Role of netrin-1 and netrin-1 dependence receptors in colorectal cancers

British Journal of Cancer

Volumn 93, Issue 1, 2005, Pages 1-6

  Mehlen, P ^a   Llambi, F ^a  

^a CENTRE LÉON BÉRARD   (France)

Author keywords

Apoptosis; Colorectal cancer; Dependence receptor

Indexed keywords

NETRIN; NETRIN 1; NETRIN 1 RECEPTOR; RECEPTOR; UNCLASSIFIED DRUG;

CARCINOGENESIS; CELL DEATH; COLORECTAL CANCER; DCC GENE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; SHORT SURVEY; TUMOR SUPPRESSOR GENE;

COLORECTAL NEOPLASMS; GENES, DCC; GENES, TUMOR SUPPRESSOR; HUMANS; NERVE GROWTH FACTORS; RECEPTORS, CELL SURFACE; TUMOR SUPPRESSOR PROTEINS;

EID: 23044459218     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6602656     Document Type: Short Survey

References (39)

1. Barratt PL, Seymour MT, Stenning SP, Georgiades I, Walker C, Birbeck K, Quirke P (2002) DNA markers predicting benefit from adjuvant fluorouracil in patients with colon cancer: a molecular study. Lancet 360: 1381-1391
2. Bordeaux MC, Forcet C, Granger L, Corset V, Bidaud C, Billaud M, Bredesen DE, Edery P, Mehlen P (2000) The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease. EMBO J 19: 4056-4063
3. Cho KR, Oliner JD, Simons JW, Hedrick L, Fearon ER, Preisinger AC, Hedge P, Silverman GA, Vogelstein B (1994) The DCC gene: structural analysis and mutations in colorectal carcinomas. Genomics 19: 525-531
4. Ellerby LM, Hackam AS, Propp SS, Ellerby HM, Rabizadeh S, Cashman NR, Trifiro MA, Pinsky L, Wellington CL, Salvesen GS, Hayden MR, Bredesen DE (1999) Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity. J Neurochem 72: 185-195
5. Fearon ER, Cho KR, Nigro JM, Kern SE, Simons JW, Ruppert JM, Hamilton SR, Preisinger AC, Thomas G, Kinzler KW, Vogelstein B (1990) Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 247: 49-56
6. Fodde R, Edelmann W, Yang K, van Leeuwen C, Carlson C, Renault B, Breukel C, Alt E, Lipkin M, Khan PM, Kucherlapati R (1994) A targeted chain-termination mutation in the mouse Ape gene results in multiple intestinal tumors. Proc Natl Acad Sci USA 91: 8969-8973
7. Forcet C, Ye X, Granger L, Corset V, Shin H, Bredesen DE, Mehlen P (2001) The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation. Proc Natl Acad Sci USA 98: 3416-3421
8. Goi T, Yamaguchi A, Nakagawara G, Urano T, Shiku H, Furukawa K (1998) Reduced expression of deleted colorectal carcinoma (DCC) protein in established colon cancers. Br J Cancer 77: 466-471
9. Hong K, Hinck L, Nishiyama M, Poo MM, Tessier-Lavigne M, Stein E (1999) A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell 97: 927-941
10. Hsu YH, Shaw CK, Chuong CM (2001) Immunohistochemical localization of deleted-in-colon-cancer (DCC) protein in human epithelial, neural, and neuro-endocrine tissues in paraffin sections with antigen retrieval. Kaohsiung J Med Sci 17: 351-357
11. Jen J, Kim H, Piantadosi S, Liu ZF, Levitt RC, Sistonen P, Kinzler KW, Vogelstein B, Hamilton SR (1994) Allelic loss of chromosome 18q and prognosis in colorectal cancer. N Engl J Med 331: 213-221
12. Kato H, Zhou Y, Asanoma K, Kondo H, Yoshikawa Y, Watanabe K, Matsuda T, Wake N, Barrett JC (2000) Suppressed tumorigenicity of human endometrial cancer cells by the restored expression of the DCC gene. Br J Cancer 82: 459-466
13. Kato HD, Kondoh H, Inoue T, Asanoma K, Matsuda T, Arima T, Kato K, Yoshikawa T, Wake N (2004) Expression of DCC and netrin-1 in normal human endometrium and its implication in endometrial carcinogenesis. Gynecol Oncol 95: 281-289
14. Klingelhutz AJ, Smith PP, Garrett LR, McDougall JK (1993) Alteration of the DCC tumor-suppressor gene in tumorigenic HPV-18 immortalized human keratinocytes transformed by nitrosomethylurea. Oncogene 8: 95-99
15. Liu J, Yao F, Wu R, Morgan M, Thorburn A, Finley Jr RL, Chen YQ (2002) Mediation of the DCC apoptotic signal by DIP13 alpha. J Biol Chem 277: 26281-26285
16. Llambi F, Causeret F, Bloch-Gallego E, Mehlen P (2001) Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. EMBO J 20: 2715-2722
17. Llambi F, Calheiros F, Gozuacik D, Guix C, Pays L, Del Rio G, Kimchi A, Mehlen P (2005) The dependence receptor UNC5H2 mediates apoptosis through DAP kinase. EMBO J 24: 1192-1201
18. Lu X, Le Noble F, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, Breant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A (2004) The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 432: 179-186
19. Matsunaga E, Tauszig-Delamasure S, Monnier PP, Mueller BK, Strittmatter SM, Mehlen P, Chedotal A (2004) RGM and its receptor neogenin regulate neuronal survival, Nat Cell Biol 6: 749-755
20. Mazelin L, Bernet A, Bonod-Bidaud C, Pays L, Arnaud S, Gespach C, Bredesen DE, Scoazec JY, Mehlen P (2004) Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature 431: 80-84
21. Mehlen P, Fearon ER (2004) Role of the dependence receptor DCC in colorectal cancer pathogenesis. J Clin Oncol 22: 3420-3428
22. Mehlen P, Mazelin L (2003) The dependence receptors DCC and UNC5H as a link between neuronal guidance and survival. Biol Cell 95: 425-436
23. Mehlen P, Rabizadeh S, Snipas SJ, Assa-Munt N, Salvesen GS, Bredesen DE (1998) The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature 395: 801-804
24. Ogunbiyi OA, Goodfellow PJ, Herfarth K, Gagliardi G, Swanson PE, Birnbaum EH, Read TE, Fleshman JW, Kodner IJ, Moley JF (1998) Confirmation that chromosome 18q allelic loss in colon cancer is a prognostic indicator. J Clin Oncol 16: 427-433
25. Park KW, Crouse D, Lee M, Karnik SK, Sorensen LK, Murphy KJ, Kuo CJ, Li DY (2004) The axonal attractant Netrin-1 is an angiogenic factor. Proc Natl Acad Sci USA 101: 16210-16215
26. Rabizadeh S, Oh J, Zhong LT, Yang J, Bitler CM, Butcher LL, Bredesen DE (1993) Induction of apoptosis by the low-affinity NGF receptor. Science 261: 345-348
27. Saito M, Yamaguchi A, Goi T, Tsuchiyama T, Nakagawara G, Urano T, Shiku H, Furukawa K (1999) Expression of DCC protein in colorectal tumors and its relationship to tumor progression and metastasis. Oncology 56: 134-141
28. Serafini T, Kennedy TE, Galko MJ, Mirzayan C, Jessell TM, Tessier-Lavigne M (1994) The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78: 409-424
29. Shibata D, Reale MA, Lavin P, Silverman M, Fearon ER, Steele Jr G, Jessup JM, Loda M, Summerhayes IC (1996) The DCC protein and prognosis in colorectal cancer. N Engl J Med 335: 1727-1732
30. Stupack DG, Puente XS, Boutsaboualoy S, Storgard CM, Cheresh DA (2001) Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J Cell Biol 155: 459-470
31. Tanaka K, Oshimura M, Kikuchi R, Seki M, Hayashi T, Miyaki M (1991) Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 5 or 18. Nature 349: 340-342
32. Tanikawa C, Matsuda K, Fukuda S, Nakamura Y, Arakawa H (2003) p53RDL1 regulates p53-dependent apoptosis. Nat Cell Biol 5: 216-223
33. Tessier-Lavigne M, Goodman CS (1996) The molecular biology of axon guidance. Science 274: 1123-1133
34. Thiagalingam S, Lengauer C, Leach FS, Schutte M, Hahn SA, Overhauser J, Willson JK, Markowitz S, Hamilton SR, Kern SE, Kinzler KW, Vogelstein B (1996) Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nat Genet 13: 343-346
35. Thibert C, Teillet MA, Lapointe F, Mazelin L, Le Douarin NM, Mehlen P (2003) Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog. Science 301: 843-846
36. Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Saurin JC, Scoazec JY, Romeo G, Mehlen P (2003) The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Proc Natl Acad Sci USA 100: 4173-4178
37. Velcich A, Corner G, Palumbo L, Augenlicht L (1999) Altered phenotype of HT29 colonic adenocarcinoma cells following expression of the DCC gene. Oncogene 18: 2599-2606
38. Watanabe T, Wu TT, Catalane PJ, Ueki T, Satriano R, Haller DG, Benson III AB, Hamilton SR (2001) Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N Engl J Med 344: 1196-1206
39. Williams ME, Strickland P, Watanabe K, Hinck L (2003) UNC5H1 induces apoptosis via its juxtamembrane domain through an interaction with NRAGE. J Biol Chem 278: 17483-17490