Multi-center comparative evaluation of subgingivally delivered sanguinarine and doxycycline in the treatment of periodontitis. II. Clinical results

Journal of Periodontology

Volumn 68, Issue 2, 1997, Pages 119-126

  Polson, Alan M ^a,b   Garrett, Steven ^b,c   Stoller, Norman H ^d   Bandt, Carl L ^e   Hanes, Philip J ^f   Killoy, William J ^g   Southard, G Lee ^b   Duke, Susan P ^b   Bogle, Gary C ^c   Drisko, Connie H ^h   Friesen, Lynn R ^g  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b QLT Inc   (United States)

^c LOMA LINDA UNIVERSITY   (United States)

^d UNIVERSITY OF COLORADO   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

^f MEDICAL COLLEGE OF GEORGIA   (United States)

^g UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^h UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

clinical trials; doxycycline therapeutic use; drug delivery systems, biodegradable; follow up studies; multi center studies; periodontitis therapy; sanguinarine chloride therapeutic use

Indexed keywords

DOXYCYCLINE; SANGUINARINE;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; HUMAN; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PERIODONTITIS; RANDOMIZED CONTROLLED TRIAL;

EID: 8244245754     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.1997.68.2.119     Document Type: Article

References (23)

1. Poison AM, Stoller NH, Hanes PJ, et al. Two multi-center trials assessing the clinical efficacy of 5% sanguinarine in a biodegradable drug delivery system. J Clin Periodontol 1996;23:782-788.
2. Pascale D, Gordon J, Lamster I, Mann P, Seiger M, Arndt W. Concentration of doxycycline in human crevicular fluid. J Clin Periodontol 1986;13:841-844.
3. Mandell RL, Tripodi LS, Savitt ED, et al. The effect of treatment on Actinobacillus actinomycetemcomitans in localized juvenile periodontitis (LJP). J Periodontol 1986;57:94-99.
4. Walker CB. Antibiotic susceptibilities of periodontal bacteria: In vitro susceptibilities to eight antimicrobial agents. J Periodontol 1985;56(Suppl.):67-74.
5. Kulkarni GV, Lee WK, Aitken S, Birek P. McCulloch CA. A randomized, placebo-controlled trial of doxycycline effect on the microflora of recurrent periodontitis lesions in high-risk patients. J Periodontol 1991;62:197-202.
6. Demirel K, Baer PN, MacNamara TF. Topical application of doxycycline on periodontally involved root surfaces in vitro: Comparative analysis of substantivity on cementum and dentin. J Periodontol 1991;62:312-316.
7. Larsen T. Occurrence of doxycycline-resistant bacteria in the oral cavity after local administration of doxycycline in patients with periodontal disease. Scand J Infect Dis 1991;23:89-95.
8. Polson AM, Southard GL, Dunn RL, et al. Periodontal pocket treatment in beagle dogs using subgingival doxycycline from a biodegradable system. I. Initial clinical responses. J Periodontol 1996;67: 1176-1184.
9. Poison AM, Garrett S, Stoller NS, et al. Multi-center comparative evaluation of subgingivally delivered sanguinarine and doxycycline in the treatment of periodontitis. I. Study design, procedures, and management. J Periodontol 1997;68:110-118.
10. Goodson JM, Cugini MA, Kent RL, et al. Multi-center evaluation of tetracycline fiber therapy. II. Clinical response. J Periodont Res 1991;26:371-379.
11. van Steenberghe D, Bercy P, Kohl J, et al. Subgingival minocycline hydrochloride ointment in moderate to severe chronic adult periodontitis: in a randomized, double-blind, vehicle-controlled, multi-center study. J Periodontol 1993;64:637-644.
12. Murayama Y, Nomura Y, Yamoaka A, et al. Local administration of minocycline for periodontitis. Double-blind, comparative study of LS-007. J Japan Assoc Periodontol 1988;30:206-222.
13. Murayama Y, Isoshima O, Kurimoto K, et al. Antibiotic therapy in crevicular regions for treatment of periodontal disease. In: Hamada S, Holt SC, McGhee JR, eds. Periodontal Disease Pathogens, vol. 29. Tokyo: Quintessence Publishing Company; 1991.
14. Minabe M, Takeuchi K, Tamura T, Hori T, Umemoto T. Subgingival administration of tetracycline on a collagen film. J Periodontol 1989;60:552-556.
15. Eckles TA, Reinhardt RA, Dyer JK, Tussing GL, Szydlowski WM, DuBous LM. Intracrevicular application of tetracycline in white petrolatum for the treatment of periodontal disease. J Clin Periodontol 1990;17:454-462.
16. Goodson JM. Discussion: Design issues specific to studies of periodontitis. J Periodont Res 1992; (Spec. Issue) 27:412-416.
17. Greenstein G. Periodontal response to mechanical non-surgical therapy: A review. J Periodontol 1992;63:118-130.
18. Newman MG, Kornman KS, Doherty FM. A 6-month multi-center evaluation of adjunctive tetracycline fiber therapy used in conjunction with scaling and root planing in maintenance patients: Clinical results. J Periodontol 1994;65:685-691.
19. Ainamo J, Ellingsen BH, Hansen BF, et al. Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis. J Clin Periodontol 1992;19:723-729.
20. Stabholz A, Soskolne WA, Friedman M, Sela MN. The use of sustained release delivery of chlorhexidine for the maintenance of periodontal pockets. J Periodontol 1991;62:429-433.
21. Drisko CH, Cobb CM, Killoy WJ, et al. Evaluation of periodontal treatments using controlled-release tetracycline fibers: Clinical responses. J Periodontol 1995;66:692-699.
22. Heijl L, Dahlen G, Sundin Y, Wenander A, Goodson JM. A four quadrant comparative study of periodontal treatment using tetracycline containing drug delivery fibers and scaling. J Clin Periodontol 1991;18:111-116.
23. Lindhe J, Socransky SS, Nyman S, Haffajee A, Westfelt E. "Critical probing depths" in periodontal therapy. J Clin Periodontol 1982;9: 323-336.