Methyl-CpG targeted transcriptional activation allows re-expression of tumor suppressor genes in human cancer cells

Biochemical and Biophysical Research Communications

Volumn 377, Issue 2, 2008, Pages 600-605

  Fukushige, Shinichi ^a   Kondo, Emiko ^a   Horii, Akira ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

CpG island; Histone modifications; JMJD2D; MeTA; Methyl CpG binding domain; MLH1; NF B transcriptional activation domain; Transcriptional repression; Tumor suppressor genes

Indexed keywords

HISTONE DEACETYLASE; HISTONE H3; LYSINE;

ACETYLATION; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DNA METHYLATION; EMBRYONIC STEM CELL; EPIGENETICS; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; MLH1 GENE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; TRANSCRIPTION INITIATION; TUMOR SUPPRESSOR GENE; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AZACITIDINE; BASE SEQUENCE; CELL LINE, TUMOR; CPG ISLANDS; DEOXYCYTIDINE; DNA METHYLATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HUMANS; MOLECULAR SEQUENCE DATA; NF-KAPPA B; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 55549138008     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.10.016     Document Type: Article

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