Cyclooxygenase-2 inhibitor inhibits hippocampal synaptic reorganization in pilocarpine-induced status epilepticus rats

Journal of Zhejiang University: Science B

Volumn 9, Issue 11, 2008, Pages 903-915

  Zhang, Hai Ju ^a   Sun, Ruo Peng ^b   Lei, Ge Fei ^b   Yang, Lu ^b   Liu, Chun Xi ^b  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

amino butyric acid (GABA); C Fos; Cyclooxygenase 2(COX 2); Epileptogenesis; Microglia; Mitogen activated protein kinase extracellular signal regulated protein kinase (MAPK ERK); Neurogenesis; Spontaneous recurrent seizure

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CARBONATE DEHYDRATASE III; CELECOXIB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DIAZEPAM; MITOGEN ACTIVATED PROTEIN KINASE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PILOCARPINE; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; CELL ACTIVATION; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME INHIBITION; EPILEPTIC STATE; EPILEPTOGENESIS; GABAERGIC TRANSMISSION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INHIBITORY POSTSYNAPTIC POTENTIAL; MALE; MICROGLIA; MINIATURE GABAERGIC INHIBITORY POSTSYNAPTIC CURRENT; NERVE EXCITABILITY; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; RAT; RECEPTOR UPREGULATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DISEASE MODELS, ANIMAL; FIBROCYSTIC BREAST DISEASE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NITROBENZENES; PILOCARPINE; PROTO-ONCOGENE PROTEINS C-FOS; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; STATUS EPILEPTICUS; SULFONAMIDES; SYNAPSES;

RATTUS;

EID: 55949092366     PISSN: 16731581     EISSN: 18621783     Source Type: Journal    
DOI: 10.1631/jzus.B0820018     Document Type: Article

References (34)

1. Altar, C.A., Laeng, P., Jurata, L.W., Brockman, J.A., Lemire, A., Bullard, J., Bukhman, Y.V., Young, T.A., Charles, V., Palfreyman, M.G., 2004. Electroconvulsive seizures regulate gene expression of distinct neurotrophic signaling pathways. J. Neurosci., 24 (11):2667-2677. [doi:10.1523/JNEUROSCI.5377-03.2004]
2. Baik, E.J., Kim, E.J., Lee, S.H., Moon, C.H., 1999. Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus. Brain Res., 843 (1-2):118-129. [doi:10.1016/S0006-8993(99)01797-7]
3. Brock, S.C., Bonsall, J., Luskin, M.B., 1998. The neuronal progenitor cells of the forebrain subventricular zone: Intrinsic properties in vitro and following transplantation. Methods, 16 (3):268-281. [doi:10.1006/meth.1998.0684]
4. Chen, C., Magee, J.C., Bazan, N.G., 2002. Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity. J. Neurophysiol., 87 (12): 2851-2857.
5. Dashtipour, K., Tran, P.H., Okazaki, M.M., Nadler, J.V., Ribak, C.E., 2001. Ultrastructural features and synaptic connections of hilar ectopic granule cells in the rat dentate gyrus are different from those of granule cells in the granule cell layer. Brain Res., 890 (2):261-271. [doi:10.1016/S0006-8993(00)03119-X]
6. Desjardins, P., Sauvageau, A., Bouthillier, A., Navarro, D., Hazell, A.S., Rose, C., Butterworth, R.F., 2003. Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis. Neurochem. Int., 42 (4):299-303. [doi:10.1016/S0197-0186(02)00101-8]
7. Dhir, A., Naidu, P.S., Kulkarni, S.K., 2006. Effect of cyclooxygenase-2 (COX-2) inhibitors in various animal models (bicuculline, picrotoxin, maximal electroshock-induced convulsions) of epilepsy with possible mechanism of action. Indian J. Exp. Biol., 44 (2):286-291.
8. Esclapez, M., Hirsch, J.C., Ben-Ari, Y., Bernard, C., 1999. Newly formed excitatory pathways provide a substrate for hyperexcitability in experimental temporal lobe epilepsy. J. Comp. Neurol., 408 (4):449-460. [doi:10.1002/(SICI)1096-9861(19990614)408:4<449::AID-CNE1>3.0.C O;2-R]
9. Gass, P., Bruehl, C., Herdegen, T., Kiessling, M., Lutzenburg, M., Witte, O.W., 1997. Induction of FOS and JUN proteins during focal epilepsy: Congruences with and differences to [14C] deoxyglucose metabolism. Brain Res. Mol. Brain Res., 46 (1-2):177-184. [doi:10.1016/ S0169-328X(96)00300-2]
10. Ivanov, A., Pellegrino, C., Rama, S., Dumalska, I., Salyha, Y., Ben-Ari, Y., Medina, I., 2006. Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons. J. Physiol., 572 (6): 789-798.
11. Jin, X., Prince, D.A., Huguenard, J.R., 2006. Enhanced excitatory synaptic connectivity in layer v pyramidal neurons of chronically injured epileptogenic neocortex in rats. J. Neurosci., 26 (18):4891-4900. [doi:10.1523/JNEUROSCI.4361-05.2006]
12. Jung, K.H., Chu, K., Kim, M., Jeong, S.W., Song, Y.M., Lee, S.T., Kim, J.Y., Lee, S.K., Roh, J.K., 2004. Continuous cytosine-b-D-arabinofuranoside infusion reduces ectopic granule cells in adult rat hippocampus with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus. Eur. J. Neurosci., 19 (12): 3219-3226. [doi:10.1111/j.0953-816X.2004.03412.x]
13. Kang, T.C., Kim, D.S., Kwak, S.E., Kim, J.E., Won, M.H., Kim, D.W., Choi, S.Y., Kwon, O.S., 2006. Epileptogenic roles of astroglial death and regeneration in the dentate gyrus of experimental temporal lobe epilepsy. Glia, 54 (4):258-271. [doi:10.1002/glia.20380]
14. Kawaguchi, K., Hickey, R.W., Rose, M.E., Zhu, L., Chen, J., Graham, S.H., 2005. Cyclooxygenase-2 expression is induced in rat brain after kainate-induced seizures and promotes neuronal death in CA3 hippocampus. Brain Res., 1050 (1-2):130-137. [doi:10.1016/j.brainres.2005.05.038]
15. Kunz, T., Oliw, E.H., 2001. The selective cyclooxygenase-2 inhibitor rofecoxib reduces kainate-induced cell death in the rat hippocampus. Eur. J. Neurosci., 13 (3):569-575. [doi:10.1046/j.1460-9568.2001.01420.x]
16. Lopez-Toledano, M.A., Shelanski, M.L., 2004. Neurogenic effect of beta-amyloid peptide in the development of neural stem cells. J. Neurosci., 24 (23):5439-5444. [doi: 10.1523/JNEUROSCI.0974-04.2004]
17. Lukiw, W.J., Cui, J.G., Musto, A.E., Musto, B.C., Bazan, N.G., 2005. Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampus. Biochem. Biophys. Res. Commun., 338 (1):77-81. [doi:10.1016/j.bbrc.2005.08.109]
18. McIntyre, D.C., Poulter, M.O., Gilby, K., 2002. Kindling: Some old and some new. Epilepsy Res., 50 (1-2):79-92. [doi:10.1016/ S0920-1211(02)00071-2]
19. Mikkonen, M., Soininen, H., Kalvianen, R., Tapiola, T., Ylinen, A., Vapalahti, M., Paljarvi, L., Pitkanen, A., 1998. Remodeling of neuronal circuitries in human temporal lobe epilepsy: Increased expression of highly polysialylated neural cell adhesion molecule in the hippocampus and the entorhinal cortex. Ann. Neurol., 44 (6):923-934. [doi:10.1002/ ana.410440611]
20. Morimoto, K., Fahnestock, M., Racine, R.J., 2004. Kindling and status epilepticus models of epilepsy: Rewiring the brain. Prog. Neurobiol., 73 (1):1-60. [doi:10.1016/j.pneurobio.2004.03.009]
21. Motte, J., Fernandes, M.J., Baram, T.Z., Nehlig, A., 1998. Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats. Brain Res., 793 (1-2):61-72. [doi:10.1016/S0006-8993(98)00135-8]
22. Okada, K., Yuhi, T., Tsuji, S., Yamashita, U., 2001. Cyclooxygenase-2 expression in the hippocampus of genetically epilepsy susceptible El mice was increased after seizure. Brain Res., 894 (2):332-335. [doi:10.1016/S0006-8993(01)02019-4]
23. Rothstein, J.D., Dykes-Hoberg, M., Pardo, C.A., Bristol, L.A., Jin, L., Kuncl, R.W., Kanai, Y., Hediger, M.A., Wang, Y., Schielke, J.P., Welty, D.F., 1996. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron, 16 (3):675-686. [doi:10.1016/S0896-6273(00)80086-0]
24. Sankar, R., Shin, D., Liu, H., Katsumori, H., Wasterlain, C.G., 2000. Granule cell neurogenesis after status epilepticus in the immature rat brain. Epilepsia, 41 (s6):S53-S56. [doi:10.1111/ j.1528-1157.2000.tb01557.x]
25. Sasaki, T., Kitagawa, K., Sugiura, S., Omura-Matsuoka, E., Tanaka, S., Yagita, Y., Okano, H., Matsumoto, M., Hori, M., 2003. Implication of cyclooxygenase-2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia. J. Neurosci. Res., 72 (4): 461-471. [doi:10.1002/jnr.10595]
26. Scharfman, H.E., Goodman, J.H., Sollas, A.L., 2000. Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: Functional implications of seizure-induced neurogenesis. J. Neurosci., 20 (9):6144-6158.
27. Seibert, K., Zhang, Y., Leahy, K., Hauser, S., Masferrer, J., Perkins, W., Lee, L., Isakson, P., 1994. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci. USA, 91 (25):12013-12017. [doi:10.1073/ pnas.91.25.12013]
28. Shafiq, N., Malhotra, S., Pandhi, P., 2003. Anticonvulsant action of celecoxib (alone and in combination with sub-threshold dose of phenytoin) in electroshock induced convulsion. Methods Find. Exp. Clin. Pharmacol., 25 (2): 87-90. [doi:10.1358/mf.2003.25.2.723681]
29. Subbaramaiah, K., Zakim, D., Weksler, B.B., Dannenberg, A., 1997. Inhibition of cyclooxygenase: A novel approach to cancer prevention. Proc. Soc. Exp. Biol. Med., 216 (2): 201-210.
30. Sweatt, J.D., 2004. Mitogen-activated protein kinases in synaptic plasticity and memory. Curr. Opin. Neurobiol., 14 (3):311-317. [doi:10.1016/j.conb.2004.04.001]
31. Tashiro, A., Goldberg, J., Yuste, R., 2002. Calcium oscillations in neocortical astrocytes under epileptiform conditions. J. Neurobiol., 50 (1):45-55. [doi:10.1002/neu.10019]
32. Torre, E.R., Lothman, E., Steward, O., 1993. Glial response to neuronal activity: GFAP-mRNA and protein levels are transiently increased in the hippocampus after seizures. Brain Res., 631 (2):256-264. [doi:10.1016/ 0006-8993(93)91543-2]
33. Tu, B., Bazan, N.G., 2003. Hippocampal kindling epileptogenesis upregulates neuronal cyclooxygenase-2 expression in neocortex. Exp. Neurol., 179 (2):167-175. [doi:10.1016/S0014-4886(02)00019-5]
34. Willingale, H.L., Gardiner, N.J., McLymont, N., Giblett, S., Grubb, B.D., 1997. Prostanoids synthesized by cyclo-oxygenase isoforms in rat spinal cord and their contribution to the development of neuronal hyperexcitability. Br. J. Pharmacol., 122 (8):1593-1604. [doi:10.1038/ sj.bjp.0701548]