Current challenges and future prospects in management of neuropathic pain

Expert Review of Neurotherapeutics

Volumn 8, Issue 11, 2008, Pages 1743-1756

  Jain, Kewal K ^a  

^a JAIN PHARMABIOTECH   (Switzerland)

Author keywords

Analgesic; Biomarker of pain; Central neuropathic pain; Chronic pain; Clinical trial of pain; Diabetic neuropathy; Molecular pain therapy; Neuropathic pain; Peripheral neuropathic pain; Postherpetic neuralgia

Indexed keywords

6 [4 DEOXY 4 (2,4 TETRADECADIENOYLGLYCYLAMINO) GLYCERO BETA MANNOHEPTOPYRANOSYLAMINO] 9H PURINE; AJULEMIC ACID; AMITRIPTYLINE; ANANDAMIDE; AV 411; BENZODIAZEPINE DERIVATIVE; BICIFADINE; BRIVARACETAM; CITALOPRAM; CLOMIPRAMINE; DOXEPIN; DULOXETINE; FLUOXETINE; GABAPENTIN; HARKOSERIDE; IBUDILAST; IMIPRAMINE; KDS 2000; KETAMINE; LAMOTRIGINE; LIDOCAINE; MEMANTINE; METHADONE; MEXILETINE; NABILONE; NEFAZODONE; NORADRENALIN UPTAKE INHIBITOR; OMEGA CONOTOXIN MVIIA; OPIATE; PAROXETINE; PREGABALIN; RANIRESTAT; TETRODOTOXIN; TOPIRAMATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VARICELLA ZOSTER VACCINE; VENLAFAXINE; VIMPAT;

ACUPUNCTURE; ALLODYNIA; BRAIN DEPTH STIMULATION; CELL THERAPY; CHEMOTHERAPY INDUCED EMESIS; CLINICAL TRIAL; DEPRESSION; DIABETIC NEUROPATHY; GENE THERAPY; GENERALIZED ANXIETY DISORDER; HERPES ZOSTER; HUMAN; HYPOTENSION; NAUSEA AND VOMITING; NEUROPATHIC PAIN; PHYSIOTHERAPY; POSTHERPETIC NEURALGIA; REVIEW; RNA INTERFERENCE; SPINAL CORD STIMULATION; THALAMOTOMY; TRANSCUTANEOUS NERVE STIMULATION; UNSPECIFIED SIDE EFFECT;

CLINICAL TRIALS AS TOPIC; HUMANS; NEURALGIA;

EID: 55849117323     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/14737175.8.11.1743     Document Type: Review

References (48)

1. Jain KK. Central neuropathic pain. In: Medlink Neurology. Gilman S (Ed.) Medlink Corporation, CA, USA (2008). • Regularly updated article on classification and pathophysiology of neuropathic pain with strategies for management of central neuropathic pain for neurologists.
2. Treede RD, Jensen TS, Campbell JN et al. Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology 70, 1630-1635 (2008). • Source for remarks on definitions.
3. Jain KK. Pain Therapeutics - Drugs, Markets and Companies. Jain PharmaBiotech Publications, Basel, Switzerland (2008). •• A substantial part of this 490-page report is devoted to neuropathic pain. Most up-to-date and complete treatise on the subject including 500 references and critical evaluations.
4. Moulin DE, Clark AJ, Gilron I et al. Pharmacological management of chronic neuropathic pain - consensus statement and guidelines from the Canadian Pain Society. Pain Res Manag. 12, 13-21 (2007). •• One of the better publications of consensus statements on neuropathic pain of various organizations.
5. Gray P. Pregabalin in the management of central neuropathic pain. Expert Opin. Pharmacother. 8, 3035-3041 (2007).
6. Saarto T, Wiffen PJ. Antidepressants for neuropathic pain. Cochrane Database Syst. Rev. 4, CD005454 (2007). • Critical review of role of antidepressants in the management of neuropathic pain.
7. Jain KK. Chronic pain. In: Medlink Neurology. Gilman S (Ed.) Medlink Corporation, CA, USA (2008).
8. Attal N, Cruccu G, Haanpää M et al. EFNS guidelines on pharmacological treatment of neuropathic pain. Eur. J. Neurol. 13, 1153-1169 (2006). •• Guidelines relevant to Europe that are due to be revised sometime in 2008.
9. Chu LF, Angst MS, Clark D. Opioid-induced hyperalgesia in humans: molecular mechanisms and clinical considerations. Clin. J. Pain 24, 479-496 (2008).
10. Bowsher D. The management of central post-stroke pain. Postgrad. Med. J. 71, 598-604 (1995).
11. Tremont-Lukats IW, Challapalli V, McNicol ED, Lau J, Carr DB. Systemic administration of local anesthetics to relieve neuropathic pain: a systematic review and meta-analysis. Anesth. Analg. 101, 1738-1749 (2005). • Review of randomized controlled trials of systemically administered local anesthetics.
12. Dworkin RH, O'Connor AB, Backonja M et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 132, 237-251 (2007). •• Evidence-based recommendations reflecting practice in the USA.
13. Finnerup NB, Biering-Sorensen F, Johannesen IL et al. Intravenous lidocaine relieves spinal cord injury pain: a randomized controlled trial. Anesthesiology 102, 1023-1030 (2005).
14. Jain KK. Ziconotide. In: Medlink Neurology. Gilman S (Ed.) Medlink Corporation, CA, USA (2008).
15. Kautio AL, Haanpää M, Saarto T, Kalso E. Amitriptyline in the treatment of chemotherapy-induced neuropathic symptoms. J. Pain Symptom Manage. 35, 31-39 (2008). • Evaluation of amytriptyline in controlled clinical trials.
16. Nieto FR, Entrena JM, Cendan CM, Pozo ED, Vela JM, Baeyens JM. Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice. Pain 137, 520-531 (2008).
17. Kadiroglu AK, Sit D, Kayabasi H, Tuzcu AK, Tasdemir N, Yilmaz ME. The effect of venlafaxine HCl on painful peripheral diabetic neuropathy in patients with type 2 diabetes mellitus. J. Diabetes Complicat. 22, 241-245 (2008).
18. Smith T, Nicholson RA. Review of duloxetine in the management of diabetic peripheral neuropathic pain. Vasc. Health Risk Manag. 3, 833-844 (2007).
19. Gilron I, Coderre TJ. Emerging drugs in neuropathic pain. Expert. Opin. Emerg. Drugs 12, 113-126 (2007). •• Excellent review, but table of emerging drugs is inadequate and contains some errors.
20. Scholz J, Woolf CJ. The neuropathic pain triad: neurons, immune cells and glia. Nat. Neurosci. 10, 1361-1368 (2007).
21. Niederberger E, Geisslinger G. Proteomics in neuropathic pain research. Anesthesiology 108, 314-323 (2008).
22. Endo T, Spenger C, Hao J et al. Functional MRI of the brain detects neuropathic pain in experimental spinal cord injury. Pain 138(2), 292-300 (2008).
23. Chen FY, Tao W, Li YJ. Advances in brain imaging of neuropathic pain. Chin. Med. J. (Engl.) 121, 653-657 (2008).
24. Siniscalco D, Rossi F, Maione S. Molecular approaches for neuropathic pain treatment. Curr. Med. Chem. 14, 1783-1787 (2007). • Review of molecular therapies for neuropathic pain up to year 2006.
25. Jain KK. Cell therapy for pain. Expert Opin. Biol. Ther. (2008) (In press). •• Detailed account of cell therapy in development for pain including neuropathic pain.
26. Jain KK. Gene therapy for pain. Expert Opin. Biol. Ther. (2008) (In press). •• Detailed account of gene therapy in development for pain including neuropathic pain.
27. Sol JC, Li RY, Sallerin B et al. Intrathecal grafting of porcine chromaffin cells reduces formalin-evoked c-Fos expression in the rat spinal cord. Cell Transplant. 14, 353-365 (2005).
28. Zhou H, Aziza J, Sol JC et al. Cell therapy of pain: Characterization of human fetal chromaffin cells at early adrenal medulla development. Exp. Neurol. 198, 370-381 (2006).
29. Cejas PJ, Martinez M, Karmally S et al. Lumbar transplant of neurons genetically modified to secrete brain-derived neurotrophic factor attenuates allodynia and hyperalgesia after sciatic nerve constriction. Pain 86, 195-210 (2000).
30. Glorioso JC, Mata M, Fink DJ. Gene therapy for chronic pain. Curr. Opin. Mol. Ther. 5, 483-488 (2003).
31. Hao S, Mata M, Wolfe D et al. Gene transfer of glutamic acid decarboxylase reduces neuropathic pain. Ann. Neurol. 57, 914-918 (2005).
32. Wolfe D, Hao S, Hu J et al. Engineering an endomorphin?2 gene for use in neuropathic pain therapy. Pain 133, 29-38 (2007).
33. Dorn G, Patel S, Wotherspoon G et al. siRNA relieves chronic neuropathic pain. Nucleic Acids Res. 32, e49 (2004).
34. Mikami M, Yang J. Short hairpin RNA-mediated selective knockdown of NaV1.8 tetrodotoxin-resistant voltage-gated sodium channel in dorsal root ganglion neurons. Anesthesiology 103, 828-836 (2005).
35. Kobayashi H, Kitamura T, Sekiguchi M et al. Involvement of EphB1 receptor/EphrinB2 ligand in neuropathic pain. Spine 32, 592-598 (2007).
36. Vit JP, Ohara PT, Bhargava A, Kelley K, Jasmin L. Silencing the Kir4.1 potassium channel subunit in satellite glial cells of the rat trigeminal ganglion results in pain-like behavior in the absence of nerve injury. J. Neurosci. 28, 4161-4171 (2008).
37. Schafers M, Sommer C. Anticytokine therapy in neuropathic pain management. Expert Rev. Neurother. 7, 1613-1627 (2007).
38. White FA, Jung H, Miller RJ. Chemokines and the pathophysiology of neuropathic pain. Proc. Natl Acad. Sci. USA 104, 20151-20158 (2007).
39. Milligan ED, Sloane EM, Watkins LR. Glia in pathological pain: a role for fractalkine. J. Neuroimmunol. 198, 113-120 (2008). • Anti-inflammatory cytokines such as IL-10 as a novel and effective approach for clinical pain control.
40. Piao ZG, Cho IH, Park CK et al. Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury. Pain 121, 219-231 (2006).
41. Weston AD, Hood L. Systems biology, proteomics, and the future of health care: toward predictive, preventative, and personalized medicine. J. Proteome Res. 3, 179-196 (2004).
42. Materi W, Wishart DS. Computational systems biology in drug discovery and development: methods and applications. Drug Discov. Today 12, 295-303 (2007).
43. Jain KK. Personalised medicine. Curr. Opin. Mol. Ther. 4, 548-558 (2002).
44. Jain KK. Personalized Medicine: Scientific and Commercial Aspects. Jain PharmaBiotech Publications, Basel, Switzerland (2008). • Published continuously since 1998, this report contains up-to-date information on the basics of personalized medicine and application to management of pain.
45. Jain KK. How will genomics affect the practice of neurology? Practical Neurology 6, 44-51 (2007).
46. Aurilio C, Pota V, Pace MC, Passavanti MB, Barbarisi M. Ionic channels and neuropathic pain: physiopathology and applications. J. Cell. Physiol. 215, 8-14 (2008). •• Excellent review of role of ion channels in neuropathic pain.
47. Finnerup NB, Sindrup SH, Jensen TS. Chronic neuropathic pain: mechanisms, drug targets and measurement. Fundam. Clin. Pharmacol. 21, 129-136 (2007).
48. Ziegler D. Painful diabetic neuropathy: treatment and future aspects. Diabetes Metab. Res. Rev. 24 (Suppl. 1), S52-S57 (2008). •• Excellent review of diabetic neuropathy.