U.K. controlled trial of intrapleural streptokinase for pleural infection

New England Journal of Medicine

Volumn 352, Issue 9, 2005, Pages 865-874

  Maskell, Nicholas A ^a   Davies, Christopher W H ^b   Nunn, Andrew J ^c   Hedley, Emma L ^a   Gleeson, Fergus V ^a   Miller, Robert ^d   Gabe, Rhian ^c   Rees, Glyn L ^a   Peto, Timothy E A ^a   Woodhead, Mark A ^e   Lane, Donald J ^a   Darbyshire, Janet H ^c   Davies, Robert J O ^a,f  

^a CHURCHILL HOSPITAL   (United Kingdom)

^b ROYAL BERKSHIRE HOSPITAL   (United Kingdom)

^c Med Res Cncl Clinical Trials Unit   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e MANCHESTER ROYAL INFIRMARY   (United Kingdom)

^f OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; DRUG ANTIBODY; HEPARIN; STREPTOKINASE; WARFARIN; ANTIINFECTIVE AGENT; FIBRINOLYTIC AGENT;

ADULT; AGED; ALLERGY; ANAEROBIC BACTERIUM; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL INFECTION; BLEEDING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENTEROBACTERIACEAE; ENTEROCOCCUS; FEMALE; FEVER; FIBRINOLYSIS; HOSPITALIZATION; HUMAN; LUNG VOLUME; MAJOR CLINICAL STUDY; MALE; MORTALITY; PH; PLEURA CAVITY; PLEURA FLUID; PLEURISY; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS; STREPTOCOCCUS CONSTELLATUS; STREPTOCOCCUS INTERMEDIUS; STREPTOCOCCUS MILLERI; STREPTOCOCCUS MITIS; STREPTOCOCCUS PNEUMONIAE; THORAX DRAINAGE; THORAX PAIN; THORAX RADIOGRAPHY; TREATMENT OUTCOME; COMMUNICABLE DISEASE; CROSS INFECTION; DRUG INSTILLATION; LENGTH OF STAY; LUNG; MIDDLE AGED; MULTICENTER STUDY; MULTIMODALITY CANCER THERAPY; PLEURA DISEASE; PLEURA EMPYEMA; PNEUMONIA; RADIOGRAPHY; UNITED KINGDOM; WOUND DRAINAGE;

ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; COMBINED MODALITY THERAPY; COMMUNITY-ACQUIRED INFECTIONS; CROSS INFECTION; DOUBLE-BLIND METHOD; DRAINAGE; EMPYEMA, PLEURAL; FEMALE; FIBRINOLYTIC AGENTS; GREAT BRITAIN; HUMANS; INSTILLATION, DRUG; LENGTH OF STAY; LUNG; MALE; MIDDLE AGED; PLEURAL DISEASES; PNEUMONIA; STREPTOKINASE;

EID: 20044365983     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMoa042473     Document Type: Article

References (23)

1. Light RW, Girard WM, Jenkinson SG, George RB. Parapneumonic effusions. Am J Med 1980;69:507-12.
2. Davies CW, Kearney SE, Gleeson FV, Davies RJ. Predictors of outcome and long-term survival in patients with pleural infection. Am J Respir Crit Care Med 1999;160:1682-7.
3. Fine MJ, Smith MA, Carson CA, et al. Prognosis and outcomes of patients with community-acquired pneumonia: a meta-analysis. JAMA 1996;275:134-41.
4. Lim WS, Macfarlane JT, Boswell TCJ, et al. Study of community acquired pneumonia aetiology (SCAPA) in adults admitted to hospital: implications for management guidelines. Thorax 2001;56:296-301.
5. Ferguson AD, Prescott RJ, Selkon JB, Watson D, Swinburn CR. The clinical course and management of thoracic empyema. QJM 1996;89:285-9.
6. Davies CWH, Gleeson FV, Davies RJO. BTS guidelines for the management of pleural infection. Thorax 2003;58:Suppl 2:18-28.
7. Colice GL, Curtis A, Deslauriers J, et al. Medical and surgical treatment of parapneumonic effusions: an evidence-based guideline. Chest 2000;118:1158-71. [Erratum, Chest 2001;119:319.]
8. Davies RJO, Traill ZC, Gleeson FV. Randomised controlled trial of intrapleural streptokinase in community acquired pleural infection. Thorax 1997;52:416-21.
9. Bouros D, Schiza S, Tzanakis N, Chalkiadakis G, Drositis J, Siafakas N. Intrapleural urokinase versus normal saline in the treatment of complicated parapneumonic effusions and empyema: a randomized, double-blind study. Am J Respir Crit Care Med 1999;159:37-42.
10. Bouros D, Schiza S, Patsourakis G, Chalkkkiadakis G, Panagou P, Siafakas NM. Intrapleural streptokinase versus urokinase in the treatment of complicated parapneumonic effusions: a prospective, double-blind study. Am J Respir Crit Care Med 1997;155:291-5.
11. Thomson AH, Hull J, Kumar MR, Wallis C, Balfour Lynn IM. Randomised trial of intrapleural urokinase in the treatment of childhood empyema. Thorax 2002;57:343-7.
12. Diacon AH, Theron J, Schuurmans MM, Van der Wal BW, Bolliger CT. Intrapleural streptokinase for empyema and complicated parapneumonic effusions. Am J Respir Crit Care Med 2004;170:49-53.
13. Maskell NA, Davies RJO. Effusions from parapneumonic infection and empyema. In: Light RW, Lee YCG, eds. Textbook of pleural diseases. London: Arnold, 2003:310-28.
14. Lee YCG. Ongoing search for effective intrapleural therapy for empyema: is streptokinase the answer? Am J Respir Crit Care Med 2004;170:1-2.
15. StataCorp. Stata statistical software, release 8. College Station, Tex.: StataCorp L.P., 2003.
16. Chin NK, Lim TK. Controlled trial of intrapleural streptokinase in the treatment of pleural empyema and complicated parapneumonic effusions. Chest 1997;111:275-9.
17. Lim TK, Chin NK. Empirical treatment with fibrinolysis and early surgery reduces the duration of hospitalization in pleural sepsis. Eur Respir J 1999;13:514-8.
18. Maskell NA, Gleeson FV. Effect of intrapleural streptokinase on a loculated malignant pleural effusion. N Engl J Med 2003;348:e4.
19. Light RW, Nguyen T, Mulligan ME, Sasse SA. The in vitro efficacy of varidase versus streptokinase or urokinase for liquefying thick purulent exudative material from loculated empyema. Lung 2000;178:13-8.
20. Simpson G, Roomes D, Heron M. Effects of streprokinase and deoxyribonuclease on viscosity of human surgical and empyema pus. Chest 2000;117:1728-33.
21. Davies CW, Traill ZC, Gleeson FV, Davies RJ. Intrapleural streptokinase in the management of malignant multiloculated pleural effusions. Chest 1999;115:729-33.
22. Simpson G, Roomes D, Reeves B. Successful treatment of empyema thoracis with human recombinant deoxyribonuclease. Thorax 2003;58:365-6.
23. Hippocrates. Aphorism 44. In: Adams LB, ed. The genuine works of Hippocrates: the classics of surgery. Birmingham, Ala.: Gryphon Editions, 1985:768-71.