Mutational analysis of vaccinia virus mRNA cap (guanine-N7) methyltransferase reveals essential contributions of the N-terminal peptide that closes over the active site

RNA

Volumn 14, Issue 11, 2008, Pages 2297-2304

  Zheng, Sushuang ^a   Shuman, Stewart ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

mRNA capping; Poxvirus; S adenosylmethionine; Sulfonium

Indexed keywords

ADENINE; ALANINE; GUANINE 7 OXIDE; MESSENGER RNA; METHYLTRANSFERASE; SULFONIUM DERIVATIVE; VIRUS ENZYME;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; GENE MUTATION; LIGAND BINDING; METHYLATION; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; RNA CAPPING; STRUCTURE ACTIVITY RELATION; VACCINIA VIRUS;

ALANINE; AMINO ACID SEQUENCE; BINDING SITES; CONSERVED SEQUENCE; DNA MUTATIONAL ANALYSIS; METHYLATION; METHYLTRANSFERASES; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; NUCLEOTIDYLTRANSFERASES; PEPTIDES; PHENYLALANINE; PHOSPHORIC MONOESTER HYDROLASES; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE; VACCINIA VIRUS;

EUKARYOTA; POXVIRIDAE; VACCINIA VIRUS;

EID: 55549130291     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.1201308     Document Type: Article

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