Genetic and Biochemical Evaluation of the Importance of Cdc6 in Regulating Mitotic Exit

Molecular Biology of the Cell

Volumn 14, Issue 11, 2003, Pages 4592-4604

  Archambault, Vincent ^a   Li, Caihong X ^a   Tackett, Alan J ^a   Wäsch, Ralph ^a,b   Chait, Brian T ^a   Rout, Michael P ^a   Cross, Frederick R ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 6; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; CYCLINE CLB2; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BIOCHEMISTRY; CELL CYCLE; CELL CYCLE G1 PHASE; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; CYTOKINESIS; ENZYME ACTIVITY; GENETICS; MITOSIS; MITOSIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; YEAST;

CELL CYCLE; CELL CYCLE PROTEINS; CELL SURVIVAL; CYCLIN B; MASS SPECTROMETRY; MITOSIS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 0345255750     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E03-06-0384     Document Type: Article

References (44)

1. Aitchison, J.D., Blobel, G., and Rout, M.P. (1996). Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science 274, 624-627.
2. Bardin, A.J., and Amon, A. (2001). Men and sin: what's the difference? Nat. Rev. Mol. Cell Biol. 2, 815-826.
3. Basco, R.D., Segal, M.D., and Reed, S.I. (1995). Negative regulation of G1 and G2 by S-phase cyclins of Saccharomyces cerevisiae. Mol. Cell Biol. 15, 5030-5042.
4. Beavis, R.C., and Chait, B.T. (1996). Matrix-assisted laser desorption ionization mass-spectrometry of proteins. Methods Enzymol. 270, 519-551.
5. Bell, S.P., and Dutta, A. (2002). DNA replication in eukaryotic cells. Annu. Rev. Biochem. 71, 333-374.
6. Bueno, A., and Russell, P. (1992). Dual functions of CDC6: a yeast protein required for DNA replication also inhibits nuclear division. EMBO J. 11, 2167-2176.
7. Calzada, A., Sacristan, M., Sanchez, E., and Bueno, A. (2001). Cdc6 cooperates with Sic1 and Hct1 to inactivate mitotic cyclin-dependent kinases. Nature 412, 355-358.
8. Calzada, A., Sanchez, M., Sanchez, E., and Bueno, A. (2000). The stability of the Cdc6 protein is regulated by cyclin-dependent kinase/cyclin B complexes in Saccharomyces cerevisiae. J. Biol. Chem. 275, 9734-9741.
9. Cross, F.R. (2003). Two redundant oscillatory mechanisms in the yeast cell cycle. Dev. Cell 4, 741-752.
10. Cross, F.R., Archambault, V., Miller, M., and Klovstad, M. (2002). Testing a mathematical model of the yeast cell cycle. Mol. Biol. Cell 13, 52-70.
11. Donovan, J.D., Toyn, J.H., Johnson, A.L., and Johnston, L.H. (1994). P40SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae. Genes Dev. 8, 1640-1653.
12. Drury, L.S., Perkins, G., and Diffley, J.F. (1997). The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast. EMBO J. 16, 5966-5976.
13. Drury, L.S., Perkins, G., and Diffley, J.F. (2000). The cyclin-dependent kinase Cdc28p regulates distinct modes of Cdc6p proteolysis during the budding yeast cell cycle. Curr. Biol. 10, 231-240.
14. Elsasser, S., Chi, Y., Yang, P., and Campbell, J.L. (1999). Phosphorylation controls timing of Cdc6p destruction: a biochemical analysis. Mol. Biol. Cell 10, 3263-3277.
15. Elsasser, S., Lou, F., Wang, B., Campbell, J.L., and Jong, A. (1996). Interaction between yeast Cdc6 protein and B-type cyclin/Cdc28 kinases. Mol. Biol. Cell 7, 1723-1735.
16. Epstein, C.B., and Cross, F.R. (1992). CLB5: a novel B cyclin from budding yeast with a role in S phase. Genes Dev. 6, 1695-1706.
17. Evans, T., Rosenthal, E.T., Youngblom, J., Distel, D., and Hunt, T. (1983). Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell 33, 389-396.
18. Field, H.I., Fenyo, D., and Beavis, R.C. (2002). RADARS, a bioinformatics solution that automates proteome mass spectral analysis, optimises protein identification, and archives data in a relational database. Proteomics 2, 36-47.
19. Jacobson, M.D., Gray, S., Yuste-Rojas, M., and Cross, F.R. (2000). Testing cyclin specificity in the exit from mitosis. Mol. Cell Biol. 20, 4483-4493.
20. Knapp, D., Bhoite, L., Stillman, D.J., and Nasmyth, K. (1996). The transcription factor Swi5 regulates expression of the cyclin kinase inhibitor p40SIC1. Mol. Cell Biol. 16, 5701-5707.
21. Knop, M., Siegers, K., Pereira, G., Zachariae, W., Winsor, B., Nasmyth, K., and Schiebel, E. (1999). Epitope tagging of yeast genes using a PCR-based strategy: more tags and improved practical routines. Yeast 15, 963-972.
22. Krutchinsky, A.N., Kalkum, M., and Chait, B.T. (2001). Automatic identification of proteins with a MALDI-quadrupole ion trap mass spectrometer. Anal. Chem. 73, 5066-5077.
23. Lengronne, A., and Schwob, E. (2002). The yeast CDK inhibitor Sic1 prevents genomic instability by promoting replication origin licensing in late G(1). Mol. Cell 9, 1067-1078.
24. Morgan, D.O., and Roberts, J.M. (2002). Oscillation sensation. Nature 418, 495-496.
25. Nasmyth, K. (1996). At the heart of the budding yeast cell cycle. Trends Genet. 12, 405-412.
26. Nguyen, V.Q., Co, C., and Li, J.J. (2001). Cyclin-dependent kinases prevent DNA re-replicaton through multiple mechanisms. Nature 411, 1068-1073.
27. Perkins, G., Drury, L.S., and Diffley, J.F. (2001). Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis. EMBO J. 20, 4836-4845.
28. Piatti, S., Lengauer, C., and Nasmyth, K. (1995). Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae. EMBO J. 14, 3788-3799.
29. Rout, M.P., Aitchison, J.D., Suprapto, A., Hjertaas, K., Zhao, Y., and Chait, B.T. (2000). The yeast nuclear pore complex: composition, architecture, and transport mechanism. J. Cell Biol. 148, 635-651.
30. Rout, M.P., Blobel, G., and Aitchison, J.D. (1997). A distinct nuclear import pathway used by ribosomal proteins. Cell 89, 715-725.
31. Schultz, M.C. (1999). Chromatin assembly in yeast cell-free extracts. Methods 17, 161-172.
32. Stem, B., and Nurse, P. (1996). A quantitative model for the cdc2 control of S phase and mitosis in fission yeast. Trends Genet. 12, 345-350.
33. Toyn, J.H., Johnson, A.L., Donovan, J.D., Toone, W.M., and Johnston, L.H. (1997). The Swi5 transcription factor of Saccharomyces cerevisiae has a role in exit from mitosis through induction of the cdk-inhibitor Sic1 in telophase. Genetics 145, 85-96.
34. Toyn, J.H., Johnson, A.L., and Johnston, L.H. (1995). Segregation of unreplicated chromosomes in Saccharomyces cerevisiae reveals a novel G1/M-phase checkpoint. Mol. Cell Biol. 15, 5312-5321.
35. Visintin, R., Craig, K., Hwang, E.S., Prinz, S., Tyers, M., and Amon, A. (1998). The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol. Cell 2, 709-718.
36. Wach, A., Brachat, A., Alberti-Segui, C., Rebischung, C., and Philippsen, P. (1997). Heterologous HIS3 marker and GFP reporter modules for PCR-targeting in Saccharomyces cerevisiae. Yeast 13, 1065-1075.
37. Wäsch, R., and Cross, F.R. (2002). APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit. Nature 418, 556-562.
38. Weinreich, M., Liang, C., Chen, H.H., and Stillman, B. (2001). Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle. Proc. Natl. Acad. Sci. USA 98, 11211-11217.
39. Weinreich, M., Liang, C., and Stillman, B. (1999). The Cdc6p nucleotide-binding motif is required for loading MCM proteins onto chromatin. Proc. Natl. Acad. Sci. USA 96, 441-446.
40. Wyrick, J.J., Aparicio, J.G., Chen, T., Barnett, J.D., Jennings, E.G., Young, R.A., Bell, S.P., and Aparicio, O.M. (2001). Genome-wide distribution of ORC and MCM proteins in S. cerevisiae: high-resolution mapping of replication origins. Science 294, 2357-2360.
41. Zachariae, W., and Nasmyth, K. (1999). Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev. 13, 2039-2058.
42. Zhang, W., and Chait, B.T. (2000). ProFound: an expert system for protein identification using mass spectrometric peptide mapping information. Anal. Chem. 72, 2482-2489.
43. Zhou, C., and Jong, A. (1990). CDC6 mRNA fluctuates periodically in the yeast cell cycle. J. Biol. Chem. 265, 19904-19909.
44. Zwerschke, W., Rottjakob, H.W., and Kuntzel, H. (1994). The Saccharomyces cerevisiae CDC6 gene is transcribed at late mitosis and encodes a ATP/GTPase controlling S phase initiation. J. Biol. Chem. 269, 23351-23356.