Periodontal regeneration using ex vivo autologous stem cells engineered to express the BMP-2 gene: An alternative to alveolaplasty

Gene Therapy

Volumn 15, Issue 22, 2008, Pages 1469-1477

  Chen, Y L ^a   Chen, P K T ^a   Jeng, L B ^b,c   Huang, C S ^a   Yang, L C ^d,e   Chung, H Y ^b   Chang, S C N ^b,c  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d E DA HOSPITAL   (Taiwan)

^e I SHOU UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BONE MORPHOGENETIC PROTEIN 2; CD11 ANTIGEN; HERMES ANTIGEN; POLOXAMER; THY 1 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BONE TISSUE; CEMENTUM; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; EX VIVO GENE TRANSFER; GENE EXPRESSION; HISTOPATHOLOGY; MESENCHYMAL STEM CELL; NONHUMAN; ORAL SURGERY; OSSIFICATION; PERIODONTAL DISEASE; PERIODONTIC DEVICE; PERIODONTICS; PRIORITY JOURNAL; RABBIT; STEM CELL GENE THERAPY; THREE DIMENSIONAL IMAGING; TISSUE ENGINEERING; TOOTH DEVELOPMENT; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; DENTAL CEMENTUM; GENE EXPRESSION; GENE THERAPY; HUMANS; IMAGING, THREE-DIMENSIONAL; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MODELS, ANIMAL; PERIODONTAL DISEASES; PERIODONTIUM; RABBITS; RANDOM ALLOCATION; RECOMBINANT PROTEINS; REGENERATION; TRANSPLANTATION, AUTOLOGOUS;

ADENOVIRIDAE; ORYCTOLAGUS CUNICULUS;

EID: 55549097785     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2008.131     Document Type: Article

References (51)

1. Ishikawa I, Kinoshita A, Oda S, Roongranphol T. Regenerative therapy in periodontal diseases. Histological observation after implantation of rhBMP-2 in the surgically created periodontal defects in dogs. Dent Jpn 1994; 31: 141-146.
2. Choi SH, Kim CK, Cho KS, Huh JS, Sorensen RG, Wozney JM et al. Effect of recombinant human bone morphogenetic protein-2/absorbable collagen sponge (rhBMP-2/ACS) on healing in 3-wall intrabony defects in dogs. J Periodontol 2002; 73: 63-72.
3. Selvig KA, Sorensen RG, Wozney JM, Wikesjo UM. Bone repair following recombinant human bone morphogenetic protein-2 stimulated periodontal regeneration. J Periodontol 2002; 73: 1020-1029.
4. Wikesjo UM, Guglielmoni P, Promsudthi A, Cho KS, Trombelli L, Selvig KA et al. Periodontal repair in dogs: Effect of rhBMP-2 concentration on regeneration of alveolar bone and periodontal attachment. J Clin Periodontol 1999; 26: 392-400.
5. Franceschi RT. Biological approaches to bone regeneration by gene therapy. J Dent Res 2005, 84: 1093-1103.
6. King GN, King N, Hughes FJ. Effect of two delivery systems for recombinant human bone morphogenetic protein-2 on periodontal regeneration in vivo. J Periodontal Res 1998; 33: 226-236.
7. Winn SR, Uludag H, Hollinger JO. Carrier systems for bone morphogenetic proteins. Clin Orthop Relat Res 1999, 367 Suppl: S95-S106.
8. Franceschi RT, Wang D, Krebsbach PH, Rutherford RB. Gene therapy for bone formation: in vitro and in vivo osteogenic activity of an adenovirus expressing BMP7. J Cell Biochem 2000; 78: 476-486.
9. Franceschi RT. Biological approaches to bone regeneration by gene therapy. J Dent Res 2005; 84: 1093-1103.
10. Jin QM, Anusaksathien O, Webb SA, Rutherford RB, Giannobile WV. Gene therapy of bone morphogenetic protein for periodontal tissue engineering. J Periodontol 2003; 74: 202-213.
11. Gafni Y, Turgeman G, Liebergal M, Pelled G, Gazit Z, Gazit D. Stem cells as vehicles for orthopedic gene therapy. Gene Therapy 2004; 11 417-426.
12. Lou J, Manske PR, Aoki M, Joyce ME. Adenovirus-mediated gene transfer into tendon and tendon sheath. J Orthop Res 1996; 14: 513-517.
13. Lou J, Xu F, Merkel K, Manske P. Gene therapy. adenovirus-mediated human bone morphogenetic protein-2 gene transfer induces mesenchymal progenitor cell proliferation and differentiation in vitro and bone formation in vivo. J Orthop Res 1999; 17: 43-50.
14. Kawaguchi H, Hirachi A, Hasegawa N, Iwata T, Hamaguchi H, Shiba H et al. Enhancement of periodontal tissue regeneration by transplantation of bone marrow mesenchymal stem cells. J Periodontol 2004; 75 1281-1287.
15. Weng Y, Wang M, Liu W, Hu X, Chai G, Yart Q et al. Repair of experimental alveolar bone defects by tissue-engineered bone. Tissue Eng 2006; 12: 1503-1513.
16. Chang SC, Chuang H, Chen YR, Yang LC, Chen JK, Mardini S et al. Cranial repair using BMP-2 gene engineered bone marrow stromal cells. J Surg Res 2004; 119: 85-91.
17. Chang SC, Wei FC, Chuang H, Chen YR, Chen JK, Lee KC et al. Ex vivo gene therapy in autologous critical-size craniofacial bone regeneration. Plast Reconstr Surg 2003; 112: 1841-1850.
18. Chang SC, Chuang HL, Chen YR, Chen JK, Chung HY, Lu YL et al. Ex vivo gene therapy in autologous bone marrow stromal stem cells for tissue-engineered maxillofacial bone regeneration. Gene Therapy 2003; 10: 2013-2019.
19. Tsuchida H, Hashimoto J, Crawford E, Manske P, Lou J. Engineered allogeneic mesenchymal stem cells repair femoral segmental defect in rats. J Orthop Res 2003; 21: 44-53.
20. Hokett SD, Cuenin MF, O'Neal RB, Brennan WA, Strong SL, Runner RR et al. Pluronic polyol effects on human gingival fibroblast attachment and growth. J Periodontol 2000; 71: 803-809.
21. Cao YL, Lach E, Kim TH, Rodriguez A, Arevalo, CA, Vacanti CA. Tissue-engineered nipple reconshuction. Plast Reconstr Surg 1998; 102: 2293-2298.
22. Saim, AB, Cao Y, Weng Y, Chang CN, Vacanti MA, Vacanti CA et al. Engineering autogenous cartilage in the shape of a helix using an injectable hydrogel scaffold. Laryngosrope 2000; 110 (10:PArt 1): 1694-1697.
23. Risbud MV, Shapiro IM. Stem cells in craniofacial and dental tissue engineering. Orthod Craniofac Res 2005; 8: 54-59.
24. Wikesjo UM, Sigurdsson TJ, Lee MB, Tatakis DN, Selvig KA. Dynamics of wound healing in periodontal regenerative therapy J Calif Dent Assoc 1995; 23: 30-35.
25. Fowler EB, Cuenin MF, Hokett SD, Peacock ME, McPherson III JC, Dirksen TR et al. Evaluation of pluronic polyols as carriers for grafting materials: Study in rat calvaria defects. J Periodontol 2002; 73: 191-197.
26. Kabanov AV, Lemieux P, Vinogradov S, Alakhov V. Pluronic block copolymers: Novel functional molecules for gene therapy. Adv Drug Deliv Rev 2002, 54: 223-233.
27. Ripamonti U. Recapitulating Development: A Template for Periodontal Tissue Engineering. Tissue Eng 2007; 13: 51-71.
28. Wikesjo UM, Selvig KA. Periodontal wound healing and regeneration. Periodontol 2000 1999; 19: 21-39.
29. Lang H, Schuler N, Arnhold S, Nolden R, Mertens T. Formation of differentiated tissues in vivo by periodontal cell populations cultured in vitro. J Dent Res 1995; 74: 1219-1225.
30. Zeichner-David M. Regeneration of periodontal tissues: Cementogenesis revisited. Periodontol 2000 2006; 41: 196-217.
31. Melcher AH, Cheong T, Cox J, Nemeth E, Shiga A. Synthesis of cementum-like tissue in vitro by cells cultured from bone: A light and electron microscope study. J Periodont Res 1986; 21: 592-612.
32. Tenorio D, Cruchley A, Hughes FJ. Immunocytochemical investigation of the rat cementoblast phenotype. J Periodont Res 1993; 28 (6:PArt 1): 411-419.
33. Tenorio D, Foyle DM, Hughes FJ. The modulatory role of cementum matrix on osteoblastic cells in vitro. J Periodont Res 1997; 32: 362-374.
34. McCulloch CA, Nemeth E, Lowenberg B, Melcher AH. Paravascular cells in endosteal spaces of alveolar bone contribute to periodontal ligament cell populations. Anat Rec 1987; 219: 233-242.
35. King GN, King N, Cruchley AT, Wozney JM, Hughes FJ. Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects. J Dent Res 1997; 76: 1460-1470.
36. Talwar R, Di SL, Hughes FJ, King GN. Effects of carrier release kinetics on bone morphogenetic protein-2-induced periodontal regeneration in vivo. J Clin Periodontol 2001; 28: 340-347.
37. Kinoshita A, Oda S, Takahashi K, Yokota S, Ishikawa I. Periodontal regeneration by application of recombinant human bone morphogenetic protein-2 to horizontal circumferential defects created by experimental periodontitis in beagle dogs. J Periodontol 1997; 68: 103-109.
38. Graves DT, Kang YM, Kose KN. Growth factors in periodontal regeneration. Compend Suppl 1994; 18: S672-S677.
39. Graves DT, Cochran DL. Periodontal regeneration with polypeptide growth factors. Curr Opin Periodontol 1994; 178-186.
40. Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J et al Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004; 364: 149-155.
41. Bruder SP, Jaiswal N, Ricalton NS, Mosca JD, Kraus KH, Kadiyala S. Mesenchymal stem cells in osteobiology and applied bone regeneration. Clin Orthop Relat Res 1998; 355 Suppl: S247-S256.
42. Bruder SP, Kurth AA, Shea M, Hayes WC, Jaiswal N, Kadiyala S. Bone regeneration by implantation of purified, cultureexpanded human mesenchymal stem cells. J Orthop Res 1998; 16: 155-162.
43. Chang SC, Chuang H, Chen YR, Yang LC, Chen JK, Mardini S et al. Cranial repair using BMP-2 gene engineered bone marrow stromal cells. J Surg Res 2004; 119: 85-91.
44. Gafni Y, Turgeman G, Liebergal M, Pelled G, Gazit Z, Gazit D. Stem cells as vehicles for orthopedic gene therapy. Gene Therapy 2004; 11 417-426.
45. Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci USA 2000; 97: 13625-13630.
46. Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG et al. SHED: Stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci USA 2003; 100: 5807-5812.
47. Chang SC, Chuang H, Chen YR, Yang LC, Chen JK, Mardini S et al. Cranial repair using BMP-2 gene engineered bone marrow stromal cells. J Surg Res 2004; 119: 85-91.
48. Long S, Truong L, Bennett K, Phillips A, Wong-Staal F, Ma H. Expression, purification, and renaturation of bone morphogenetic protein-2 from Escherichia coli. Protein Expr Purif 2006; 46: 374-378.
49. Langenfeld EM, Calvano SE, bou-Nukta F, Lowry SF, Amenta P, Langenfeld J. The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells. Carcinogenesis 2003; 24: 1445-1454.
50. Uusitalo H, Rantakokko J, Ahonen M, Jamsa T, Tuukkanen J, KaHari V et al. A metaphyseal defect model of the femur for studies of murine bone healing. Bone 2001; 28: 423-429.
51. Lo LJ, Lin WY, Wong HF, Lu KT, Chen YR. Quantitative measurement on three-dimensional computed tomography: An experimental validation using phantom objects. Chang Gung Med J 2000; 23: 354-359.