Aspects of intracerebral hematomas - An update

Acta Neurologica Scandinavica

Volumn 118, Issue 6, 2008, Pages 347-361

  Ronning P ^a   Sorteberg, W ^b   Nakstad, P ^a   Russell, D ^b   Helseth, E ^b  

^a ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Brain; Cerebrovascular disease; Intracerebral hamatoma; Review

Indexed keywords

BLOOD CLOTTING FACTOR 7A; PLACEBO; VITAMIN K GROUP; WARFARIN;

ANTICOAGULANT THERAPY; BRAIN HEMATOMA; BRAIN HERNIA; CLINICAL TRIAL; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; GLASGOW COMA SCALE; HUMAN; HYDROCEPHALUS; HYPERTENSION; HYPERVENTILATION; MEDLINE; MORBIDITY; MORTALITY; NEUROSURGERY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; POPULATION; PREVALENCE; PRIMARY PREVENTION; REVIEW; SEDATION;

EID: 55949089092     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/j.1600-0404.2008.01023.x     Document Type: Review

References (138)

1. Thrift AG, Dewey HM, Macdonell RA, McNeil JJ, Donnan GA. Incidence of the major stroke subtypes: initial findings from the North East Melbourne stroke incidence study (NEMESIS). Stroke 2001 32 : 1732 8.
2. Gebel JM, Broderick JP. Intracerebral hemorrhage. Neurol Clin 2000 18 : 419 38.
3. Flaherty ML, Woo D, Haverbusch M et al. Racial variations in location and risk of intracerebral hemorrhage. Stroke 2005 36 : 934 7.
4. Inagawa T, Ohbayashi N, Takechi A, Shibukawa M, Yahara K. Primary intracerebral hemorrhage in Izumo City, Japan: incidence rates and outcome in relation to the site of hemorrhage. Neurosurgery 2003 53 : 1283 97.
5. Giroud M, Creisson E, Fayolle H et al. Risk factors for primary cerebral hemorrhage: a population-based study - the Stroke Registry of Dijon. Neuroepidemiology 1995 14 : 20 6.
6. Inagawa T. What are the actual incidence and mortality rates of intracerebral hemorrhage? Neurosurg Rev 2002 25 : 237 46.
7. Thrift AG, McNeil JJ, Forbes A, Donnan GA. Three important subgroups of hypertensive persons at greater risk of intracerebral hemorrhage. Melbourne Risk Factor Study Group. Hypertension 1998 31 : 1223 9.
8. Brott T, Thalinger K, Hertzberg V. Hypertension as a risk factor for spontaneous intracerebral hemorrhage. Stroke 1986 17 : 1078 83.
9. Broderick J, Brott T, Tomsick T, Leach A. Lobar hemorrhage in the elderly. The undiminishing importance of hypertension. Stroke 1993 24 : 49 51.
10. Song YM, Sung J, Lawlor DA, Davey SG, Shin Y, Ebrahim S. Blood pressure, haemorrhagic stroke, and ischaemic stroke: the Korean national prospective occupational cohort study. BMJ 2004 328 : 324 5.
11. Zhu XL, Chan MS, Poon WS. Spontaneous intracranial hemorrhage: which patients need diagnostic cerebral angiography? A prospective study of 206 cases and review of the literature. Stroke 1997 28 : 1406 9.
12. Ariesen MJ, Claus SP, Rinkel GJ, Algra A. Risk factors for intracerebral hemorrhage in the general population: a systematic review. Stroke 2003 34 : 2060 5.
13. Woo D, Sauerbeck LR, Kissela BM et al. Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study. Stroke 2002 33 : 1190 5.
14. Premkumar DR, Cohen DL, Hedera P, Friedland RP, Kalaria RN. Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease. Am J Pathol 1996 148 : 2083 95.
15. Qureshi AI, Tuhrim S, Broderick JP, Batjer HH, Hondo H, Hanley DF. Spontaneous intracerebral hemorrhage. N Engl J Med 2001 344 : 1450 60.
16. Mandybur TI. Cerebral amyloid angiopathy: the vascular pathology and complications. J Neuropathol Exp Neurol 1986 45 : 79 90.
17. Vonsattel JP, Myers RH, Hedley-Whyte ET, Ropper AH, Bird ED, Richardson EP Jr. Cerebral amyloid angiopathy without and with cerebral hemorrhages: a comparative histological study. Ann Neurol 1991 30 : 637 49.
18. Gilbert JJ, Vinters HV. Cerebral amyloid angiopathy: incidence and complications in the aging brain. I. Cerebral hemorrhage. Stroke 1983 14 : 915 23.
19. Vinters HV, Gilbert JJ. Cerebral amyloid angiopathy: incidence and complications in the aging brain. II. The distribution of amyloid vascular changes. Stroke 1983 14 : 924 8.
20. Masuda J, Tanaka K, Ueda K, Omae T. Autopsy study of incidence and distribution of cerebral amyloid angiopathy in Hisayama, Japan. Stroke 1988 19 : 205 10.
21. Knudsen KA, Rosand J, Karluk D, Greenberg SM. Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria. Neurology 2001 27 : 56.
22. O'Donnell HC, Rosand J, Knudsen KA et al. Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage. N Engl J Med 2000 342 : 240 5.
23. Feldmann E, Broderick JP, Kernan WN et al. Major risk factors for intracerebral hemorrhage in the young are modifiable. Stroke 2005 36 : 1881 5.
24. Hillbom M, Juvela S, Numminen H. Alcohol intake and the risk of stroke. J Cardiovasc Risk 1999 6 : 223 8.
25. Segal AZ, Chiu RI, Eggleston-Sexton PM, Beiser A, Greenberg SM. Low cholesterol as a risk factor for primary intracerebral hemorrhage: a case-control study. Neuroepidemiology 1999 18 : 185 93.
26. Sturgeon JD, Folsom AR, Longstreth WT Jr., Shahar E, Rosamond WD, Cushman M. Risk factors for intracerebral hemorrhage in a pooled prospective study. Stroke 2007 38 : 2718 25.
27. Bak S, Andersen M, Tsiropoulos I et al. Risk of stroke associated with nonsteroidal anti-inflammatory drugs: a nested case-control study. Stroke 2003 34 : 379 86.
28. Johnsen SP, Pedersen L, Friis S et al. Nonaspirin nonsteroidal anti-inflammatory drugs and risk of hospitalization for intracerebral hemorrhage: a population-based case-control study. Stroke 2003 34 : 387 91.
29. Gorelick PB, Weisman SM. Risk of hemorrhagic stroke with aspirin use: an update. Stroke 2005 36 : 1801 7.
30. Saloheimo P, Ahonen M, Juvela S, Pyhtinen J, Savolainen ER, Hillbom M. Regular aspirin-use preceding the onset of primary intracerebral hemorrhage is an independent predictor for death. Stroke 2006 37 : 129 33.
31. Toyoda K, Okada Y, Minematsu K et al. Antiplatelet therapy contributes to acute deterioration of intracerebral hemorrhage. Neurology 2005 65 : 1000 4.
32. Wong KS, Mok V, Lam WW et al. Aspirin-associated intracerebral hemorrhage: clinical and radiologic features. Neurology 2000 54 : 2298 301.
33. Rosand J, Eckman MH, Knudsen KA, Singer DE, Greenberg SM. The effect of warfarin and intensity of anticoagulation on outcome of intracerebral hemorrhage. Arch Intern Med 2004 164 : 880 4.
34. Fang MC, Chang Y, Hylek EM et al. Advanced age, anticoagulation intensity, and risk for intracranial hemorrhage among patients taking warfarin for atrial fibrillation. Ann Intern Med 2004 141 : 745 52.
35. Steiner T, Rosand J, Diringer M. Intracerebral hemorrhage associated with oral anticoagulant therapy: current practices and unresolved questions. Stroke 2006 37 : 256 62.
36. Flibotte JJ, Hagan N, O'Donnell J, Greenberg SM, Rosand J. Warfarin, hematoma expansion, and outcome of intracerebral hemorrhage. Neurology 2004 28 : 63.
37. Flaherty ML, Kissela B, Woo D et al. The increasing incidence of anticoagulant-associated intracerebral hemorrhage. Neurology 2007 68 : 116 21.
38. Hanger HC, Wilkinson TJ, Fayez-Iskander N, Sainsbury R. The risk of recurrent stroke after intracerebral haemorrhage. J Neurol Neurosurg Psychiatry 2007 78 : 836 40.
39. Mayer SA, Rincon F. Treatment of intracerebral haemorrhage. Lancet Neurol 2005 4 : 662 72.
40. Arboix A, Comes E, Garcia-Eroles L et al. Site of bleeding and early outcome in primary intracerebral hemorrhage. Acta Neurol Scand 2002 105 : 282 8.
41. Fisher CM. Pathological observations in hypertensive cerebral hemorrhage. J Neuropathol Exp Neurol 1971 30 : 536 50.
42. Pedersen HK, Bakke SJ, Hald JK et al. CTA in patients with acute subarachnoid haemorrhage. A comparative study with selective, digital angiography and blinded independent review. Acta Radiol 2001 42 : 43 9.
43. Stapf C, Mast H, Sciacca RR et al. Predictors of hemorrhage in patients with untreated brain arteriovenous malformation. Neurology 2006 66 : 1350 5.
44. Cordonnier C, Al-Shahi SR, Wardlaw J. Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting. Brain 2007 130 : 1988 2003.
45. Koennecke HC. Cerebral microbleeds on MRI: prevalence, associations, and potential clinical implications. Neurology 2006 66 : 165 71.
46. Takebayashi S, Kaneko M. Electron microscopic studies of ruptured arteries in hypertensive intracerebral hemorrhage. Stroke 1983 14 : 28 36.
47. Takebayashi S. Ultrastructural morphometry of hypertensive medial damage in lenticulostriate and other arteries. Stroke 1985 16 : 449 53.
48. Astrup J, Siesjo BK, Symon L. Thresholds in cerebral ischemia - the ischemic penumbra. Stroke 1981 12 : 723 5.
49. Fujii Y, Tanaka R, Takeuchi S, Koike T, Minakawa T, Sasaki O. Hematoma enlargement in spontaneous intracerebral hemorrhage. J Neurosurg 1994 80 : 51 7.
50. Rosand J, Eskey C, Chang Y, Gonzalez RG, Greenberg SM, Koroshetz WJ. Dynamic single-section CT demonstrates reduced cerebral blood flow in acute intracerebral hemorrhage. Cerebrovasc Dis 2002 14 : 214 20.
51. Zazulia AR, Diringer MN, Videen TO et al. Hypoperfusion without ischemia surrounding acute intracerebral hemorrhage. J Cereb Blood Flow Metab 2001 21 : 804 10.
52. Schellinger PD, Fiebach JB, Hoffmann K et al. Stroke MRI in intracerebral hemorrhage: is there a perihemorrhagic penumbra? Stroke 2003 34 : 1674 9.
53. Mayer SA, Lignelli A, Fink ME et al. Perilesional blood flow and edema formation in acute intracerebral hemorrhage: a SPECT study. Stroke 1998 29 : 1791 8.
54. Nilsson OG, Polito A, Saveland H, Ungerstedt U, Nordstrom CH. Are primary supratentorial intracerebral hemorrhages surrounded by a biochemical penumbra? A microdialysis study Neurosurgery 2006 59 : 521 8.
55. Kim-Han JS, Kopp SJ, Dugan LL, Diringer MN. Perihematomal mitochondrial dysfunction after intracerebral hemorrhage. Stroke 2006 37 : 2457 62.
56. Vespa P, Bergsneider M, Hattori N et al. Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study. J Cereb Blood Flow Metab 2005 25 : 763 74.
57. Brott T, Broderick J, Kothari R et al. Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke 1997 28 : 1 5.
58. Zazulia AR, Diringer MN, Derdeyn CP, Powers WJ. Progression of mass effect after intracerebral hemorrhage. Stroke 1999 30 : 1167 73.
59. Inaji M, Tomita H, Tone O, Tamaki M, Suzuki R, Ohno K. Chronological changes of perihematomal edema of human intracerebral hematoma. Acta Neurochir Suppl 2003 86 : 445 8.
60. Wagner KR, Xi G, Hua Y et al. Lobar intracerebral hemorrhage model in pigs: rapid edema development in perihematomal white matter. Stroke 1996 27 : 490 7.
61. Sansing LH, Kaznatcheeva EA, Perkins CJ, Komaroff E, Gutman FB, Newman GC. Edema after intracerebral hemorrhage: correlations with coagulation parameters and treatment. J Neurosurg 2003 98 : 985 92.
62. Carhuapoma JR, Barker PB, Hanley DF, Wang P, Beauchamp NJ. Human brain hemorrhage: quantification of perihematoma edema by use of diffusion-weighted MR imaging. AJNR Am J Neuroradiol 2002 23 : 1322 6.
63. Carhuapoma JR, Wang PY, Beauchamp NJ, Keyl PM, Hanley DF, Barker PB. Diffusion-weighted MRI and proton MR spectroscopic imaging in the study of secondary neuronal injury after intracerebral hemorrhage. Stroke 2000 31 : 726 32.
64. Carhuapoma JR, Hanley DF, Banerjee M, Beauchamp NJ. Brain edema after human cerebral hemorrhage: a magnetic resonance imaging volumetric analysis. J Neurosurg Anesthesiol 2003 15 : 230 3.
65. Xi G, Keep RF, Hoff JT. Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol 2006 5 : 53 63.
66. Wang J, Tsirka SE. Neuroprotection by inhibition of matrix metalloproteinases in a mouse model of intracerebral haemorrhage. Brain 2005 128 : 1622 33.
67. Lee KR, Kawai N, Kim S, Sagher O, Hoff JT. Mechanisms of edema formation after intracerebral hemorrhage: effects of thrombin on cerebral blood flow, blood-brain barrier permeability, and cell survival in a rat model. J Neurosurg 1997 86 : 272 8.
68. Lee KR, Colon GP, Betz AL, Keep RF, Kim S, Hoff JT. Edema from intracerebral hemorrhage: the role of thrombin. J Neurosurg 1996 84 : 91 6.
69. Xi G, Hua Y, Bhasin RR, Ennis SR, Keep RF, Hoff JT. Mechanisms of edema formation after intracerebral hemorrhage: effects of extravasated red blood cells on blood flow and blood-brain barrier integrity. Stroke 2001 1 : 32.
70. Steiner T, Kaste M, Forsting M et al. Recommendations for the management of intracranial haemorrhage - part I: spontaneous intracerebral haemorrhage. The European stroke initiative writing committee and the writing committee for the EUSI executive committee. Cerebrovasc Dis 2006 22 : 294 316.
71. McKissock W, Richardson A, Taylor J. Primary intracerebral hemorrhage: a controlled trial of surgical and conservative treatment in 180 unselected cases. Lancet 1961 2 : 221 226. Ref Type: Generic
72. Hattori N, Katayama Y, Maya Y, Gatherer A. Impact of stereotactic hematoma evacuation on activities of daily living during the chronic period following spontaneous putaminal hemorrhage: a randomized study. J Neurosurg 2004 101 : 417 20.
73. Chen X. Acta Acad Med Shanghai 1992 19.
74. Cheng XC. Chin J Clin Neurosci 2001 9 : 365.
75. Morgenstern LB, Frankowski RF, Shedden P, Pasteur W, Grotta JC. Surgical treatment for intracerebral hemorrhage (STICH): a single-center, randomized clinical trial. Neurology 1998 51 : 1359 63.
76. Batjer HH, Reisch JS, Allen BC, Plaizier LJ, Su CJ. Failure of surgery to improve outcome in hypertensive putaminal hemorrhage. A prospective randomized trial. Arch Neurol 1990 47 : 1103 6.
77. Auer LM, Deinsberger W, Niederkorn K et al. Endoscopic surgery versus medical treatment for spontaneous intracerebral hematoma: a randomized study. J Neurosurg 1989 70 : 530 5.
78. Zuccarello M, Brott T, Derex L et al. Early surgical treatment for supratentorial intracerebral hemorrhage: a randomized feasibility study. Stroke 1999 30 : 1833 9.
79. Teernstra OP, Evers SM, Lodder J, Leffers P, Franke CL, Blaauw G. Stereotactic treatment of intracerebral hematoma by means of a plasminogen activator: a multicenter randomized controlled trial (SICHPA). Stroke 2003 34 : 968 74.
80. Mendelow AD, Gregson BA, Fernandes HM et al. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial. Lancet 2005 29 : 365.
81. Hosseini H. Cerebrovasc Dis 2003 16 : 57. Ref Type: Generic
82. Juvela S, Heiskanen O, Poranen A et al. The treatment of spontaneous intracerebral hemorrhage. A prospective randomized trial of surgical and conservative treatment. J Neurosurg 1989 70 : 755 8.
83. Prasad K, Shrivastava A. Surgery for primary supratentorial intracerebral haemorrhage. Cochrane Database Syst Rev 2000 2 : CD000200.
84. Hankey GJ, Hon C. Surgery for primary intracerebral hemorrhage: is it safe and effective? A systematic review of case series and randomized trials Stroke 1997 28 : 2126 32.
85. Rohde V, Rohde I, Reinges MHT, Mayfrank L, Gilsbach JM. Frameless stereotactically guided catheter placement and fibrinolytic therapy for spontaneous intracerebral hematomas: technical aspects and initial clinical results. Minim Invasive Neurosurg 2000 43 : 9 17.
86. Schaller C, Rohde V, Meyer B, Hassler W. Stereotaxic puncture and lysis of spontaneous intracerebral hemorrhage using recombinant tissue plasminogen activator. Neurosurgery 1995 36 : 328 33.
87. Thiex R, Rohde V, Rohde I et al. Frame-based and frameless stereotactic hematoma puncture and subsequent fibrinolytic therapy for the treatment of spontaneous intracerebral hemorrhage. J Neurol 2004 251 : 1443 50.
88. Nakano T, Ohkuma H, Ebina K, Suzuki S. Neuroendoscopic surgery for intracerebral haemorrhage - Comparison with traditional therapies. Minim Invasive Neurosurg 2003 46 : 278 83.
89. Morgenstern LB, Demchuk AM, Kim DH, Frankowski RF, Grotta JC. Rebleeding leads to poor outcome in ultra-early craniotomy for intracerebral hemorrhage. Neurology 2001 56 : 1294 9.
90. Mendelow AD, Unterberg A. Surgical treatment of intracerebral haemorrhage. Curr Opin Crit Care 2007 13 : 169 74.
91. Steiner T, Diringer MN, Schneider D et al. Dynamics of intraventricular hemorrhage in patients with spontaneous intracerebral hemorrhage: risk factors, clinical impact, and effect of hemostatic therapy with recombinant activated factor VII. Neurosurgery 2006 59 : 767 73.
92. Naff NJ, Carhuapoma JR, Williams MA et al. Treatment of intraventricular hemorrhage with urokinase: effects on 30-day survival. Stroke 2000 31 : 841 7.
93. Coplin WM, Vinas FC, Agris JM et al. A cohort study of the safety and feasibility of intraventricular urokinase for nonaneurysmal spontaneous intraventricular hemorrhage. Stroke 1998 29 : 1573 9.
94. Flaherty ML, Haverbusch M, Sekar P et al. Location and outcome of anticoagulant-associated intracerebral hemorrhage. Neurocrit Care 2006 5 : 197 201.
95. Kirollos RW, Tyagi AK, Ross SA, van Hille PT, Marks PV. Management of spontaneous cerebellar hematomas: a prospective treatment protocol. Neurosurgery 2001 49 : 1378 86.
96. Broderick J, Connolly S, Feldmann E et al. Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update. A guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group. Stroke 2007 38 : 2001 23.
97. Juttler E, Schwab S, Schmiedek P et al. Decompressive surgery for the treatment of malignant infarction of the middle cerebral artery (DESTINY): a randomized, controlled trial. Stroke 2007 38 : 2518 25.
98. Murthy JM, Chowdary GV, Murthy TV, Bhasha PS, Naryanan TJ. Decompressive craniectomy with clot evacuation in large hemispheric hypertensive intracerebral hemorrhage. Neurocrit Care 2005 2 : 258 62.
99. Davis SM, Broderick J, Hennerici M et al. Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage. Neurology 2006 66 : 1175 81.
100. Mayer SA, Brun NC, Begtrup K et al. Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med 2005 352 : 777 85.
101. Hedner U, Erhardtsen E. Potential role of recombinant factor VIIa as a hemostatic agent. Clin Adv Hematol Oncol 2003 1 : 112 9.
102. Qureshi AI, Bliwise DL, Bliwise NG, Akbar MS, Uzen G, Frankel MR. Rate of 24-hour blood pressure decline and mortality after spontaneous intracerebral hemorrhage: a retrospective analysis with a random effects regression model. Crit Care Med 1999 27 : 480 5.
103. Fogelholm R, Avikainen S, Murros K. Prognostic value and determinants of first-day mean arterial pressure in spontaneous supratentorial intracerebral hemorrhage. Stroke 1997 28 : 1396 400.
104. Becker KJ, Baxter AB, Cohen WA et al. Withdrawal of support in intracerebral hemorrhage may lead to self-fulfilling prophecies. Neurology 2001 56 : 766 72.
105. Reilly PL. Management of intracranial pressure and cerebral perfusion pressure. In : Reilly PL, Bullock R, eds. Head injury pathophysiology and management, second edn. Arnold, 2005 331 55.
106. Moraine JJ, Berre J, Melot C. Is cerebral perfusion pressure a major determinant of cerebral blood flow during head elevation in comatose patients with severe intracranial lesions? J Neurosurg 2000 92 : 606 14.
107. Wakai A, Roberts I, Schierhout G. Mannitol for acute traumatic brain injury. Cochrane Database Syst Rev 2005 4 : CD001049.
108. Stocchetti N, Maas AI, Chieregato A, van der Plas AA. Hyperventilation in head injury: a review. Chest 2005 127 : 1812 27.
109. Rhoney DH, Parker D Jr. Use of sedative and analgesic agents in neurotrauma patients: effects on cerebral physiology. Neurol Res 2001 23 : 237 59.
110. Marion DW. Controlled normothermia in neurologic intensive care. Crit Care Med 2004 32 (2 Suppl S43 S45.
111. Tokutomi T, Morimoto K, Miyagi T, Yamaguchi S, Ishikawa K, Shigemori M. Optimal temperature for the management of severe traumatic brain injury: effect of hypothermia on intracranial pressure, systemic and intracranial hemodynamics, and metabolism. Neurosurgery 2003 52 : 102 11.
112. Kawai N, Kawanishi M, Okauchi M, Nagao S. Effects of hypothermia on thrombin-induced brain edema formation. Brain Res 2001 895 : 50 8.
113. Kawanishi M. Effect of hypothermia on brain edema formation following intracerebral hemorrhage in rats. Acta Neurochir Suppl 2003 86 : 453 6.
114. Jauch EC, Lindsell CJ, Adeoye O et al. Lack of evidence for an association between hemodynamic variables and hematoma growth in spontaneous intracerebral hemorrhage. Stroke 2006 37 : 2061 5.
115. Powers WJ, Zazulia AR, Videen TO et al. Autoregulation of cerebral blood flow surrounding acute (6 to 22 hours) intracerebral hemorrhage. Neurology 2001 57 : 18 24.
116. Qureshi AI, Mohammad YM, Yahia AM et al. A prospective multicenter study to evaluate the feasibility and safety of aggressive antihypertensive treatment in patients with acute intracerebral hemorrhage. J Intensive Care Med 2005 20 : 34 42.
117. Vermeer SE, Algra A, Franke CL, Koudstaal PJ, Rinkel GJ. Long-term prognosis after recovery from primary intracerebral hemorrhage. Neurology 2002 59 : 205 9.
118. Nilsson OG, Lindgren A, Brandt L, Saveland H. Prediction of death in patients with primary intracerebral hemorrhage: a prospective study of a defined population. J Neurosurg 2002 97 : 531 6.
119. McGuire AJ, Raikou M, Whittle I, Christensen MC. Long-term mortality, morbidity and hospital care following intracerebral hemorrhage: an 11-year cohort study. Cerebrovasc Dis 2007 23 : 221 8.
120. Barton CW, Hemphill JC III. Cumulative dose of hypertension predicts outcome in intracranial hemorrhage better than American Heart Association guidelines. Acad Emerg Med 2007 14 : 695 701.
121. Gebel JM Jr., Jauch EC, Brott TG et al. Relative edema volume is a predictor of outcome in patients with hyperacute spontaneous intracerebral hemorrhage. Stroke 2002 33 : 2636 41.
122. Hemphill JC III., Bonovich DC, Besmertis L, Manley GT, Johnston SC. The ICH score: a simple, reliable grading scale for intracerebral hemorrhage. Stroke 2001 32 : 891 7.
123. Clarke JL, Johnston SC, Farrant M, Bernstein R, Tong D, Hemphill JC. External validation of the ICH Score. Neurocrit Care 2004 1 : 53 60.
124. Godoy DA, Boccio A. ICH score in a rural village in the Republic of Argentina. Stroke 2003 34 : e150 e151.
125. Jamora RD, Kishi-Generao EM Jr., Bitanga ES, Gan RN, Apaga NE, San Jose MC. The ICH score: predicting mortality and functional outcome in an Asian population. Stroke 2003 34 : 6 7.
126. Fernandes H, Gregson BA, Siddique MS, Mendelow AD. Testing the ICH score. Stroke 2002 33 : 1455 6.
127. Ariesen MJ, Algra A, van der Worp HB, Rinkel GJ. Applicability and relevance of models that predict short term outcome after intracerebral haemorrhage. J Neurol Neurosurg Psychiatr 2005 76 : 839 44.
128. Haacke C, Althaus A, Spottke A, Siebert U, Back T, Dodel R. Long-term outcome after stroke: evaluating health-related quality of life using utility measurements. Stroke 2006 37 : 193 8.
129. Boeer A, Voth E, Henze T, Prange HW. Early heparin therapy in patients with spontaneous intracerebral haemorrhage. J Neurol Neurosurg Psychiatr 1991 54 : 466 7.
130. Kleindienst A, Harvey HB, Mater E et al. Early antithrombotic prophylaxis with low molecular weight heparin in neurosurgery. Acta Neurochir (Wien) 2003 145 : 1085 90.
131. Lacut K, Bressollette L, Le GG et al. Prevention of venous thrombosis in patients with acute intracerebral hemorrhage. Neurology 2005 27 : 65.
132. Gentile NT, Seftchick MW, Huynh T, Kruus LK, Gaughan J. Decreased mortality by normalizing blood glucose after acute ischemic stroke. Acad Emerg Med 2006 13 : 174 80.
133. Van den Berghe G, Wilmer A, Hermans G et al. Intensive insulin therapy in the ICU. N Engl J Med 2006 354 : 449 461.
134. Gray CS, Hildreth AJ, Sandercock PA et al. Glucose-potassium-insulin infusions in the management of post-stroke hyperglycemia: the UK glucose insulin in stroke trial (GIST-UK). Lancet Neurol 2007 6 : 397 406.
135. Martin A, Rojas S, Chamorro A, Falcon C, Bargallo N, Planas AM. Why does acute hyperglycemia worsen the outcome of transient focal cerebral ischemia? Role of corticosteroids, inflammation, and protein O-glycosylation Stroke 2006 37 : 1288 95 (Apr 6).
136. Horn SD, DeJong G, Smout RJ, Gassaway J, James R, Conroy B. Stroke rehabilitation patients, practice, and outcomes: is earlier and more aggressive therapy better? Arch Phys Med Rehabil 2005 86 (12 Suppl 2 S101 S114.
137. Dennis MS, Lewis SC, Warlow C. Effect of timing and method of enteral tube feeding for dysphagic stroke patients (FOOD): a multicentre randomised controlled trial. Lancet 2005 365 : 764 72.
138. Indredavik B. Stroke units - the Norwegian experience. Cerebrovasc Dis 2003 15 (Suppl 1 19 20.