovascular disease. Trends Cardiovasc Med 14:180-186.
    • (2004) Trends Cardiovasc Med , vol.14 , pp. 180-186
    • Plow, E.F.1    Hoover-Plow, J.2
  • 2
    • 2442534668 scopus 로고    scopus 로고
    • Novel aspects and new roles for the serine protease plasmin
    • Syrovets T, Simmet T (2004) Novel aspects and new roles for the serine protease plasmin. Cell Mol Life Sci 61:873-885.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 873-885
    • Syrovets, T.1    Simmet, T.2
  • 3
    • 34249305192 scopus 로고    scopus 로고
    • Vascular functions of the plasminogen activation system
    • Fay WP, Garg N, Sunkar M (2007) Vascular functions of the plasminogen activation system. Arterioscler Thromb Vasc Biol 27:1231-1237.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 1231-1237
    • Fay, W.P.1    Garg, N.2    Sunkar, M.3
  • 4
    • 0344474540 scopus 로고    scopus 로고
    • Co-localization of fibrinolytic activators and inhibitors with macrophages in atherosclerotic vessels
    • Falkenberg M, Björnheden T, Lindnér P, Risberg B (1998) Co-localization of fibrinolytic activators and inhibitors with macrophages in atherosclerotic vessels. Cardiovasc Pathol 7:223-231.
    • (1998) Cardiovasc Pathol , vol.7 , pp. 223-231
    • Falkenberg, M.1    Björnheden, T.2    Lindnér, P.3    Risberg, B.4
  • 5
    • 0029092453 scopus 로고
    • Plasminogen activator system in human coronary atherosclerosis
    • Raghunath PN, et al. (1995) Plasminogen activator system in human coronary atherosclerosis. Arterioscler Thromb Vasc Biol 15:1432-1443.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 1432-1443
    • Raghunath, P.N.1
  • 6
    • 0031885829 scopus 로고    scopus 로고
    • Relation of urokinase-type plasminogen activator expression to presence and severity of atherosclerotic lesions in human coronary arteries
    • Kienast J, et al. (1998) Relation of urokinase-type plasminogen activator expression to presence and severity of atherosclerotic lesions in human coronary arteries. Thromb Haemost 79:579-586.
    • (1998) Thromb Haemost , vol.79 , pp. 579-586
    • Kienast, J.1
  • 7
    • 3142516202 scopus 로고    scopus 로고
    • Overexpression of urokinase receptor and cell surface urokinase-type plasminogen activator in the human vessel wall with different types of atherosclerotic lesions
    • Steins MB, et al. (2004) Overexpression of urokinase receptor and cell surface urokinase-type plasminogen activator in the human vessel wall with different types of atherosclerotic lesions. Blood Coagul Fibrinolysis 15:383-391.
    • (2004) Blood Coagul Fibrinolysis , vol.15 , pp. 383-391
    • Steins, M.B.1
  • 8
    • 0001867395 scopus 로고    scopus 로고
    • eds Colman, RW, Hirsh, J, Marder, VJ, Clowes, AW, George, JN Lippincott, Williams, and Wilkins, Philadelphia, pp
    • Bachmann F (2001) in Hemostasis and Thrombosis: Basic Principles and Clinical Practice, eds Colman, RW, Hirsh, J, Marder, VJ, Clowes, AW, George, JN (Lippincott, Williams, and Wilkins, Philadelphia), pp 275-320.
    • (2001) Hemostasis and Thrombosis: Basic Principles and Clinical Practice , pp. 275-320
    • Bachmann, F.1
  • 9
    • 0025883277 scopus 로고
    • Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor
    • Ellis V, Behrendt N, Danø K (1991) Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor. J Biol Chem 266:12752-12758.
    • (1991) J Biol Chem , vol.266 , pp. 12752-12758
    • Ellis, V.1    Behrendt, N.2    Danø, K.3
  • 10
    • 0035051534 scopus 로고    scopus 로고
    • Prospective study of fibrinolytic factors and incident coronary heart disease: The atherosclerosis risk in communities (ARIC) Study
    • Folsom AR, et al. (2001) Prospective study of fibrinolytic factors and incident coronary heart disease: The atherosclerosis risk in communities (ARIC) Study. Arterioscler Thromb Vasc Biol 21:611-617.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 611-617
    • Folsom, A.R.1
  • 11
    • 0032974070 scopus 로고    scopus 로고
    • Fibrinolytic activation markers predict myocardial infarction in the elderly. The Cardiovascular Health Study
    • Cushman M, et al. (1999) Fibrinolytic activation markers predict myocardial infarction in the elderly. The Cardiovascular Health Study. Arterioscler Thromb Vasc Biol 19:493-498.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 493-498
    • Cushman, M.1
  • 12
    • 0033050104 scopus 로고    scopus 로고
    • Relationship of plasmin generation to cardiovascular disease risk factors in elderly men and women
    • Sakkinen PA, et al. (1999) Relationship of plasmin generation to cardiovascular disease risk factors in elderly men and women. Arterioscler Thromb Vasc Biol 19:499-504.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 499-504
    • Sakkinen, P.A.1
  • 13
    • 0032521250 scopus 로고    scopus 로고
    • Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice
    • Ploplis VA, et al. (1998) Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice. Blood 91:2005-2009.
    • (1998) Blood , vol.91 , pp. 2005-2009
    • Ploplis, V.A.1
  • 14
    • 20844446624 scopus 로고    scopus 로고
    • Enzymatic modification of low-density lipoprotein in the arterial wall: A new role for plasmin and matrix metalloproteinases in atherogenesis
    • Torzewski M, et al. (2004) Enzymatic modification of low-density lipoprotein in the arterial wall: A new role for plasmin and matrix metalloproteinases in atherogenesis. Arterioscler Thromb Vasc Biol 24:2130-2136.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 2130-2136
    • Torzewski, M.1
  • 15
    • 16944363984 scopus 로고    scopus 로고
    • Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation
    • Carmeliet P, et al. (1997) Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation. Nat Genet 17:439-444.
    • (1997) Nat Genet , vol.17 , pp. 439-444
    • Carmeliet, P.1
  • 16
    • 0030885955 scopus 로고    scopus 로고
    • Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis
    • Xiao Q, et al. (1997) Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis. Proc Natl Acad Sci USA 94:10335-10340.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10335-10340
    • Xiao, Q.1
  • 17
    • 2442591844 scopus 로고    scopus 로고
    • Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death
    • Cozen AE, et al. (2004) Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death. Circulation 109:2129-2135.
    • (2004) Circulation , vol.109 , pp. 2129-2135
    • Cozen, A.E.1
  • 18
    • 0036906177 scopus 로고    scopus 로고
    • uPAR: A versatile signalling orchestrator
    • Blasi F, Carmeliet P (2002) uPAR: A versatile signalling orchestrator. Nat Rev Mol Cell Biol 3:932-943.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 932-943
    • Blasi, F.1    Carmeliet, P.2
  • 19
    • 0031021357 scopus 로고    scopus 로고
    • An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus
    • Tsirka SE, et al. (1997) An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus. J Neurosci 17:543-552.
    • (1997) J Neurosci , vol.17 , pp. 543-552
    • Tsirka, S.E.1
  • 20
    • 0033597411 scopus 로고    scopus 로고
    • Nonproteolytic neuroprotection by human recombinant tissue plasminogen activator
    • Kim Y-H, Park J-H, Hong SH, Koh J-Y (1999) Nonproteolytic neuroprotection by human recombinant tissue plasminogen activator. Science 284:647-650.
    • (1999) Science , vol.284 , pp. 647-650
    • Kim, Y.-H.1    Park, J.-H.2    Hong, S.H.3    Koh, J.-Y.4
  • 21
    • 0027077443 scopus 로고
    • Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor
    • Naldini L, et al. (1992) Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. EMBO J 11:4825-4833.
    • (1992) EMBO J , vol.11 , pp. 4825-4833
    • Naldini, L.1
  • 22
    • 36849007621 scopus 로고    scopus 로고
    • Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling
    • Hu K, Wu C, Mars WM, Liu Y (2007) Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling. J Clin Invest 3821-3832.
    • (2007) J Clin Invest , pp. 3821-3832
    • Hu, K.1    Wu, C.2    Mars, W.M.3    Liu, Y.4
  • 23
    • 36049037332 scopus 로고    scopus 로고
    • Urokinase plasminogen activator (uPA) stimulates cholesterol biosynthesis in macrophages through activation of SREBP-1 in a PI3-kinase and MEK-dependent manner
    • Fuhrman B, et al. (2007) Urokinase plasminogen activator (uPA) stimulates cholesterol biosynthesis in macrophages through activation of SREBP-1 in a PI3-kinase and MEK-dependent manner. Atherosclerosis 195:e108-116.
    • (2007) Atherosclerosis , vol.195
    • Fuhrman, B.1
  • 24
    • 0031034998 scopus 로고    scopus 로고
    • Impaired arterial neointima formation in mice with disruption of the plasminogen gene
    • Carmeliet P, et al. (1997) Impaired arterial neointima formation in mice with disruption of the plasminogen gene. J Clin Invest 99:200-208.
    • (1997) J Clin Invest , vol.99 , pp. 200-208
    • Carmeliet, P.1
  • 25
    • 0032533903 scopus 로고    scopus 로고
    • Reduced transplant arteriosclerosis in plasminogen-deficient mice
    • Moons L, et al. (1998) Reduced transplant arteriosclerosis in plasminogen-deficient mice. J Clin Invest 102:1788-1797.
    • (1998) J Clin Invest , vol.102 , pp. 1788-1797
    • Moons, L.1
  • 26
    • 34248336675 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta1-induced intimal growth: Plasminogen-independent activities of plasminogen activator inhibitor-1 and heterogeneous origin of intimal cells
    • Otsuka G, Stempien-Otero A, Frutkin AD, Dichek DA (2007) Mechanisms of TGF-beta1-induced intimal growth: Plasminogen-independent activities of plasminogen activator inhibitor-1 and heterogeneous origin of intimal cells. Circ Res 100:1300-1307.
    • (2007) Circ Res , vol.100 , pp. 1300-1307
    • Otsuka, G.1    Stempien-Otero, A.2    Frutkin, A.D.3    Dichek, D.A.4
  • 27
    • 0037432766 scopus 로고    scopus 로고
    • LRP: Role in vascular wall integrity and protection from atherosclerosis
    • Boucher P, et al. (2003) LRP: Role in vascular wall integrity and protection from atherosclerosis. Science 300:329-332.
    • (2003) Science , vol.300 , pp. 329-332
    • Boucher, P.1
  • 28
    • 0021044136 scopus 로고
    • Optimal conditions for proliferation of bone marrow-derived mouse macrophages in culture: The roles of CSF-1, serum, Ca2+, and adherence
    • Hume DA, Gordon S (1983) Optimal conditions for proliferation of bone marrow-derived mouse macrophages in culture: The roles of CSF-1, serum, Ca2+, and adherence. J Cell Physiol 117:189-194.
    • (1983) J Cell Physiol , vol.117 , pp. 189-194
    • Hume, D.A.1    Gordon, S.2
  • 29
    • 33744962186 scopus 로고    scopus 로고
    • Mechanisms of cardiac fibrosis induced by urokinase plasminogen activator
    • Stempien-Otero A, et al. (2006) Mechanisms of cardiac fibrosis induced by urokinase plasminogen activator. J Biol Chem 281:15345-15351.
    • (2006) J Biol Chem , vol.281 , pp. 15345-15351
    • Stempien-Otero, A.1


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