Recombinant tissue plasminogen activator in the treatment of pleural infections in adults

Respiratory Medicine

Volumn 102, Issue 12, 2008, Pages 1694-1700

  Froudarakis, Marios E ^a   Kouliatsis, George ^a   Steiropoulos, Paschalis ^a   Anevlavis, Stavros ^a   Pataka, Athanasia ^a   Popidou, Maria ^a   Mikroulis, Demitrios ^a   Pneumatikos, Ioannis ^a   Bouros, Demosthenes ^a  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

Author keywords

Actilyse; Empyema; Fibrinolytics; Parapneumonic effusion; Pleural infection; r TPA

Indexed keywords

ALTEPLASE; C REACTIVE PROTEIN;

ADULT; AGED; ARTICLE; BLEEDING; CLINICAL ARTICLE; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG INSTILLATION; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HUMAN; LEUKOCYTE COUNT; MALE; PAIN; PARAPNEUMONIC PLEURAL EFFUSION; PHASE 2 CLINICAL TRIAL; PLEURA; PLEURA EFFUSION; PLEURA EMPYEMA; PLEURA FLUID; PLEURISY; PRIORITY JOURNAL; SURGICAL DRAINAGE; TREATMENT OUTCOME; TUBE; ULTRASOUND;

ADOLESCENT; ADULT; AGED; C-REACTIVE PROTEIN; CHEST TUBES; DRAINAGE; EMPYEMA, PLEURAL; FEMALE; HUMANS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; PLEURAL EFFUSION; PNEUMONIA, BACTERIAL; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; TISSUE PLASMINOGEN ACTIVATOR; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME; YOUNG ADULT;

EID: 55649087768     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rmed.2008.08.012     Document Type: Article

References (30)

1. Davies C.W., Gleeson F.V., and Davies R.J. BTS guidelines for the management of pleural infection. Thorax 58 Suppl. 2 (2003) ii18-ii28
2. Davies W., Kearney S., Gleeson F., and Davies R. Predictors of outcome and long-term survival in patients with pleural infection. Am J Respir Crit Care Med 160 (2003) 1682-1686
3. Strange C., Allen M.L., Harley R., Lazarchick J., and Sahn S.A. Intrapleural streptokinase in experimental empyema. Am Rev Respir Dis 147 (1993) 962-966
4. Bouros D., Schiza S., and Siafakas N. Fibrinolytics in the treatment of parapneumonic effusions. Monaldi Arch Chest Dis 54 (1999) 258-263
5. Bouros D., Schiza S., Panagou P., Drositis J., and Siafakas N. Role of streptokinase in the treatment of acute loculated parapneumonic pleural effusions and empyema. Thorax 49 (1994) 852-855
6. Bouros D., Schiza S., Tzanakis N., Drositis J., and Siafakas N. Intrapleural urokinase in the treatment of complicated parapneumonic pleural effusions and empyema. Eur Respir J 9 (1996) 1656-1659
7. Diacon A.H., Theron J., Schuurmans M.M., Van de Wal B.W., and Bolliger C.T. Intrapleural streptokinase for empyema and complicated parapneumonic effusions. Am J Respir Crit Care Med 170 (2004) 49-53
8. Maskell N.A., Davies C.W., Nunn A.J., Hedley E.L., Gleeson F.V., Miller R., et al. U.K. Controlled trial of intrapleural streptokinase for pleural infection. N Engl J Med 352 (2005) 865-874
9. Bouros D., Antoniou K.M., and Light R.W. Intrapleural streptokinase for pleural infection. BMJ 332 (2006) 133-134
10. Bouros D. A trial of intrapleural streptokinase. N Engl J Med 352 (2005) 2243-2245 [author reply-5]
11. Ray T.L., Berkenbosch J.W., Russo P., and Tobias J.D. Tissue plasminogen activator as an adjuvant therapy for pleural empyema in pediatric patients. J Intensive Care Med 19 (2004) 44-50
12. Weinstein M., Restrepo R., Chait P.G., Connolly B., Temple M., and Macarthur C. Effectiveness and safety of tissue plasminogen activator in the management of complicated parapneumonic effusions. Pediatrics 113 (2004) e182-e185
13. Wells R.G., and Havens P.L. Intrapleural fibrinolysis for parapneumonic effusion and empyema in children. Radiology 228 (2003) 370-378
14. Idell S., Girard W., Koenig K.B., McLarty J., and Fair D.S. Abnormalities of pathways of fibrin turnover in the human pleural space. Am Rev Respir Dis 144 (1991) 187-194
15. Philip-Joet F., Alessi M.C., Philip-Joet C., Aillaud M., Barriere J.R., Arnaud A., et al. Fibrinolytic and inflammatory processes in pleural effusions. Eur Respir J 8 (1995) 1352-1356
16. Light R.W. Parapneumonic effusions and empyema. Clin Chest Med 6 (1985) 55-62
17. Davies R.J., Traill Z.C., and Gleeson F.V. Randomised controlled trial of intrapleural streptokinase in community acquired pleural infection. Thorax 52 (1997) 416-421
18. Bouros D., Schiza S., Patsourakis G., Chalkiadakis G., Panagou P., and Siafakas N.M. Intrapleural streptokinase versus urokinase in the treatment of complicated parapneumonic effusions: a prospective, double-blind study. Am J Respir Crit Care Med 155 (1997) 291-295
19. Gates R.L., Hogan M., Weinstein S., and Arca M.J. Drainage, fibrinolytics, or surgery: a comparison of treatment options in pediatric empyema. J Pediatr Surg 39 (2004) 1638-1642
20. Aelony Y. Parapneumonic effusion does not equal empyema. Chest 114 (1998) 658-659
21. Wiegand J., Tschopp J.M., Froudarakis M., Tassi G., Brutsche M., and ESMITTE Study Group. A randomized controlled study of early mini-invasive medical thoracoscopy vs simple chest tube drainage in complicated parapneumonic effusions or pleural empyema - ESMITTE (European study on mini-invasive thoracoscopy in empyema) - an intermediate report. Proc Am Thorac Soc 3 (2006) A540
22. Kouliatsis G., Anevlavis S., Pataka A., Didilis V., Mikroulis D., Froudarakis M.E., et al. Intrapleural tissue plasminogen activator vs VATS in loculated pleural infections. Proc Am Thorac Soc 3 (2006) A361
23. Lee Y.C.G. Ongoing search for effective intrapleural therapy for empyema: is streptokinase the answer?. Am J Respir Crit Care Med 170 (2004) 1-2
24. Chin N.K., and Lim T.K. Controlled trial of intrapleural streptokinase in the treatment of pleural empyema and complicated parapneumonic effusions. Chest 111 (1997) 275-279
25. Moulton J.S., Benkert R.E., Weisiger K.H., and Chambers J.A. Treatment of complicated pleural fluid collections with image-guided drainage and intracavitary urokinase. Chest 108 (1995) 1252-1259
26. Davies C.W., Lok S., and Davies R.J. The systemic fibrinolytic activity of intrapleural streptokinase. Am J Respir Crit Care Med 157 (1998) 328-330
27. Bouros D., Schiza S., Tzanakis N., Chalkiadakis G., Drositis J., and Siafakas N. Intrapleural urokinase versus normal saline in the treatment of complicated parapneumonic effusions and empyema. A randomized, double-blind study. Am J Respir Crit Care Med 159 (1999) 37-42
28. Hua C.C., Chang L.C., Chen Y.C., and Chang S.C. Proinflammatory cytokines and fibrinolytic enzymes in tuberculous and malignant pleural effusions. Chest 116 (1999) 1292-1296
29. Chung C.L., Chen C.H., Sheu J.R., Chen Y.C., and Chang S.C. Proinflammatory cytokines, transforming growth factor-beta1, and fibrinolytic enzymes in loculated and free-flowing pleural exudates. Chest 128 (2005) 690-697
30. Park C.S., Chung W.M., Lim M.K., Cho C.H., Suh C.H., and Chung W.K. Transcatheter instillation of urokinase into loculated pleural effusion: analysis of treatment effect. AJR Am J Roentgenol 167 (1996) 649-652