Evaluation of the toxicity and antiulcerogenic activity of the ethanol extract of Maytenus obtusifolia Mart. leaves

Revista Brasileira de Farmacognosia

Volumn 18, Issue 3, 2008, Pages 441-446

  Mota, Kelly Samara De Lira ^a   Pita, João Carlos Lima Rodrigues ^a   Estevam, Ethiene Castellucci ^a   Medeiros, Viviane Marcelino ^a   Tavares, Josean Fechine ^a   Agra, Maria De Fátima ^a   Diniz, Margareth De Fátima Formiga Melo ^a   Da Silva, Marcelo Sobral ^a   Batista, Leônia Maria ^a  

^a FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

Acute oral toxicity; Antiulcerogenic activity; Artemia salina; Celastraceae; Maytenus obtusifolia

Indexed keywords

EID: 55849096647     PISSN: 0102695X     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0102-695X2008000300019     Document Type: Article

References (39)

1. Agra MF, França PF, Barbosa-Filho JM 2007. Synopsis of the plants known as medicinal and poisonous in Northeast of Brazil. Rev Bras Farmacogn 17: 114-140.
2. Almeida RN, Falcão ACGM, Diniz RST, Quintans-Júnior LJ, Polari RM, Barbosa-Filho JM, Agra MF, Duarte JC, Ferreira CD, Antoniolli AR, Araújo CC 1999. Metodologia para avaliação de plantas com atividade no Sistema Nervoso Central e alguns dados experimentais. Rev Bras Farm 80: 72-76.
3. Andrade SF, Lemos M, Comunello E, Noldin VF, Cechinel-Filho V, Niero R 2007. Evaluation of the antiulcerogenic activity of Maytenus robusta (Celastraceae) in different experimental ulcer models. J. Ethnopharmacol 113: 252-257.
4. Bandyopadhyay D, Biswas K, Bhattacharyya M, Reiter RJ, Banerjee RK 2001. Gastric toxicity and mucosal ulceration induced by oxygen-derived reactive species: protection by melatonin. Curr Mol Med 1: 501-513.
5. Bhattacharjee M, Bhattacharjee S, Gupta A, Banerjee RK 2002. Critical role of an endogenous gastric peroxidase in controlling oxidative damage in H. pylori-mediated and non-mediated gastric ulcer. Free Radical Bio Med 32: 731-743.
6. Brandão MGL, Cosenza GP, Moreira RA, Monte-Mor RLM 2006. Medicinal plants and other botanical products from the Brazilian Official Pharmacopoeia. Rev Bras Farmacogn 16: 408-420.
7. Bruni R, Rossi D, Muzzoli M, Romagnoli C, Paganetto G, Besco E, Choquecillo F, Peralta K, Lora WS, Sacchetti G 2006. Antimutagenic, antioxidant and antimicrobial properties of Maytenus krukovii bark. Fitoterapia 77: 538-545.
8. Bueno NR, Castilho RO, Costa RB, Pott A, Pott JV, Sheidt GN, Silva-Batista M 2005. Medicinal plants used by Kaiowá and Guaranti indegenous populations in the Caarapó Reserve. Mato Grosso do Sul, Brazil. Acta Bot Bras 19: 39-44.
9. Carvalho ACB, Balbino EE, Maciel A, Perfeito JPS 2008. Situação do registro de medicamentos fitoterápicos no Brasil. Rev Bras Farmacogn 18: 314-319.
10. Chow JYC, Ma L, Cho CH 1998. The role of adhesion molecules in gastric ulcer healing. WJG 4: 467-468.
11. Corrêa MP 1984. Dicionário das Plantas Úteis do Brasil e das Exóticas Cultivadas. IBDF-Ministério da Agricultura. Rio de Janeiro 6: 149.
12. De Sousa DP, de Almeida RN 2005. Neuroleptic-like properties of the chloroform extract of Maytenus obtusifolia Mart. roots. Biol Pharm Bull 28: 224-225.
13. El Tahir A, Satti GMH, Khalid SA 1999. Antiplasmodial activity of selected Sudanese medicinal plants with emphasis on Maytenus senegalensis (Lam.) Exell. J. Ethnopharmacol 64: 227-233.
14. Feng X, Gao Z, Li S, Jones SH, Hecht SM 2004. DNA polymerase, lyase inhibitors from Maytenus putterlickoides. J Nat Prod 67: 1744-1747.
15. Freire MO 1998. Estudo fitoquímico e psicofarmacológico das raízes de Maytenus obtusifolia Mart. (Celastraceae). Dissertação de Mestrado - Programa de Pós- Graduação em Produtos Naturais e Sintéticos Bioativos, Universidade Federal da Paraíba, João Pessoa.
16. Gessler MC, Tanner M, Chollet J, Nkunya MHH, Heinrich M 1995. Tanzanian medicinal-plants used traditionally for the treatment of malaria - in vivo antimalarial and in vitro cytotoxic activities. Phytother Res 9: 504-508.
17. Gonzalez FG, Portela TY, Stipp EJ, Di Stasi LC 2001 Antiulcerogenic and analgesic effects of Maytenus aquifolium, Sorocea bomplandii and Zolernia ilicifolia. J. Ethnopharmacol 77: 41-47.
18. Iversen PO, Nicolaysen G 2003. Water-for life. Tidsskrift for den Norske Laegeforening 123: 3402-3405.
19. Jorge RM, Leite JPV, Oliveira AB, Tagliati CA 2004. Evaluation of antinociceptive, anti-inflammatory and antiulcerogenic activities of Maytenus ilicifolia. J Ethnopharmacol 94: 93-100.
20. Kloucek P, Svobodova B, Polesny Z, Langrova I, Smrcek S, Kokoska L 2007. Antimicrobial activity of some medicinal barks used in Peruvian Amazon. J Ethnopharmacol 111: 427-429.
21. Liu C, Crawford JM 2005. O Trato Gastrointestinal. In: Kumar, V.; Abbas, A. K.; Fausto, N. Robbins & Cotram - Patologia - Bases Patológicas das Doenças. 7 ed. Rio de Janeiro: Elsevier Editora Ltda, p.838-918.
22. Lopes WB, Moroni FT, Brandeburgo MIH, Hamaguchi A 2002. Desenvolvimento de um método alternativo ao uso de animais de laboratório para avaliação da toxicidade de extratos vegetais. Revista Eletrônica Horizonte Científico 1: 1-11
23. Martins ER, Castro DM, Castellani DC, Dias JE 2003. Plantas Medicinais. 5. ed. Ver. Viçosa: UFV, p. 15-19.
24. Matu EN, van Staden J 2003. Antibacterial and antiinflammatory activities of some plants used for medicinal purposes in Kenya. J Ethnopharmacol 87:35-41.
25. Maity P, Biswas K, Roy S, Barnergee RK, Bandyopadhyay U 2003. Smoking and pathogenesis of gastroduodenal ulcer - recent mechanistic update. Mol Cell Biochem 253: 329-338.
26. Melo SF, Soares SF, Costa RF, Silva CR, Oliveira MB, Bezerra RJ, Caldeira-de-Araujo A, Bernardo-Filho M 2001. Effect of the Cymbopogon citrates, Maytenus ilicifolia and Baccharis genistelloides extracts against the stannous chloride oxidative damage in Escherichia coli. Mutat Res 496: 33-38.
27. Mizui T, Doteuchi M 1981. Effect of polyamines on acidified ethanol-induced gastric lesions in rats. Jap J Pharmacol 33: 939-945.
28. Otake T, Mori H, Morimoto M, Namba T, Otake T, Sutardjo S, Ueba N 1995. Screening of Indonesian plant extracts for anti-human immunodeficiency virus type 1 (HIV-1) activity. Phytother Res 9: 6-10.
29. 50 value) in mice, to determine oral acute toxicity of plant extracts. Phytomedicine 8: 395-400.
30. Perez-Victoria JM, Tincusi BM, Jimenez IA, Bazzocchi IL, Gupta MP, Castanys S, Gamarro F, Ravelo AG 1999. New natural sesquiterpenes as modulators of daunomycin resistance in a multidrug-resistant Leishmania tropica line. J Med Chem 42: 4388-4393.
31. Raza M, Al-Shabanah OA, El-Hadiyah TM, Al-Majed AA 2002. Effect of prolonged vigabatrin treatment on hematological and biochemical parameters in plasma, liver and kidney of Swiss albino mice. Scientia Pharmaceutica 70: 135-145.
32. Santos VL, Costa VBM, Agra MF, Silva BA, Batista LM 2007. Pharmacological studies of ethanolic extracts of Maytenus rigida Mart (Celastraceae) in animal models. Rev Bras Farmacogn 17: 336-342.
33. Silva MS, Sousa DP, Medeiros VM, Folly MAB, Tavares JF, Barbosa-Filho JM 2008. Alkaloid, flavonoids, and pentacyclic triterpenoids of Maytenus obtusifolia Mart. Biochem Syst Ecol 36: 500-503.
34. Stevens PF, 2001. Angiosperm Phylogeny Website. Version 7. Available at: http://www.mobot.org/MOBOT/research/APweb/. Access in May 2007.
35. Szelenyi I, Thiemer K 1978. Distention ulcer as a model for testing of drugs for ulcerogenic side effects. Arch Toxicol 41: 99-105.
36. Tarnawski, AS 2005. Cellular and molecular mechanisms of gastrointestinal ulcer healing. Digest Dis Sci 50: 24-33.
37. Teo S, Stirling D, Thomas S, Hoberman A, Kiorpes A, Khetani V 2002. A 90-day oral gavage toxicity study of d-methylphenidate and d,l-methylphenidate in Sprague Dawley rats. Toxicology 179: 183-196.
38. Veiga-Junior VF 2008. Estudo do consumo de plantas medicinais na Região Centro-Norte do Estado do Rio de Janeiro: aceitação pelos profissionais de saúde e modo de uso pela população. Rev Bras Farmacogn 18: 308-313.
39. Vellosa JCR, Khalil NM, Formenton VAF, Ximenes VF, Fonseca LM, Furlan M, Brunetti IL, Oliveira OMMF 2006. Antioxidante activity of Maytenus ilicifolia root bark. Fitoterapia 77: 243-244.