Alternative splicing of hMSH2 in normal human tissues

Human Genetics

Volumn 99, Issue 5, 1997, Pages 590-595

  Mori, Yuriko ^a,b   Shiwaku, Hiromi ^a   Fukushige, Shinichi ^a   Wakatsuki, Shigeru ^a   Sato, Masami ^a   Nukiwa, Toshihiro ^b   Horii, Akira ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; NUCLEOTIDE;

ALTERNATIVE RNA SPLICING; ARTICLE; CODON; COLORECTAL CANCER; DNA HELIX; EXON; FRAMESHIFT MUTATION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; INTRON; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION;

EID: 0030892133     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004390050411     Document Type: Article

References (27)

1. Aaltonen LA, Peltomäki P, Leach FS, Sistonen P, Rylkkanen L, Mecklin JP, Järvinen JH, Powell SM, Jen J, Hamilton SR, Petersen GM, Kinzler KW, Vogelstein B, Chapelle A de la (1993) Clues to the pathogenesis of familial colorectal cancer. Science 260 : 812-816
2. Bronner CE, Baker SM, Morrison PT, Warren G, Smith LG, Lescoe MK, Kane M, Earabino C, Lipford J, Lindblom A, Tannergård P, Bollag RJ, Godwin AR, Ward DC, Nordenskjøld M, Fishel R, Kolodner R, Liskay RM (1994) Mutation in the DNA mismatch repair gene homolog hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368 : 258-261
3. Chalbonnier F, Martin C, Scotte M, Sibert L, Moreau V, Frebourg T (1995) Alternative splicing of MLH1 messenger RNA in human normal cells. Cancer Res 55 : 1839-1841
4. Cleaver JE (1994) It was a very good year for DNA repair. Cell 76 : 1-4
5. Fishel R, Lescoe MK, Rao MRS, Copeland NG, Jenkins NA, Garber J, Kane M, Kolodner R (1993) The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75 : 1027-1038
6. Fishel R, Ewel A, Lascoe MK (1994) Purified human MSH2 protein binds to DNA containing mismatched nucleotides. Cancer Res 54 : 5539-5542
7. Hattori M, Sakaki Y (1986) Dideoxy sequencing method using denatured plasmid templates. Anal Biochem 152 : 232-238
8. Horii A, Nakatsuru S, Ichii S, Nagase H, Nakamura Y (1993) Multiple forms of the APC gene transcripts and their tissue-specific expression. Hum Mol Genet 2 : 283-287
9. Horii A, Han H-J, Sasaki S, Shimada M, Nakamura Y (1994) Cloning, characterization and chromosomal assignment of the human genes homologous to yeast PMS1, a member of mismatch repair genes. Biochem Biophys Res Commun 204 : 1257-1264
10. Ionov YM, Peinado A, Malkhosyan S, Shibata D, Perucho M (1993) Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363 : 558-561
11. Kolodner RD, Hall NR, Lipford J, Kane MF, Rao MRS, Morrison P, Wirth L, Finan PJ, Burn J, Chapman P, Earabino C, Merchant E, Bishop DT (1994) Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations. Genomics 24 : 516-526
12. Leach FS, Nicolaides NC, Papadopoulos N, Liu B, Jen J, Parsons R, Peltomäki P, Sistonen P, Aaltonen LA, Nyström-Lahti M, Guan X-Y, Zhang J, Meltzer PS, Yu J-W, Kao F-T, Chen DJ, Cerosaletti KM, Fournier REK, Todd S, Lewis T, Leach RJ, Naylor SL, Weissenbach J, Mecklin J-P, Järvinen H, Petersen GM, Hamilton SR, Green J, Jass J, Watson P, Lynch HT, Trent JM, Chapelle A de la, Kinzler KW, Vogelstein B (1993) Mutation of a mutS homolog in hereditary nonpolyposis colorectal carcinoma. Cell 75 : 1215-1225
13. Liu B, Parsons RE, Hamilton SR, Petersen GM, Lynch HT, Watson P, Markowitz S, Willson JKV, Green J, Chapelle A de la, Kinzler KW, Vogelstein B (1994) hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds. Cancer Res 54 : 4590-4594
14. Lynch HT, Lanspa S, Smyrk T, Boman B, Watson P, Lynch J (1991) Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II). Genetics, pathology, natural history, and cancer control, part I. Cancer Genet Cytogenet 53 : 143-160
15. Modrich P (1994) Mismatch repair, genetic stability, and cancer. Science 266 : 1959-1960
16. Nakamura Y, Ogawa M, Nishide Emi M, Kosaki G, Himeno S, Matsubara K (1984) Sequences of cDNAs for human salivary and pancreatic α-amylase. Gene 28 : 263-270
17. Nicolaides NC, Papadopoulos N, Liu B, Wei Y-F, Carter KC, Ruben SM, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM, Adams MC, Venter JC, Dunlop MG, Hamilton SR, Petersen GM, Chapelle A de la, Vogelstein B, Kinzler KW (1994) Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature 371 : 75-80
18. Nicolaides NC, Carter KC, Shell BK, Papadopoulos N, Vogelstein B, Kinzler KW (1995) Genomic organization of the human PMS2 gene family. Genomics 30 : 195-206
19. Papadopoulos N, Nicolaides NC, Wei Y-F, Ruben SM, Carter KC, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM, Adams MD, Venter JC, Hamilton SR, Petersen GM, Watson P, Lynch HT, Peltomäki P, Mecklin J-P, Chapelle A de la, Kinzler KW, Vogelstein B (1994) Mutation of a mutL homolog in hereditary colon cancer. Science 263 : 1625-1629
20. Parsons R, Li G-M, Longley M, Modrich P, Liu B, Berk T, Hamilton SR, Kinzler KW, Vogelstein B (1995) Mismatch repair deficiency in phenotypically normal cells. Science 268 : 738-740
21. Sanger F, Nicklen S, Coulson AR (1977) DNA sequencing with chain-termination inhibitors. Proc Natl Acad Sci USA 74 : 5463-5467
22. Sato T, Tanigami A, Yamakawa K, Akiyama G, Kasumi F, Sakamoto G, Nakamura Y (1990) Allelotype of breast cancer: cumulative allele losses promote tumor progression in primary breast cancer. Cancer Res 50 : 7184-7189
23. Tarn WY, Steitz J (1996) A novel spliceosome containing U11, U12, and U15 snRNPs excises a minor class (AT-AC) intron in vivo. Cell 84 : 801-811
24. Thibodeau SN, Bren G, Schaid D (1993) Microsatellite instability in cancer of the proximal colon. Nature 363 : 558-561
25. Watson P, Lynch HT (1993) Extracolonic cancer in hereditary nonpolyposis colorectal cancer. Cancer 71 : 677-685
26. Wilson TM, Ewel A, Duguid JR, Eble JN, Lescoe MK, Fishel R, Kelley MR (1995) Differential cellular expression of the human MSH2 repair enzyme in small and large intestine. Cancer Res 55 : 5146-5150
27. Xia L, Shen W, Ritacca F, Mitri A, Madlensky L, Berk T, Cohen Z, Gallinger S, Bapat B (1996) A truncated hMSH2 transcript occurs as a common variant in the population: implications for genetic diagnosis. Cancer Res 56 : 2289-2292