Identification of MSA1, a cell cycle-regulated, dosage suppressor of drc1/sld2 and dpb11 mutants

Cell Cycle

Volumn 7, Issue 21, 2008, Pages 3388-3398

  Li, Ju Mei ^a   Tetzlaff, Michael T ^a   Elledge, Stephen J ^b,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cdc28; Cdc6; DNA replication; Dpb11; Drc1; Msa1; Msa2

Indexed keywords

CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 14 1; CELL CYCLE PROTEIN 28 1N; CELL CYCLE PROTEIN 6; CELL CYCLE PROTEIN 7; CYCLIN DEPENDENT KINASE 1; GENOMIC DNA; MSA1; MUTANT PROTEIN; PHOSPHOPROTEIN PHOSPHATASE CDC14; POL PROTEIN; POL2 12; PROTEIN DPB11; PROTEIN DRC1; PROTEIN MSA2; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL SYNCHRONIZATION; CONTROLLED STUDY; DELETION MUTANT; DNA REPLICATION; GENE CONTROL; GENE DOSAGE; GENE EXPRESSION; GENE IDENTIFICATION; GENE REPRESSION; MSA1 GENE; NONHUMAN; PARALOGY; PHENOTYPE; PROTEIN ANALYSIS; RECIPROCAL CHROMOSOME TRANSLOCATION; STRUCTURAL GENE; SUPPRESSOR GENE; TEMPERATURE SENSITIVE MUTANT; TEMPERATURE SENSITIVITY;

EID: 55849108428     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.7.21.6932     Document Type: Article

References (38)

1. Bell SP, Dutta A. DNA replication in eukaryotic cells. Annu Rev Biochem 71; 333-74.
2. Takeda DY, Dutta A. DNA replication and progression through S phase. Oncogene 2005; 24:2827-43.
3. Labib K, Gambus A. A key role for the GINS complex at DNA replication forks. Trends in Cell Biology 2007; 17:271-8.
4. Araki H, Leem SH, Phongdara A, Sugino A. Dpb11, which interacts with DNA polymerase II (epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint. Proc Natl Acad Sci USA 1995; 92:11791-5.
5. Masumoto H, Sugino A, Araki H. Dpb11 controls the association between DNA polymerasesalpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 2000; 20:2809-17.
6. Kamimura Y, Masumoto H, Sugino A, Araki H. Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 1998; 18:6102-9.
7. Wang H, Elledge SJ. DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 1999; 96:3824-9.
8. Masumoto H, Muramatsu S, Kamimura Y, Araki H. S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast. Nature 2002; 415:651-5.
9. Tak YS, Tanaka Y, Endo S, Kamimura Y, Arak H. A CDK-catalysed regulatory phosphorylation for formation of the DNA replication complex Sld2-Dpb11. EMBO J 2006; 25:1987-96.
10. 1-specific transcription in Saccharomyces cerevisiae. J Biol Chem 2008; 283:6040-9.
11. Pramila T, Wu W, Miles S, Noble WS and Breeden LL. The forkhead transcription factor Hcm1 regulates chromosome segregation genes and fills the S-phase gap in the transcriptional circuitry of the cell cycle. Genes Dev 2006; 20:2266-78.
12. Ubersax JA, Woodbury EL, Quang PN, Paraz M, Blethrow JD, Shah K, Shokat KM, Morgan DO. Targets of the cyclin-dependent kinase Cdk1. Nature 2003; 425:859-64.
13. Bloom J, Cross FR. Novel role for Cdc14 sequestration: Cdc14 dephosphorylates factors that promote DNA replication. Mol Cell Biol 2007; 27:842-53.
14. Sanchez M, Calzada A, Bueno A. The Cdc6 protein is ubiquitinated in vivo for proteolysis in Saccharomyces cerevisiae. J Biol Chem 1999; 26:9092-7.
15. Visintin R, Craig K, Hwang ES, Prinz S, Tyers M, Amon A. The Phosphatase Cdc14 Triggers Mitotic Exit by Reversal of Cdk-Dependent Phosphorylation. Mol Cell 1998; 709-18.
16. Surana U, Robitsch H, Price C, Schuster T, Fitch I, Futcher AB, Nasmyth K. The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae. Cell 1991; 65:145-61.
17. Harbison CT, Gordon DB, Lee TI, Rinaldi NJ, Macisaac KD, Danford TW, Hannett NM, Tagne JB, Reynolds DB, Yoo J, Jennings EG, Zeitlinger J, Pokholok DK, Kellis M, Rolfe PA, Takusagawa KT, Lander ES, Gifford DK, Fraenkel E, Young RA. Transcriptional regulatory code of a eukaryotic genome. Nature 2004; 431:99-104.
18. Wong J, Nakajima Y, Westermann S, Shang C, Kang JS, Goodner C, Houshmand P, Fields S, Chan CS, Drubin D, Barnes G, Hazbun T. A protein interaction map of the mitotic spindle. Mol Biol Cell 2007; 18:3800-9.
19. Tanaka S, Umemori T, Hirai K, Muramatsu S, Kamimura Y, Araki H. CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 2007; 445:328-32.
20. Zegerman P, Diffley JF. Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 2007; 445:281-5.
21. Jackson AL, Pahl PM, Harrison K, Rosamond J, Sclafani RA. Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein. Mol Cell Biol 1993; 13:2899-908.
22. Yoon HJ, Loo S, Campbell JL. Regulation of Saccharomyces cerevisiae CDC7 function during the cell cycle. Mol Biol Cell 1993; 4:195-208.
23. Archambault V, Li CX, Tackett AJ, Wasch R, Chait BT, Rout MP, Cross FR. Genetic and biochemical evaluation of the importance of Cdc6 in regulating mitotic exit. Mol Biol Cell 2003; 14:4592-604.
24. Yuste-Rojas M, Cross FR. Mutations in CDC14 result in high sensitivity to cyclin gene dosage in Saccharomyces cerevisiae. Mol Gen Genet 2000; 263:60-72.
25. Hardy CF. Characterization of an essential Orc2p-associated factor that plays a role in DNA replication. Mol Cell Biol 1996; 16:1832-41.
26. Hogan E, Koshland D. Addition of extra origins of replication to a minichromosome suppresses its mitotic loss in cdc6 and cdc14 mutants of Saccharomyces cerevisiae. Proc Natl Acad Sci USA 1992; 89:3098-102.
27. Loo S, Fox CA, Rine J, Kobayashi R, Stillman B, Bell S. The origin recognition complex in silencing, cell cycle progression and DNA replication. Mol Biol Cell 1995; 6:741-56.
28. Young ET, Dombek KM, Tachibana C, Ideker T. Multiple pathways are co-regulated by the protein kinase Snf1 and the transcription factors Adr1 and Cat8. J Biol Chem 2003; 278:26146-58.
29. Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, Elledge SJ. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 1996; 86:263-74.
30. Feldman RM, Correll CC, Kaplan KB, Deshaies RJ. A Complex of Cdc4p, Skp1p and Cdc53p/Cullin catalyzes ubiquitination of the phosphorylated CDK Inhibitor Sic1p. Cell 1997; 91:221-30.
31. Skowyra D, Craig KL, Tyers M, Elledge SJ, Harper JW. F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex. Cell 1997; 91:209-19.
32. 1 Cdk required for its degradation and entry into S phase. Science 1997; 278:455-60.
33. Liu Q, Li MZ, Leibham D, Cortez D, Elledge SJ. The univector plasmid-fusion system, a method for rapid construction of recombinant DNA without restriction enzymes. Curr Biol 1998; 8:1300-9.
34. Longtine MS, McKenzie A III, Demarini DJ, Shah NG, Wach A, Brachat A, Philippsen P, Pringle JR. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 1998; 14:953-61.
35. Connelly C, Hieter P. Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression. Cell 1996; 86:275-85.
36. Aparicio OM, Weinstein DM, Bell SP. Components and dynamics of DNA replication complexes in S. cerevisiae: restriction of MCM proteins and Cdc45 during S phase. Cell 1997; 91:59-69.
37. Zou L, Stillman B. Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase. Mol Cell Biol 2000; 20:3089-96.
38. Lee TI, Johnstone SE, Young RA. Chromatin immunoprecipitation and microarray-based analysis of protein location. Nature Protocols 2006; 1:729-48.