In vitro transdifferentiation of adult hematopoietic stem cells: An alternative source of engraftable hepatocytes

Journal of Hepatology

Volumn 49, Issue 6, 2008, Pages 998-1007

  Khurana, Satish ^a   Mukhopadhyay, Asok ^a  

^a NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

Author keywords

Cytochrome p450; Engraftment; Gene expression; Hematopoietic stem cells; Hepatocytes; Transdifferentiation

Indexed keywords

ALBUMIN; CYTOCHROME P450; CYTOKERATIN 18;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL FUNCTION; CELL ORGANELLE; CELL SUBPOPULATION; CELL ULTRASTRUCTURE; ENGRAFTMENT; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIVER CELL; LIVER INJURY; LIVER TRANSPLANTATION; MICROENVIRONMENT; MICROVILLUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY;

ADULT STEM CELLS; ALBUMINS; ANIMALS; BONE MARROW CELLS; CARBON TETRACHLORIDE; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; HEMATOPOIETIC STEM CELLS; HEPATOCYTES; KERATIN-18; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION;

EID: 55549095112     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2008.05.019     Document Type: Article

References (36)

1. Fausto N., Campbell J.S., and Riehle K.J. Liver regeneration. Hepatology 43 (2006) S45-S53
2. Alison M. Liver stem cells: a two compartment system. Curr Opin Cell Biol 10 (1998) 710-715
3. Rhim J.A., Sandgren E.P., Degen J.L., Palmiter R.D., and Brinster R.L. Replacement of diseased mouse liver by hepatic cell transplantation. Science 263 (1994) 1149-1152
4. Muraca M., Gerunda G., Neri D., Vilei M., Granato A., Feltracco P., et al. Hepatocyte transplantation as a treatment for glycogen storage disease type 1a. The Lancet 359 (2002) 317-318
5. Lake J.R. Hepatocyte transplantation. New Eng J Med 338 (1998) 1422
6. Strain A.J., and Neuberger J.M. A bioartificial liver-state of the art. Science 295 (2002) 1005-1009
7. Lagasse E., Connors H., Al-Dhalimy M., Reitsma M., Dohse M., Osborne L., et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 6 (2000) 1229-1234
8. Jang Y., Collector M.I., Baylin S.B., Diehl A.M., and Sharkis S. Hematopoietic stem cells convert into liver cells within days without fusion. Nat Cell Biol 6 (2004) 532-539
9. Huiling X., Inagaki M., Arikura J., Ozaki A., Onondera K., Ogawa K., et al. Hepatocytes derived from peripheral blood stem cells of granulocyte-colony stimulating factor treated F344 rats in analbuminemic rat livers. J Surg Res 122 (2004) 75-82
10. Danet G.H., Luongo J.L., Butler G., Lu M.M., Tenner A.J., Simon M.C., et al. C1qRp defines a new human stem cell population with hematopoietic and hepatic potential. Proc Natl Acad Sci USA 99 (2002) 10441-10445
11. Wang X., Ge S., McNamara G., Hao Q., and Crooks G.M. Albumin-expressing hepatocyte-like cells develop in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic stem cells. Blood 101 (2003) 4201-4208
12. Avital I., Inderbitzin D., Aoki T., Tyan D.B., Cohen A.H., Ferraresso C., et al. Isolation, characterization, and transplantation of bone marrow-derived hepatocyte stem cells. Biochem Biophys Res Commun 288 (2001) 156-164
13. Miyazaki M., Hardjo M., Masaka T., Tomiyama K., Mahmut N., Medina R.J., et al. Isolation of bone marrow-derived stem cells line with high proliferation potential and its application for preventing acute fatal liver failure. Stem Cells 25 (2007) 2855-2863
14. Khurana S., and Mukhopadhyay A. Characterization of the potential subpopulation of bone marrow cells involved in the repair of injured liver tissue. Stem Cells 25 (2007) 1439-1447
15. Gilgenkrantz H. Mesenchymal stem cells: an alternative source of hepatocytes?. Hepatology 40 (2004) 1256
16. Lian G., Wang C., Teng C., Zhang C., Du L., Zhong Q., et al. Failure of hepatocyte marker-expressing hematopoietic progenitor cells to efficiently convert into hepatocytes in vitro. Exp Hematol 34 (2006) 348-358
17. Theise N.D., Badve S., Saxena R., Henegariu O., Sell S., Crawford J.M., et al. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology 31 (2000) 235-240
18. Schwartz R.E., Reyes M., Koodie L., Jiang Y., Blackstad M., Lund T., et al. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest 109 (2002) 1291-1302
19. Chien C.C., Yen B.L., Lee F.K., Laj T.H., Chen Y.C., Chan S.H., et al. In vitro differentiation of human placenta-derived multipotent cells into hepatocyte like cells. Stem Cells 24 (2006) 1759-1768
20. Fiegel H.C., Lioznov M.V., Cortes-Deticks L., Lange C., Kluth D., Fehse B., et al. Liver-specific gene expression in cultured human hematopoietic stem cells. Stem Cells 21 (2003) 98-104
21. Kakinuma S., Tanaka Y., Chinzei R., Watanabe M., Saito-Shimizu K., Hara T., et al. Human umbilical cord blood as a source of transplantable hepatic progenitor cells. Stem Cells 21 (2003) 217-227
22. Overturf K., Al-Dhalimy M., Ou C.N., Finegold M., and Grompe M. Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am J Pathol 151 (1997) 1273-1280
23. Tzanakakis E.S., Hsiao C.C., Matsushita T., Remmel R.P., and Hu W.S. Probing enhanced cytochrome p450 2B1/2 activity in rat hepatocyte spheroids through confocal laser scanning microscopy. Cell Transplant 10 (2001) 329-342
24. Michalopeulos G.K., and DeFrances M.C. Liver regeneration. Science 276 (1997) 60-66
25. Kamiya A., Kinoshita T., Ito Y., Matsui T., Morikawa Y., Senba E., et al. Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO J 18 (1999) 2127-2136
26. Kinoshita T., Sekiguchi T., Xu M., Ito Y., Kamiya A., Tsuji K., et al. Hepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis. Proc Natl Acad Sci USA 96 (1999) 7265-7270
27. Schmidt C., Bladt F., Goedcke S., Brinkmann V., Zschiesche W., Sharpe M., et al. Scatter factor/hepatocyte growth factor is essential for liver development. Nature 373 (1995) 699-702
28. Webber E.M., Wu J.C., Wang L., Merlino G., and Fausto N. Over expression of transforming growth factor-alpha causes liver enlargement and increased hepatocyte proliferation in transgenic mice. Am J Pathol 145 (1994) 398-408
29. Roskams T.J. Different types of liver progenitor cells and their niches. J Hepatol 45 (2006) 1-4
30. Lange K. Role of microvillar cell surfaces in the regulation of glucose uptake and organization of energy metabolism. Am J Physiol-Cell Physiol 282 (2002) 1-26
31. Chiba H., Sakai N., Murata M., Osanai M., Ninomiya T., Kojima T., et al. The nuclear receptor hepatocyte nuclear factor-4α acts as a morphogen to induce the formation of microvilli. J Cell Biol 175 (2006) 971-980
32. Courtois C., Morgan J.C., Campbell L.A., Fourel C., and Crabtree C.R. Interaction of a liver-specific nuclear factor with the fibrinogen and czl-antitrypsin promoters. Science 238 (1987) 688-692
33. Cereghini S., Blumenfeld M., and Yaniv M. A liver-specific essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells. Genes Dev 2 (1988) 957-974
34. Hardon E., Frain M., Paonessa G., and Cortese R. Two distinct factors interact with the promoter regions of several liver specific genes. EMBO J 7 (1988) 1711-1719
35. Costa R.H., Crayson D.R., and Darnell J.E. Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and a1-antitrypsin genes. Mol Cell Biol 9 (1989) 1415-1425
36. Sladek F.M. Hepatocyte nuclear factor 4 (HNF4). In: Tmnche F., and Yaniv M. (Eds). Liver gene transcription (1994), R.G. Landes Co., Austin, Texas 207-223